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The Effect of a Video Exercise Program on Cancer-related Fatigue, Physical Function and Emotional Status in Patients with Cancer during Chemotherapy (동영상 운동프로그램이 항암 화학요법을 받는 암환자의 피로와 신체기능 및 정서상태에 미치는 효과)

  • Cho, Mee Young;Park, Ji Young;Lee, Chung Eun;Song, Su Kyung;Lee, Sun Hi;Byun, Eun Sung;Kim, Ji Youn;Park, Ok Sun;Kim, Soon Ho;Kang, Young Lynn;Han, Soo Young;Lee, Hyang Kyu;Choi, Hye Jin
    • Journal of Korean Clinical Nursing Research
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    • v.18 no.3
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    • pp.368-380
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    • 2012
  • Purpose: The purpose of this study was to evaluate the effects of a home-based video exercise program on cancer-related fatigue, physiological and psychological status in patients with colon and rectal cancers undergoing chemotherapy. Methods: The study design was a non-equivalent control group non-synchronized design. Data were collected from patients with colo-rectal cancers in Yonsei cancer center from July 5th to October 31st in 2011. There were 40 participants; 20 in the experimental group and 20 in the control group. The structured questionnaire was used to measure fatigue, physical function and emotional status. Data were analyzed using SPSS 18.0 and a chi-squre test, Fisher's exact test, Mann-Whitney U test and Wilcoxon signed- rank test were conducted to examine the homogeneity and the research hypotheses. Results: There was a statistically significant difference in White Blood Cell count in the experimental group compared with that of the control group. The exercise group showed a slight decrease of White Blood Cell count compared with that of the control group after 4 week program (z=-2.935, p=.003). However, there were no significant differences in fatigue, physiological and psychological status between the two groups. Conclusion: In this study, the developed video exercise program was effective in markedly slightly decreasing White Blood Cell count in patients with colo-rectal cancers undergoing chemotherapy. Therefore, utilizing the video exercise program can be an useful method to promote health among patients with cancer in clinical practice.

Radiolabeling of 11C-sertraline by fast and easy loop method with [11C]CH3OTf

  • Lee, Hak Jeong;Jeong, Jae Min;Lee, Sang-Yoon;Ido, Tatsuo
    • Journal of Radiopharmaceuticals and Molecular Probes
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    • v.3 no.1
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    • pp.32-37
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    • 2017
  • Cis-(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tertrahydro-N-methyl-1-naphthalenamine (sertraline) hydrochloride from among selective serotonin reuptake inhibitors (SSRIs) is a treatment of major depression. For the differential diagnosis by metabolizing serotonin in a patient with neurological disorders, the radiolabeled $^{11}C$-sertraline was developed for non-invasive positron emission tomography in living brain and use the evaluation of new drug for SSRIs. We release the results of a fast and easy radiolabeling method applied a one-step loop method with $[^{11}C]CH_3OTf$ for routine clinical applications of $^{11}C$-sertraline. 1 mg of a precursor for $^{11}C$-sertraline in 0.1 mL DMF and $5{\mu}L$ of 1N NaOH, were injected into the loop of semi-prep high-performance liquid chromatography (HPLC). $[^{11}C]CH_3OTf$ was passed through the loop at room temperature (RT). The $^{11}C$-sertraline was separated by the semi-preparative HPLC. $^{11}C$-sertraline was eluted at 28.0 min was collected and evaluated by analytical HPLC and mass spectrometer. The total radiolabeling efficiency of $^{11}C$-sertraline was $30.7{\pm}8.7%$. The specific activity was $64.8{\pm}51.4GBq/{\mu}mol$. The radiochemical and chemical purities were higher than 99%. The mass spectrum of the product showed m/z peaks at 307.1 (M+1), indicating the mass of sertraline. By the one-step loop method with $[^{11}C]CH_3OTf$, $^{11}C$-sertraline could be quickly and easily prepared for clinical application.

