• Journal of Microbiology and Biotechnology
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• v.24 no.3
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• pp.371-378
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• 2014

The aim of the present study was to investigate the antigenotoxic properties of the probiotic Lactobacillus rhamnosus IMC501; DNA damage was induced by one representative food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mice were treated orally with suspensions of lactobacilli for 10 days before administration of food mutagen. During the treatment, the abundance of lactobacilli in feces, as assessed by qPCR analysis, increased, whereas ${\beta}$-glucuronidase and N-acetyl-${\beta}$-glucosaminidase activities decreased. The extent of DNA damage was measured in colon and liver cells by comet assay. In colonocytes, diet supplementation with IMC501 resulted in a significant inhibition of DNA damage induced by PhIP. The results obtained in this in vitro study suggest that Lactobacillus rhamnosus IMC501 used as a dietary supplement can provide a useful integration of antimutagen food components of the normal diet, which are generally lower than the protective level.

• Korean Journal of Soil Science and Fertilizer
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• v.10 no.2
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• pp.75-78
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• 1977

Corn (Zea may, L.) was grown alternatively in nutrient solution and hydroxy Al or Al-citrate solution to identify the form of Al which induces Al toxicity on Corn seedlings. Corn seedlings exposed to hydroxy Al solution was very toxic but Al-citrate solution did not show any toxic symptoms. At pH 7 with Al-citrate solution, severe Fe, deficiency was induced probably by the decrease of stability constant of Al-and Fe-oganic complexes and subsequent precipitation of Al-and Fe-as a hydroxide form. Addition of humic acid ameliorated the Al toxicity somewhat at pH 4.7 with hydroxy-Al solution but at pH 7 it induced more severe Fe deficiency.

• Bulletin of the Korean Chemical Society
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• v.19 no.11
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• pp.1211-1216
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• 1998

Bis(diethyldithiocarbamato)ioxomolybdenum(VI), cis-MoO2(S2CNEt2)2, 1, reacted with chlorotrimethylsilane (Me33SiCl) to give a seven-coordinate, pentagonal bipyramidal complex MoOC12(S2CN]Et2)2, 3, in which the oxo ligand is trans to the chloride ligand and the two chloride ligands are mutually cis. The monooxo molybdenum complex bis(diethyidithiocarbamato)oxomolybdenum(IV), MoO(S2CNEt2)2, 2, reacted with phenyl isocyanate (PhNCO) to give an Mo dimer MO2{μ-N(CONPh)Ph}(μ-NPh)(NPh)2(S2CNEt2)2, 4, which contains an Mo-Mo bond, two diethyldithiocarbamato ligands, two terminal imido (NPh) ligands, and two bridging hnido (NPh) ligands. One of the two bridging NPh ligands seemed to have been attacked by the electrophilic phenyl isocyanate carbon, which suggests that the bridging imido NPh ligand is more nucleophilic than the terminal one. Crystallographic data for 3: monoclinic space group P21/c, a=8.908(l) Å, b=17.509(3) Å, c=12.683(2) Å, β=110.15(1)°, Z=4, R(wR2)=0.0611(0.1385). Crystallographic data for 4-THF: orthorhombic space group P212121, a=17.932(4) Å, b=22.715(5) Å, c=11.802(3) Å, Z=4, R(wR2)=0.0585(0.1286).

• Archives of Pharmacal Research
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• v.26 no.8
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• pp.612-619
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• 2003

In this study, we evaluated the effects of oral administration of DA-8159, a selective phosphodiesterase-5 inhibitor, on the development of pulmonary hypertension (PH) induced by monocrotaline (MCT). Rats were administered either MCT (60 mg/kg) or saline. MCT-treated rats were divided into three groups and received orally administered vehicle, or 1 mg/kg or 5 mg/kg of DA-8159, twice a day for twenty-one days. The MCT group demonstrated increased right ventricular weights, medial wall thickening in the pulmonary arteries, myocardial fibrosis and the level of plasma cyclic guanosine monophosphate (cGMP), along with decreased body weight gains. However, DA-8159 markedly and dose-dependently reduced the development of right ventricular hypertrophy and medial wall thickening. DA-8159 also amplified the increase in plasma cGMP level and significantly increased the level of lung cGMP, compared with the MCT group. Although the body weight gain was still lower from the saline-treated control group, DA-8159 demonstrated a significant increase in body weight gains, in both 1 mg/kg and 5 mg/kg groups, when compared with the MCT group. In myocardial morphology, MCT-induced myocardial fibrosis was markedly prevented by DA-8159. These results suggest that DA-8159 may be a useful oral treatment option for PH.

