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Study on the Anti-stress Effect of Chenwangbosim-Dan Extract∘Fermented Rice Extract (GABA ː gamma-aminobutyric acid 30%) Complex : A double-blind, randomized, placebo-controlled study (천왕보심단(天王補心丹)∘쌀발효추출물(GABAːgamma-aminobutyric acid 30%) 복합물의 항(抗)스트레스에 대한 유효성 연구ː무작위 배정 및 이중맹검)

  • Choyoung, Hong;Seo, Sang Gwon;Seunggon, Na;Hosong, Cho;Mi-Kyung, Lee;Mu Hyun, Jin;Seok-Seon, Roh;Youngsung, Ju
    • The Korea Journal of Herbology
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    • v.38 no.2
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    • pp.1-7
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    • 2023
  • Objectives : From this study, we sight to identify Anti-stress effect of Chenwangbosim-Dan (Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex Methods : In order to measure the degree of functional evaluation of tension relief due to stress, it was evaluated whether the psychological indicators VAS(Visual Analog Scale) and POMS(Profile Of Mood State) were improved. Which is generally used for stress measurement and has a high frequency of clinical use. All clinical trial subjects were required to take the drug once a day at 9 ± 30 min in the morning for 2 weeks. Results : After intake, the group that Chenwangbosim-Dan(Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex had a statistically significant improvement effect compared to before intake due to an improved 30.81% of the VAS scores. The POMS-T score improved 54.13%, the POMS-V score improved 117.5% and the POMS-F score improved 59%, which had a statistically significant effect compared to Placebo group (p<0.001). There is a significant difference between two group, so even considering the placebo effect, the anti stress effect was confirmed in the Chenwangbosim-Dan (Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex intake group. Conclusions : The above results showed that the Chenwangbosim-Dan(Tianwangbuxin-Dan) Extract∘Fermented Rice Extract (GABA : gamma-aminobutyric acid 30%) Complex had an anti-stress effect. Therefore, it is expected to be developed as a safe and comfortable mental care health functional food that can reduce the risk of drug abuse.

Multi-objective Genetic Algorithm for Variable Selection in Linear Regression Model and Application (선형회귀모델의 변수선택을 위한 다중목적 유전 알고리즘과 응용)

  • Kim, Dong-Il;Park, Cheong-Sool;Baek, Jun-Geol;Kim, Sung-Shick
    • Journal of the Korea Society for Simulation
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    • v.18 no.4
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    • pp.137-148
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    • 2009
  • The purpose of this study is to implement variable selection algorithm which helps construct a reliable linear regression model. If we use all candidate variables to construct a linear regression model, the significance of the model will be decreased and it will cause 'Curse of Dimensionality'. And if the number of data is less than the number of variables (dimension), we cannot construct the regression model. Due to these problems, we consider the variable selection problem as a combinatorial optimization problem, and apply GA (Genetic Algorithm) to the problem. Typical measures of estimating statistical significance are $R^2$, F-value of regression model, t-value of regression coefficients, and standard error of estimates. We design GA to solve multi-objective functions, because statistical significance of model is not to be estimated by a single measure. We perform experiments using simulation data, designed to consider various kinds of situations. As a result, it shows better performance than LARS (Least Angle Regression) which is an algorithm to solve variable selection problems. We modify algorithm to solve portfolio selection problem which construct portfolio by selecting stocks. We conclude that the algorithm is able to solve real problems.

Variation of Earth Pressure Acting on Cut-and-Cover Tunnel Lining with Settlement of Backfill (되메움토의 침하에 따른 개착식 터널 라이닝에 작용하는 토압의 변화)

  • Bautista F.E.;Park Lee-Keun;Im Jong-Chul;Lee Young-Nam
    • Journal of the Korean Geotechnical Society
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    • v.22 no.6
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    • pp.27-40
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    • 2006
  • Damage of cut-and-cover tunnel lining can be attributed to physical and mechanical factors. Physical factors include material property, reinforcement corrosion, etc. while mechanical factors include underground water pressure, vehicle loads, etc. This study is limited to the modeling of rigid circular cut and cover tunnel constructed at a depth of $1.0{\sim}1.5D$ in loose sandy ground and subjected to a vibration frequency of 100 Hz. In this study, only damages due to mechanical factors in the form of additional loads were considered. Among the different types of additional, excessive earth pressure acting on the cut-and-cover tunnel lining is considered as one of the major factors that induce deformation and damage of tunnels after the construction is completed. Excessive earth pressure may be attributed to insufficient compaction, consolidation due to self-weight of backfill soil, precipitation and vibration caused by traffic. Laboratory tunnel model tests were performed in order to determine the earth pressure acting on the tunnel lining and to investigate the applicability of existing earth pressure formulas. Based on the difference in the monitored and computed earth pressure, a factor of safety was recommended. Soil deformation mechanism around the tunnel was also presented using the picture analysis method.

