• 한국체육학회지인문사회과학편
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• v.51 no.3
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• pp.437-445
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• 2012

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and manganese superoxide dismutase (MnSOD) has been hypothesized as a mediator in the activation of multiple pathways implicated in the pathogenesis of diabetic disease. The objective of this study was to understand the mechanism that aerobic exercise activate GAPDH and MnSOD in pancreatic cells. To achieve the purpose of this study, thirty male Sprague-Dawley rats were assigned to control group, diabetic group and diabetic exercise group. 10 rats were forced to exercise according to exercise protocol for 8weeks and 20 rats were untrained for control and diabetic group. Pancreatic tissue were extracted from the each. Expressions of GAPDH and MnSOD in diabetic pancreatic tissues were significantly decreased compare to control group. However, swimming (trained diabetic group) significantly increased expressions of GAPDH and MnSOD compare to diabetic group, respectively. In hyperglycemia, GAPDH and MnSOD in pancreatic cells is activated by aerobic exercise, and this inactivates multiple pathways implicated in the pathogenesis of diabetic disease. In conclusion, these findings suggest that increased activity of GAPDH and MnSOD by exercise have beneficial effects on mitochondrial dysfunction and arresting the progression of diabetic disease.

• The Journal of Internal Korean Medicine
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• v.43 no.6
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• pp.1045-1062
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• 2022

Objectives: The aim of this study was to analyze the latest clinical studies on Korean medicine treatment of idiopathic thrombocytopenic purpura (ITP) in the Chinese National Knowledge Infrastructure (CNKI) database. Methods: We searched the last 6 years of clinical studies discussing Oriental medicine-based treatments for ITP in the CNKI database. A meta-analysis of 13 RCTs was performed by synthesizing the outcomes, including the measured platelet count and total effective rate. The quality of the studies was assessed using Cochrane's risk of bias (RoB) tool. RevMan 5.4.1 software was used for data analysis. Results: Of the 15 selected studies, 1 was a non-randomized controlled trial (nRCT), 2 were case series, and 12 were randomized controlled trials (RCTs). Treatments in all studies included oral herbal medicine. The most frequently used herbal decoction was the Liangxue Jiedu prescription (凉血解毒方), and the most commonly used herb was Agrimonia pilosa (仙鶴草), Astragali Radix (黃芪), Fossilia Glycyrrhizae Radix et Rhizoma (甘草), and Rehmannia glutinosa Liboschitz ex Steudel (地黃). The meta-analysis showed significantly better improvement in platelet counts and total effective rate for ITP in the treatment group than in the control group. Conclusion: Treatment with herbal medicine was effective in treating ITP. However, the significance of this conclusion is somewhat limited due to the low quality of the available studies. Multifaceted and scientifically designed clinical studies are required to develop treatments for ITP based on Korean medicine. The results of this study could be used as basic data for further ITP studies.

• Journal of Environmental Health Sciences
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• v.49 no.1
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• pp.22-29
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• 2023

Background: The existing research results on the combined toxicity of these pollutants using mammals, such as rodents, are insufficient, especially in relation to changes in the immune system. Objectives: This study aims at evaluating the cellular immune response to PE-MPs solely or when combined with Pb, which possess excellent adsorption capacity with PE-MPs and is commonly co-exposed in our daily lives. Methods: The study investigated the cellular immune function of 9-week ICR mice with 28 days exposure to PE-MPs (2 mg/mouse/day) and Pb (0.1 mM in distilled water) individually and in combination. PE-MPs were administered via gastric intubation while the lead intake was conducted via the oral drinking water route. Cellular immunity was evaluated by analyzing the production for T_H1 cytokines namely, TNF-α and IFN-𝛾 and T_H2 cytokines, IL-4 and IL-6 in culture supernatants from polyclonally activated splenic mononuclear cells ex vivo. Results: Both the PE-MPs only and the PE-MPs+Pb exposure group revealed an increased T_H1 response with elevated TNF-α and IFN-𝛾 levels and downregulated T_H2 response with low IL-4, and IL-6 production levels compared to the control group. Furthermore, an increased IFN-𝛾/IL-4 ratio was found in the PE-MPs only and PE-MPs+Pb exposure groups, which indicated the skewedness to T_H1 response. Meanwhile, reduced blood hemoglobin levels and increased levels of IL-4, the dominant T_H2 cytokine in the Pb-only exposure group, were observed. Conclusions: Our current findings on the predominance of T_H1 immune response in the PE-MPs and PE-MPs+Pb groups suggest that PE-MPs could be responsible for the predominant induction of the cellular immune changes. This finding could be used as an important landmark in research related to T_H1 predominance, such as autoimmune diseases. It suggests that additional research on immune modulation using longer exposure durations or the same exposure route is required to elucidate stronger findings.

