• Journal of applied mathematics & informatics
• /
• 제31권5_6호
• /
• pp.695-709
• /
• 2013

Calcium is well known role for signal transduction in a neuron cell. Various processes and parameters modulate the intracellular calcium signaling process. A number of experimental and theoretical attempts are reported in the literature for study of calcium signaling in neuron cells. But still the role of various processes, components and parameters involved in calcium signaling is still not well understood. In this paper an attempt has been made to develop two dimensional finite element model to study calcium diffusion in neuron cells. The JRyR, JSERCA and JLeak, the exogenous buffers like EGTA and BAPTA, and diffusion coefficients have been incorporated in the model. Appropriate boundary conditions have been framed. Triangular ring elements have been employed to discretized the region. The effect of these parameters on calcium diffusion has been studied with the help of numerical results.

• 기술혁신연구
• /
• 제12권2호
• /
• pp.47-66
• /
• 2004

The relationship between innovation policies and locational competitiveness has emerged as an important area in the analysis of economic development, reflecting both the centralisation and decentralisation of globalising economic activities. The underlying spatial and institutional components are subject to a pattern of cumulative causation in which strategic interventions of policy actors exercise a decisive role in shaping competitive advantages, while promoting interactions with local and foreign partners both from the private and public sectors. The Singaporean development experience illustrated these strategic interdependencies of innovation policies and locational competitiveness. Based on her role as a manufacturing and service hub, Singapore is viewed as an infrastructural nodal point which is interconnected to global production networks. Paralleling efforts in the domain of technological innovation, Singapore's policies for locational competitiveness aim at an adaptive harmonisation of the needs of international investors with local developmental objectives. This orientation characterises also current efforts in promoting Singapore as a knowledge agglomeration with a distinct science base, expanding R&D operations and an innovation-driven pattern of economic development. In conclusion, the locational rationale of Singapore's innovation policies provides lessons for dealing with the spatial and institutional implications of technological globalisation.

• Journal of Power Electronics
• /
• 제16권4호
• /
• pp.1316-1323
• /
• 2016

Multilevel inverters (MLIs) have been preferred over conventional two-level inverters due to their inherent properties such as reduced harmonic distortion, lower electromagnetic interference, minimal common mode voltage, ability to synthesize medium/high voltage from low voltage sources, etc. On the other hand, they suffer from an increased number of switching devices, complex gate pulse generation, etc. This paper develops an ingenious symmetrical MLI topology, which consumes lesser component count. The proposed level dependent sources concoction multilevel inverter (LDSCMLI) is basically a multilevel dc link MLI (MLDCMLI), which first synthesizes a stepped dc link voltage using a sources concoction module and then realizes the ac waveform through a conventional H-bridge. Seven level and eleven level versions of the proposed topology are simulated in MATLAB r2010b and prototypes are constructed to validate the performance. The proposed topology requires lesser components compared to recent component reduced MLI topologies and the classical topologies. In addition, it requires fewer carrier signals and gate driver circuits.

• 한국정보디스플레이학회:학술대회논문집
• /
• 한국정보디스플레이학회 2003년도 International Meeting on Information Display
• /
• pp.227-229
• /
• 2003

We present a process for printing active matrix displays. In this process, transistors are fabricated using soluble semi-conducting and conducting materials. Accurate definition of the transistor channel and other circuit components is achieved by direct inkjet printing combined with surface energy patterning. We present results on our 4,800 pixel, 50 dpi, active matrix displays.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2000년도 추계학술대회 논문집 학회본부 A
• /
• pp.6-9
• /
• 2000

This paper presents the detailed derivation of optimal nodal price for active power to regionally evaluate system loss and congestion cost. The method is to decompose them into different components corresponding to system loss, transmission congestion, voltage constraint, and so on. The decomposed information for nodal price can be used to provide economic signals for generation or transmission investment as well as to improve the efficient usage of power grid and congestion management. The result of case study on IEEE 30 bus system is reported to illustrate the proposed method.

