• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.2
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• pp.207-212
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• 2001

Purpose: Mycoplasma pneumoniae infection is relatively common in childhood. Its extrapulmonary manifestations have been reported so much, but hepatitis associated with it has not been studied yet until now in Korea. Methods: We performed the prospective study of 19 cases that had AST and ALT>50 IU/L respectively without evidence of hepatitis A, B, C, cytomegalovirus, and Ebstein-Barr virus infections amongst 143 patients with M. pneumoniae pneumonia who were admitted to the Department of Pediatrics, Seoul Red Cross Hospital from Jan. 1999 to Dec. 2000. Results: 1) Hepatitis occurred in 13.3% of Mycoplasma pneumoniae infection, especially in fall and winter times. The average age was 4.86 years and male to female ratio was 2.2:1. 2) Vomiting was developed in 21.1%, diarrhea in 36.8%, and hepatomegaly in 21.1%, respectively. And leukocytosis was noted in 21.1%, eosinophilia in 15.4%, anemia in 10.5%, and thrombocytosis in 5.3%, respectively. The average level of C-reactive protein was $6.34{\pm}4.82$ mg/dl. 3) There was no hyperbilirubinemia, but hypoalbuminemia was detected in 42.1%. The average serum levels of AST and ALT were $214.05{\pm}183.22$ IU/L and $284.16{\pm}286.84$ IU/L, respectively. 4) Chest radiology showed lobar or lobular consolidation in 73.7%, bronchial infiltration in 26.3%, and pleural effusion in 31.6%. 5) The average length of hospitalization was 7.9 days, and the average length of normalization of serum transaminases was 8.8 days. All patients recovered within 2 weeks completely. Conclusion: The prognosis of M. pneumoniae hepatitis is good. However, its incidence is not so low that liver function should be considerately checked in case of M. pneumoniae infection.

• Clinical and Experimental Pediatrics
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• v.48 no.1
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• pp.104-107
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• 2005

Choledochal cyst is considered to be congenital anomalies of the biliary tract, characterized by varying degrees of cystic dilatation at various segments of the biliary tract. A 20-month-old girl was admitted to Eul-Ji general hospital because of abdominal distension. Physical examination revealed marked splenomegaly and hepatomegaly with nodular surface and hard consistency. Laboratory examination showed elevated transaminase level, alkaline phosphatase level and gamma glutamyltranspeptidase level without evidence of cholestasis. Diagnostic imaging study revealed choledochal cyst with Todani classification type 1. Cholecystectomy and Roux-en-Y choledochojejunostomy was performed, and wedge liver biopsy showed diffuse periportal fibrosis with cirrhotic change and ductular proliferation in the portal area. After operation, hepatosplenomegaly and abnormal laboratory examinations improved rapidly, and in 9 months, the liver and spleen became not palpable. We experienced a case of choledochal cyst complicated by liver cirrhosis on pathology in a 20 month-old girl, and removal of choledochal cyst improved clinical manifestations rapidly.

• 대한핵의학회:학술대회논문집
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• 1967.11a
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• pp.102.2-102.2
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• 1967

• Research in Community and Public Health Nursing
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• v.19 no.2
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• pp.234-246
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• 2008

Purpose: This study was performed in order to examine the effects of an smoking cessation counselling program for smoking cessation success. Method: Among a total of 468 persons who had ceased from smoking for 6-months and had visited the smoking cessation clinic of a public health center from January 2nd to December 31th in 2006, 61 in all who had a negative reaction in the urine nicotine check were selected for this study. Collected data were expiratory CO concentration, BMI, blood pressure, liver function, and lipid metabolism. These data were analyzed by descriptive statistics, repeated measured ANOVA and paired t-test with the SPSS/PC(Version 12.0) program. Result: There were significant changes in expiratory CO concentration, SBP, DBP, AST, ALT, and TG, but not in BMI, $\gamma$-GTP, TC, HDL-C, and LDL-C. Conclusion: This study showed that smoking cessation through a smoking cessation counselling program has partially positive effects for smoking cessation success. The results of this study show that the smoking cessation counselling program at the smoking cessation clinic of a public health center should be continued for smoking cessation success.

• Parasites, Hosts and Diseases
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• v.31 no.1
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• pp.71-74
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• 1993

A 43-year-old Korean woman with billary ascariasis accompanied by cholellthiasis is reported. Her chief complaints were abdominal pain, nausea, and vomiting. She had the past history of several attacks of abdominal pain in her childhood. ciliary stones were recovered from the left hepatic duct after cholecystectomy, which contained degenerated cuticle or body wall, and numerous eggs of Ascaris lumbriooides. It is strongly suggested that the ciliary stones were formed from the dead Ascmis worm(s). This is a rare case of biliary ascariasis during the recent 5 years in Korea.

