• Title/Summary/Keyword: $a_1=a_2=a_3=1$

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Synthesis and Antibacterial Activity of New Tetrazole Derivatives (새로운 Tetrazole유도체의 합성과 항균활성)

  • Mulwad, V.V.;Pawar, Rupesh B;Chaskar, Atul C
    • Journal of the Korean Chemical Society
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    • v.52 no.3
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    • pp.249-256
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    • 2008
  • 3-Acetyl/Formyl 4-hydroxy-2H(1)-benzopyran-2-one on treatment with malonitrile and ethyl cyanoacetate yielded 1,1-dicyano-2-[4/-hydroxy-2/H(1)-benzopyran-2/-one-3/-yl] ethene/propene 2a-h and ethyl-2-cyano-3-[4/-hydroxy-2/H (1)-benzopyran-2/-one-3/-yl] propenoate/butenoate 3a-h respectively. The 1,3 dipolar reaction of 2a-h with NaN3 gave the tetrazole derivative 4a-h. 3a-h on cyclization with PPA gave 3-cyano-2H,5H-pyrano [3, 2-c] benzopyran-2,5-diones 5a-h which on 1,3 dipolar reaction with NaN3 to gave 3-(1/H-tetrazol-5/-yl)-2H,5H-pyrano[3, 2-c] benzopyran-2,5-diones 6a-h. The structures of the compounds have been established on the basis of the spectral and analytical data. All the compounds were screened for their antimicrobial activities and have been found to exhibited significant antibacterial activities. Compounds 2h and 4h showed the activity 50g/mL.

Changes in the Growth and Quality of Creeping Bentgrass (Agrostis palustris Huds. 'Penn A1') Following Gibberelinic Acid (GA3) Treatment (지베렐린산(GA3) 처리에 따른 크리핑 벤트그래스 (Agrostis palustris Huds. 'Penn A1')의 생장 및 품질 변화)

  • Woo-Sung Kim;Tae-Wooung Kim;Young-Sun Kim;Chi-Hwan Lim
    • Korean Journal of Environmental Agriculture
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    • v.42 no.4
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    • pp.389-395
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    • 2023
  • This study evaluated the effects of gibberellic acid (GA3) on the growth and quality of creeping bentgrass (Agrostis palustris Huds.). Experimental treatments included a No application of fertilizer and GA3 (NFG) Control [3 N active ingredient (a.i.) g/m2], 0.3GA3 (GA3 0.3 a.i. mg/m2/200 mL), 0.6GA3 (GA3 0.6 a.i. mg/m2/200 mL), 1.2GA3 (GA3 1.2 a.i. mg/m2/200 mL), and 2.4GA3 (GA3 2.4 a.i. mg/m2/200 mL). Additionally, the study included a 1.5N+GA3 experiment with similar GA3 treatments combined with 1.5N a.i. g/m2 : NFG, Control (3N a.i. g/m2), 1.5N+ 0.3GA3 (1.5N a.i. g/m2+GA3 0.3 a.i. mg/m2/200 mL), 1.5N+0.6GA3 (1.5N a.i. g/m2+GA3 0.6 a.i. mg/m2/200 mL), 1.5N+1.2GA3 (1.5N a.i. g/m2+GA3 1.2 a.i. mg/m2/ 200 mL), and 1.5N+2.4GA3 (1.5N a.i. g/m2+GA3 2.4 a.i. mg/m2/200 mL). Compared to the NFG, turf color index chlorophyll content was not significantly different (p< 0.05). However, shoot length in 1.2GA3, 2.4GA3, 1.5N+0.3GA3, 1.5N+0.6GA3, 1.5N+1.2GA3, and 1.5N+2.4GA3 treatments increased by 0.8%, 10.6%, 5.15%, 8.3%, 13.5 %, and 21.6%, respectively, compared to the control. As compared to the control, clipping yield in 1.5N+1.2GA3 and 1.5N+2.4GA3 treatments increased by 7.1% and 14.3 %, respectively. These results indicated that GA3 application increased shoot length, with the 1.2GA3 treatment showing shoot length similar to the control (3N a.i. g /m2 ).