The Slow Strain Rate Dependence of Zircaloy-4 Cladding Tube in Iodine Atmosphere (I) (요드분위기에서 지르칼로이 피복재의 저변형율속도 의존성(I))

  • Choi, Y.;Kang, Y.H.;Ryu, W.S.;Rim, C.S.
    • Nuclear Engineering and Technology
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    • v.17 no.3
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    • pp.211-215
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    • 1985
  • The effects of temperature and strain rate on the I-SCC behaviors of Zircaloy-4 were investigated by constant load test at 30$0^{\circ}C$ and constant elongation rate test at 300, 350 and 40$0^{\circ}C$ in 3.34mg $I_2$/㎤. The results showed that I-SCC susceptibility increased as the strain rate decreased or the temperature increased. The empirical relation between the stress and the time to failure at 30$0^{\circ}C$ was given by 1/ $t_{f}$∝exp (0.3$\sigma$/$\sigma$$_{UTS}$-31.5) When the I-SCC susceptibility was expressed by the ratio of fracture energy in iodine atmosphere to that in the inert atmosphere, severe I-SCC susceptibility was found near 7.6$\times$10$^{-6}$ sec at 30$0^{\circ}C$ and the maximum point of I-SCC susceptibility tended to shift to the higher strain rate with increasing the temperature. The quasi-cleavage fracture was observed in I-SCC fracture surface. From these results, it was certain that the film repture step was involved as an important process in the I-SCC mechanism of Zircaloy-4.4.

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Expression of Antisense Mouse Obese Gene in Transgenic Mice (형질전환 생쥐에서 Antisense 비만유전자의 발현)

  • Kwon, B.S.;Hong, K.H.;Jahng, J.W.;Lee, H.T.;Chung, K.S.
    • Korean Journal of Animal Reproduction
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    • v.24 no.4
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    • pp.419-428
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    • 2000
  • Leptin, the product of obese (ob) gene, is an adipocyte-derived satiety factor that plays a major role in the regulation of food intake, energy homeostasis, body weight, reproductive physiology and neuropeptide secretion. The present study was designed to generate transgenic mice expressing antisense mouse ob (mob) gene. Total RNA was extracted from the adipose tissues of mouse, then reverse transcription was performed. The 303 and 635 bp fragments of anti I and II cDNAs were amplified from mob cDNAs by PCR. The two mob cDNAs were reversely ligated into between adipose tissue specific aP2 promote and SV40 poly(A) site. Transgenic mice carrying two different kinds of antisense mob transgenes were generated by DNA microinjection into pronucleus. Total 14 transgenic mice were born, and the 4 and 5 founder lines of the transgenic mice with anti I and II transgenes were respectively established. Antisense mRNA expression was detected in transgenic F$_1$ mice by RT-PCR analysis. This result suggests that the transgenic mice expressing antisense mob mRNA may be useful as an animal disease model to be obesity caused by decreased amount of leptin secretion.

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Applicability Analysis of HSPF Model for Management of Total Pollution Load Control at Tributary (지류총량관리를 위한 HSPF 모형의 적용성 분석)

