• Journal of Applied Biological Chemistry
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• 제59권2호
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• pp.113-124
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• 2016

홍삼은 인삼을 찌고 말리는 과정을 거쳐 제조한 것으로 많은 약리 및 생리활성이 알려져 있다. Cisplatin은 항암제로 사용되고 있으나 부작용으로 골수억제, 위장관계독성, 신경독성, 신독성 등이 보고되어있다. 특히 cisplatin이 신장에 집중적으로 축적됨으로써 투여환자의 25-30%에서 신장독성이 유발된다. 따라서 본 실험에서는 발효홍삼을 이용한 cisplatin의 부작용인 신독성예방효능을 확인하고자 하였다. 시료에 따른 DPPH와 ABTS 라디칼소거능을 실험 결과 RG8F3에서 가장 우수한 소거능을 확인하였고 따라서 RG0SF0와 RG8F3 간의 비교실험이 가능할 것으로 사료되었다. 동물실험은 정상군, 대조군, RG0SF0 투여군 및RG8F3 투여군 4그룹으로 나누었다. 약물투여군은 200 mg/kg/day의 농도로 4일간 투여한 후,cisplatin은 20 mg/kg으로 대조군 및 약물투여군에복강주사하였다. RG8F3 투여한 결과 대조군과 비교하여 GSH의 수치는 증가하였고 ROS, BUN, creatinine 및 염증인자들의 감소를 보였다. 조직학적 결과에서도 신손상으로 인한 변형이 거의 없었다. 결론적으로 발효홍삼은 cisplatin으로 유발되는 신 손상 예방에 유의한 효과를 보이는 것으로 사료된다.

• 한국의상디자인학회지
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• 제18권2호
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• pp.115-125
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• 2016

This study analyzes the characteristics of the motifs and colors in flower and bird paintings which contain and present Korea's unique aesthetics based on its richest data among all other types of Korean folk paintings. With a theoretical exploration of folk paintings and an analysis of the motifs and colors, textile design with an aim to present highly valued korean modern fashion design was developed. Two hundred and seventy flower and bird paintings were selected from relevant materials, resulting in an extraction of 5,068 colors. A palette of representative colors was made based on densely distributed hues and tones. The research can be summarized as follows: Flower and bird paintings contain flowers, birds, trees and animals and the motifs in the paintings stand for spirituality, philosophies from different times and other symbols of our nation. Each of the motifs in these paintings is a prayer for good luck, especially conjugal harmony and fecundity to bring about happiness and richness. Colors in flower and bird paintings are characteristic of the order: YR(25.5%)>R(19.2%)>Y(10.6%)>PB(9.2%)>G(7.9%), with low-chromatic YR and highly bright R taking up a larger percent. The order of tones is: d(13.5%)>dk (10.5%)>s(10.4%)>dkg(10.0%)>sf(9.1%)and the tone is dark in general. YR, taking up the largest percent, was dull, light, and soft. As for the achromatic colors, the order is: W(5.2%)>Gy(1.9%)>Bk(0.7%). Based on the above analyzed color data, those colors which were high in their hue and tone were extracted to present representative colors. In this way, representative colors like yellow, yellowish red, red, green, and purplish blue were extracted. This was the basis to present motifs and colors originating from subjects of folk paintings in various patterns using Illustrator CS6, to create modern fashion design.

• Archives of Plastic Surgery
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• 제34권6호
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• pp.705-712
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• 2007

Purpose: Transsexualism is considered to be the extreme end of the spectrum of gender identity disorders characterized by, among other things, a pursuit of sex reassignment surgery (SRS). We evaluated psychologic status, health-related quality of life in female-to-male (FTM), male-to-female (MTF) transgender individuals. Methods: We used the Minnesota Multiphasic Personality Inventory, Beck Anxiety Inventory, Beck Depression Inventory, Moudsley obsessive-compulsive Inventory, SCL-90-R, Short-Form 36-Question Health Survey version 2 (SF-36v2). We enrolled 40 transsexual participants. Results: Analysis of quality of life health concepts demonstrated statistically significant (p<0.01) diminished quality of life among the transsexual participants as compared to the Korea male and female population. FTM transgender participants reported more higher hostile, phobic than MTF transgenders. Overall, in all psychologic status examination, Transgender individuals are within normal population boundary. On all category, result is improved post-operatively. Conclusion: Transgender participants reported mental status within normal boundary. SRS improved their quality of life and mental stability.

