• Journal of Life Science
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• v.20 no.2
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• pp.275-280
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• 2010

Sulforaphane is a naturally occurring member of the iosothiocyanate family, which reveals chemopreventive capacities including anti-cancer, anti-inflammation and inhibition of MMP-9 activities. In this study, we investigated the effect of sulforaphane on the expression of matrix metalloproteinase-9 (MMP-9) in lipopolysaccharide (LPS)-induced Raw 264.7 cells. Sulforaphane strikingly suppressed the LPS-induced MMP-9 activity and mRNA expression in a dose-dependent manner. In addition, sulforaphane inhibited not only the LPS-induced MMP-9 promoter activity but also LPS-mediated activator protein-1 (AP-1) and nuclear factor-kB (NF-${\kappa}B$) promoter activity. Transient transfection by MMP-9 constructs, in which specific transcriptional factors were mutagenized, indicated that the effects of LPS and sulforaphane were mediated via AP-1 and NF-${\kappa}B$ response elements. We found that sulforaphane had the ability to suppress LPS-induced invasion in vitro. Taken together, these results demonstrated that sulforaphane effectively suppressed LPS-induced MMP-9 expression via modulation of promoter elements (AP-1 and NF-${\kappa}B$) in MMP-9 transcriptional activation.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.19 no.3
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• pp.274-294
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• 2007

The most reasonable method of counting the number of the estuaries in Korea may be counting the number of streams flowing into the sea. The number counting of the streams should be carried out based on the river classes (National River, Regional 1st Class River and Regional 2nd Class River) given by the River Act. The National River scale estuaries are totaled to thirteen, i.e. Han River(including Imjin River), Anseongcheon, Sapgyocheon, Geum River, Mankyeong River, Dongjin River, Yeoungsan River, Tamjin River, Seomjin River, Gawhacheon, Nakdong River(including West Nakdong River), Taewha River, and Hyeongsan River estuaries. The Regional 1st Class River scale estuaries are counted as four, i.e. Yeoungdeok Osipcheon, Samcheok Osipcheon, Gangneung Namdaecheon, and Yangyang Namdaecheon. While, the Regional 2nd Class River estuaries are arranged as the Province and counted as total 444; Jeonnam, Gyeongnam, Chungnam, Jeju Province have the 108, 94, 52, and 35 estuaries, respectively. The counted estuary numbers, however, can be slightly increased/decreased on what references are applied, e.g. whether or not including the streams lost estuary functions by the sea-dike construction or integrated nearby streams, and so on.

• Korean journal of food and cookery science
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• v.26 no.4
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• pp.381-389
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• 2010

In this study, we investigated the quality characteristics of cookies containing mesangi powder (MP). The cookies were stored at 30 $^{\circ}C$ for 28 days. The pH of the dough decreased significantly upon the addition of MP. The spread factor of the cookies also decreased significantly with more MP added to the cookie recipe. The loss rate of cookies was significantly higher in 3% and 5% cookies than in control and 7% cookies. The leavening rate was significantly decreased upon the addition of MP. Hardness was significantly higher in 5% and 7% cookies than in control cookies. The L, a, b values of cookies were significantly reduced at higher MP content. The results of sensory evaluation showed that cookies made with MP did not differ significantly from the control, except in color and moistness. The mineral contents of cookies increased in dose-dependent fashion with MP concentration. The acid and peroxide values were lower in cookies with 5% MP than other cookies.

• Korean Chemical Engineering Research
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• v.61 no.2
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• pp.175-188
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• 2023

Global interest in hydrogen energy is increasing as an eco-friendly future energy that can replace fossil fuels. Accordingly, a next-generation hydrogen production technology using microorganisms, nuclear power, etc. is being developed, while a lot of time and effort are still required to overcome the cost of hydrogen production based on fossil fuels. As a way to minimize greenhouse gas emissions in the hydrocarbon-based hydrogen production process, methane direct decomposition technology has recently attracted attention. In order to improve the economic feasibility of the process, the simultaneous production of value-added carbon materials with hydrogen can be one of the most essential aspects. For that purpose, various studies on catalysis related to the quality and yield of high-value carbon materials such as carbon nanotubes (CNTs). In terms of process technology, a number of the research and development of fluidized-bed reactors capable of continuous production and improved gas-solid contact efficiency has been attempted. Recently, methane direct decomposition technology using a fluidized bed has been developed to the extent that it can produce 270 kg/day of hydrogen and 1000 kg/day of carbon. Plus, with the development of catalyst regeneration, separation and recirculation technologies, the process efficiency can be further improved. This review paper investigates the recent development of catalysts and fluidized bed reactor for methane direct pyrolysis to identify the key challenges and opportunities.

