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The Study and Measurement of Three Dimensional Spatial Dose Rate from Radioiodine Therapy (고용량 옥소 치료 시 3차원적 공간선량률 측정 및 연구)

  • Chang, Boseok
    • Journal of the Korean Society of Radiology
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    • v.7 no.3
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    • pp.251-257
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    • 2013
  • Spatial dose rates of high dose $^{131}I$ therapy patients were Measured Three dimensional (X, Y, Z) distributions. I have constructed geometrical an aluminum support structure for spatial dose meters placed in 5 different heights, 8 different azimuthal angles, 6 different time interval and distance 100 cm from High dose$^{131}I$ therapy patients. when the height of vertical plane Spatial dose distribution is 100 cm, the Spatial dose rates is max and the error range is low. the vertical plane Spatial dose rates was found to be 71.85 ${\mu}Sv/h$ on the average at a distance of 100 cm, height 100 cm, from the patients 24 hours after $^{131}I$ oral administration. I divided 12 patients into two groups. I have analysed group A (drinking 5 L water) and group B (drinking 3 L water) in order to measure decrease spatial dose rates. I have found the spatial distributions of patient dose rates is $44.9{\pm}7.2$ ${\mu}Sv/h$ in group A and $100.3{\pm}8.1$ ${\mu}Sv/h$ in group B by 24 after $^{131}I$ oral administration. the reduction factor was found to be approximately 54 % through drinking 5 L water during 24 hours.

Comparative Assay Fungus Population and Resistant Genes about Magnaporthe grisea between Korea and China (한국·중국 벼 도열병균 생리형 분석 및 품종 저항성 특성 비교)

  • Kim, Dong-Yun;Shim, Hong-Sik;Cailin, Lei;Ling, Zhong Zhuan;Han, Seong-Sook
    • Research in Plant Disease
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    • v.10 no.4
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    • pp.217-226
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    • 2004
  • One hundred isolates of Magnaporthe grisea from Korea and China were characterized for pathogenicity using eight Korean differential varieties(KDV), six Chinese differential varieties(CDV) and six near isogenic lines(NILs) developed in China. The restriction length polymorphism of M. grisea isolates from each country also was analyzed using MGR586 as a probe. One hundred Korean isolates classified into 17 races on KDV were grouped into 29 pathotypes on Chinese near isogenic lines(NILs). Virulence of 46% of Korean isolates against all the six Chinese NILs indicated that the current six Chinese NILs alone was not enough to be used as differential varieties in Korea. Especially, susceptibility of the BL1 carrying resistance gene Pi-b to 70% of tested Korean isolates suggested that BL1(Pi-b) may not be a useful resistance source to Korean blast. Based on the virulence assays of M. grisea populations from each country were divided into two groups. About 50% of Chinese isolates showed similarity to the 30% of the Korean isolates. Especially, the isolates from northern part of China, where Japonica rice cultivars were grown, showed high similarity to the Korean isolates, while isolates from southern part of China, where Indica rice were mainly grown, showed low similarity to Korean isolates. The genome RFLPs of Korean isolates were quite different from those of southern part of China using MGR586 as a probe. These data indicated that the physiological and genetical characteristics of M. grisea population might be determined by strong interaction with cultivated rice.

Fluoxetine Simultaneously Induces Both Apoptosis and Autophagy in Human Gastric Adenocarcinoma Cells