• Korean Association of Arts Management
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• no.52
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• pp.135-156
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• 2019

The purpose of this study is to derive more practical and concrete policy implications for the successful implementation of the Cultural City Designation Project, which is emerging as a main topic of cultural policy. To this end, the background and implementation system of the European Capitals of Culture(ECOC), which is the subject of benchmarking in various aspects, were examined. As a result, it was confirmed that there is a possibility that the Cultural City Designation Project can reveal its limitations in the background and process, and the improvement is as follows. First, rather than creating an ideal cultural city model to achieve its goals in a short period of time, efforts should be made to secure diversity and expand insufficient infrastructure in accordance with local autonomous decisions. Second, in order to secure the continuity of the business, it is necessary to secure and educate professional manpower for organizational operation in the form of independent or direct agency of each local government. Finally, careful policy consideration should be made at the national level to balance regional interests. Therefore, there is a need for an organized 'government-level organization' that can take on the role of the city selection process, support system, and ex post evaluation. In short, successful cultural city projects require critical acceptance and efforts to remedy fundamental problems rather than benchmarking unconditional overseas cases in terms of cultural policy.

• Journal of Intelligence and Information Systems
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• v.29 no.2
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• pp.129-148
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• 2023

Bitcoin is a blockchain technology-based digital currency that has been recognized as a representative cryptocurrency and a financial investment asset. Due to its highly volatile nature, Bitcoin has gained a lot of attention from investors and the public. Based on this popularity, numerous studies have been conducted on price and trend prediction using machine learning and deep learning. This study employed LSTM (Long Short Term Memory) and CNN (Convolutional Neural Networks), which have shown potential for predictive performance in the finance domain, to enhance the classification accuracy in Bitcoin price trend prediction. XAI(eXplainable Artificial Intelligence) techniques were applied to the predictive model to enhance its explainability and interpretability by providing a comprehensive explanation of the model. In the empirical experiment, CNN was applied to technical indicators and Google trend data to build a Bitcoin price trend prediction model, and the CNN model using both technical indicators and Google trend data clearly outperformed the other models using neural networks, SVM, and LSTM. Then SHAP(Shapley Additive exPlanations) was applied to the predictive model to obtain explanations about the output values. Important prediction drivers in input variables were extracted through global interpretation, and the interpretation of the predictive model's decision process for each instance was suggested through local interpretation. The results show that our proposed research framework demonstrates both improved classification accuracy and explainability by using CNN, Google trend data, and SHAP.

• Journal of Korean Tunnelling and Underground Space Association
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• v.12 no.1
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• pp.43-49
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• 2010

The escape connecting gallery in a tunnel on a road is one of emergency equipment to ensure safety for passer in the tunnel against the tunnel fire. Government stipulate over 500m tunnel has the cross passage at intervals of less then 250 m. However, this lump estimated interval is generated the concerns of exaggeration and under construction because peculiarity of the tunnel ex. The velocity of the tunnel airflow, an incline, degree of a fire, and innering area are not considered. The study indicate the way to estimate of the cross passage considered an incline and the velocity of the tunnel airflow for efficient application of cross passage on the tunnel design. As a result, in 0.0 m/s and 1.0 m/s of the velocity of the tunnel airflow case, the movement of smoke is influenced by the incline however, in 20 m/s case, it isn't influenced by incline much. According to the velocity of tunnel airflow and the incline, optimum interval of cross passage is not corresponded. Therefore established lump estimate that has 250 m intervals would be changed to estimate of optimum interval of cross passage that considered about the properties of tunnel, the velocity of the tunnel airflow, incline, degree of a fire and innering area of the tunnel.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.5B
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• pp.519-524
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• 2010

This study was carried out to select suitable plants for beach revegetation as a preliminary study for quantifying the effect of decreasing sand movement. After planting some herbal plants in field, monitoring of temporal change of vegetation coverage which was index of the growth rate was conducted. Through literature reviews, 24 candidate plants for beach revegetation were selected, then seven species of them, Peucedanum japonicum Thunb., Dianthus japonicus Thunb. ex Murray, Sedum oryzifolium Makino, Sedum takesimense Nakai, Sedum spectabile Boreau, Farfugium japonicum (L.) Kitam., Aster sphathulifolius Maxim. were picked through salinity tolerance experiments in laboratory. Seven species selected by salinity tolerance experiments and two additional herbal plants, Prunella vulgaris var. lilacina Nakai and Linaria vulgaris Mill., not the candidates, were nine final species which were planted in the beach around Osan port, Uljin, Korea. The changes of vegetation coverage of each species were investigated from photos periodically taken for about a year using image processing methods. As a result of the monitoring, Sedum takesimensei, Dianthus japonicus and Aster sphathulifolius were observed with high coverages during the whole monitoring while Prunella vulgaris var. lilacina and Linaria vulgaris were observed with low coverage during the same period. Consequently, Sedum takesimensei, Dianthus japonicus and Aster sphathulifolius were concluded as the most suitable plants for beach revegetation. Furthur study to quantify the effects of decreasing sand movement by the selected species is needed.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.46 no.3
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• pp.15-22
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• 2023

