• Asian-Australasian Journal of Animal Sciences
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• 제28권5호
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• pp.605-611
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• 2015

A synthetic strain of ducks (Anas platyrhynchos) was developed by introducing genes for long duration of fertility to be used as mother of mule ducklings and a seven-generation selection experiment was conducted to increase the number of fertile eggs after a single artificial insemination (AI) with pooled Muscovy semen. Reciprocal crossbreeding between Brown Tsaiya LRI-2 (with long duration of fertility) and Pekin L-201 (with white plumage mule ducklings) ducks produced the G0. Then G1 were intercrossed to produce G2 and so on for the following generations. Each female duck was inseminated 3 times, at 26, 29, and 32 weeks of age. The eggs were collected for 14 days from day 2 after AI. Individual data regarding the number of incubated eggs (Ie), the number of fertile eggs at candling at day 7 of incubation (F), the total number of dead embryos (M), the maximum duration of fertility (Dm) and the number of hatched mule ducklings (H) with plumage colour were recorded. The selection criterion was the breeding values of the best linear unbiased prediction animal model for F. The results show high percentage of exhibited heterosis in G2 for traits to improve (19.1% for F and 12.9% for H); F with a value of 5.92 (vs 3.74 in the Pekin L-201) was improved in the G2. Heritabilities were found to be low for Ie ($h^2=0.07{\pm}0.03$) and M ($h^2=0.07{\pm}0.01$), moderately low for Dm ($h^2=0.13{\pm}0.02$), of medium values for H ($h^2=0.20{\pm}0.03$) and F ($h^2=0.23{\pm}0.03$). High and favourable genetic correlations existed between F and Dm ($r_g=0.93$), between F and H ($r_g=0.97$) and between Dm and H ($r_g=0.90$). The selection experiment showed a positive trend for phenotypic values of F (6.38 fertile eggs in G10 of synthetic strain vs 5.59 eggs in G4, and 3.74 eggs in Pekin L-201), with correlated response for increasing H (5.73 ducklings in G10 vs 4.86 in G4, and 3.09 ducklings in Pekin L-201) and maximum duration of the fertile period without increasing the embryo mortality rate. The average predicted genetic response for F was 40% of genetic standard deviation per generation of selection. The mule ducklings' feather colour also was improved. It was concluded that this study provided results for a better understanding of the genetics of the duration of fertility traits in the common female duck bred for mule and that the selection of a synthetic strain was effective method of improvement.

• Clinical and Experimental Reproductive Medicine
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• 제15권1호
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• pp.40-52
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• 1988

Estradiol-17${\beta}$($E_2$) levels in the blood were estimated according to varying the time and amount of the administration of $Clomid^{(R)}$. $Clomid^{(R)}$ were administered on the 2nd, 3rd and 4th menstrual day corresponding to the recruitment period and on the 5th menstrual day corresponding to the selection period of the ovarian follicles, respectively. And $Clomid^{(R)}$ were administered 50 mg, 100 mg and 150 mg/day, repectively. The effects of the sequential HMG to $E_2$ levels in the blood were also estimated. The results were as following : 1. Blood $E_2$ levels according to the day and amount of administration of $Clomid^{(R)}$ were the highest in the group 3(D $2{\sim}6$, 150 mg/day, with HMG) and the lowest in the group 6(D $5{\sim]9$, 50 mg/day, without HMG). $E_2$ levels showed increasing tendency to 0 day. 2. In the cases of the administration of $Clomid^{(R)}$ during the $2nd{\sim}6th$ menstrual day, $E_2$ levels according to the amount were similar among groups and showed increasing tendency daily. 3. In the cases of administration of $Clomid^{(R)}$ during the $2nd{\sim}6th$ menstrual day, $E_2$ levels according to the sequential HMG independent of the amount of $Clomid^{(R)}$ were higher in the with HMG group than without HMG groups. 4. In the case of the administration of $Clomid^{(R)}$ during the $5th{\sim}9th$ menstrual day, $E_2$ levels according to the amount were the highest in the 100 mg/day group and the lowest in the 50mg/day group. 5. In the cases of administration of $Clomid^{(R)}$ independent of the amount during the 5th${\sim}$9th menstrual day, $E_2$ levels according to the sequential HMG were higher in the with HMG group than without HMG group. 6. $E_2$ levels according to the amount independent of the day of the administration of $Clomid^{(R)}$ were the highest in the 100 mg/day group and 150 mg/day, 50 mg/day group in low sequence. 7. $E_2$ levels according to the sequential HMG independent of the day and amount of the administration of $Clomid^{(R)}$ were higher in the with HMG group than the without HMG group. 8. $E_2$ levels according to the day of the administration of $Clomid^{(R)}$ independent of the amount of $Clomid^{(R)}$ and sequential HMG were the highest in the group D 2${\sim}$6 and the lowest in the group D 5${\sim}$9. According to the above results, there were higher $E_2$ levels in the group with sequential HMG than without HMG. Therefore, the hypothesis, postulated initially by the author, was not verified that sequential HMG would not affect the $E_2$ levels which were related to the process of the selection of the ovarian follicle in the connection with 'FSH window'. Because it may be the stimulation after the selection of later predominant follicle. And the highest level of $E_2$ was estimated in the $Clomid^{(R)}$ 150 mg/day group with sequential HMG on the 2nd${\sim}$6th day, and the higher levels were estimated in the 2nd${\sim}$6th day, 3rd${\sim}$7th day and 4th${\sim}$8th day groups than the 5th${\sim}$9th day group. The lower levels were estimated in the $Clomid^{(R)}$ 50 mg/day group without HMG than 100 mg/day and 150 mg/day on the 5th${\sim}$9th day. Therefore, further study will be needed that combines analyses of the E2 levels in the blood according to the various administration of $Clomid^{(R)}$ with or without sequential HMG and determination of the numbers and size of the ovarian follicles by ultrasonogram.

