• Journal of Korean Ophthalmic Optics Society
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• v.11 no.2
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• pp.109-114
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• 2006

We evaluated the contour using corneal asphericity of the myopic cornea in Korea and investigated the relationship between refractive error and other ocular dimensions in Korean myopia, including anterior chamber depth and asphericity. The monoocular asphericity value of 50 myopes with $-4.83{\pm}2.38$ D between early 20 age and early 30 age in adult was included. Cycloplegic refraction, corneal asphericity and anterior chamber depth using corneal topography were examined. The mean asphericity values were$-0.27{\pm}0.13$ and the corneas of 96.0% were prolate ellipse. Refractive error was related to asphericity and anterior chamber depth among myopes. However, asphericity only were significant difference in high and low myopia group. Corneal configuration on the contact lens fits are discussed. We think that the longitudinal study for myopia and asphericity was required.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.1
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• pp.111-120
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• 2014

Purpose: This study was to investigate changes in the thickness of cornea, curvature of cornea, and aberration depending on the water contents, materials, and refractive power of contact lens. Methods: The differences in the corneal thickness between pre- and post-wearing the lenses were compared using 5 kinds of lenses. The changes in the corneal thickness, the curvatures of the anterior and posterior cornea, and high order aberration (HOA) before and after wearing the lenses were investigated at the center of the cornea, and the different distance and the direction away from the center of the cornea. For the equipments of measurement, ORB ScanII (Bausch & Lomb Inc, ver 3.14) was used to measure the corneal topography and thickness, and Zywave (Bausch & Lomb Inc, ver 5.20) was used to analyze the high order aberration. Results: Five (S1, S2, S3, T1, T2) of the lens was used for this study, excluding the lens T2 lens has four lenses and the thickness of the corneal shape, but the impact is minimal. In the case of the hydrogel soft contact lenses (T2 lens) with low oxygen permeability, the corneal thickness showed distinct increasing patterns. The high order aberration and coma aberration were most changed in the silicon hydrogel toric lens, while the depth of anterior was most changed in the hydrogel toric lens. Conclusion: Among the 5 kinds of contact lenses with different water contents, materials, and refractive power used for this study, the corneal shape change was small for the lenses with an oxygen permeability (Dk) of more than 28, and the largest for the lenses with a very low oxygen permeability.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.3
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• pp.273-281
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• 2011

Purpose: In order to provide the fundamental information for the design development of RGP lenses and its clinical prescription, the corneal types of Korean twenties were analyzed according to corneal shapes, astigmatic degree, and the certain distance from the corneal apex. Methods: Corneal types of total 252 eyes in 20s were firstly classified, then their corneal radii from the certain distance from the corneal apex were measured by corneal topography and further analyzed based on the astigmatic degree. Results: Korean 20s' corneal types were classified as 14.3%(36 eyes) of round, 31.3%(79 eyes) of oval, 28.6%(72 eyes) of symmetric bow tie, 17.5%(44 eyes) of asymmetric bow tie, 8.3%(21 eyes) of irregular shapes. The round and oval typed corneas had mild astigmatic degree whereas the higher astigmatic degree in symmetric and asymmetric bow tie typed corneas were shown. The relative corneal radii of round and oval typed corneas at each distance from corneal apex were shown to consistently increase regardless of astigmatic degrees when they measured at certain distances from the corneal apex. However, the relative corneal radii of symmetric and asymmetric bow tie typed corneas within 1.0-1.5mm from the corneal apex were decreased, which showed steeper slope than it within 1.0 mm and somewhat different based on astigmatic degrees. Bigger change of corneal radii outer 3.5 mm from the corneal apex in symmetric bow tie typed corneas with astigmatism of 1.50-2.00 D and 2.25-2.75 D appeared. Conclusions: The consideration of radial change from the central cornea to peripheral cornea is necessary for manufacturing RGP lens and its prescription since they showed different change in corneal radii by corneal patterns and astigmatic degrees.