BNKT Ceramics, one of the representative Pb free based piezoelectric ceramics, constitutes a perovskite(ABO3) structure. At this time, the perovskite structure (ABO3) is in the form where the corners of the octahedrons are connected, and in the unit cell, two ions, A and B, are cations, A ion is located at the body center, B ion is located at each corner, and an anion O is located at the center of each side. Since Bi, Na, and K sources constituting the A site are highly volatile at a sintering temperature of 1100℃ or higher, it is difficult to maintain uniformity of the composition. In order to solve this problem, there should be suppression of volatilization of the A site material or additional compensation of the volatilized. In this study, the basic composition of BNKT Ceramics was set to Bi_0.5(Na_0.78K_0.22)_0.5TiO₃ (= BNKT), and volatile site (Bi, Na, and K sources) were coated in the form of a shell to compensate additionally for the A site ions. In addition, the physical and electrical properties of BNKT and its coated with shell additives(= @BNK) were compared and analyzed, respectively. As a result of analyzing the crystal structure through XRD, both BNKT(Core) and @BNK(Shell) had perovskite phases, and the crystallinity was almost similar. Although the Curie temperature of the two sintered bodies was almost the same (TC = 290 ~ 300 ℃), it was confirmed that the d33 (piezoelectric coefficient) and Pr (residual polarization) values were different. The experimental results indicated that the additional compensation for a shell additive causes the coarsening, resulting in a decrease in sintering density and Pr(remanent polarization). However, coating shell additives to compensate for A site ion is an effective way to suppress volatilization. Based on these experimental results, it would be the biggest advantage to develop an eco-friendly material (Lead-free) that replaced lead (Pb), which is harmful to the human body. This lead-free piezoelectric material can be applied to a biomedical device or products(ex. earphones (hearing aids), heart rate monitors, ultrasonic vibrators, etc.) and skin beauty improvement products (mask packs for whitening and wrinkle improvement).

• Korean Journal of Construction Engineering and Management
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• v.24 no.6
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• pp.3-11
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• 2023

To address the high accident rate in the construction industry, there is a growing interest in implementing virtual reality (VR)-based construction safety training. However, existing training approaches often failed to consider learners' individual characteristics, resulting in inadequate training for some individuals. This study aimed to investigate the impact of personal characteristics on learning performance in VR-based construction safety training using machine learning and SHAP (SHAPley Additional exPlanations). This study revealed that age exerted the greatest influence on learning performance, while work experience had the least impact. Furthermore, age exhibited a negative relationship with learning performance, indicating that the introduction of VR-based construction safety training can be effective for younger individuals. On the other hand, academic degree, qualifications, and work experience exhibited a positive relationship. To enhance learning performance for individuals with lower academic degree, it is necessary to provide content that is easier to understand. The lower qualifications and work experience have minimal impact on learning performance, so it is important to consider other learners' characteristics so as to provide appropriate educational content. This study confirmed that personal characteristics can significantly affect learning performance in VR-based construction safety training, highlighting the potential for leveraging these findings to provide effective safety training for construction workers.

• Korean Journal of Psychosomatic Medicine
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• v.31 no.2
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• pp.100-107
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• 2023

Objectives : This study aimed to examine the mediating effect of sleep quality and interpretation bias for ambiguity in the relationship between hopelessness and suicidal ideation in psychiatric patients. Methods : A total of 231 psychiatric outpatients and inpatients completed the Beck Hopelessness Scale, Pittsburgh Sleep Quality Index, Ambiguous/Unambiguous Situations Diary-Extended Version, and Ultra-Short Suicidal Ideation Scale. Data analysis was conducted using regression analyses and bootstrap sampling. Results : The results of this study showed that hopelessness had a direct effect on suicidal ideation, and that sleep quality and interpretation bias for ambiguity mediated the association between hopelessness and suicidal ideation. Moreover, there was a significant double mediating effect of sleep quality and interpretation bias for ambiguity on the relationship between hopelessness and suicidal ideation. Conclusions : These results suggest that it is important to consider both sleep quality and interpretation bias for ambiguity to prevent hopelessness from leading to suicidal idea. These results suggest that considering both sleep quality and interpretation bias for ambiguity may be important in preventing hopelessness from leading to suicidal ideation.