• Journal of the Korean GEO-environmental Society
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• v.15 no.12
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• pp.97-107
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• 2014

Settlement prediction has been conducted using Hyperbolic, Hoshino, and Monden methods, etc in the fields. These methods are only able to predict settlement after finishing the final filling stage. A new method is proposed to make up for such a weak point. This method was named as SPSFC (Settlement Prediction for Staged Filling Construction) method, which can be able to predict the settlement both the final filling stage and the staged filling from the initial filling stage in soft ground. To verify the applicability of the SPSFC method, firstly. The settlement predicted by the existed methods are compared with that obtained by the SPSFC method. The comparison results indicate the SPSFC has enough reliability to use for prediction of settlement. Secondly. by analyzing the settlement data measured during the initial filling stage, the soil parameters which need to predict the settlement are obtained by the SPSFC method. Then using the obtained soil parameters the time-settlement curve is predicted and compared. The predicted settlement is well matched with the measured one. From the study, the SPSFC method can be possible to predict settlement during the staged filling with only the initial settlement data.

• Journal of Acupuncture Research
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• v.27 no.6
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• pp.31-42
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• 2010

Objectives : The aim of this study was to investigate the anti-obesity potential and mechanisms of action of Rhizoma Atractylodis(RA) herbal acupuncture in high fat diet- induced obese ICR mice. Methods : Sample solutions for herbal acupuncture were prepared from the Rhizoma Atractylodis water extract powder at concentration of 150mg/kg and 300mg/kg with distilled water. Five week-old ICR mice acclimatized to the laboratory environment for 1 week were allocated into four groups: regular diet group (RD), high fat diet group(HFD), groups fed HFD with 150mg/kg RA herbal acupuncture treatment (RAE 150) and with 300mg/kg RA herbal acupuncture treatment(RAE 300). Herbal acupuncture groups were injected with either 150mg/kg or 300mg/kg of Rhizoma Atractylodis(RA) subcutaneously onto both Sinsu($BL_{23}$) alternately on the same time everyday for 30days. Body weight, gross appearance of epididymal fat area, blood glucose, insulin, insulin resistance(HOMA-IR), non-esterified fatty acid, cholesterol, triglyceride, AST, ALT, histological analysis of white adipose tissue, gene expression responsible for adipocyte differentiation and AMPK activation were analyzed. Results : RA herbal acupuncture inhibited the development of weight gain, hyperglycemia, hyperinsulinemia, hyperlipidemia, increases of AST and ALT, and the enlargement of fat cell size induced by HFD. Also, RA herbal acupuncture inhibited the expression of PPAR-${\gamma}$, C/$EBP{\alpha}$, aP2, LPL, FAS, SCD-1 and enhanced the activation of AMP-activated protein kinase. Conclusions : The results of this study demonstrate that RA herbal acupuncture can exert the anti-obesity effect and it is partially mediated by activation of AMPK and inhibition of the gene expressions responsible for adipocyte differentiation. Further studies will be required to ascertain the nti-obesity effect and mechanisms of action of RA herbal acupuncture in animal models and human for aclinical application.

• Composites Research
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• v.13 no.2
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• pp.30-39
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• 2000

It is difficult for civil engineer to apply composite materials of laminated type to structure for civil construction because of complicated theory although those have much merit. A simple method by which one can predict "exact" values of the natural frequency of vibration of laminated plates is presented. Many laminates with particular orientations have negligible values of $B_{16}$ and $B_{26}$ as the number of plies increases. Such laminates, with $D_{16}$ = $D_{26}$ ->0 can be solved by the same equation as for the special orthotropic laminates(1991,1995). If the quasi-isotrpic constants are used, It is possible to simplify analysis procedure since the equations for isotropic plates can be used. Use of some coefficients can produce "exact" values for laminates with such configuration. This coefficient, in fact, represents the effect of the anisotropy of the laminate. D. H. Kim proposed to use a correction factor, he developed, to produce "exact" solution out of the approximate solution obtained by using the quasi-isotropic constants(1995). In this paper, the fiber orienation studied is [$\alpha$/$\beta$/$\beta$/$\gamma$/$\alpha$/$\alpha$/$\beta$]r, with $\alpha$=-$\beta$, and $\gamma$${\gamma}$=$0^{\circ}$ or $90^{\circ}$ and the above-mentioned method is used to obtain the natural frequencies of plates with such orientations, and detailed result is presented for the use of engineers.nted for the use of engineers.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.5
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• pp.263-274
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• 2018