• Journal of Korean Ophthalmic Optics Society
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• v.11 no.3
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• pp.241-247
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• 2006

Purpose : To define the distribution of normal corneal topographic patterns of Korean college students and compare them with previously published western data, Bogan et al's study. Methods : Computerized corneal topography was performed 220eyes normal subjects using CTK-922(Topography, swiss made). Mean age of the subjects was 23.2 yr.(range 19 to 57 yr.). The color-coded videokeratographs were classified by a masked observer according to the Bogan et al's classification such as round, oval, symmetric bow tie, asymmetric bow tie, and irregular. Results: The results revealed 57 eyes(25.9%) had round, 14 (6.4%) oval , 41(18.6%)symmetric bow tie, 78(35.5%) asymmetric bow tie, and 30(13.6%) irregular pattern. Conclusions : Our results of topographic patterns show the tendency of more irregular and less round topographic pattern in Korean college students, as compared to that of western adults.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.3
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• pp.383-387
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• 2014

Purpose: To investigate the effect of corneal unique shape to changes of refractive full corrections when pupil size changes. Methods: Subjective refraction for monocular full correction was performed to 30 subjects ($23.33{\pm}1.78$ of age, 60 eyes) in two room conditions, 760 lx and 2 lx, respectively. Pupillary diameter was measured in two conditions and the change pattern was analyzed using a peak data of corneal topography. Results: Pupillary diameter was 3.74~4.00 mm in 760 lx and 5.52~5.90 mm in 2 lx. By comparison with refractive data in 760 lx, those data in 2 lx was changed as follows: more (-) spherical power of 17 eyes (28.3%), more (+) spherical power of 10 eyes (17.7%), more (-) cylinderical power of 17 eyes (28.8%), less (-) cylinderical power of 9 eyes (15.3%), and astigmatic axis rotation of 36 eyes (62.1%). From peak data of corneal topography, the changing pattern of two principal meridians was classified into 4 types. Conclusions: Expansion of the corneal refractive surface accompanied with pupillary dilation may be a main factor that effects the changing a values of subjective refraction because of unique corneal shape. Therefore, subjective refraction should be performed under the nearest lighting condition to a main living environment.

• Journal of Korean Ophthalmic Optics Society
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• v.7 no.2
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• pp.89-93
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• 2002

The physiology and morphology of cornea has effected on the ocular refractive status. Therefore the measurement of the anterior corneal surface by keratometer is used the treatment of the spectacles and contact lens by optician, optometrist, and ophthalmologist. Furthermore, currently the most corneal topographic mapping system have used the clinical optical shop, eye research center, and eye hospital. Because this method have a very fine data comparative to the previous instrument. The authors have measurement the cornea of the man college students by the corneal topographic mapping method. Especially this data will applied the clinical practice for the contact lens fitting. Especially in Korea, many man college students use the contact lens for the visual acuity and a beauty. Therefore the contact lens wear have increase per every year.

• Applied Microscopy
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• v.29 no.2
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• pp.231-239
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• 1999

Morphological changes of Drosophila ocellar corneagenous cells were studied to the development with electron microscopy, and the movement of produced proteins was traced with autoradiography. Corneagenous cells of immediate postemergence showed very active secretion pattern. However, a few days after the emergence, the secretory activity of corneagenous cell was supposed to be dropped suddenly. In autoradiography, almost of proteins that produced by corneagenous cells moved toward lens. From this, it was supposed that the corneagenous cells do not function in photoreceptor cells rather in the formation of lens at the postemergence stage. Corneagenous cells of pupal stage were well developed. In the period of lens formation, rER of corneagenous cells were well developed and it suggested very active material metabolism. Granules and microtubules were also frequently observed and the later would be a pathway of the movement of materials. In conclusion, corneagenous cells were well developed at vigorous lens forming stage. After emergence, when the lens formation was completed, both the function and the size of corneagenous cells were reduced.

