• 대한세포병리학회지
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• 제9권2호
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• pp.221-225
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• 1998

Malignant tumors of the breast with stromal multinucleated giant cells are rare entity of uncertain clinical significance. There have been few reports on the fine needle aspiration cytologic(FNAC) findings about these rare tumors. We report a FNAC case of invasive mammary carcinoma with osteoclast-like giant cells not only for its rare occurrence but in particular for its distinctive cytologic picture on aspirated material. The patient was a 40-year-old woman who presented with a right breast mass for one month. Mammography showed a well-demarcated rounded mass density without calcification. The aspirates of FNAC were highly cellular and two main cell types were seen; malignant epithelial cells and osteoclast-like multinucleated giant cells. The carcinoma cells occurred singly or arranged in loose clusters with ill-defined cytoplasm, oval nuclei, coarse chromatin and small but distinct nucleoli. The multinucleated giant cells showed variable number of nuclei with prominent nucleoli and abundant dense oxyphilic cytoplasm. The immunocytochemical studies suggested that osteoclast-like giant cells were not of epithelial origin, but rather of histlocytic origin.

• 한국식품영양과학회지
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• 제39권8호
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• pp.1107-1112
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• 2010

발아 전후 6종의 벼(일품벼, 백진주벼, 설갱벼, 고아미2, 거대배아벼 및 흑광벼)의 물 및 에탄올 추출물에 대한 암세포주 성장억제효과를 간암세포주(HepG2), 전립선암세포주(PC-3) 및 유방암세포주(MCF-7)에 대하여 살펴보았다. 물추출물은 1 mg/mL 농도에서 3종의 암세포주에 대하여 118.97~44.85% 범위의 높은 생존율을 보여 항암효과가 낮았지만 에탄올 추출물은 90.82~5.04% 범위의 생존율을 보여 물 추출물보다 높은 암세포 성장억제 효과를 나타내었다. 일품벼 발아 전후 에탄올 추출물은 간암세포주에 대하여 1 mg/mL 농도에서 각각 27.23 및 42.36%의 생존율을 보여 발아 시 항암효과가 증가하였으며, 특히 유방암세포주에 대해서는 0.25 mg/mL 농도에서 각각 48.20 및 56.82%의 생존율을 보여 다른 품종보다 성장억제율이 높았다. 또한 설갱벼발아 전후 에탄올 추출물은 전립선암세포에 대하여 1 mg/mL 농도에서 각각 44.52 및 64.51%의 생존율을 보여 발아 항암효과가 증가하였다. 추후 항암활성 물질의 분리 동정과 메커니즘 규명에 대한 연구가 수행되어야 할 것으로 판단된다.

• 대한세포병리학회지
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• 제18권1호
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• pp.69-73
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• 2007

Mammary carcinoma with osteoclast-like giant cells is an unusual neoplasm characterized by giant cells, mononuclear stromal cells, and hemorrhage accompanying a low grade carcinoma. We present the cytological findings in a case of invasive ductal carcinoma with osteoclast-like giant cells that was initially confused with a fibroadenoma, due to its well-demarcated and soft mass and the young age of the patient. A 28-year-old female presented with a 4.5 cm, well demarcated, soft and nontender mass in the right breast. Fine needle aspiration cytology (FNAC) showed a combination of low grade malignant epithelial cell clusters and osteoclast-like giant cells. The atypical epithelial cells were present in cohesive sheets and clusters. Osteoclast-like giant cells and bland-looking mononuclear cells were scattered. An histological examination revealed the presence of an invasive ductal carcinoma with osteoclast-like giant cells. We report here the cytological findings of this rare carcinoma in a very young woman. The minimal atypia of the epithelial cells and its soft consistency may lead to a false negative diagnosis in a young woman. The recognition that osteoclastlike giant cells are rarely present in a low grade carcinoma, but not in benign lesion, can assist the physician in making a correct diagnosis.