Tetrodotoxin in a Pufferfish, Fugu xanthopterus (Korean Name, Ggachibog) (까치복(Fugu xanthopterus)의 독성)

  • Hyun-Dae Kim;Yeung-Ho Park;Dong-Soo Kim
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.23 no.3
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    • pp.502-508
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    • 1994
  • A total of 24 specimens of the pufferfish, Fugu xanthopterus, purchased at a fixhmarket in Pusan, korea were examined for toxicity using the assay method of tetrodotoxin (TTX). Also, the toxins isolated from the puffer liver were partially purified and analyzed for their chemical composition by instrumental behaviors. On the whole, when the level of toxicity in each organ was analyzed compared to that of liver, they were 100 % of the lover, 92 % for the intestine, 75% for the skin, 17% for the muscle, 785 for the testis, 87% for the ovary, and 71% for bile. The highest and average scores of toxicity for the liver were 917 and $231{\pm}51MU/g$ liver, respectively. The toxins of the puffer gave four peaks in HPLC whose retention times (10, 20, 22 and 25 min) were close to those of TDA, TTX, 4-epi-TTX, and and -TTX, respectively.

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Archaismen im heutigen Deutsch (현대 독일어에 나타난 고어)

  • Kim Jong-Soo
    • Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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    • v.2
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    • pp.29-48
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    • 2000
  • Archaismen als sprachliches $Ph\"{a}nomen$, das zeitspezifischen Bewertungen unterliegt, sind bis jetzt in der Sprachwissenschaft wenig beachtet worden. In vorliegender Arbeit werden die $vielf\"{a}ltigen$ archaischen Formen behandelt, die noch heute in einem bestimmten Kontext gebraucht werden. Das Wort Archaismus starnmt von dem griechischen archaios 'altertumlich', und wird $haupts\"{a}chlich$ als Stilmittel der Rhetorik benutzt, um poetische, pathetische oder ironische Effekte hervorzurufen. Unter Archaismus wird em aus verschiedenen $Gr\"{u}nden$ veraltendes und veraltetes Wortgut verstanden, das aber noch im $Bewu{\ss}tsein\;der\;Sprachtr\"{a}ger$ lebt und im gegenwartssprachlichen Text verwendet wird. Ein Instrument zur deskriptiven Erfassung von Archaismen kann das $W\"{o}rterbuch\;sein.\;In\;W\"{o}rterb\"{u}chern$ der deutschen Gegenwartssprache werden Angaben $\"{u}ber$ zeitspezifische Markierungen eines Lexems gemacht: z.B. 'veraltet' , 'veraltend', $'fr\"{u}her'$, 'selten' 'historisch', 'nationalsozialistisch', , 'modern', , modisch , usw. Aber liber Art und Zahl der Markierung einerseits $\"{u}ber$ liber ihre Trennscharfe andererseits besteht noch keineswegs Klarheit. Der Vorgang des Veraltens - der Archaisierung - von Lexemen ist ein $Proze{\ss}$, der schwieriger festzustellen ist als das Aufkommen von neuen $W\"{o}rtern$. Hier sol1 nur eine von verschiedenen Ursachen genannt werden: $W\"{o}rter$ veralten mit ihren Denotaten. Wenn das Denotat aus dem gesellschaftlichen Leben verschwindet, ist auch die Benennung nicht mehr notwendig. Archaismen sind keineswegs auf den lexikalischen Bereich beschrankt, obwohl sie dort am meisten auffallen. Sie treten vielmehr auf allen Strukturebenen, vom Laut bis zum Text, auf: - auf der lautlichen Ebene: Kur/$K\"{u}r$, Melodie/Melodei, $g\"{u}lden$/golden - auf der morphologischen Ebene: gerne, am Tage, geschmecket/ geschmeckt - auf der graphematischen Ebene: That vs. Tat, Capital vs. Kapital - auf der lexikalischen Ebene: Oheim, Knabe, Kerker, Schulmeister - auf der Wortbildungsebene: Afterglauben, $Sch\"{o}ne$, kleineln - auf der syntaktischen Ebene: guten Mutes sein, einer Verbindung halber, $R\"{o}slein$ rot - auf der Textebene: Wollen der Herr unten speisen? Archaismen treten in unterschiedlichen Texten und Textsorten auf. Eine spezielle Funktion haben Archaismen im Sprachkunstwerk. Autoren nutzen sie, urn Zeitkolorit zu schaffen. Im Alltagsleben $k\"{o}nnen$ Archaismen Lebensumstande und -erfahrungen signalisieren. Altes Wortgut wird als kostbarer nationaler Besitz angesehen. Man kann heute immer wieder den $R\"{u}ckgriff\;auf\;\"{a}lteres$ Sprachgut beobachten, entweder urn Vergangenes und Vergessenes neu zu beleben oder urn die jeweilige Gegenwartssprache mit Hilfe yon Archaismen historisch zu vertiefen und gleichzeitig zu erweitern. Archaismen sind somit die sprachlichen Zeugen der Vergangenheit. Zugleich sind Sie auch Zeichen $f\"{u}r$ die 'Gleichzeitigkeit des Ungleichzeitigen' in heutigen Sprachen, weil sie 'kommunikativ mehrere Generationen, kulturell viele Jahrhunderte oder sogar Jahrtausende $\"{u}berbr\"{u}cken\;k\"{o}nnen$'.