  • Po, Wah Wah;Thein, Wynn;Khin, Phyu Phyu;Khing, Tin Myo;Han, Khin Wah Wah;Park, Chan Hee;Sohn, Uy Dong
    • Biomolecules & Therapeutics
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    • v.28 no.2
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    • pp.202-210
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    • 2020
  • Fluoxetine is used widely as an antidepressant for the treatment of cancer-related depression, but has been reported to also have anti-cancer activity. In this study, we investigated the cytotoxicity of fluoxetine to human gastric adenocarcinoma cells; as shown by the MTT assay, fluoxetine induced cell death. Subsequently, cells were treated with 10 or 20 µM fluoxetine for 24 h and analyzed. Apoptosis was confirmed by the increased number of early apoptotic cells, shown by Annexin V- propidium iodide staining. Nuclear condensation was visualized by DAPI staining. A significant increase in the expression of cleaved PARP was observed by western blotting. The pan-caspase inhibitor Z-VAD-FMK was used to detect the extent of caspase-dependent cell death. The induction of autophagy was determined by the formation of acidic vesicular organelles (AVOs), which was visualized by acridine orange staining, and the increased expression of autophagy markers, such as LC3B, Beclin 1, and p62/SQSTM 1, observed by western blotting. The expression of upstream proteins, such as p-Akt and p-mTOR, were decreased. Autophagic degradation was evaluated by using bafilomycin, an inhibitor of late-stage autophagy. Bafilomycin did not significantly enhance LC3B expression induced by fluoxetine, which suggested autophagic degradation was impaired. In addition, the co-administration of the autophagy inhibitor 3-methyladenine and fluoxetine significantly increased fluoxetine-induced apoptosis, with decreased p-Akt and markedly increased death receptor 4 and 5 expression. Our results suggested that fluoxetine simultaneously induced both protective autophagy and apoptosis and that the inhibition of autophagy enhanced fluoxetine-induced apoptosis through increased death receptor expression.

Eccentric Axial Load Test of Prefabricated Composite Columns Using Bolt-connected Steel Angles (볼트접합 앵글을 사용한 PSRC 합성기둥의 편심 압축실험)

  • Kim, Hyeon Jin;Hwang, Hyeon Jong;Park, Hong Gun;Kim, Dong Kwan;Yang, Jong Min
    • Journal of Korean Society of Steel Construction
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    • v.29 no.3
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    • pp.249-260
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    • 2017
  • In order to investigate the structural performance of a novel prefabricated-SRC column using bolt-connected steel angles(PSRC column), eccentric axial loading tests were performed for six PSRC column specimens and two conventional SRC column specimens. The test parameters were the spacing and sectional configurations of lateral reinforcement, and eccentricity ratio of axial load. The test results showed that, due to high axial-stiffness of the angles located at the corners of the cross section, the compressive load-carrying capacity and deformation capacity of the PSRC specimens were greater than those of the SRC specimens in the large eccentricity ratio of axial load. Closely spaced lateral steel plates and Z-shaped lateral steel plates improved lateral confinement, which increased the load-carrying capacity of the PSRC specimens. The combined flexural and axial load-carrying capacity of the specimens by tests and nonlinear numerical analysis were greater than the predictions by current design codes. The numerical analysis agreed well with the test results including the initial stiffness, peak strength, and post-peak strength degradation.

Interaction in Model of Herbicide Combination Using Oxyfluorfen to Control Orchard Weeds (Oxyfluorfen을 주재(主材)로 한 과수원(果樹園) 제초제(除草劑) 조합처리(組合處理) 모형(模型)의 상호작용(相互作用) 효과(效果) 해석연구(解析硏究))

  • Guh, J.O.;Cho, Y.W.;Kwon, S.L.;Lee, W.Z.
    • Korean Journal of Weed Science
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    • v.4 no.1
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    • pp.88-95
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    • 1984
  • The study was intended to analyze the interaction effects of paraquat and oxytluorfen as an orchard herbicide-mixture. Data were prepared from the former report of authors. The algebraic expression for the actions of paraquat and oxyfluorfen on the control percentages of peach orchard weeds, and their interactions were determined from the multiple regression polynomial and plotted in three-dimensional graphs. As a result of treatments by combination of paraquat and oxyfluorfen on the field which was dominated by perennial weeds, the most effective interactions were detected at combination rates of $245\;gHa^{-1}$ paraquat and $470-705\;gHa^{-1}$ oxyfluorfen. However, to develope the long-term weeding-efficacies, the combination rates of paraquat are expected to raise up to $500-700\;gHa^{-1}$, and oxyfluorfen to fit at lower limits of rates, respectively.