• 기술혁신연구
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• 제6권2호
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• pp.208-237
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• 1998

We are faced with the crisis of the R&D investment because of the effects of the IMF conditions. Most of the laboratories are going to restructure by the cutting off of money, man power and the reduction of R&D theme. Therefore it is necessary to allocate the R&D resources effectively to R&D projects. The evaluation and the selection of R&D projects have been recognized as the most important process for the allocation of the R&D resources. The result of the KITA(1997) shows that the commercial success rate of the R&D from new-product brain storming is only 5.8%. This study aims to analyze the actual conditions of the cost benefit analysis(CBA) of R&D projects of selected laboratories and to study measure methods of the R&D benefits. The research method of this study reviews the CBA of R&D firstly, and surveys 200 selected high ranking labs of R＆D expenditures. For the comparison of the results between '87 and '97, this survey used the same questionary for each year. As the result of the survey only 27 labs(response rate 13.5%) responded. The result of the '97 survey is as follows : The CBA is used by 44% of responding labs. The economic evaluation method for the R&D project selection is used by 48% of labs and this numbers increased by over 10 percents points compared with the result of '87. The CBA is used for about 40% about each of the budget preparing and the budget analysis, and by 30% of labs to analyze sales and expenditures of the overall period of the project. As the measurement of benefits of R&D projects, 30% of labs responded that it is impossible to measure the benefits, and 20% of labs measured the benefits between sales and expenditures of R&D projects.

• 한국재료학회지
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• 제33권4호
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• pp.164-174
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• 2023

The bandgap characteristics of semiconductor materials are an important factor when utilizing semiconductor materials for various applications. In this study, based on data provided by AFLOW (Automatic-FLOW for Materials Discovery), the bandgap of a semiconductor material was predicted using only the material's compositional features. The compositional features were generated using the python module of 'Pymatgen' and 'Matminer'. Pearson's correlation coefficients (PCC) between the compositional features were calculated and those with a correlation coefficient value larger than 0.95 were removed in order to avoid overfitting. The bandgap prediction performance was compared using the metrics of R² score and root-mean-squared error. By predicting the bandgap with randomforest and xgboost as representatives of the ensemble algorithm, it was found that xgboost gave better results after cross-validation and hyper-parameter tuning. To investigate the effect of compositional feature selection on the bandgap prediction of the machine learning model, the prediction performance was studied according to the number of features based on feature importance methods. It was found that there were no significant changes in prediction performance beyond the appropriate feature. Furthermore, artificial neural networks were employed to compare the prediction performance by adjusting the number of features guided by the PCC values, resulting in the best R² score of 0.811. By comparing and analyzing the bandgap distribution and prediction performance according to the material group containing specific elements (F, N, Yb, Eu, Zn, B, Si, Ge, Fe Al), various information for material design was obtained.

• 한국간호교육학회지
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• 제22권2호
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• pp.182-190
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• 2016

Purpose: This study explored factors that influence happiness in nursing students. Methods: The participants were 182 nursing students at a university in B city. Data were collected with a structured questionnaire. Data were analyzed using descriptive analysis, t-test, ANOVA, Pearson correlation coefficients, and multiple regression with the SPSS Win 22.0. Results: Happiness in nursing students correlated significantly with resilience (r=.79, p<.001) and self-differentiation (r=.38, p<.001). Resilience, subjective health status, and selection motivation to study nursing explained 69.1% of the variance in happiness. Conclusion: The study shows resilience, subjective health status, and selection motivation to study nursing are important factors for happiness in nursing students. These findings can be utilized to develop strategies for increasing nursing students' happiness.