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THE FRACTURE RESISTANCE AND STRESS DISTRIBUTION OF ALL CERAMIC CROWNS WITH TWO TYPES OF FINISH LINE ON MAXILLARY CENTRAL INCISOR (상악중절치에서 전부도재관의 finish line형태에 따른 파절강도와 응력 분포에 관한 연구)

  • Ki Tae-Seok;Kim Kyea-Soon;Lee Jin-Han;Kim Yu-Lee;Dong Jin-Keun
    • The Journal of Korean Academy of Prosthodontics
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    • v.41 no.4
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    • pp.405-420
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    • 2003
  • Purpose : The purpose of this study was to compare the fracture resistance of the IPS Empress ceramic crown with 1.0mm width rounded shoulder, which is usually recommended in all ceramic crown. and 0.5mm width chamfer finish lines on the maxillary central incisor. Material and method : After 15 metal dies were made for each group, the IPS Empress all ceramic crowns were fabricated and cemented with resin cement(Bistite resin cement, Tokuyama Soda Co. LTD., Japan) on the metal die. The cemented crowns were mounted on the positioning jig and the universal testing machine(Zwick Z020, Zwick Co. Germany)was used to measure the fracture strength with loading on the incisal edge. And also, three-dimensional finite element stress analysis was used to measure the stress distribution with the various types of the finish lines(1.0mm width rounded shoulder, 0.5mm width chamfer), the loading site(incisal edge, incisal $\frac{1}{3}$) and the type of loading(concentration loading, distribution loading). Results and conclusion : 1. In the fracture resistance experiment according to the finish line, the mean fracture strength of rounded shoulder(876N) and the mean fracture strength of chamfer(882N) did not skew any significant difference between each other(p>0.05). 2. The stress distribution of all ceramic crown in three dimensional finite element analysis showed concentration aspect at loading point and cervical area or labial surface. 3. In metal die, there were no differences in stress distribution between finish lines, but in natural teeth model, chamfer finish line showed higher stress than rounded shoulder finish line. 4. When force was loaded on the incisal edge the stress was concentrated on the incisal edge and the cervical area of labial surface. When force was loaded on the incisal $\frac{1}{3}$, the stress concentrated on the cervical area of labial surface and the cingulum area. 5. Generally, natural teeth model showed higher and various stress than the metal die.

GALAXIES ON DIET: FEEDBACK SIGNATURES IN RADIO-AGN HOST GALAXIES

  • Karouzos, Marios;Im, Myungshin;Trichas, Markos;Goto, Tomogotsu;Malkan, Matthew;Ruiz, Angel;Jeon, Yiseul;Kim, Ji Hoon;Lee, Hyung Mok;Kim, Seong Jin;Oi, Nagisa;Matsuhara, Hideo;Takagi, Toshinobu;Murata, Kazumi;Wada, Takehiko;Wada, Kensuke;Shim, Hyunjin;Hanami, Hitoshi;Serjeant, Stephen;White, Glenn;Pearson, Chris;Ohyama, Youichi
    • Publications of The Korean Astronomical Society
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    • v.32 no.1
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    • pp.201-203
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    • 2017
  • There exists strong evidence supporting the co-evolution of central supermassive black holes and their host galaxies; however it is still under debate how such a relation comes about and whether it is relevant for all or only a subset of galaxies. An important mechanism connecting AGN to their host galaxies is AGN feedback, potentially heating up or even expelling gas from galaxies. AGN feedback may hence be responsible for the eventual quenching of star formation and halting of galaxy growth. A rich multi-wavelength dataset ranging from the X-ray regime (Chandra), to far-IR (Herschel), and radio (WSRT) is available for the North Ecliptic Pole field, most notably surveyed by the AKARI infrared space telescope, covering a total area on the sky of 5.4 sq. degrees. We investigate the star formation properties and possible signatures of radio feedback mechanisms in the host galaxies of 237 radio sources below redshift z = 2 and at a radio 1.4 GHz flux density limit of 0.1 mJy. Using broadband SED modelling, the nuclear and host galaxy components of these sources are studied simultaneously as a function of their radio luminosity. Here we present results concerning the AGN content of the radio sources in this field, while also offering evidence showcasing a link between AGN activity and host galaxy star formation. In particular, we show results supporting a maintenance type of feedback from powerful radio-jets.