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THE EFFECTS OF VARIOUS ALL-ETCHING AGENTS AND VARIED ETCHING TIME ON ENAMEL MORPHOLOGY AND BOND STRENGTH (수종의 All-Etching Agent와 산부식시간에 따른 법랑질 산부식형태 및 전단 결합강도에 관한 연구)

  • Kwon, So-Ran;Yoon, Tae-Hyun;Park, Dong-Soo
    • Restorative Dentistry and Endodontics
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    • v.21 no.1
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    • pp.136-149
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    • 1996
  • The effects of various All-Etching Agents (10% phosphoric acid, 10% maleic acid and 10 % citric acid) and 32 % phosphoric acid and varied etching time were evaluated by observing the morphology of the etched enamel surfaces using Scanning electron microscopy and by measuring the shear bond strength of a composite resin to human enamel. A total of 156 extracted premolar and molar teeth free of irregularities were employed in this study. Specimens for the observation of enamel morphology were divided into 12 groups of 3 teeth each, based on the type of etchant used and application time. After exposure to the etching agent specimens were washed air-dried and then glued to aluminum stubs and coated with a layer of gold for examination in the scanning electron microscope. Specimens for the evaluation of bond strength were divided into 12 groups of 10 teeth each also based on the type of etchant used and application time. After exposure to the etching agent the specimens were washed, air-dried and a thin layer of bonding agent was applied using a brush. Z 100 composite resin was light cured to the surface and stored at $37^{\circ}C$, 100% humidity for 7 days. An Instron Universal Testing Machine was used to apply a shearing force at $90^{\circ}$ angle from the enamel surface. It is concluded from this study that commercial All-etching agents can be used with a 15-second etching without adversely affecting retention of dental resin materials. At the same time, the acid concentration is probably a suitable compromise regarding the acid's function as a dentin demineralizing all-etch conditioning agent. The following results were obtained. 1. Specimens etched with 10 % citric acid showed a random superficial etching pattern which could not be related to prism morphology. 2. Specimens etched with 10 % and 32 % phosphoric acid and 10 % maleic acid showed a type I pattern in which core material was preferentially removed leaving the prism peripheries relatively intact or a type II pattern in which prism peripheries were preferentially removed. This delineation became more distinguished as etching time was increased. 3. All-Etching Agents and 32 % phosphoric acid showed a statistically significant higher shear bond strength at 15 seconds etching time.(p<0.05) 4. 10 % maleic acid and 32 % phosphoric acid exhibited a statistically significant higher shear bond strength than 10 % phosphoric and citric acid at 15 seconds etching time.(p<0.05).

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A Study on the Evaluation of Prognosis with Hemodynamic data in Corrective Surgery of Tetralogy of Fallot - PA-LA peak pressure gradient as a new criteria - (활로 4징증 수술 전후 압력 측정치가 예후에 미치는 영향에 관한 연구)

  • Kim, Eung-Su;Kim, Geun-Ho
    • Journal of Chest Surgery
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    • v.20 no.1
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    • pp.30-38
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    • 1987
  • Sixty-eight consecutive patients have been subjected to total corrective surgery of tetralogy of Fallot at the Hanyang University Hospital between August 1975 and December 1984. Of these, the pressure of chambers and great arteries were measured, before and immediately following an operation in 39 of the survived group and 11 of the expired group. The values of postoperative peak pressure were correlated with the outcome of the operation. The result are as followings; 1] Compared to the average peak pressure of right atrium in the survived group, 14.46*4.16 mmHg, that in the expired group, 19.36*8.19 mmHg, was significantly lower, 2] Compared to the average systolic pressure of right ventricle in the survived group, 56.72z16.37 mmHg, that in the expired group, 70.45*15.26 mmHg, was significantly lower. 3] Compared to the average systolic pressure of pulmonary artery in the survived group, 33.26*12.95 mmHg, that in the expired group, 37.55*11.63 mmHg, was higher. But the difference was not significant. 4] Compared to the average peak pressure of left atrium in the survived group, 17.41*6.90 mmHg, that in the expired group, 31.18*12.47 mmHg, was significantly higher. 5] Compared to the average systolic pressure of left ventricle in the survived group, 103.82~12.83 mmHg, that in the expired group, 90.55*20.02 mmHg, was significantly lower. 6] Compared to the average value of the right ventricle-pulmonary artery systolic pressure gradient [RV-PA] in the survived group, 24.95a15.44 mmHg, that in the expired group, 35.09*17.01 mmHg, was significantly higher. 7] Compared to the average value of the right ventricle to left ventricle systolic pressure ratio [RV/LV] in the survived group, 0.55*0.15, that in the expired group, 0.80a0.20, was significantly higher. 8] Compared to the average value of the pulmonary artery-left atrium peak pressure gradient [PA-LA] in 15.85x12.29 mmHg that in the expired group, 4.18x6.00 mmHg, was significantly lower. It is, therefore, suggested that in the operating room, PA-LA is as valuable as RV - PA, RV/LV in making important surgical decision and predicting the prognosis.

