• Journal of Applied Biological Chemistry
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• v.55 no.2
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• pp.109-115
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• 2012

The aim of this study was to determine hepatoprotective effects of pig placenta hydrolysates (PLA) on liver damage-induced rats. Sprague Dawley rats were subcutaneously injected with carbon tetrachlorides and divided into 4 groups: negative control (DMSO treated), two PLA treated groups, low dosage of PLA (LPLA; 300 mg/kg body weight) and high dosage of PLA (HPLA; 1000 mg/kg body weight), and silymarin treated group (80 mg/kg body weight). Rats in each group orally received assigned compounds for 3 weeks. For the normal control group vehicle (corn oil) was injected. After 3 weeks, liver and spleen weights were greater in the two PLA and silymarin groups than the negative control group. After bromosulfalein (BSP) treatment, the clearance rates were in the descending order of negative control > LPLA > HPLA = silymarin and serum BSP levels exhibited the opposite trends of the clearance rates. Serum levels of aspartate aminotransferase, alanine aminotransferase, triglyceride, and cholesterol lowered with PLA in a dose-dependent manner. The decrease with HPLA was similar to that with silymarin. In addition, triglyceride, cholesterol, lipid peroxides levels in the liver decreased in HPLA and silymarin compared to the negative control. The liver morphometry was improved in HPLA- or silymarin-treated rats in comparison to the negative control. In conclusion, HPLA administration ameliorated the hepatotoxicity as much as silymarin in rats injected with carbon tetrachlorides.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.6
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• pp.965-972
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• 2004

In the present study, it is observed that Monascus diet may have a hepatoprotective effect on the liver damage induced by bromobenzene in rats. By treatment with bromobenzene (400 mg/kg, i.p.) once a day for 3 consecutive days, the liver damage was reduced in rats fed 2% Monascus diet, based on the liver functional and histopathological findings. Furthermore, retreatment of bromobenzene to the animals with damaged liver showed higher decreasing rate of hepatic glutathione content and increasing rate of cytochrome P450 dependent aniline hydroxylase activity at 4 h in rats fed 2% Monascus diet than those fed STD diet, and V$_{max}$ in glutathione S-transferase was higher in liver of rats fed 2% Monascus diet than those fed STD diet. On the other hand, activities of antioxidant enzymes such as hepatic glutathione S-transferase, catalase and superoxide dismutase were generally higher both in bromobenzene and 2% Monascus diet treated group than those fed STD diet. In conclusion, the rats fed 2% Monascus diet showed lower liver damage than those fed STD diet, which may be due to the acceleration of bromobenzene metabolism and detoxication of oxygen free radicals.s.

• Journal of the Korean Applied Science and Technology
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• v.37 no.5
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• pp.1078-1087
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• 2020

The current study was carried out to investigate the effect of oral administration for 30 days of the Jijang kimchi extracts on prevention of diabetes, alcoholic liver injury and reduction of blood lipids in laboratory rats with alcoholic liver injury and diabetes induced by streptozotocin. In a diabetic model animals, the blood lipid profile, ALT, and AST levels were lower in kimchi extract groups compared to DC (diabetes control) group, and blood glucose level of DCJK (DC+oral administration with Jijang kimchi extracts) group was lower than that of DCCK (DC+oral administration with commercial kimchi extracts) group. Insulin levels were increased in order of NC (normal control), DCJK > DCCK > DC groups. In alcoholic liver injury model animals, ALT, AST and bilirubin were lowed in order of AC (alcohol group received 1 bottle of soju) > ACCK (1 bottle of soju plus oral administration with commercial kimchi extracts) ACJK (AC plus oral administration with Jijang kimchi extracts) > NC groups. In the clinical pathologic findings of liver tissue, AC group was severely injured, and tended to be improved in groups eating a 1 bottle of soju plus oral administration with kimchi extracts, especially Jijang kimchi extract group. The results suggest that eating Jijang kimchi can improve insulin secretion ability while lowering blood lipid profile, blood sugar and ALT, AST, and bilirubin levles in diabetic and alcoholic liver injury model animals.