In this study, the applicability and external/internal stability of a MSEW abutment with a slab were investigated. Structural analysis of slab bridges between 10 ~ 20.0 m and thicknesses of 0.7 ~ 0.9 m was carried out to calculate the reaction forces due to dead and live loads acting on the bridge supports. The slab bridge with a length of 20.0 m satisfied the allowable contact pressure of 200 kPa for the true MSEW abutment. Because the external stability of the true MSEW abutment was dominated by the geometry of the MSE wall, the change in the factor of safety due to the load of the super-structure is small. Because the stiffness of the foundations is fixed and the load of the super-structure is increased, the factor of safety of the bearing capacity was reduced. As the load of the super-structure was increased, the horizontal earth pressure of the true MSEW abutment increased greatly. As a result, the pullout and fracture of the uppermost reinforcement, which are the factors of safety, did not meet the design criteria. Therefore, it is necessary to increase the pullout resistance and the long-term allowable tensile force of the reinforcement placed on the top of the reinforced soils to ensure efficient design and performance of a true MSEW abutment.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1994.04a
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• pp.82-87
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• 1994

자동차 엔진의 주기적인 연소과정 동아네 생성된 힘에 의해 엔진의 크랭크 샤프트에 회전 불균일성이 나타난다. 이것은 엔진 플라이휘일 부분에 비틀림 변동토크를 발생시키고, 이 토크는 클러치를 통하여 변속기의 인풋기어(input gear)에 전달되어 변속기에 비틀림 진동을 일으키는 주요 원인이 된다. 공회전시 변속기에서 기어의 충돌은 주로 이 비틀림 변동토크에 의해 발생하며, 이 충돌은 차내 소음의 원인이 된다. 또한 엔진의 경량화 및 고출력화에 따른 회전수 변동의 증가는 비틀림 변동토크를 증가시켜 변속기에 커다란 진동을 초래한다. 시뮬레이션을 사용한 클러치 비틀림 기구의 적절한 특성치를 구하는 것은 클러치 설계에 효율적이고, 이미 여러 연구 결과들이 보고되었다. H.Arai은 2자유도 비선형 모델을 사용하여 클러치 접속시 발생하는 외란과 계의 안정성을 고려하여 치타음 저감을 위한 시뮬레이션을 수행하였고, S.Ohnuma은 비선형 2단 비틀림 특성을 가진 클러치 디스크의 설계에 대해서, 그리고, T.Fujimoto와 R.J.Comparin는 치타음의 발생구조와 특성을 고찰하고 비선형 비틀림 공진 저감에 의한 치타음 저감 기법에 대하여 연구하였다. 그리고, Wu Hui-Le는 자동차 동력전달계의 비틀림 진동 현상을 실험과 이론적인 계산을 통해 연구하였고, G.J.Fudala는 다자유도 모델을 이용하여 클러치의 비틀림 특성에 따라 주파수분석을 수행하여 치타음 저감 방법을 연구하였다. 또한, T.Sakai는 5자유도 모델을 이용하여 엔진 공회전시 발생하는 치타음에 대해 이론과 실험을 통해 해석하고, 엔진 회전수 변동, 클러치 특성, 변속기의 드래그(drag) 토크의 영향과 치타음 저감을 위한 개선된 클러치 특성을 제시하였다. 클러치는 동력을 전달 또는 차단하는 기능 뿐만 아니라 엔진이나 변속기에서 발생하는 소음이나 진동을 저감시키는 기능을 가지고 있다. 따라서 엔진 공회전시에 발생하는 치타음(rattle noise)이나 비틀림 진동을 저감시키는 방법으로는 여러가지가 있으나 클러치 디스크(clutch disc)의 비틀림 기구의 설계 인자들을 적절히 조절함으로써 변속기의 인풋기어에 전달되는 비틀림 진동을 저감시키는 방법이 일반적으로 수행되어지고 있다. 본 연구는 4 실린더 4 싸이클 1.5L 엔진을 장착한 경승용차의 실차실험을 통해 공회전시 엔진 플라이휘일과 인풋기어에서의 회전수 변동을 측정하고, 이 실험 데이타를 기초로 하여 엔진 토크 및 변속기에서의 드래그 토크를 계산하여 엔진-변속기 인풋기어의 반한정계 2자유도 진동모델과 비틀림 특성을 가진 클러치 디스크의 프리댐퍼 영역에 대해 시뮬레이션을 수행하여 클러치 비틀림 기구의 설계인자인 비틀림 강성, 히스테리시스 토크에 따른 비틀림 진동 저감 효과를 연구하고자 한다.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.5
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• pp.1066-1072
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• 2005