• Clinical Endoscopy
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• v.51 no.6
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• pp.563-569
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• 2018

Background/Aims: To evaluate patients with portal hypertension (PH) of varied etiologies for portal hypertensive enteropathy (PHE) using the PillCam SB3 capsule endoscopy (CE) system. Methods: Consecutive patients with PH presenting with unexplained anemia and/or occult gastrointestinal bleeding were evaluated using the PillCam SB3 CE system. Abnormal findings were categorized as vascular or non-vascular. The patients with ongoing bleeding caused by PHE were treated. The correlation of the CE scores of PHE with the clinical, laboratory, and endoscopic features was determined. Results: Of the 43 patients included in the study, 41 (95.3%) showed PHE findings. These included varices (67.4%), red spots (60.5%), erythema (44.2%), villous edema (46.5%), telangiectasia (16.3%), and polyps (16.3%). The CE scores varied from 0 to 8 ($mean{\pm}standard$ deviation, $4.09{\pm}1.8$). Five patients (11.6%) showed evidence of ongoing or recent bleeding due to PHE. Three of these five patients underwent endotherapy, and one patient underwent radiological coil placement. Conclusions: The PillCam SB3 CE system revealed a high prevalence of PHE in the patients with PH. Using this system, evidence of bleeding due to PHE was found in a small but definite proportion of the patients.

• International Journal of Knowledge Content Development & Technology
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• v.12 no.2
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• pp.41-56
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• 2022

This research paper presents the use of different forms of literature by the PhD researchers of the Department of Political Science and the Department of Public Administration, Punjabi University, Patiala. It is assessed by analyzing the resources cited in the PhD theses awarded by Punjabi University, Patiala during 2015-2019. The different bibliographic forms of the references have been analyzed in order to find out the year-wise submission, average citations per thesis, authorship pattern, chronology, use of electronic resources, and format of citations in both the subjects under study. It has been found in this study that average citations per thesis in Political Science is more (200.53) than Public Administration (160.6). Books are most preferred form in both the subjects. Majority of the citations in both the subjects are from the period 2000-2009. Ranked list of journals for both the subjects have been prepared to identify core journals. The core journals in both the subjects are 9. Bradford Multipliers have been calculated and application of Bradford Law of Scattering has also been tested for both the subjects. It is expected that the present study will help librarians in selecting, retaining and cancelling the existing journals in Political Science and Public Administration.

• International journal of advanced smart convergence
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• v.11 no.4
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• pp.247-252
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• 2022

The purpose of the domestic physician scientist support program is to promote the development of various biotechnology. Therefore, it can be said that examining whether the purpose of support is being faithfully implemented has an important meaning for the future domestic biotechnology development ecosystem. Therefore, this study limited the subject of analysis to 79 MD-PhD experts who participated or participated in doctor scientist programs at major universities in Korea. Among them, a total of 25 researchers, one researcher from each classroom in parasitology, microbiology, pharmacology, biochemistry, physiology, and anatomy, which had the highest paper citations in the last five years (2016-2021), were selected to examine the relationship between joint research. It was selected as the subject of review. As a result, 25 selected pseudo-scientists(MD-PhD) identified domestic and foreign researchers who participated as co-researchers when publishing in overseas academic journals for the last 5 years(2016-2021), and identified the affiliation and name of the top 5 among them, as well as the pseudo-scientist(MD-PhD), it was possible to identify the relationship of a total of 123 co-researchers(excluding 2 missing values) of the top 5 co-researchers with a high degree of cooperation with respect to the researcher(25 in total), and the collaboration of pseudo-scientists. Relationships, major researchers, and research institutes were examined. Nodexl Basic 2018 ver. (Microsof) was used for the analysis, and the relationship between researchers could be visualized by applying network analysis techniques.