• Journal of the Korean Data and Information Science Society
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• 제27권2호
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• pp.499-510
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• 2016

생존분석 회귀모형에서 적절한 변수를 선택하는 것은 매우 중요하다. 본 논문에서는 "frailtyHL" R 패키지 (Ha 등, 2012)를 기반으로 하여 다수준 프레일티 모형 (multi-level frailty models)에서 벌점화 변수선택 방법 (penalized variable-selection method)의 절차를 소개한다. 여기서 모형 추정은 벌점화 다단계 가능도에 기초하며, 세 가지 벌점 함수 (LASSO, SCAD 및 HL)가 고려된다. 개발된 방법의 예증을 위해 벨기에 EORTC (European Organization for Research and Treatment of Cancer; 유럽 암 치료기구)에서 수행된 다국가/다기관 임상시험 자료를 이용하여 세 가지 변수 선택 방법의 결과를 비교하고, 그 결과들의 상대적 장 단점에 대해 토론한다. 특히, 자료 분석 결과에 의하면 SCAD와 HL방법이 LASSO보다 중요한 변수를 잘 선택하는 것으로 나타났다.

• 구강회복응용과학지
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• 제29권1호
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• pp.81-93
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• 2013

육안과 기계 ($ShadeEye-Ncc^{(R)}$ dental chroma meter 와 $Shadepilot^{TM}$ system) 를 이용한 치아 색조 선택의 정확성을 비교하고 날씨와 개인경험에 따른 색조 측정의 정확성의 차이를 분석하고자 하였다. 수복물이 없으며 치주적으로 건강한 정상적인 치관부의 형태를 가진 상악 중절치를 가진 30명을 대상으로 육안 관찰과 $ShadeEye-Ncc^{(R)}$ dental chroma meter 와 $Shadepilot^{TM}$ system, 2종의 기계로 치아의 색조를 선택, 비교하였다. 먼저 3명의 검사자가 육안과 기계를 이용해 피험자의 치아 색조 선택해 일치도를 평가 후 비교하였다. 두 번째로 1인의 숙련된 검사자가 자연광 하에 육안 및 기계로 맑은 날과 흐린 날의 피험자의 광원에 따른 치아 색조 일치도를 평가, 비교하였다. 마지막으로 숙련자 2인과 비숙련자 2인간의 육안으로 색조 선택 후 피험자의 치아색조 일치도를 평가해 술자의 숙련도에 따른 색조 선택의 차이를 비교하였다. 모든 실험에서 치아 색조 일치도 외에 색조 차이(${\Delta}E$) 값을 비교해 평가하였다. 육안과 기계의 치아 색조 일치도는 3번 모두 일치한 경우는 육안(23.3%)과 $ShadeEye^{(R)}$(16.7%)보다 $Shadepilot^{TM}$(60%)이 높았다. 색조 차이값(${\Delta}E$)은 $ShadeEye^{(R)}$($3.83{\pm}1.38$)과 육안($4.04{\pm}1.61$)보다 $Shadepilot^{TM}$($2.62{\pm}0.74$)이 유의하게 낮았다(p<0.001). 날씨에 따른 색조 선택은 자연광 하에서 육안으로 보았을 때 흐린 날($4.35{\pm}1.70$)보다 맑은 날($3.53{\pm}1.31$)의 ${\Delta}E$값이 통계적으로 유의하게 낮았다. $Shadepilot^{TM}$와$ShadeEye^{(R)}$ 2종의 기계로 측정 시 맑은 날과 흐린 날간 날씨에 따른 평균 ${\Delta}E$ 값은 유의한 차이가 없었다. 술자의 숙련도에 따른 색조 선택은 육안 관찰 시 피검자 색조가 모두 일치하는 경우가 숙련자(73.3%)인 경우 비숙련자(36.7%)보다 높았고, 평균 ${\Delta}E$ 값은 숙련자($3.60{\pm}1.47$)군이 비숙련자 ($4.70{\pm}1.67$)보다 유의하게 낮았다(p<0.001). 육안 관찰 시 흐린 날씨와 숙련 여부에 따라 정확도가 떨어 질 수 있으며 술자의 숙련도와 날씨와 같은 광원에 영향을 받지않는 기계, 특히 보다 정확한 $Shadepilot^{TM}$를 이용하는 것이 주관성과 광원 등의 요인에 따른 편차를 보이지 않는 정확한 색조 선택에 도움이 될 수 있다.