• Asian-Australasian Journal of Animal Sciences
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• 제20권10호
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• pp.1473-1477
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• 2007

Four-and-a-half LIM-only protein 3 (FHL3) is a member of the LIM protein superfamily and can participate in mediating protein-protein interaction by binding one another through their LIM domains. In this study, the 5'- and 3'- cDNA ends were characterized by RACE (Rapid Amplification of the cDNA Ends) methodology in combination with in silico cloning based on the partial cDNA sequence obtained. Bioinformatics analysis showed FHL3 protein contained four LIM domains and four LIM zinc-binding domains. In silico mapping assigned this gene to the gene cluster MTF1-INPP5B-SF3A3-FHL3-CGI-94 on pig chromosome 6 where several QTL affecting intramuscular fat and eye muscle area had previously been identified. Transcription of the FHL3 gene was detected in spleen, liver, kidney, small intestine, skeletal muscle, fat and stomach, with the greatest expression in skeletal muscle. The A/G polymorphism in exon II was significantly associated with birth weight, average daily gain before weaning, drip loss rate, water holding capacity and intramuscular fat in a Landrace-derived pig population. Together, the present study provided the useful information for further studies to determine the roles of FHL3 gene in the regulation of skeletal muscle cell growth and differentiation in pigs.

• Journal of Microbiology and Biotechnology
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• 제8권4호
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• pp.369-377
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• 1998

Rotavirus is a major cause of severe gastroenteritis in young children and animals throughout the world. The VP7 of rotavirus is thought to induce the synthesis of neutralizing antibodies and to be responsible for determining viral serotypes. The cDNA coding for the VP7 capsid protein of human rotavirus, obtained from Korean patients (HRV-Y14), was cloned and its nucleotide sequence was determined. Comparative analysis of the nucleotide sequences between VP7 of Y14 and that of other foreign isolates showed $92.7~95.2\%$ homology to G1 serotypes (RV-4, KU, K8, WA), $74.2\%$ homolgy to G2 serotype HU-5, $76.4\%$ homology to G3 serotype SA-11, and $77.6\%$ homology to G4 serotype A01321. These data suggest that HRV-Y14 can be classified as a G1 serotype. cDNA coding for VP7 of HRV-YI4 was subcloned into the baculovirus vector and the VP7 glycoprotein was expressed in insect cells. The expressed proteins in Sf9 cell extract and tissue culture fluid were separated on SDS-PAGE, and Western blot analysis with monoclonal antibody raised against the synthetic peptide containing 21 amino acids within the VP7 conserved region was performed. The molecular weight of recombinant VP7 was estimated to be 36 kDa which is about the same size as the native VP7. Addition of tunicamycin in the culture media caused a reduction of the molecular weight of the recombinant VP7 indicating that the expressed protein was glycosylated.

• 대한한방소아과학회지
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• 제27권2호
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• pp.1-10
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• 2013

Objectives The aim of this study was to explore the effect of parental attitude on the behavioral problems in children who visited the traditional Korean pediatrics clinic. Methods The subjects were consist of 190 outpatients ($56.6{\pm}12.9$ months) and their mother. The Behavior problems of children were measured with Korean version of Child Behavior Checklist for Ages 1.5-5 (K-CBCL1.5-5) while parental perception of child vulnerability, parent overprotection, parenting stress were measured by Child Vulnerability Scale (CVS), Parent Protection Scale (PPS), Korean-Parenting Stress Index-Short Form scale (K-PSI-SF), respectively. Correlation and multiple regression were conducted for the analysis. Results Significant correlations between child total problems score and child vulnerability (r=.272, p<.001), parent overprotection (r=.243, p=.001), and parenting stress (r=.597, p<.001) were reported. Multiple regression analysis revealed that the parenting stress (${\beta}$=.548, p<.001) was a major predictor for the child behavior problems rather than child vulnerability and parent overprotection. Conclusions It was shown that the parenting stress has a significant influence on the emotional and behavioral development of children. These results can be useful for improving clinical diagnosis and treatment in traditional Korean pediatrics.