  • Kim, Jung Soo;Song, Chul Min;Lee, Min Sung;Kim, Seo Jun
    • Proceedings of the Korea Water Resources Association Conference
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    • 2021.06a
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    • pp.438-438
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    • 2021
  • 우리나라의 수질오염총량관리제도는 수계 내 모든 유역을 관리대상으로 동일 기준유량 조건에 동일한 대상물질로 관리하고 있지만, 본류는 지류의 영향을 받고 있으며 지류는 사람이 거주하는 지역 인근에 있어 본류 수질에 직접적인 영향을 미치고 있다. 이는 지류의 시급한 개선이 필요한 오염물질의 실질적인 관리가 어려워 이를 개선하기 위해 오염도가 높은 지류의 총량관리를 위한 지류총량제도의 추가 도입이 필요한 실정이다. 본 연구에서는 지류총량제 시행에 따른 효과를 예측하기 위해 팔당수계 유역을 소유역 단위로 분할하고 HSPF 모형을 적용하여 팔당수계 소유역 지류에서의 수질 변화 양상이 본류에 미치는 영향을 분석하였다. 연구대상지역은 팔당수계 중권역 유역(남한강 하류 유역, 경안천 유역, 북한강 하류 유역)으로 구분하고 유역 유출 및 수질 모델링은 지류하천을 포함하는 57개 소유역을 대상으로 수행하였다. 입력자료는 공간자료(표고, 경사, 토지이용, 토양도 등)와 기상자료(춘천, 양평, 이천, 수원관측소)는 2008년~2018년의 강수량, 최고기온, 최저기온, 평균풍속, 평균습도 등의 시단위 자료를 사용하였다. 모의결과, BOD는 남한강 하류유역의 주요 지천 유역인 복하천, 양화천, 청미천 및 흑천 유역에서 0.54~0.56mg/L의 범위로 주변 유역보다 높게 나타났으며, 경안천 유역은 경안천 유역의 중·하류 유역에서 2.63~4.22mg/L의 범위로 높게 나타났고, 북한강 유역은 조종천 하류 및 북한강 상류 유역에서 1.36~3.31mg/L의 범위로 주변 유역보다 높게 나타났다. T-P는 남한강 하류 유역은 주요 지천 유역인 복하천, 양화천, 청미천 유역에서 0.07~0.19mg/L의 범위로 주변 유역보다 높게 나타났고, 남한강 하류 유역의 중간 지점 유역인 한강(E1, E2, E4, E6)에서 높게 나타났다. 경안천 유역은 중·하류 유역의 좌안측 유역인 경안(A4, A3, B2, B1, F9)에서 0.1~0.14mg/L의 범위로 높게 나타났으며, 북한강 유역은 전체 유역에서 0.06mg/L 이하로 남한강 하류 및 경안천 유역보다 전반적으로 낮게 나타났다. 이와 같이 지류총량관리에 HSPF 모형의 적용은 가능하였으나 HSPF 모형을 이용한 소유역 단위의 유량 및 수질 예측을 위해서는 기존의 유량 및 수질 관측망을 소유역 단위로 좀 더 정밀하게 계획하는 것이 필요하다고 판단된다.

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Monitoring of Groundwater quality according to groundwater use for agriculture (농업용 지하수 사용에 따른 지하수질 모니터링 평가)

  • Ha, Kyoochul;Ko, Kyung-Seok;Lee, Eunhee;Kim, Sunghyun;Park, Changhui;Kim, Gyoo-Bum
    • Proceedings of the Korea Water Resources Association Conference
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    • 2020.06a
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    • pp.30-30
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    • 2020
  • 본 연구에서는 여름철에 농업용수(벼농사용)로서 집중적으로 지하수를 사용하는 지역에서 시기별 지하수 사용에 따른 지하수 수질변화를 평가하기 위해 수행되었다. 연구지역은 충남 홍성군 양곡리와 신곡리 일부를 포함하는 면적 2.83 ㎢(283.3 ha)에 해당하는 지역이다. 연구지역 지하수 수질의 공간적 분포 및 시간적 변화 특성 평가를 위하여 2019년 2회(7월, 10월)에 걸쳐 지하수 관정(21개소)에 대하여 조사 및 분석을 수행하였다. 지하수 샘플은 현장에서 온도(T), pH, 용존산소(DO) 및 전기전도도(EC), 산화환원전위(Eh) 등을 측정하였고, 실험실에서 주요 양이온 및 미량원소(Ca, Mg, Na, K, Si, Sr), 음이온(F, Cl, Br, NO2, NO3, PO4, SO4), 알칼리도, 용존 유기탄소(DOC)와 용존 유기물(DOM) 등을 분석하였다. 지하수 수질조사 결과, 전체의 14~15개소(67~71%)가 Ca-HCO3 유형으로 분류되었으며, 다음으로는 Ca-Cl 유형이 4~5개소(19~24%)가 관찰되었다. 얕은 심도의 관정에서 상대적으로 심도가 깊은 관정보다 대부분 성분(TDS, Ca, Mg, Na, K, Cl, SO4, HCO3, DOC)에서 높은 농도를 나타내었다. 지하수의 수질자료를 이용하여 다변량통계분석법인 주성분분석(PCA: Principal Components Analysis)과 계층적 군집분석(HCA: Hierachical Cluster Anlaysis)를 수행한 결과, 초기 3개 주요 고유성분(eigenvalue)는 PC1 54.0%, PC2 14.2%, PC3 12.3%로 전체 분산의 88.3%를 설명할 수 있었다. PC1은 Ca, Mg, Na, K, Cl, SO4, DOC가 주요한 영향 인자였으며 PC2는 HCO3, NO3, DO에 영향 받음을 확인하였다. 계층적 군집분석 결과, 연구지역 지하수는 Na-Cl 유형의 C-3 관정을 제외하고는 크게 두 그룹으로 구분되어 졌다. 다변량통계분석의 결과에서도 수리지화학, 동위원소, 용존유기물 등의 특성에서 나타나는 것과 유사한 연구지역의 수질특성을 확인할 수 있었다. 연구지역은 차시기 동안 수질변화는 일부 관정을 제외하고는 유의할 만한 수준으로 관찰되지는 않았고, 지하수 사용에 따른 지하수위 회복도 빠르게 진행되고 있는 것으로 나타났다.