Genetic Analysis of Some Polymorphic Isozymes in Pinus densiflora(II) - Inheritance of acid phosphatase, alcohol dehydrogenase and catalase isozymes - (소나무의 몇가지 다형적(多形的) 동위효소(同位酵素)의 유전분석(遺傳分析)(II) - Acid phosphatase, alcohol dehydrogenase와 catalase 동위효소(同位酵素)의 유전양식(遺傳樣式) -)

  • Kim, Z.S.;Hong, Y.P.
    • Journal of Korean Society of Forest Science
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    • v.68 no.1
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    • pp.32-36
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    • 1985
  • Megagametophyte tissues of Pinus densiflora were subjected to study the inheritance of acid phosphatase (ACP), alcohol dehydrogenase (ADH) and catalase (CAT) isozymes by starch gel zone-electrophoresis. At least three or four zones were segregated for ACP isozyme. However, as one isozyme of ACP-A zone was separated clearly, only that isozyme was analysed. Five isozyme phenotypes (A1-A5), observed in ACP-A zone, were segregated to a simple Mendelian ratio, suggesting that these are controlled by five codominant alleles existed at ACP-A locus. Two zones of activity were segregated in the gels after staining for ADH, the more anodal zone (ADH-A) of the two was invariant in our materials. Three isozyme phenotypes (B1-B3) were observed in ADH-B zone and these variants showed a 1:1 segregation pattern, suggesting that each variant is controlled by three codominant alleles at ADH-B locus. A total of five isozyme phenotypes, composed of multiple bands, were observed in CAT isozyme. The segregation of these phenotypes in heterozygous trees did not show any significant deviation from a 1:1 segregation. Therefore, the genetic control of CAT isozyme in Pinus densiflora seeds seems to be based on a single locus (CAT-A) with Five codominant alleles ($A_1-A_5$).

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Cognitive Impairment and Decreased Quality of Life in Elderly Patients with Subsyndromal Depression (노인 아증후군적 우울증 환자의 인지기능 및 삶의 질 저하)

  • Ryu, Jae Sung;Kim, Moon Doo;Lee, Chang In;Park, Joon Hyuk
    • Korean Journal of Biological Psychiatry
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    • v.20 no.2
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    • pp.45-53
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    • 2013
  • Objectives Non-major depression with fewer symptoms than required for a Diagnostic and Statistical Manual of Mental Disorders-4th edition diagnosis of major depressive disorder (MDD) has consistently been found to be associated with functional impairment. In this study, we aim to estimate the cognitive impairment and the quality of life in elderly patients with subsyndromal depression (SSD) compared with non-depressive elderly (NDE). Methods The Korean version of Mini International Neuropsychiatric Interview was administered to 194 outpatients with depression and 108 normal controls. SSD is defined as having five or more current depressive symptoms with core depressive symptoms (depressive mood or loss of interest or pleasure) during more than half a day and more than seven days over two weeks. Depression was evaluated by the Korean form of Geriatric Depression Scale of a 15-item short version. Global cognition was assessed by Mini-Mental State Examination in the Korean version of CERAD assessment packet (MMSE-KC). Subjective cognitive impairment was assessed by the Subjective Memory Complaint Questionnaire. Quality of life was evaluated by the Korean Version of Short-Form 36-Item Health Survey. Results The mean score of the MMSE-KC in the SSD group was lower than that in the NDE group with adjustment for age, gender, and education [F = 4.270, p = 0.04, analysis of covariance (ANCOVA)]. If we defined those having Z-score of MMSE-KC < -1.5 as a high risk group of cognitive impairment, the odds ratio for the high risk group of cognitive impairment was 1.86 [95% confidence intervals (CI) 1.04-3.34] in SSD and 7.57 (95% CI 3.50-16.40) in MDD compared to NDE. The scores of physical component summary (F = 9.274, p = 0.003, ANCOVA) and mental component summary (F = 53.166, p < 0.001, ANCOVA) in the SSD group were lower than those in the NDE group with adjustment for age, gender, and education. Conclusions The subjects with SSD, as well as those with MDD, showed impairment of global cognition and also experienced low quality of life in both physical and mental aspects, compared to the NDE group.