• 대한본초학회지
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• 제28권5호
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• pp.1-6
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• 2013

Objectives : This study was conducted to identify the original Sinomini Caulis et Rhizoma plant among Stephania tetrandra, Cocculus trilobus, and Aristolochiae fangchi to develop the genetic marker for Sinomini Caulis et Rhizoma. Methods : Sinomenium acutum was identified by the classification and identification committee of the National Center for Standardization of Herbal Medicines. The chloroplast ndhF gene was amplified. We performed sequences alignment analysis of Sinomenium acutum, Stephania tetrandra, C. trilobus, and A. fangchi using BioEdit program. The SFR markers designed were consisted of SF01, SR04, and SR05 primers. Results : Many variations of Sinomeni Caulis et Rhizoma are currently commercialized as herbal medicine. We compared the base sequences of the ndhF intergenic space of chloroplast DNA with Sinomenium acutum, Stephania tetrandra, C. trilobus, and A. fangchi. According to the results, it showed that the nucleotide variations were seen in 30 genes of four species. Phylogenetic analysis revealed that 4 species were classified into five groups based on an inter-group divergence in nucleotide sequence of 9%. We developed SFR marker nucleotides enough to authenticate respective species and confirmed its application on the band size at 419 base pair. These sequence differences at corresponding positions were available genetic markers to identity the Sinomeni Caulis et Rhizoma. Conclusions : Base on these results, the ndhF region was effective in distinguishing Sinomini Caulis et Rhizoma The SFR genetic marker was useful for identifying Sinomini Caulis et Rhizoma with other species.

• 대한전자공학회논문지TC
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• 제47권3호
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• pp.22-30
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• 2010

본 논문은 AMC(Adaptive Modulation and Coding)와 MIMO(Multiple Input Multiple Output)를 결합하여 전송률 및 전송 신뢰도 향상을 가져오는 통신 시스템을 구현한다. 또한 Precoding과 Antenna Subset Selection을 효율적으로 적용하고 MIMO 선택 기법을 결합하여, 최종적으로 AMC와 MIMO 선택 기법이 결합된 통신 시스템을 설계하고 성능을 분석한다. 모의 실험 환경은 안테나 간 상관성이 존재하지 않는 주파수비 선택적 레일리 페이딩 채널을 고려하였으며, 확산인자는 16을 적용하였다. 그 외의 여러 모의 실험 환경은 HSDPA(High Speed Downlink Packet Access) 표준에 근거하여 구성하도록 노력하였다. 본 논문에서 제안한 "AMC와 MIMO 선택 기볍이 결합된 시스템"은 기존의 "AMC와 각 MIMO의 결합 시스템들" 보다 높은 보여주었으며, 열악한 채널 환경에서도 안정적인 전송률을 확보해 주었다. 제안된 시스템은 약 8dB에서 최대 전송률을 나타내었으며, 제안된 시스템과 동일한 최대 전송률올 갖눈 기종의 "AMC와 D-STTD $4{\times}2$ 결합 시스템"과 비교하였을 때 약 6dB 정도 먼저 최대 전송률을 나타냈다. 또한 최대 전송률에 이르기 전까지 거의 모든 SNR(Signal to Noise Ratio)서 기존의 시스템보다 약 2배 정도 높은 전송률을 보였다. 구체적으로 SNR이 2dB인 지점에서 기존의 시스템은 약 2.5Mbps의 전송률을 나타냈으며, 제안된 시스템은 그 2배가 넘는 약 6.4MBps의 전송률을 나타냈다. 또한 SNR이 2dB인 지점에서는 각각 약 7.5Mbps와 15.3Mbps의 전송률을 나타내어 역시 2배에 가까운 차이가 나는 것을 확인할 수 있었다. 제안된 시스템은 AMC 기법을 사용하는 주 목적인 전송률의 향상에 크게 기여하였으며, 특히 평균 전송률의 향상에 효과적임을 확인하였다.