The effects of La concentration in PLZT (z/30/70) thin film prepared by sol-gel method are investigated for the NVFRAM application. As the La concentration increases, the dielectric constants at 10 kHz increase from 450 to 600, while the loss tangent and the leakage current density at 100 kV/cm decrease from 0.075 to 0.025 and from $5.83{\times}10^{-7}\;to\;1.38{\times}10^{-7}\;A/cm^2,$ respectively. In the results of hysteresis loops measured at 175 kV/cm, the remanent polarization and the coercive field decrease from 20.8 to $10.5{\mu}C/cm^2$ and from 54.48 to 32.12 kV/cm, respectively, with the increase of La concentration from 0 to $10mol\%.$ After applying for $10^9$ cycles of square pulses with ${\pm}5V$ height, the remanent polarization of the PLZT (10/30/70) thin film decreases $40\%$ from the initial state, while that of the PLZT (10/30/70) thin film decreases $64\%.$.

• Korean Journal of Microbiology
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• v.39 no.4
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• pp.216-222
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• 2003

Human caspase-9, an essential apoptosis initiator protease, was excessively degraded when expressed in Escherichia coli under the conventional induction condition. To optimize the conditions for induction and develop a rapid purification method for obtaining significant amounts of wild-type procaspase-9, we expressed procaspase-9 as GST fusion in E. coli. The addition of 0.01 mM IPTG as an inducer to the bacterial culture and decreasing the culture temperature to 25oC improved the production of procasapse-9 protein by circumventing proteolytic degradation in E. coli. The wild-type procaspae-9 was purified to approximately 70% purity with relatively high yields using the method developed in this study. In addition, we found that GST-caspase-9 is autocatalytically cleaved after aspartic acid 315, which is the same site for processing in mammalian cells, during expression in E. coli.

• Journal of Acupuncture Research
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• v.17 no.2
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• pp.169-186
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• 2000