• Journal of Korea Water Resources Association
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• v.57 no.2
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• pp.87-97
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• 2024

This study analyzed the water shortage hotspot areas in South Korea using spatial clustering analysis for water shortage estimates in 2030 of the Master Plans for National Water Management. To identify the water shortage cluster areas, we used water shortage data from the past maximum drought (about 50-year return period) and performed spatial clustering analysis using Local Moran's I and Getis-Ord Gi*. The areas subject to spatial clusters of water shortage were selected using the cluster map, and the spatial characteristics of water shortage areas were verified based on the p-value and the Moran scatter plot. The results indicated that one cluster (lower Imjin River (#1023) and neighbor) in the Han River basin and two clusters (Daejeongcheon (#2403) and neighbor, Gahwacheon (#2501) and neighbor) in the Nakdong River basin were found to be the hotspot for water shortage, whereas one cluster (lower Namhan River (#1007) and neighbor) in the Han River Basin and one cluster (Byeongseongcheon (#2006) and neighbor) in the Nakdong River basin were found to be the HL area, which means the specific area have high water shortage and neighbor have low water shortage. When analyzing spatial clustering by standard watershed unit, the entire spatial clustering area satisfied 100% of the statistical criteria leading to statistically significant results. The overall results indicated that spatial clustering analysis performed using standard watersheds can resolve the variable spatial unit problem to some extent, which results in the relatively increased accuracy of spatial analysis.

• Economic and Environmental Geology
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• v.48 no.4
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• pp.273-285
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• 2015

The extensive hydrothermal deposits have been found, for the first time, on the western TA25 seamount caldera in the Tonga arc. The seafloor hydrothermal vents are active and immature, emitting the transparent fluids of which temperatures range from $150^{\circ}C$ to $242^{\circ}C$ (average=$203^{\circ}C$). The recovered hydrothermal sulfides are mainly composed of sphalerite, pyrite, marcasite, galena, chalcopyrite, covellite, tennantite, enargite and sulfates such as barite, gypsum/anhydrite. Predominant sphalerite categorize it into Zn-rich hydrothermal ore body. Zn-rich sulfide ores have minor enargite, indicating that mineralization occurred in high sulfidation environment. The proportion and FeS content of sphalerite increase from outside to inside of the hydrothermal ores, respectively. In particular, sphalerite has a great silver content (up to ~10 wt.%). Chalcopyrite is more frequently observed in mound than in the chimney, implying mineralization temperature in the mound is higher than in the chimney. Homogenization temperatures and salinities from fluid inclusions in barite at the mound range from $148^{\circ}C$ to $341^{\circ}C$ (average=$213^{\circ}C$) and 0.4 to 3.6 equiv. wt.% NaCl, respectively. Homogenization temperatures suggest that sulfides in the mound mineralized at a higher temperature (${\geq}200^{\circ}C$) than in the chimney.

• Journal of Environmental Impact Assessment
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• v.27 no.2
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• pp.203-214
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• 2018

The purpose of this study is to estimate the concentrated distribution area of nutria (Myocastor coypus) and potential suitable habitat and to provide useful data for the effective management direction setting. Based on the nationwide distribution data of nutria, the cross-validation value was applied to analyze the distribution density. As a result, the concentrated distribution areas thatrequired preferential elimination is found in 14 administrative areas including Busan Metropolitan City, Daegu Metropolitan City, 11 cities and counties in Gyeongsangnam-do and 1 county in Gyeongsangbuk-do. In the potential suitable habitat estimation using a MaxEnt (Maximum Entropy) model, the possibility of emergency was found in the Nakdong River middle and lower stream area and the Seomjin riverlower stream area and Gahwacheon River area. As for the contribution by variables of a model, it showed DEM, precipitation of driest month, min temperature of coldest month and distance from river had contribution from the highest order. In terms of the relation with the probability of appearance, the probability of emergence was higher than the threshold value in areas with less than 34m of altitude, with $-5.7^{\circ}C{\sim}-0.6^{\circ}C$ of min temperature of the coldest month, with 15-30mm of precipitation of the driest month and with less than 1,373m away from the river. Variables that Altitude, existence of water and wintertemperature affected settlement and expansion of nutria, considering the research results and the physiological and ecological characteristics of nutria. Therefore, it is necessary to reflect them as important variables in the future habitable area detection and expansion estimation modeling. It must be essential to distinguish the concentrated distribution area and the management area of invasive alien species such as nutria and to establish and apply a suitable management strategy to the management site for the permanent control. The results in this study can be used as useful data for a strategic management such as rapid management on the preferential management area and preemptive and preventive management on the possible spreading area.

• Journal of Hospice and Palliative Care
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• v.7 no.2
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• pp.200-213
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• 2004

Purpose: The purpose of this study was to create an electronic nursing record form to build a hospice nursing process database to be used in the u-hospital EMR system. Specific aims of the study were: 1. To generate a complete, accurate, and simple electronic nursing record form. 2. To verify its appropriateness following documentation with the standardized hospice protocol. 3. To verify its validity and finalize the hospice nursing process database through discussion among hospice professionals. Methods: Nursing records from three independent hospice organizations were collected and analyzed by five expert hospice nurses with more than 10 years of experience, and a nursing record database was developed. This database was applied to 81 hospice patients at three hospice organizations to verify its completeness. Results: 1. An electronic nursing record form with completeness, accuracy, and simplicity was developed. 2. The completeness of the standardized home hospice service protocol was 95.86 percent. 3. The hospice nursing process database contains 18 items on health problems, 79 items on related causes and major symptoms, and 229 items on nursing interventions. Conclusion: The new nursing record form and database will reduce documentation time and articulate and streamline the working process among team members. They can also improve the quality of hospice services, and ultimately enable us to estimate hospice service costs.