• Journal of Physiology & Pathology in Korean Medicine
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• v.22 no.6
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• pp.1500-1508
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• 2008

The author investigated whether Chwiyeon-tang(PC), Haengso-tang(PH), Jawanchihyo-san(PJ) and Gamisocheongryong-tang(PS) significantly affect both PMA-induced mucin production and MUC5AC gene expression in airway epithelial cells and sulfur-dioxide-induced airway goblet cell hyperplasia and mucus hypersecretion animal model using rat. Possible cytotoxicity of each herbal medicine was assessed by measuring the survival and proliferation rate of NCI-H292 cells. Confluent NCI-H292 cells were pretreated for 30 min in the presence of PC, PH, PJ and PS, respectively, and treated with PMA(10 $ng/m{\ell}$), to assess the effect of each herbal medicine on PMA-induced mucin production by enzyme-linked immunosorbent assay(ELISA). Effects of each herbal medicine on PMA-induced MUC5AC gene expression from the same cells were investigated. Also, hypersecretion of airway mucus and goblet cell hyperplasia were induced by exposure of rats to $SO_2$ during 3 weeks. Effects of orally-administered PC, PH, PJ and PS during 1 week on intraepithelial mucosubstances and hyperplasia of goblet cells were examined using histological analysis after staining the epithelial tissue with PAS-alcian blue. (1) PC, PJ, PS and PH did not show significant effects on the survival and proliferation of NCI-H292 cells ; (2) PC, PJ and PS significantly decreased PMA-induced mucin production from NCI-H292 cells ; (3) PC, PJ and PS significantly inhibit the expression levels of PMA-induced MUC5AC gene in NCI-H292 cells ; (4) Among PC, PJ, PS and PH, only PS decreased $SO_2$-induced hyperplasia of airway goblet cells and intraepithelial mucosubstances. This result suggests that PC, PJ and PS can not only affect the production of mucin but also affect the expression of mucin gene and this can explain, at least in part, the traditional use of PC, PJ and PS for controlling airway diseases showing hypersecretion of mucus in oriental medicine.

• Horticultural Science & Technology
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• v.16 no.3
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• pp.374-376
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• 1998

Effects of traditional fumigation (methyl bromide; MB) and combined fumigation (methyl bromide/phosphide; $MB/PH_3$) on the disinfestation, and phytotoxicity and longevity of cut flowers (lily and rose) were investigated. Combined fumigation with low concentrations of $7/3g/m^3\;(MB/PH_3$) at $10^{\circ}C$ immediately after transportation from harvested place was found to be much more effective in disinfestation of aphid, mite, and thrips than fumigation with $MB\;48g/m^3$ only at $20^{\circ}C$ after simulated transportation for 2 days. Quality and longevity of cut flowers measured after fumigation were better in flowers treated by combined fumigation ($7/3g/m^3,\;MB/PH_3$) at $10^{\circ}C$ for 2.5-3 hrs, irrespective of pretreatment with pulsing solution immediately after transporation, even though phytotoxicity varied with cut flowers fumigated. On the other hand, fumigation with $MB\;48g/m^3$ only at $20^{\circ}C$ after simulated transportation for 2 days showed tendency of enhanced insect disinfestation, but caused phytotoxicity to both lily and rose, regardless of pretreatment and moreover, reduced the longevity of the cut flowers.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.4
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• pp.242-249
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• 2016

This study was to investigate the anti-inflammatory effects of Prunellae Herba(PH). The generation of superoxide anion radical (․O₂-), nitric oxide (NO), peroxynitrite (ONOO-) and Prostaglandin E₂(PGE₂) were measured in the H₂O₂-Treated renal epithelial cells(LLC-PK1 cell) of mouse. And the effects of Prunellae Spica on the expression of NF-κB (p50, p65), IKK-α, phospho-IκB-α and inflammation-related proteins, COX-2, iNOS, IL-1β and VCAM-1, were examined by western blot. The fluorescent probes, 2',7'-dichlorodihydrofluorescein diacetate (DCFDA), 4,5-diaminofluorescein (DAF-2) and dihyldrorhodamine 123 (DHR 123) were used to estimate the scavenging effect of Prunellae Spica on ․O₂-, NO, ONOO-. Western blot was conducted to assess the protein expression levels of NF-κB (p50, p65), IKK-α, phospho-IκB-α, inflammation-related proteins, COX-2, iNOS, IL-1β, VCAM-1. PH inhibited H₂O₂-treated cell death dose-dependently. It reduced the generation of ·O₂-, NO, ONOO- and PGE₂ in the H₂O₂-treated renal epitheial cells(LLC-PK₁ cell) of mouse in vitro. PH reduced the expression of NF-κB, IKK-α, phospho-IκB-α, COX-2, iNOS, IL-1β and VCAM-1 genes through means of decreasing activation of NF-κB signaling as well. According to these results, PH has an antioxidative activity and anti-inflammatory effect by regulating the NF-κB pathway. This suggest that PH is expected to be used to regulating inflammatory process and treating inflammation-related disease.