• 대한기계학회:학술대회논문집
• /
• 대한기계학회 2001년도 춘계학술대회논문집A
• /
• pp.871-876
• /
• 2001

One-touch fittings are important components that can make a quick and tight connection between pneumatic pipe systems. In this study, the stress analyses with various working pressures on these one-touch fittings are carried out using finite element method. Material properties, to use the stress analyses, are measured by the universal tester and digital Vickers hardness tester. The stress analyses on the circular shell spring forced by various pressures(100, 150, 200, 250kpa) and on the main body due to the fluid-structural interaction are investigated. Results show that the stresses of one-touch fitting are concentrated to supported part of main body and the soundness of a circular shell spring with maximum pressure 250kpa was confirmed.

• Genomics & Informatics
• /
• 제9권4호
• /
• pp.173-180
• /
• 2011

Recent trends in generating multiple, large-scale datasets provide new challenges to manipulating the relationship of different types of components, such as gene expression and drug response data. Integrative analysis of compound response and gene expression datasets generates an opportunity to capture the possible mechanism of compounds by using signature genes on diverse types of cancer cell lines. Here, we integrated datasets of compound response and gene expression profiles on NCI60 cell lines and constructed a network, revealing the relationship for 801 compounds and 341 gene probes. As examples, obtusol, which shows an exclusive sensitivity on a small number of colon cell lines, is related to a set of gene probes that have unique overexpression in colon cell lines. We also found that the SLC7A11 gene, a direct target of miR-26b, might be a key element in understanding the action of many diverse classes of anticancer compounds. We demonstrated that this network might be useful for studying the mechanisms of varied compound response on diverse cancer cell lines.

• Steel and Composite Structures
• /
• 제20권1호
• /
• pp.185-203
• /
• 2016

Shear connectors are key components to ensure the efficient composite action and satisfactory transfer of shear forces at the steel-concrete interface in composite beams. Under hazardous circumstances, such as fire in a building, the performance of a composite beam significantly relies on the performance of shear connectors. Studies on the behavior of shear connectors subjected to elevated temperatures performed in the last decade are reviewed in this paper. The experimental testing of push-out specimens, the design approaches provided by researchers and different codes, the major failure modes, and the finite element modeling of shear connectors are highlighted. The critical research review showed that the strength of a shear connector decreases proportionally with the increase in temperature. Compared with the volume of work published on shear connectors at ambient temperatures, a few studies on the behavior of shear connectors under fire have been conducted. Several areas where additional research is needed are also identified in this paper.

• 유공압시스템학회논문집
• /
• 제5권3호
• /
• pp.15-22
• /
• 2008

The road simulators have become common tools within the automotive industry for evaluation of vehicle and vehicle system durability performance. These simulators need appropriate input signal generation algorithms to realize the actual driving conditions due to non-linear vehicle and test rig behaviour. Although somewhat unconventional from a control standpoint, the iteration approach has proven to be a very effective method for control of complex, multiple degree-of-freedom systems where the tracking parameter is known a priori. In this paper, the road profile replication algorithm is verified by applying Belgian road to the developed road simulator. The simulation and experimental results are included to evaluate the performance of this simulator. This road simulator provides considerable savings in cost, development time, and testing risk during developing automotive components.

• 소성∙가공
• /
• 제28권3호
• /
• pp.123-129
• /
• 2019

Hypereutectic Al-Si alloys have been widely utilized for wear-resistant components in the automotive industry. In order to expand the application of Hypereutectic Al-Si alloys, the addition of alloying elements forming a stable precipitate at high temperature is required. Thermally stable inter metallic compounds can be formed through the addition of transition elements such as Fe, Ni to Al alloys. However, the amount of transition element to be added to Al alloys is limited due to their low solid solubility. Also, hypereutectic Al-Si-Fe alloys form coarse primary Si phases and needle-shaped intermetallic compounds during solidification in the general casting processes. In this study, the effects of the destruction of Intermetallic compound and Si phase are investigated via hot extrusion. Both the microstructure and mechanical properties are discussed under different extrusion conditions.