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Analysis of the Forest Vegetation of Mt. Ilwol (일월산의 삼림식생 분석)

  • Lee, Ho-Joo;Heung-Lak Choung;Doo-Weon Byun;Chang-Ho Kim
    • The Korean Journal of Ecology
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    • v.16 no.3
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    • pp.239-259
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    • 1993
  • The vegetation types and distributional characteristics of the forest vegetation on Mt. Ilwol were investigated by the Z-M school method. Geographical distribution of the vegetation was a central/montane(CEMO) type of the Korean Peninsula subtype. The forest was classified into five vegetation units: Artemisio-Quercetum mongolicae (Artemisio-Quercetum typicum subass. nov., Artemsio-Quercetum pinetosum dens~florae subass. nov. ). Lychno-Quercetum mongolicae (Lychno-Quercetum Calamagrostetosum arundinaceae subass. nov.. Lychno-Quercetum ligularetosum f~scherii subass. nov.), Fraxinus rhynchophylla community, Quercus variabilis community and Larix leptolepis afforestation. Species with percentage constance degree more than 61% are Quercus mongolica (89.5%, V), Lespedeza maximowiczii (73.7%, IV), Isodon japonicus(73.7%, IV), Fraxinus rhynchophylla (68.%, IV), Arlemisia stolonifera (65, 8%, IV), etc. Artemisio-Quercetum mongolicae was chiefly distributed on the ridge lines of low altitudes (570~700m) and on the ground with exposed rocks in sloping surface (800~1, 000m). Both Fraxinus sievoldiana and Rhododendrou schlippenbachii of the Artemisio-Quercetum mongolicae showed a predominant condition all over the subtree and shrub layers. Of Artemisio-Quercetum pinetosum densifloraes, Pinus densiflora becomes powerful over the tree layer and, on the other hand, Quercus mongolica over the subtree layer. Lychno-Quercetum mongolicae was distributed somewhat on the humid region of the high altitude area (840~1.200m). Fraxinus rhynchophylla community was chiefly distributed in the vicinity of the ravines. Quereus rariabilis community was distributed at subxeric slope on southeast side of the mountain. Larix leptolepis has been reforested at the ecotone between Artemisio-Quercetum mongolicae and Lychno-Quercetum mongolicae. Percentage cover degrees of the subtree layer In Lychno-Quercetum mongolicae, Quereus rariabilis community and Larix leptolepis afforestation were relatively low, 15.3%, 5% and 2.5%, respectively.The contents of moisutre and organic matter in the soil were much higher in Luchno-Quercetum monogolicae and Larix leptolepis afforestaion than in the other communities. Contents o Ca, Mg, K and the available phosphorus were relaively high compared with forests of the other area. This result seems to be influenced by a forest fire. As the altitude increases, the moisure content in the forest soil also increases.