• The Journal of Internal Korean Medicine
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• v.44 no.4
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• pp.751-756
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• 2023

Objective: This study attempts to increase awareness of hepatotoxicity caused by antipsychotic drugs and to provide updated information on drug-induced liver injury (DILI) to physicians in Korean medicine (KM) clinics. Methods: This study presents a detailed case of a female patient diagnosed with DILI attributed to antipsychotic drugs, highlighting the improvement observed through laboratory findings. Results: A 56-year-old female patient with underlying disorders, including mixed connective tissue disease and depression, was under medical care. One day, she reported experiencing intense fatigue and distressing sensations, prompting the author to order blood tests. The levels of AST and ALT were significantly elevated by more than 2.5-fold, indicating hepatocellular DILI. The RUCAM score for antipsychotic drugs was 9, as no other medications, including herbal medicine, were being taken. Upon discontinuation of the antipsychotic drugs, the patient's laboratory findings returned to normal levels within 2 weeks, accompanied by a recovery of subjective symptoms. Conclusion: This study presents a noteworthy case of hepatotoxicity caused by antipsychotic drugs, serving as an illustrative example that highlights the crucial need for awareness among doctors of KM in clinical settings.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.20 no.3
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• pp.229-237
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• 2007

In this study, an artificial neural network (ANN)-based damage detection algorithm using acceleration signals is developed for real-time alarming locations of damage in beam-type structures. A new ANN-algorithm using output-only acceleration responses is designed tot damage detection in real time. The cross-covariance of two acceleration-signals measured at two different locations is selected as the feature representing the structural condition. Neural networks are trained lot potential loading Patterns and damage scenarios of the target structure for which its actual loadings are unknown. The feasibility and practicality of the proposed method are evaluated from laboratory-model tests on free-free beams for which accelerations were measured before and after several damage cases.

• The Academic Congress of Korean Shoulder and Elbow Society
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• 1995.05a
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• pp.7-7
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• 1995

최근에 스키가 동계스포츠로 각광받으면서 스키인구가 폭발적으로 증가함에 따라 스키손상도 많이 발생하게 되어 스키손상은 스포츠외상에서 중요한 비중을 차지하게 되었다. 스키인구의 증가에 따라 스키손상에 대한 정확한 분석과 이에 대한 예방대책이 절실히 요구되며 이에 경희대학교 의과대학 정형외과학 교실에서는 1982년 12월부터 1995년 3월까지( 1986년과 1987년을 제외 ) 11년간 용평스키장내에 동계스포츠클리닉을 개설하여 상기 기간 중 내장한 총 스키인구 3,093,667명중 스키손상으로 동계스포츠클리닉에 내원한 7,172명의 환자$(0.23\%)$에 대하여 스키손상의 년도별 발생빈도, 스키손상의 특징 스키골절과 탈구의 발생빈도 및 특징 등에 대하여 11년 간의 변화추세를 분석하였다. 11년 간의 스키장의 내장객수는 1983년을 기준 (83,100)으로 하였을 때 1995년에 $977\%로 국부 큰 증가를 보였으며, 스키인구 1000명당 손상율은 1983년의 3.4에서 1995년의 1.4(평균 2.3)로 감소하는 추세를 보였다. 스키손상의 형태는 단순열상 및 타박상등을 제외하고 슬관절 인대손상이 $22.6\%로 가장 많이 발생하였으며, 조사기간동안 수치상의 의미 있는 변화는 없었다. 스키골절 및 탈구는 스키인구 1000명당 평균 0.35였으며, 1983년의 0.90으로부터 점차 감소하여 1995년에는 0.21에 이르렀다. 연령별 스키골절 및 탈구는 20세 이하에서 평균 $41.6\%로 전체적으로 성인에서 더 많이 발생하였으며, 이는 처음 3년 간 20세 이하 골절 및 탈구가 $70.5\%로 높은 발생빈도를 보였으나 1995년도의 20세 이하 골절 및 탈구가$30.3\%까지 감소하게되어 년도가 증가함에 따라 청장년 층에 비하여 소아골절 및 탈구가 전체적으로 감소하는 경향을 보였다. 스키골절의 부위별 발생빈도는 1990년 이전까지 하지골절 및 탈구가 많았으나 이후 점차 상지의 골절 탈구가 증가하였다 하지에서 가장 많은 골절은 경골 골절이었으며, 경골골절은 회전력에 의한 나선형골절이 $76.5\%로 가장 많았고 년도에 따른 변화는 보이지 않았다. 스키손상의 발생빈도는 초기에 비하여 점차 감소하는 경향을 보였으며, 손상의 특성도 부위별, 연령별로 다양한 변화를 나타내었다.