Ab Initio and Semi-Empirical Calculations of the Tautomers of Pyrazole Derivatives (Pyrazole 유도체들의 Tautomer들에 대한 Ab Initio와 Semi-Empirical 계산)

  • Lee, Hong Gi;Yim, Seon Hwa;Jung, Sung Gyung;Kang, Sung Kwon
    • Journal of the Korean Chemical Society
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    • v.39 no.3
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    • pp.150-156
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    • 1995
  • Molecular orbital calculations at the ab initio, AM1, and PM3 levels have been carried out to investigate the lactam-lactim tautomerism of 1,2,4-triazolidine-3,5- dione(1) and 1,3,4-oxa(or thia)diazolidine-2,5-dione(2, 3). Most stable tautomer in 1 compound has been calculated to be a dilactam 1a and next one is lactam-lactim 1b. The relative energies between 1a and 1b are 4.1~12.6 kcal/mol depending on computational methods. The optimized 1a structure at ab initio level is in good agreement with X-ray structure. While the stabilities of 2 tautomers are in order of 2a>2b>2c, the stabilities of 3 tautomers are dependent on methods. According to 3-21G basis set, 3a tautomer is more stable by 4.9 kcal/mol over 3b tautomer. In contrast, the heat of formation of 3a at AM1 is higher by 2.71 kcal/mol than 3b.

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Synthesis and Antitumor Evaluation of cis-(1,2-Diaminoethane) dichloroplatinum (II) Complexes Linked to 5- and 6-Methyleneuracil and -uridine Analogues

  • Kim, Jack-C.;Lee, Min-Hwa;Choi, Soon-Kyu
    • Archives of Pharmacal Research
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    • v.21 no.4
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    • pp.465-469
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    • 1998
  • The search for platinum (II)-based compounds with improved therapeutic properties was prompted to design and synthesize a new family of water-soluble, third generation cis-diaminedichloroplatinum (II) complexes linked to uracil and uridine. Six heretofore unreported uracil and uridine-platinum (II) complexes are; [N-(uracil-5-yl-methyl)ethane-1,2-di-amine]dichloroplatinum (II) (3a), [N-(uracil-6-yl-methyl)ethane-1,2-diaminel dichloroplatinum (II) (3b), t[N-($2^1$, $3^1$,$5^1$-tri-O-acetyl)uridine-5-yl-methyl] ethane-1,2-diamineldichloroplatinum (II) (6a), {[N-($2^1$,$3^1$, $5^1$-tri-O-acetyl) uridine-6-yl-methyl]ethane-1,2-diamine)dichloroplatinum (II) (6b),[N-(uridine- 5-yl-methyl)ethane-1,2-diamine]dichloroplatinum (II) (7a), [N-(uridine-6-yl- methyl)ethane-1,2-diamine]dichloroplatinum (II) (7b). These analogues were prepared from the key starting materials, 5-chloromethyluracil (1a) and 6-chloromethyluracil (1b) which were reacted with ethylenediamine to afford the respective 5-[(2-aminoethyl)aminol methyluracil (2a) and 6-[(2-aminoethyl)amino]methyluracil (2b). The cis-platin complexes 3a and 3b were obtained through the reaction of the respective 2a and 2b with potassium tetrachloroplatinate (II). The heterocyclic nucleic acid bases 1a and 1b were efficiently introduced on the .betha.-D-ribose ring via a Vorbruggen-type nucleoside coupling procedure with hexamethyldisilazane, trimethylchlorosilane and stannic chloride under anhydrous acetonitrile to yield the stereospecific .betha.-anomeric 5-chloromethyl- $2^1$,$3^1$,$5^1$-tri-O-acetyluridine (4a) and 6-chloromethyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (4b), respectively. The nucleosides 4a and 4b were coupled with ethylenediamine to provide the respective 5-[(amino-ethyl)aminolmethyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (5a) and 6-[(aminoethyl)amino] methyl-$2^1$,$3^1$,$5^1$-tri-O-acetyluridine (5b). The diamino-uridines 5a and 5b were reacted with potassium tetrachloroplatinate (II) to give the novel nucleoside complexes, 6a and 6b, respectively which were deacetylated into the free nucleosides, 7a and 7b by the treatment with CH$_{3}$ONa. The cytotoxic activities were evaluated against three cell lines (FM-3A, P-388 and J-82) and none of the synthesized compounds showed any significant activity.