Authentication of Sesame Oil with Addition of Perilla Oil Using Electronic Nose Based on Mass Spectrometry (전자코-Mass spectrometry를 이용한 들기름이 혼합된 참기름의 판별 분석)

  • Son, Hee-Jin;Kang, Jin-Hee;Hong, Eun-Jeung;Lim, Chae-Lan;Choi, Jin-Young;Noh, Bong-Soo
    • Korean Journal of Food Science and Technology
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    • v.41 no.6
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    • pp.609-614
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    • 2009
  • Sesame oil was sometimes replaced by mixed oil due to high price in Korean market. To find out authentic sesame oil, electronic nose (E-nose) based on mass spectrometer system was used. Sesame oil was blended with perilla oil at the ratio of 97:3, 94:6, 91:9, 88:12 and 85:15, respectively. Intensities of each fragment from sesame oil by E-nose based on MS were completely different from those of perilla oil. The obtained data was used for discriminant function analysis. For quantitative analysis, the partial least square algorithm was used. The added concentration of perilla oil to sesame oil was correlated with discriminant function first score (DF1) and second score (DF2). From this relationship it could be found out how much perilla oil added. DFA plot indicated a significant separation of pure sesame oil and pure perilla oil. The different geographical origin of sesame oil was used for blending with perilla oil were closed to that of sesame oil. Korean sesame oil mixture and Indian sesame oil one were well separated. And the correlation between mixing ratios and DF1 values was found at the ratio of 97:3, 91:9, and 85:15 (SE vs PE oil), respectively. But the added concentration of perilla oil to sesame oil was correlated with discriminant function first score (DF1). E-nose based on MS system could be used as an efficient method for purity of oil quality.

INVESTIGATION OF RUNNING BEHAVIORS OF AN LPG SI ENGINE WITH OXYGEN-ENRICHED AIR DURING START/WARM-UP AND HOT IDLING

  • Xiao, G.;Qiao, X.;Li, G.;Huang, Z.;Li, L.
    • International Journal of Automotive Technology
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    • v.8 no.4
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    • pp.437-444
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    • 2007
  • This paper experimentally investigates the effects of oxygen-enriched air (OEA) on the running behaviors of an LPG SI engine during both start/warm-up (SW) and hot idling (HI) stages. The experiments were performed on an air-cooled, single-cylinder, 4-stroke, LPG SI engine with an electronic fuel injection system and an electrically-heated oxygen sensor. OEA containing 23% and 25% oxygen (by volume) was supplied for the experiments. The throttle position was fixed at that of idle condition. A fueling strategy was used as following: the fuel injection pulse width (FIPW) in the first cycle of injection was set 5.05 ms, and 2.6 ms in the subsequent cycles till the achieving of closed-loop control. In closed-loop mode, the FIPW was adjusted by the ECU in terms of the oxygen sensor feedback. Instantaneous engine speed, cylinder pressure, engine-out time-resolved HC, CO and NOx emissions and excess air coefficient (EAC) were measured and compared to the intake air baseline (ambient air, 21% oxygen). The results show that during SW stage, with the increase in the oxygen concentration in the intake air, the EAC of the mixture is much closer to the stoichiometric one and more oxygen is made available for oxidation, which results in evidently-improved combustion. The ignition in the first firing cycle starts earlier and peak pressure and maximum heat release rate both notably increase. The maximum engine speed is elevated and HC and CO emissions are reduced considerably. The percent reductions in HC emissions are about 48% and 68% in CO emissions about 52% and 78%; with 23% and 25% OEA, respectively, compared to ambient air. During HI stage, with OEA, the fuel amount per cycle increases due to closed-loop control, the engine speed rises, and speed stability is improved. The HC emissions notably decrease: about 60% and 80% with 23% and 25% OEA, respectively, compared to ambient air. The CO emissions remain at the same low level as with ambient air. During both SW and HI stages, intake air oxygen enrichment causes the delay of spark timing and the increased NOx emissions.