• Journal of Nutrition and Health
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• v.48 no.5
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• pp.390-397
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• 2015

Purpose: In this study, we investigated the effects of chronic alcohol and excessive iron intake on mitochondrial DNA (mtDNA) damage and the progression of alcoholic liver injury in rats. Methods: Twenty-four Sprague-Dawley male rats were divided into four groups (Control, EtOH, Fe, and EtOH + Fe), and fed either control or ethanol (36% of total calories) liquid diet with or without 0.6% carbonyl iron for eight weeks. Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, liver malondialdehyde concentrations were measured by colorimetric assays. Liver histopathology was examined by Hematoxylin-eosin staining of the fixed liver tissues. The integrity of the hepatic mtDNA and nuclear DNA was measured by long-range PCR. The gene expression levels of cytochrome c oxidase subunit 1 (Cox1) and NADH dehydrogenase subunit 4 (Nd4) were examined by real-time PCR. Results: Serum ALT and AST activities were significantly higher in the EtOH+Fe group, as compared to the Control group. Similarly, among four groups, liver histology showed the most severe lipid accumulation, inflammation, and necrosis in the EtOH + Fe group. PCR amplification of near-full-length (15.9 kb) mtDNA showed more than 50% loss of full-length product in the liver of the EtOH + Fe group, whereas amounts of PCR products of a nuclear DNA were unaffected. In addition, the changes in the mtDNA integrity showed correlation with reductions in the mRNA levels of mitochondrial gene Cox1 and Nd4. Conclusion: Our data suggested that the liver injury associated with excessive iron and alcohol intake involved mtDNA damage and corresponding mitochondrial dysfunction.

• Biomedical Science Letters
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• v.5 no.1
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• pp.51-58
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• 1999

To evaluate an effect of liver damage on the dermal oxygen free radical metabolizing enzyme activities, the $CCl_4$ (0.1 ml/ 100 g body wt., 50% $CCl_4$ in olive oil) was intraperitoneally given to the rats every other day for 2 weeks. Based on the histopathological findings, liver weight (%), serum alanine aminotransferase, xanthine oxidase activities and hepatic lipid peroxide contents, the animals were induced severe liver damage. In the present liver damaged animal, all the activities of dermal scavenging enzymes such as superoxide dismutase, catalase and glutathione peroxidase were significantly decreased compared with central. And under the cytochemical electron microscopy the more coarse granules of cerrous perhydroxide were found compared with the control. In conclusion, the $CCl_4$-induced liver damage may influence upon the activities of some dermal oxygen free radical scavenging enzymes.

• Proceedings of the Korean Institute of IIIuminating and Electrical Installation Engineers Conference
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• 2005.05a
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• pp.311-318
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• 2005

이 논문은 다른 종류의 유도전동기 구름베어링 손상을 유도전동기 고정자 전류신호해석을 통하여 검출하고 실시간으로 손상을 진단하는 알고리즘을 개발하였다. 유도전동기 구름베어링의 손상을 검출하기 위하여 정상적인 베어링을 갖는 유도전동기, 축정열에 불량을 가지고 있는 전동기와 베어링 외륜에 구멍을 가지고 있는 2가지 종류의 비정상 베어링을 갖는 유도전동기 3set를 실험시스템을 구축하였다. 또한 유도전동기의 구름베어링시스템의 비정상적인 상태에서 고정자전류을 검출하기 위하여 TMS320F2407 DSP 칩을 이용하여 데이터 획득보드를 개발하였다. 이 고정자전류신호를 해석을 통하여 베어링 손상을 검출하기 위한 방법으로 FPT, 웨이브렛 분석 및 내적에 의한 평균신호패던에 의한 분석결과를 제시하였다. 특히 내적에 의한 신호분석을 통하여 베어링 손상 여부를 실시간으로 진단할 수 있는 새로운 알고리즘과 분석방법을 제시하였다.

• KIISE Transactions on Computing Practices
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• v.24 no.2
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• pp.59-66
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• 2018

In this paper, we propose a system to detect various damage automatically inflicted on road pavement by collecting and analyzing data from acceleration and camera sensors in real time. The proposed system sends the collected images, acceleration signals, and GPS coordinates to the road manager and the database in the remote server, shortly after detecting the damage to the road pavement. Our study makes three key contributions. The proposed system 1) enables road managers to maintain road conditions quickly, accurately, and conveniently; 2) allows road mangers to take care of various kinds of damage to the road pavement at the initial stage; and finally 3) even makes it possible to track the damage, which suggests that the integration of a high-level decision support function becomes affordable. We tested the sensitivity and precision of the proposed system against real-time data obtained from the vehicles driving on the highway at an average speed of 100 km/h. With ten iterations, the proposed system achieved an average sensitivity of 74% and an average precision of 84% in road pavement damage detection, which is comparable with the best competing schemes.