• 한국콘텐츠학회논문지
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• 제20권6호
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• pp.381-391
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• 2020

본 연구는 밀키트 상품 선택속성의 요인과 구매행동, 만족도 간의 영향관계를 규명하고자 하였다. 연구의 표본추출은 최근 외식기업에서 출시 된 밀키트 상품 이용 경험이 있는 고객을 대상으로 편의표본추출을 사용하여 설문조사를 진행하였다. 조사기간은 2020년 2월1일부터 1달간 진행되었으며, 설문지는 287부를 분석에 사용하였다. 가설검증을 위해 수집된 자료는 통계패키지인 SPSS 20.0을 이용하여 빈도분석, 신뢰도분석, 요인분석, 상관관계분석을 실시하였으며, 가설 검증을 위해 다중회귀분석을 실시하였다. 분석결과 첫째, 가설 1의 밀키트 상품 선택속성과 구매행동 간의 전체설명력(R2)은 42.9%로 분석되었으며, 다양성(β=.026)과 품질(β=.927)에 유의한 영향이 있는 것으로 나타났다. 가설 2의 밀키트 상품 선택속성과 만족도 간의 전체설명력(R2)은 34.9%이며, 편의성(β=.503)과 가격(β=.121)에 유의한 영향이 있는 것으로 나타났다. 셋째, 가설 3의 구매행동에서 만족도에 대한 전체설명력(R2)은 31.5%이며, 구매행동(β=.561)이 만족도에 유의한 영향을 미치는 것으로 나타났다. 마지막으로 본 연구를 통해 밀키트 상품 관련 연구를 수행하는 연구자들에 대한 기초자료를 제공될 것으로 기대하며, 외식기업에서의 상품 개발에 대한 방향성 제시와 마케팅 전략을 활용할 수 있는 이론적 근거를 제공하고자 한다.

• Reproductive and Developmental Biology
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• 제33권2호
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• pp.107-111
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• 2009

The transfection efficiency of a transgene into pig and goat fetal fibroblast cells (PFF and GFF, respectively) was tested using co-transfection of a human tissue-type plasminogen activator (tPA) transgene and neomycin-resistant ($Neo^r$) gene, followed by G418 selection. To initially test G418 resistance, GFF and PFF were incubated in culture medium containing different concentration of G418 for 2 weeks, and cell survival was monitored over time. Based on the obtained results, the concentrations chosen for G418 selection were 800 ug/ml and 200 ug/ml for GFF and PFF, respectively. For co-transfection experiments, the pBC1/tPA and $Neo^r$ vectors were co-transfected into GFF and PFF ($1{\times}10^6$ cells in each case) using the FuGENE6 transfection reagent, and resistant colonies were obtained following 14 days of G418 selection. We obtained 96 and 93 drug-resistant colonies of GFF and PFF, respectively, only 54 and 39 of which, respectively, continued proliferating after drug selection. PCR-based screening revealed that 23 out of 54 analyzed GFF colonies and 5 out of 39 analyzed PFF colonies contained insertion of the tPA gene. Thus, the experimentally determined transfection efficiencies for tPA gene co-transfection with the $Neo^r$ gene were 42.6% for GFF and 12.8% for PFF. These findings suggest that co-transfection of a transgene with the $Neo^r$ gene can aid in the successful integration of the transgene into fetal fibroblast cells.

• 수산해양기술연구
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• 제40권4호
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• pp.247-254
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• 2004

동해안의 연안성 어족인 빨간횟대에 대해 망목크기 등을 달리한 8종류의 장구형 통발을 사용하여, 2003년 6월부터 12월까지 총 6차례에 걸쳐 어선 2척을 용선하여 조업한 어획실험으로부터 망목선택성 곡선을 구하여 합리적인 자원관리에 대한 기초 자료를 구하고자 하였다. 망목 크기가 20mm와 35mm인 두 통발의 빨간횟대 어획물로부터 체장에 따른 어획비율의 차이에 대해 특별한 경향을 발견할 수 없었다. 망목 크기가 20mm와 55mm인 두 통발의 경우에 대해 SELECT방법을 이용하여 equal split model 과 estimated split model을 적용한 결과, AIC 값이 적은 전자가 더 적절한 모델이므로, 빨간횟대의 경우는 이들 두 통발에 대한 입망률의 차이는 없는 것으로 나타났다. 망목 55mm의 통발에서 SELECT 모델로 구한 50% 어획될 빨간횟대의 전장은 22.0cm였다. 망목 크기가 20mm, 35mm, 55mm인 통발의 어획 자료에 Kitahara의 방법으로 logistic식을 적용하여 추정된 선택성 곡선식은 $s(R)\;=\;\frac{1}{1+exp(-0.3545R+2.141)$와 같았고, 현재 규정 망목 크기인 35mm 장구형 통발에 대해 50% 어획될 빨간횟대의 전장은 21.4cm이었다.