To study anti-cancer effect and molecular biological mechanism of bee venom for aqua-acupuncture, the effects of bee venom on cell viability, apoptosis, and cell cycle were analyzed using MTT assay, tryphan blue assay, [3H]thymidine release assay, flow cytometric analysis, activity of caspase-3 protease activity assay, and immunocytometric analysis of PCNA. To explore whether anti-cancer effects of bee venom are associated with the transcriptional control of gene expression, quantitative RT-PCR analysis of apoptosis- and cell cycle-related genes was performed. The obtained results are summarized as follows: 1. The MTT assay demonstrated that cell viability was decreased by bee venom in a dose-dependant manner. 2. Significant induction of apoptosis was identified using tryphan blue assay, [$^3H$]thymidine release assay, and flow cytometric analysis of sub $G_1$ fraction. 3. In analysis of caspase-3 protease activity, the activity had increased significantly, in a dose-dependant manner. 4. Quantitative RT-PCR analysis of the apoptosis-related genes showed that Bcl-2 and $Bcl-X_L$ were down-regulated whereas Bax was up-regulated by bee venom treatment. 5. In flow cytometric analysis of cell cycle and immunocytometric analysis of PCNA expression, cell numbers of $G_1$ phase was increased by a dose-dependant manner. 6. In quantitative RT-PCR analysis of the cell cycle-related genes, p21, p27, and p57 were increased, while Cyclin D1, CDK4, c-Myc, c-Fos, and Histone H3 were decreased. In contrast, there were no remarkable changes in expression levels of CDC2 and c-Jun.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.561-567
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• 2018

This study was carried out to improve the ride quality of high-speed electric multiple unit. Through dynamic analysis of the HEMU-430X, the range of the equivalent conicity with a critical speed of 300 km/h was between 0.05 and 0.25. The initial adopted wheel profile of HEMU-430X was S1002. The equivalent conicity of S1002 with the mileage of more than 40,000 km was about 0.033 and it was confirmed that XP55 is more suitable for stable operation because XP55 has the equivalent conicity of over 0.061. In order to improve ride quality of high-speed electric multiple unit, the change of installation angle of the yaw damper was suggested from $7.35^{\circ}$ to $0^{\circ}$. From sensitivity analysis and optimization, the air spring lateral and vertical stiffness was suggested to be reduced by 30% and the secondary vertical and lateral damper damping coefficient was increased by 50%. By applying this, it was expected that the car body acceleration could be improved by about 20% on average. The HEMU-430X's yaw damper installation angle was changed to $0^{\circ}$ and the damping coefficient of the lateral damper was increased by 30%. When the test run was carried out at the speed of 300 km/h on the Kyungbu high-speed line, the vehicle lateral acceleration had improved by 34.3%. The effect of additional improvement measures proposed in this paper will be tested in the on track test. The riding quality improvement process used in this study can be used to solve ride quality problems that can occur in commercial operation of high-speed electric multiple unit in the future.

• Journal of Gastric Cancer
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• v.7 no.4
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• pp.185-192
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• 2007

Purpose: RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer. In the present study, we examined the pattern of RUNX3 expression in gastric cancer cells from gastric cancer specimens and the impact of its alteration on clinical outcome. Materials and Methods: A total of 124 samples of both gastric cancer and normal tissue were obtained from 124 patients who underwent curative gastrectomy at the Seoul Medical Center from January 2001 to December 2005. RUNX3 expression was determined by immunohistochemical staining, and the results were analyzed. Statistical analysis wabased on clinicopathological findings and differences in survival rates. Results: The mean age of the patients was 61 years, and the male:female ratio was 1.9:1. The expression rate of RUNX3 was 59.7% (74/124). The expression rate was higher in differentiated gastric cancers (nucleus: 9.1%, cytoplasm: 57.6%) than in the undifferentiated types (nucleus: 5.2%, cytoplasm: 46.6%) (P=0.133). The 5-year survival rates according to RUNX3 expression determined from cancer tissue were 88.9% for the nucleus $\pm$ cytoplasm(+) group of patients, 76.1% for the cytoplasm only (+) group of patients, and 65.3% for the RUNX3 negative expression group of patients (P=0.626). Only UICC TNM staging showed statistical significance related to the survival rate, as determined by multivariate analysis. Conclusion: The RUNX3 expression rate was higher in differentiated gastric cancer than in the undifferentiated types without significance. Although RUNX3 expression predicted better survival, based on multivariate analysis, the finding was not statistically significant. More cases should be further evaluated.