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The Crystal and Molecular Structure of Trifluoromethyltriphenyl-1,2,4-Trioxolane (트리풀르오로메칠트리페닐-1,2,4-트리오키소란의 결정 및 분자구조)

  • 안중태;서일환
    • Korean Journal of Crystallography
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    • v.5 no.1
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    • pp.14-19
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    • 1994
  • Tlifluoromethyltriphenyl-1,2,4-tioxolane(C2IHlsF303)is triclinic, space group P1 with a=10.477(1), b= 11.056(1), c=9.917(3) A, a=104.7(1), B=122.7(1), r=63.9(1), Z=2, V=867.9(3) A3, Dc=1.43 g/cm3, λ(Mo Ka)=0.71069 A, μ=0.0116 cm-1,F(000)=384, and R=0.067 for 1713 unique observed reflections with I > 1.0 o(I). The structure was solved by direct methods and refined by fall-matrix least-squares refinement with the fixed C-H bond lengths at 0.96 A. Two phenyl rings((2) and (3)) that have the dihydral angle of 106.0°.

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JACOBI'S THETA FUNCTIONS AND THE NUMBER OF REPRESENTATIONS OF A POSITIVE INTEGER AS A SUM OF FOUR TRIANGULAR NUMBERS

  • Kim, Aeran
    • Honam Mathematical Journal
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    • v.38 no.4
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    • pp.753-782
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    • 2016
  • In this paper we deduce the number of representations of a positive integer n by each of the six triangular forms as $${\frac{1}{2}}x_1(x_1+1)+{\frac{3}{2}}x_2(x_2+1)+{\frac{3}{2}}x_3(x_3+1)+{\frac{3}{2}}x_4(x_4+1),\\{\frac{1}{2}}x_1(x_1+1)+{\frac{1}{2}}x_2(x_2+1)+{\frac{3}{2}}x_3(x_3+1)+{\frac{3}{2}}x_4(x_4+1),\\{\frac{1}{2}}x_1(x_1+1)+{\frac{1}{2}}x_2(x_2+1)+{\frac{1}{2}}x_3(x_3+1)+{\frac{3}{2}}x_4(x_4+1),\\x_1(x_1+1)+x_2(x_2+1)+{\frac{3}{2}}x_3(x_3+1)+{\frac{3}{2}}x_4(x_4+1),\\x_1(x_1+1)+{\frac{3}{2}}x_2(x_2+1)+{\frac{3}{2}}x_3(x_3+1)+3x_4(x_4+1),\\{\frac{1}{2}}x_1(x_1+1)+{\frac{1}{2}}x_2(x_2+1)+3x_3(x_3+1)+3x_4(x_4+1).$$

Synthesis of the New Saccharin Derivatives Containing Imidazolidine-2,4,5-trione or 2-Thio-imidazolidine-4, 5-dione Group (Imidazolidine-2,4,5-trione 혹은 2-thio-imidazolidine-4,5-dione기를 포함하는 새로운 saccharin 유도체의 합성)

  • Jung, Dai-Il;Byun, Suk-In;Kim, Yun-Young;Kim, Young-Hwan;Lee, Do-Hun;Song, Hyun-Ae;Lee, Yong-Gyun;Park, Yu-Mi;Choi, Soon-Kyu;Han, Jung-Tae
    • Journal of Life Science
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    • v.14 no.2
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    • pp.351-355
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    • 2004
  • Saccharin derivatives were synthesized by means of 4 reaction steps involved the reaction of 1-methylurea (or 1-methylthiourea) and oxalyl chloride. 1-Alkyl(or phenyl)-3-(1,1,3-trioxo-1,3-dihydro-1$^{6}$ -benzo[d]isothiazol-2-ylmethyl)-imidazolidine-2,4,5-trione 5 and 1-alkyl(or phenyl)-2-thioxo- 3-(1,1,3-trioxo-1,3-dihydro-1$^{6}$ -benzo-[d]isothiazol-2-ylmethyl)-imidazolidine-4,5-dione 12 were obtained by means of 4 reaction steps involved the reaction of 1-methyl-urea(or 1-methylthiourea) and oxalyl chloride.