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The gene expression programming method to generate an equation to estimate fracture toughness of reinforced concrete

  • Ahmadreza Khodayari;Danial Fakhri;Adil Hussein, Mohammed;Ibrahim Albaijan;Arsalan Mahmoodzadeh;Hawkar Hashim Ibrahim;Ahmed Babeker Elhag;Shima Rashidi
    • Steel and Composite Structures
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    • v.48 no.2
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    • pp.163-177
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    • 2023
  • Complex and intricate preparation techniques, the imperative for utmost precision and sensitivity in instrumentation, premature sample failure, and fragile specimens collectively contribute to the arduous task of measuring the fracture toughness of concrete in the laboratory. The objective of this research is to introduce and refine an equation based on the gene expression programming (GEP) method to calculate the fracture toughness of reinforced concrete, thereby minimizing the need for costly and time-consuming laboratory experiments. To accomplish this, various types of reinforced concrete, each incorporating distinct ratios of fibers and additives, were subjected to diverse loading angles relative to the initial crack (α) in order to ascertain the effective fracture toughness (Keff) of 660 samples utilizing the central straight notched Brazilian disc (CSNBD) test. Within the datasets, six pivotal input factors influencing the Keff of concrete, namely sample type (ST), diameter (D), thickness (t), length (L), force (F), and α, were taken into account. The ST and α parameters represent crucial inputs in the model presented in this study, marking the first instance that their influence has been examined via the CSNBD test. Of the 660 datasets, 460 were utilized for training purposes, while 100 each were allotted for testing and validation of the model. The GEP model was fine-tuned based on the training datasets, and its efficacy was evaluated using the separate test and validation datasets. In subsequent stages, the GEP model was optimized, yielding the most robust models. Ultimately, an equation was derived by averaging the most exemplary models, providing a means to predict the Keff parameter. This averaged equation exhibited exceptional proficiency in predicting the Keff of concrete. The significance of this work lies in the possibility of obtaining the Keff parameter without investing copious amounts of time and resources into the CSNBD test, simply by inputting the relevant parameters into the equation derived for diverse samples of reinforced concrete subject to varied loading angles.

A Study on the Vegetables Mentioned in the Bible (성서에 언급된 채소류에 관한 연구)