• Korean Journal of Microbiology
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• v.45 no.4
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• pp.411-415
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• 2009

Some microorganisms are capable of leaching Mn(II) from nonsulfidic manganese ores indirectly via nonenzymatic processes. Such reductive dissolution requires organic substrates, such as glucose, sucrose, or galactose, as a source of carbon and energy for microbial growth. This study investigated characteristics of Mn(II) leaching from manganese nodules by using heterotrophic Bacillus sp. strain MR2 provided with corn starch as a less-expensive substrate. Leaching of Mn(II) at 25.6 g Mn(II) $kg^{-1}$ nodule $day^{-1}$ was accompanied with cell growth, but part of the produced Mn(II) re-adsorbed onto residual $MnO_2$ particles after 24 h. Direct contact of cells to manganese nodule was not necessary as a separation between them with a dialysis tube produced similar amount [24.6 g Mn(II) $kg^{-1}$ nodule $day^{-1}$]. These results indicated an involvement of extracellular diffusible compound(s) during Mn(II) leaching by strain MR2. In order to optimize a leaching process we tested factors that influence the reaction, and the most efficient conditions were $25\sim35^{\circ}C$, pH 5~7, inoculum density of 1.5~2.5% (v/v), pulp density of 2~3 g/L, and particle size <75 ${\mu}m$. Although Mn(II) leaching was enhanced as particle size decrease, we suggest <212 ${\mu}m$ as a proper size range since more grinding means more energy consumption The results would help for the improvement of bioleaching of manganese nodule as a less expensive, energy-efficient, and environment-friendly technology as compared to the existing physicochemical metal recovery technologies.

• Journal of the Korean Association of Geographic Information Studies
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• v.18 no.2
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• pp.174-189
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• 2015

The objective of this study was to reconstruct spatial information using the results of the investigation and evaluation of the health of the living organisms, habitat, and water quality at the investigation points for the aquatic ecosystem health of the Nakdong River basin, to support the rational decision making of the aquatic ecosystem preservation and restoration policies of the Nakdong River basin using spatial analysis techniques, and to present efficient management methods. To analyze the aquatic ecosystem health of the Nakdong River basin, punctiform data were constructed based on the position information of each point with the aquatic ecosystem health investigation and evaluation results of 250 investigation sections. To apply the spatial analysis technique, the data need to be reconstructed into areal data. For this purpose, spatial influence and trends were analyzed using the Kriging interpolation(ArcGIS 10.1, Geostatistical Analysis), and were reconstructed into areal data. To analyze the spatial distribution characteristics of the Nakdong River basin health based on these analytical results, hotspot(Getis-Ord Gi, $G^*_i$), LISA(Local Indicator of Spatial Association), and standard deviational ellipse analyses were used. The hotspot analysis results showed that the hotspot basins of the biotic indices(TDI, BMI, FAI) were the Andong Dam upstream, Wangpicheon, and the Imha Dam basin, and that the health grades of their biotic indices were good. The coldspot basins were Nakdong River Namhae, the Nakdong River mouth, and the Suyeong River basin. The LISA analysis results showed that the exceptional areas were Gahwacheon, the Hapcheon Dam, and the Yeong River upstream basin. These areas had high bio-health indices, but their surrounding basins were low and required management for aquatic ecosystem health. The hotspot basins of the physicochemical factor(BOD) were the Nakdong River downstream basin, Suyeong River, Hoeya River, and the Nakdong River Namhae basin, whereas the coldspot basins were the upstream basins of the Nakdong River tributaries, including Andong Dam, Imha Dam, and Yeong River. The hotspots of the habitat and riverside environment factor(HRI) were different from the hotspots and coldspots of each factor in the LISA analysis results. In general, the habitat and riverside environment of the Nakdong River mainstream and tributaries, including the Nakdong river upstream, Andong Dam, Imha Dam, and the Hapcheon Dam basin, had good health. The coldspot basins of the habitat and riverside environment also showed low health indices of the biotic indices and physicochemical factors, thus requiring management of the habitat and riverside environment. As a result of the time-series analysis with a standard deviation ellipsoid, the areas with good aquatic ecosystem health of the organisms, habitat, and riverside environment showed a tendency to move northward, and the BOD results showed different directions and concentrations by the year of investigation. These aquatic ecosystem health analysis results can provide not only the health management information for each investigation spot but also information for managing the aquatic ecosystem in the catchment unit for the working research staff as well as for the water environment researchers in the future, based on spatial information.