• KSBB Journal
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• v.21 no.6 s.101
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• pp.439-443
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• 2006

Biocompatibility and tissue regenerating capacity are essential characteristics in the design of collagenous biomaterials for tissue engineering. Attachment of glycosaminoglycans to collagen may add to these characteristics by creating an appropriate micro-environment. In this study, porous type I collagen matrices were crosslinked using dehydrothermal treatment and 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide, in the presence and absence of chondroitin sulfate (CS). The scaffold like discs in 3 mm diameter were inserted into the intralamellar stromal pockets of rabbit cornea. In 8 weeks of follow up, clinical evaluation including corneal neovascularization, opacity and transparency of the graft scaffold was performed, and the inflammatory reaction and migration of corneal fibroblast were evaluated histologically. No inflammation, neovascularization and opacity in any of the implant were observed. CS increased the corneal fibroblast invasion and the transparency. It is concluded that the type I collagen sponge showed a biocompatibility in corneal stromal layer and addition of CS slightly improved the quality of the bioartificial corneal stromal layer. These results could be useful for the development of corneal substitutes.

• Journal of Korean Ophthalmic Optics Society
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• v.5 no.2
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• pp.27-31
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• 2000

As the functional test of cornea. The clinical value of keratometric information was important for assessment the curvature of the cornea, the quality of the corneal surface, the stability of the corneal curvature, and the direction of the corneal astigmatism. This study was performed the comparative analysis of male and female of adult on the base curve, power and astigmatism of the Cornea. On the corneal base curve, the male right eye was 7.656 mm in vertical and 7.966 mm in horizontal. But, the male left cornea was 7.714 mm in vertical base curve and 8.026 mm in horizontal base curve. On the other hand, the female right eye cornea was 7.559 mm in vertical base curve and 7.695 mm in horizontal base curve. But, the female left eye cornea was 7.444 mm in vertical base curve and 7.742 mm in horizontal base curve. On the corneal diopter power, the male right eye was 44.063 diopter in vertical and 43.738 diopter in horizontal. But the male left eye was 44.046 diopter in vertical and 42.304 diopter in horizontal. On the other hand, the female right eye was 44.082 diopter in vertical and 43.77 diopter in horizontal. But, the female left eye was 44.347 diopter in vertical and 43.495 diopter in horizontal. According to the corneal astigmatism axis. The male right eye have 89.9% positive for with the - rule astigmatism, and 8.1 % positive for against - the - rule astigmatism. But, he male left eye have 91.89% positive for with - the - rule astigmatism, and 8.11 % positive for against - the - rule astigmatism. On the other hand, The female right eye have 76.92% positive for with - the - rule astigmatism, and 23.08 % positive for against - the - rule astigmatism. But, the female left have 80.76 % positive for with - the - rule astigmatism, and 17.31 % positive for against - the - rule as tigmatism. The diopter power of corneal astigmatism have 25.57% positive for behind 1 diopter, 44.89% positive for 1 diopter, 18.18% positive for 2 diopter, 5.11% positive for 3 diopter and 6.25% positive for over 4 diopter.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.1
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• pp.107-116
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• 2011

Purpose: The review article was written to establish an excel program that could calculate minimal Dk of contact lens without $O^2$ deficiency and actual $O^2$ concentration on cornea when contact lens were being fitted by changing lens-related factors. Methods: An excel program was formulated to calculate the thickness of post-lens lacrimal layer, Dk of contact lens and $O^2$ concentration on cornea. Results: With the excel program established, minimal $O^2$ concentration needed on cornea could be calculated when the thickness of post-lens lacrimal layer was changed by varying lens-related factors. A different route in the excel program was needed to choose based on the shape of lacrimal layer. The thickness of lacrimal layer was determined by the shape of meniscus made of tear between lens edge and cornea with flat fit. Thus, the $O^2$ concentration showing negative number in calculation decreased on peripheral cornea with flatter fitting and actual $O^2$ concentration would be zero on cornea. With tight fitting, the thickness of post-lens lacrimal layer is much thicker than lens itself thus negative number in calculation by the excel program is shown indicating zero oxygen on cornea. It can cause $O^2$ deficiency regardless of Dk of contact lens. Conclusions: The calculation of thickness of post-lens lacrimal layer and $O^2$ concentration on cornea by the established excel program is suggested to avoid $O^2$ deficiency when fitting state is varied by changing lens-related factors.