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http://dx.doi.org/10.12925/jkocs.2020.37.5.1078

Protective effects of Jijang-kimchi extracts on diabetes mellitus and alcoholic liver injury in laboratory rats  

Kim, Chang-Hyu (School of Animal Life Convergence Science, Hankyong National University,)
Park, Byung-Sung (College of Animal Life Sciences, Kangwon National University)
Um, Kyung-Hwan (College of Animal Life Sciences, Kangwon National University)
Publication Information
Journal of the Korean Applied Science and Technology / v.37, no.5, 2020 , pp. 1078-1087 More about this Journal
Abstract
The current study was carried out to investigate the effect of oral administration for 30 days of the Jijang kimchi extracts on prevention of diabetes, alcoholic liver injury and reduction of blood lipids in laboratory rats with alcoholic liver injury and diabetes induced by streptozotocin. In a diabetic model animals, the blood lipid profile, ALT, and AST levels were lower in kimchi extract groups compared to DC (diabetes control) group, and blood glucose level of DCJK (DC+oral administration with Jijang kimchi extracts) group was lower than that of DCCK (DC+oral administration with commercial kimchi extracts) group. Insulin levels were increased in order of NC (normal control), DCJK > DCCK > DC groups. In alcoholic liver injury model animals, ALT, AST and bilirubin were lowed in order of AC (alcohol group received 1 bottle of soju) > ACCK (1 bottle of soju plus oral administration with commercial kimchi extracts) ACJK (AC plus oral administration with Jijang kimchi extracts) > NC groups. In the clinical pathologic findings of liver tissue, AC group was severely injured, and tended to be improved in groups eating a 1 bottle of soju plus oral administration with kimchi extracts, especially Jijang kimchi extract group. The results suggest that eating Jijang kimchi can improve insulin secretion ability while lowering blood lipid profile, blood sugar and ALT, AST, and bilirubin levles in diabetic and alcoholic liver injury model animals.
Keywords
Kimchi; rat; diabetes; alcoholic liver; blood biomarkers; insulin; liver pathology;
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