• 아시안잔디학회지
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• 제23권1호
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• pp.111-122
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• 2009

본 연구는 완효성 질소 성분이 함유된 복합비료의 시비가 크리핑벤드그래스 생육과 토양 중 변화에 미치는 영향을 시험하고자 2007년 7월부터 12월까지 6개월간 수행하였다. 처리구는 비료를 처리하지 않은 무처리구(NF), 속효성질소복합비료(11-5-7)를 처리한 대조구(CF), MU 질소성분이 함유된 복합비료를 처리한 처리구 1(MU), IBDU 질소성분이 함유 된 복합비료를 처리한 처리구 2(IBDU 1)과 처리구3(IBDU 2) 등 5개 처리를 난괴댑으로 수행하였다. 시비 후 속효성질소성분과 완효성질소성분의 경과시간에 따른 토양 중 변화와 염색지수와 엽록소함량과 같은 잔디품질과 잔디 생육량, 잔디밀도 등 잔디 생육을 조사하였고, 그 결과를 요약하면 아래와 같다. 암모니아태질소와 질산태질소는 모든 처리구에서 시비 후 시간이 경과함에 따라 점차증가하는 경향을 보였고, 총질소는 점차 감소하였다. 질산태질소와 총질소는 속효성 비료처리구(CF)보다는 완효성 비료 처리구(MU, IBDU 1, IBDU 2)에서 높게 나타났으며, 시비 후 경과시간에 따른 토양 중 가용성질소의 변화는 시비초기에는 속효성 비료의 가용성 질소가 많으나 시비 후 30일 정도까지는 속효성 비료와 완효성 비료의 가용성 질소 비율은 비슷하고 30일 이후에는 완효성 비료 처리구에서 가용성 질소 비율이 증가하였다. 염색지수와 엽록소함량을 NF와 비교한 결과, 엽색지수는 CF, MU, IBDU 1 및 IBDU 2에서 각각 6.5%, 6.7%, 5.9%, 5.5% 증가하였고, 엽록소함량은 33.2%, 38.4%, 35.1%, 37.1% 증가하여 MU 처리구에서 높게 나타났다. 잔디생육량은 CF, MU, IBDU 1 및 IBBU 2가 NF보다 76.2%, 77.7%, 69.5%, 72.3% 각각 높게 나타났으나 대조구와 처리구간 예초물량은 비슷하였고, 잔디밀도는 무처리구보다 비료 처리구에서 증가하였고, 속효성 비료처리구(CF)보다 완효성 비료 처리구(MU, IBDU 1, IBDU 2)에서 잔디밀도가 증가했다. 본 결과들을 통해 완효성 질소 성분함유비료가 속효성 질소에 비해 토양 중 가용성 질소의 함량을 높여 질소비효기간을 연장시키고, 염색지수와 엽록소함량은 비슷하며 예초물량은 비슷하거나 감소시키지만 잔디밀도는 향상시켜 완효성질소 함유비료의 시비가 잔디생육에 효과적인 것으로 평가되었다.

• 생물정신의학
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• 제20권1호
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• pp.6-11
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• 2013

Objectives There are only a limited number of studies on instruments assessing fatigue in university students, although fatigue exerts negative influences on their health and academic performances and fatigue-related complaints are more frequently reported in young adults than middle-aged adults. The aim of this study was to validate the 9-item Fatigue Severity Scale (FSS) among university students including both undergraduate and graduate students in South Korea. Methods A total of 176 university students completed a battery of self-report questionnaires, including the FSS, the Brief Fatigue Inventory (BFI), the Beck Depression Inventory-II (BDI-II), the Beck Anxiety Inventory (BAI), the Medical Outcomes Study Short Form 36 version 2 (MOS-SF36v2), and the Inclusion of Community in the Self Scale (ICS). The data were collected from February of 2012 to June of 2012. The reliability, convergent validity, divergent validity, and exploratory factor analyses were conducted to assess psychometric properties of the FSS. Results The mean FSS score was 3.20 (standard deviation = 1.43). The FSS demonstrated an excellent internal consistency (Cronbach's ${\alpha}$ = 0.93) and item-total correlations ranged from 0.56 to 0.90. Correlations of the FSS with the BFI (r = 0.71, p < 0.01), BDI-II (r = 0.54, p < 0.01), BAI (r = 0.46, p < 0.01), MOS-SF36v2 physical component summary (r = -0.28, p < 0.01), MOS-SF36v2 mental component summary (r = -0.55, p < 0.01), and ICS (Spearman's rho = -0.07, p = 0.33) showed acceptable convergent and divergent validity. Exploratory factor analysis defined one underlying factor (eigenvalue = 5.67) that explained 93.50% of the total variance. Conclusions To the best of our knowledge, this is the first study to investigate reliability and validity of the FSS in university students. The FSS exhibits good psychometric properties for evaluation of fatigue among university students in South Korea. Since the FSS is easy to administer, score, and interpret, it could be a useful tool in research and practice for assessing fatigue among university students.