Refinement of the Structure of p-Dimethylaminobenzaldehyde 4-(p-Ethoxyphenyl) Thiosemicarbazone (p-Dimethylaminobenzaldehyde 4-(p-Ethoxyphenyl) Thiosemicarbazone구조의 정밀화)

  • Seo, Il-Hwan;Seo, Chu-Myeong;Park, Yeong-Ja
    • Korean Journal of Crystallography
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    • v.2 no.1
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    • pp.12-16
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    • 1991
  • C18H22N4OS, Mr=342.47, monoclinic, P2₁/c,a=11.802(2), b=31.962(2), c=9.829(2)A, β=100.12(1)˚, V=3694.8A3,F(000)=1472, Z=8, Dx=1.246 Mg m-3, Dm=1.17Mg m-3,λ=0.71073 A, μ=0.15mm-1, T=294 K. final R=0.0856 for 3718 observed reflection (Fo>3σ(Fo)) There are two molecules in an asymmetric unit and a major difference between these molecules is in the C(9)-N(1)-C(6)-C(7) torsion angles [58.8(8)˚and 1(1)˚]. Both molecules have intramolecular N(1)-H(10)'N(3) hydrogen bonds [ 2.613(7) and 2.566(7) A] and assume V-shaped conformation with N(2) atoms at the verices. The two independent molecules are linked by the two N(2)-H(11)'S' hydrogen bonds[3.367(5) A and 3.421(4)A] and the dimergen are held together by van der Waals forces.

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LOCAL PERMUTATION POLYNOMIALS OVER FINITE FIELDS

  • Lee, Jung-Bok;Ko, Hyoung-June
    • Communications of the Korean Mathematical Society
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    • v.9 no.3
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    • pp.539-545
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    • 1994
  • Let $q = p^r$, where p is a prime. A polynomial $f(x) \in GF(q)[x]$ is called a permutation polynomial (PP) over GF(q) if the numbers f(a) where $a \in GF(Q)$ are a permutation of the a's. In other words, the equation f(x) = a has a unique solution in GF(q) for each $a \in GF(q)$. More generally, $f(x_1, \cdots, x_n)$ is a PP in n variables if $f(x_1,\cdots,x_n) = \alpha$ has exactly $q^{n-1}$ solutions in $GF(q)^n$ for each $\alpha \in GF(q)$. Mullen ([3], [4], [5]) has studied the concepts of local permutation polynomials (LPP's) over finite fields. A polynomial $f(x_i, x_2, \cdots, x_n) \in GF(q)[x_i, \codts,x_n]$ is called a LPP if for each i = 1,\cdots, n, f(a_i,\cdots,x_n]$ is a PP in $x_i$ for all $a_j \in GF(q), j \neq 1$.Mullen ([3],[4]) found a set of necessary and three variables over GF(q) in order that f be a LPP. As examples, there are 12 LPP's over GF(3) in two indeterminates ; $f(x_1, x_2) = a_{10}x_1 + a_{10}x_2 + a_{00}$ where $a_{10} = 1$ or 2, $a_{01} = 1$ or x, $a_{00} = 0,1$, or 2. There are 24 LPP's over GF(3) of three indeterminates ; $F(x_1, x_2, x_3) = ax_1 + bx_2 +cx_3 +d$ where a,b and c = 1 or 2, d = 0,1, or 2.

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Synthesis of sulphonic acids and sultam derivatives

  • Ismail, Ibrahim-Imam
    • Archives of Pharmacal Research
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    • v.13 no.1
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    • pp.1-4
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    • 1990
  • Reaction of propane-1, 3-sultone with amines gave N-substituted aminosulphonnic acids 2a-i, Dehydration of 2a-c with $POCI_3$ gave the corresponding sultams 3a-c. Propane-1, 3-sultone 1 reacted with tertury amines to give the betaiene salts 4-11. 2-4-Dimethyl-1, 3-butadiene-1, 4-sultone 12 condensed with amines to give N-substituted-2, 4-dimethyl-1, 3-butadiene-1, 4-sultames 13a and 13b. The reaction of 3a, 13a with hydrazine hydrate gave acid hydrazides 3d or 13c. Compounds 3d, 13c reacted with isocyanates to yield urea derivatives 14a-c, 15a-c.

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