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Aboveground biomass, growth and yield for some selected introduced tree species, namely Cupressus lusitanica, Eucalyptus saligna, and Pinus patula in Central Highlands of Ethiopia

  • Tesfaye, Mehari Alebachew;Gardi, Oliver;Anbessa, Tesfaye Bekele;Blaser, Jurgen
    • Journal of Ecology and Environment
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    • v.44 no.1
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    • pp.8-25
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    • 2020
  • Background: Species of the genera Eucalyptus, Cupressus, and Pinus are the most widely planted tree species in the country in general and in Chilimo dry Afromontane forest in particular. Eucalyptus covers 90% of the total planted forest area in the country. However, only limited information exists in the country regarding aboveground biomass (AGB), belowground biomass (BGB), growth, and yield. This study was conducted to assess the variables on 25 and 30 years of age for three planted species: Cupressus lusitanica, Eucalyptus saligna, and Pinus patula in Chilimo plantation forest, in the Central Highlands of Ethiopia. A two-times inventory was conducted in 2012 and 2017. A total of nine square sampled plots of 400 ㎡ each, three plots under Cupressus lusitanica, 3 Eucalyptus saligna, and 3 Pinus patula were used for data collection. Data on height, diameter, soil, and tree stumps were collected. Percent C, % N, and bulk density was performed following chemical procedure. Results: The aboveground biomass ranged from 125.76 to 228.67 t C ha-1 and the basal area and number of stems from 3.76 to 25.50 ㎡ ha-1 and 483 to 1175 N ha-1, respectively. The mean annual basal area and volume increment were between 0.97 and 1.20 ㎡ ha-1 year-1 and 10.79 and 16.22 ㎥ ha-1 year-1. Both carbon and nitrogen stock of the planted forest was non-significant among the tree species. Conclusion: The aboveground biomass, growth, and yield significantly varied among the species. Cupressus lusitanica had the highest aboveground biomass, volume, and basal area, while Eucalyptus saligna had the lowest value. To a depth of 1 m, total carbon stored ranged from 130.13 to 234.26 t C ha-1. The total annual carbon sequestration potential was 12,575.18 t CO2 eq. Eucalyptus has the highest carbon stock density and growth rate than other species.

First-order Wire-wound SQUID Gradiometer System Having Compact Superconductive Connection Structure between SQUID and Pickup Coil (SQUID와 검출코일의 초전도 결합방식이 개선된 1차 권선형 미분계 시스템)

  • Lee, Y.H.;Yu, K.K.;Kim, J.M.;Kwon, H.;Kim, K.;Park, Y.K.
    • Progress in Superconductivity
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    • v.9 no.1
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    • pp.23-28
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    • 2007
  • In order to have a superconductive connection between the wire-wound pickup coil and input coil, typically Nb terminal blocks with screw holes are used. Since this connection structure occupies large volume, large stray pickup area can be generated which can pickup external noise fields. Thus, SQUID and connection block are shielded inside a superconducting tube, and this SQUID module is located at some distance from the distal coil of the gradiometer to minimize the distortion or imbalance of uniform background field due to the superconducting module. To operate this conventional SQUID module, we need a higher liquid He level, resulting in shorter refill interval. To make the fabrication of gradiometers simpler and refill interval longer, we developed a novel method of connecting the pickup coil into the input coil. Gradiometer coil wound of 0.125-mm diameter NbTi wires were glued close to the input coil pads of SQUID. The superconductive connection was made using an ultrasonic bonding of annealed 0.025-mm diameter Nb wires, bonded directly on the surface of NbTi wires where insulation layer was stripped out. The reliability of the superconductive bonding was good enough to sustain several thermal cycling. The stray pickup area due to this connection structure is about $0.1\;mm^2$, much smaller than the typical stray pickup area using the conventional screw block method. By using this compact connection structure, the position of the SQUID sensor is only about 20-30 mm from the distal coil of the gradiometer. Based on this compact module, we fabricated a magnetocardiography system having 61 first-order axial gradiometers, and measured MCG signals. The gradiometers have a coil diameter of 20 mm, and the baseline is 70 mm. The 61 axial gradiometer bobbins were distributed in a hexagonal lattice structure with a sensor interval of 26 mm, measuring $dB_z/dz$ component of magnetocardiography signals.

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