• Korean Journal of Biological Psychiatry
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• v.2 no.1
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• pp.100-106
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• 1995

Antibodies to hepatitis C drew attention because of high morbidity to chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV was known to be transmitted by transfusion, sexual behavior and parenteral drug use. However, some kind of autoimmune mechanism was suggested to be involved in the genesis of HCV-induced liver diseases. We hypothesized the prevalence of having anti-HCV might be higher in psychiatric patients rather than general population because of the characteristic route of transmission. Using Abbott HCV BA kit, anti-HCV was detected in the sera of 113 psychiatric inpatients from early December in 1992 to late May in 1994. The Positivity of anti-HCY was significantly(P<0.05) higher among psychiatric inpatients(10.6%) than in healthy controls(3.0%). There were no disease specificity among psychiatric inpatients who had anti-HCV, though alcoholics tended to have more anti-HCV. We couldn't find any significant correlation of anti-HCV with age, seasons of birth, lymphocytes (%) and liver function.

• Radiation Oncology Journal
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• v.3 no.2
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• pp.163-168
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• 1985

Intraocular melanoma is the most common primary occular malignancy in adult above the age of 20. Before treatment of intraocular melanoma, it is essential to do complete work-ups including LFT (LDH, SGPT), chest X-ray, whole body bone scan. Also, liver-spleen and brain scan will be done if clinically indicated. Though, malignant melanoma is radioresistant, however, show rapid tumor shrinkage after irradiation with total tumor dose of 7,000 to 8,000 rads in 7-8 weeks.

• Journal of Yeungnam Medical Science
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• v.7 no.1
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• pp.121-126
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• 1990

Halothane is usually a safe and effective inhalation anesthetic agent but it rarely has damaged liver. The authors selected 11 patients who had HBsAg positive and increased SGOT, SGPT at Yeungnam university hospital. Their physical status was ASA class 1 and 2. They had no previous history of operation or liver disease. The liver function tests were performed before surgery, and on 3rd, 7th and 10th postoperative days. The result were as follows : 1) The values of SGOT and SGPT were gradually increased on 3rd postoperative day and markedly increased on the 7th and 10th postoperative day 2) Alkaline phosphatase, total protein, albumin, total bilirubin and direct bilirubin were not significantly changed.

• Journal of Preventive Medicine and Public Health
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• v.21 no.2 s.24
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• pp.329-339
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• 1988

The study is carried out to investigate the effect of drinking and smoking for the activities of aspartate aminotransferase(AST, or GOT) and alanine aminotransferase(ALT or GPT), from December 25, 1986 to April 30, 1987. The male physical examinees for employment, 900 who had visited to the Taegu Medical Center were subjected. And the positive cases of HBs-Ag, Anti-HBs and skin test for Clonorchis sinensis were excluded. The general characters of drinking and smoking pattern were introduced by interview with questionnaire provided for. In drinking cases, the longer duration was significantly effected the higher rate of abnormality in AST and ALT level. But the amount and the frequency were not. It was not appeared effects by mackgulri which is a Korean traditional wine and small amount of beers. In smoking cases, also same pattern. The age was related in all cases. By the way, when the effect is related the positive results with other factors: HBs-Ag, Anti-HBs, skin test for Clonorchiasis and harmful occupational history, it is higher abnormal rate of AST and ALT in the duplicated cases with two factors or more. Particularly in HBs-Ag positive cases, those who had smoking was the highest in rate of abnormality, and drinking was the follows. In correlation matrix among seven factors; HBs-Ag, age, drinking amount, drinking period, drinking frequency, smoking amount and smoking period, correlation coefficient was significant between the abnormal rate and to with age, drinking period, smoking period, and smoking amount.

• Parasites, Hosts and Diseases
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• v.32 no.3
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• pp.177-184
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• 1994

Nine rabbits were fed with Clonorchis sinenis metacercariae (MC) and the blood samples chronologically obtained were analyzed biochemically. Rabbits Infected by less than 100 flukes were grouped into Group I, and by 100-250 flukes into Group II. The serum level of alanine amlnotransferase (ALT) was increased from 3 weeks after the Infection of the metacercariae (AIM) and showed a peak at 8 weeks, and decreased from 12 weeks ASM. The serum level of aspartate aminotransferase (AST) was raised to $92.3{\;}{\pm}{\;}65.4{\;}U/L$ at 3 weeks AIM and stayed high until 8 weeks, then lowered thereafter. The serum level of ${\gamma}-glutamyl$ transpeptidase (${\gamma}-GT$) was increased rapidly to the highest value ($18.9{\;}{\pm}{\;}14.6{\;}U/L$) at 16 weeks ASM, and decreased to the control level after 20 weeks. The serum level of alkaline phosphatase (ALP) was headed down from the early infection to 52 weeks AIM. The serum cholesterol level was increased from 8 weeks and reached at a peak 16 weeks AIM, and decreased thereafter to the control level. It is suggested that serum ALT, AST, ALP and ${\gamma}-GT$ tests be useful to diagnose the early infEction of C. sinensis.