  • Woo, Ja-Won
    • Journal of the Korean Society of Food Culture
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    • v.22 no.1
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    • pp.1-9
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    • 2007
  • This paper is intended to study what kinds of the vegetables are mentioned in the Bible and how they were used in those days. While one hundred and twenty-eight different plants are mentioned in the Bible, there are today 2,384 plant species in modem Israel, most of which have been introduced in recent centuries. These plants obviously did not exist there in biblical times and were only recently introduced from Australia and South America, respectively. This article will study only the vegetables mentioned in the Bible and known to have existed in the old and new testament times. Since the first book devoted exclusively to biblical botany was that of Levinus Lemmens in 1566, the modem systematic study of biblical plants, began with F. Hasselquist, a student of Linnaeus, the founder of modem botany. In 1928, Immanuel Loew approached the subject differently, reviewing all known data pertaining to biblical plants. His work not only discussed biblical plants, but also plants in later Jewish literature, particularly the Talmud. The British scholar G. E. Post provided a broad field study of modem plants in Palestine, Syria, Lebanon, and Jordan. More recent major treatments of the subject include those of A. and H. Moldenke (1952), M. Zohary (1982), N. Hareuveni (1984), and Y. J. Choi(1996). Today, articles on specific biblical plants listed in the Bible can be found in any number of encyclopedias. This study attempts to provide a synthesis of the work of a number of scholars who studied the vegetables and plants mentioned in the Bible. As a preliminary study on the culture of food in the biblical period, this study has focused on the identity and features of the vegetables of the Bible. In only a limited number of instances, because of the paucity of the informations and the broad and generic descriptions of the plants, we can't be certain about the identification of the vegetables named in the Bible. In many instances the traditions established by the Greek, Aramaic, and English translations are helpful, although sometimes they are misleading. This paper subdivides the vegetables into broad areas, the general vegetables and the flavoring herbs. Vegetables formed very important part of the diet in the biblical times. Two main types were used: those whose nutritious seeds could be easily stored and those which were eaten freshly gathered from gardens. Pulse seeds provided a useful source of vegetable protein, while fresh green vegetables were vitamin rich. Pulses could be eaten boiled, or their dried seeds could be ground up into flour and then made into nutritious soups. Fresh vegetables were eaten either raw or lightly cooked, usually by boiling in water. The general vegetables in the Bible are herbs(garden rocket), cucumber(snake cucumber), watermelon, leeks, chicory, and onions. Also the flavoring herbs in the Bible are rue, dill, cummin, black cummin, frankincense, cinnamon, cassia, myrrh, black mustard, coriander, mint, saffron, ginger grass, syrian hyssop, aloes(eagle wood), manna which have the flavor, aroma, and medical values.

Analysis of whole genome sequencing and virulence factors of Vibrio vulnificus 1908-10 isolated from sea water at Gadeok island coast

  • Hee-kyung Oh;Nameun Kim;Do-Hyung Kim;Hye-Young Shin;Eun-Woo Lee;Sung-Hwan Eom;Young-Mog Kim
    • Fisheries and Aquatic Sciences
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    • v.26 no.9
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    • pp.558-568
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    • 2023
  • Vibrio vulnificus is an aquatic bacterium causing septicemia and wound infection in humans. To understand this pathogen at the genomic level, it was performed whole genome sequencing of a cefoxitin-resistant strain, V. vulnificus 1908-10 possessing virulence-related genes (vvhA, viuB, and vcgC) isolated from Gadeok island coastal seawater in South Korea. The genome of V. vulnificus 1908-10 consisted of two circular contigs and no plasmid. The total genome size was estimated to be 5,018,425 bp with a guanine-cytosine (GC) content of 46.9%. We found 119 tRNA and 34 rRNA genes respectively in the genome, along with 4,352 predicted protein sequences. Virulence factor (VF) analysis further revealed that V. vulnificus 1908-10 possess various virulence genes in classes of adherence, antiphagocytosis, chemotaxis and motility, iron uptake, quorum sensing, secretion system, and toxin. In the comparison of the presence/absence of virulence genes, V. vulnificus 1908-10 had fur, hlyU, luxS, ompU, pilA, pilF, rtxA, rtxC, and vvhA. Of the 30 V. vulnificus comparative strains, 80% of the C-genotype strains have all of these genes, whereas 40% of the E-genotype strains have all of them. In particular, pilA were identified in 80% of the C-type strains and 40% of the E-type strains, showing more difference than other genes. Therefore, V. vulnificus 1908-10 had similar VF characteristics to those of type C strains. Multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin of V. vulnificus 1908-10 contained 8 A-type repeats (GXXGXXXXXG), 25 B.1-type repeats (TXVGXGXX), 18 B2-type repeats (GGXGXDXXX), and 7 C-type repeats (GGXGXDXXX). The National Center for Biotechnology Information (NCBI) Basic Local Alignment Search Tool (BLAST) showed that the RtxA protein of V. vulnificus 1908-10 had the effector domain in the order of cross-liking domain (ACD)-C58_PaToxP-like domain- α/β hydrolase-C58_PaToxP-like domain.