• Journal of Acupuncture Research
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• 제27권2호
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• pp.51-58
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• 2010

Objectives : The purpose of this study was to assess the effect of $PC_6$ moxibustion treatment for reducing mental stress using power spectrum analysis of the heart rate variability(HRV). Methods : 20 healthy volunteers(simple rest group : 10, moxibustion treatment group : 10) participated in this study. After instrumentation and 5-minutes rest period, mental stress by operation was provided for 5-minutes. HRV was recorded before and after the mental stress. And then the simple rest group rested for 15-minutes. The moxibustion treatment group was treated by $PC_6$ moxibustion and rested for 15-minutes. And then HRV was recorded. Results : In simple rest group, LF norm and HF norm showed a significant change after mental stress. In moxibustion treatment group, LF, HF, LF norm, HF norm and LF/HF showed a significant change after mental stress. But there were no significant difference between two groups(p>0.05) except HF. In moxibustion treatment group, LF, LF norm, HF norm and LF/HF showed a significant change after moxibustion treatment. There were significant differences between two groups(p<0.05). Conclusions : The result suggests that $PC_6$ moxibustion treatment can regulate and prevent the alteration of autonomic nerve system by mental stress.

• 대한한방내과학회지
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• 제27권3호
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• pp.698-705
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• 2006

Objectives : This study was designed to investigate the effect of PC6 and SP4 on autonomic nerve system in healthy adults. Methods : 22 healthy adults were recruited and randomized into the study group or control group. The study group (real acupuncture group) was acupuncturcd on PC6 and SP4. The control group (sham acupuncture group) was acupunctured superficially near PC6 and SP4 but not the exact points. The subjects rested for 10 minutes, and were then acupunctured. After 15 minutes, acupuncture needles were removed and the subjects rested for another 15 minutes. Heart rate variability(HRV) was continuously measured during the study period by FM-150 (digital Holter ECG recorder). Results : In the real acupuncture group. LF(low frequency) significantly decreased during the acupuncture period(p<0.05). LF/HF ratio also had a significant decrease during acupuncture period and the decrease was maintained during the post-treatment period as compared with the pre-treatment period. In the sham acupuncture group. LF significantly increased during the acupuncture period but LF/HF ratio had no significant changes. Conclusions : The results suggest that acupuncture on PC6 and SP4 can increase parasympathetic activity and balance autonomic nervous system.

• 한국자원식물학회지
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• 제13권1호
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• pp.80-88
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• 2000

금강초롱꽃 자생지 6지역(오대산, 향로봉, 대암산, 화악산, 점봉산, 설악산)에 대한 형태적 유연관계를 알아보기 위하여 외부형태, 주성분분석과 유집분석 등 수리분류학적 연구를 실시하였다. 연구 결과, 외부형태형질 중 자생지간에 뚜렷한 차이를 보이는 형질은 없었으며 형질의 연속성이 인정되었다. 조사된 6개 자생지의 71개체와 outgroup으로 사용한 검산초롱꽃 7개체, 총78개체 중 향로봉과 설악산 정상부에서 자라는 일부 개체들은 잎, 포엽의 형태 등 에서 다소 차이를 보여 구별이 가능하였다. Outgroup으로 사용된 검산초롱꽃은 꽃받침의 형태가 넓은 난형 으로 선형 또는 선상피침형인 금강초롱꽃과 구별되었으며 나머지 형질들은 비슷한 경향을 보였다. 17가지의 양적 형질을 이용한 주성분분석 결과 주성분1(22.3%), 주성분2(15.7%), 주성분3(12.0%)이 총 50.07%의 기여율을 보였으며, 주성분 1과 2를 이차원공간에 도시한 결과 6개 자생지 집단은 서로 중복되어 나타나 구별이 불가능하였다. 평균연결방법과 Ward's법 에 의한 유집분석 결과도 주성분분석과 매우 유사한 결과를 보여 유집이 불가능하였다.

• Structural Engineering and Mechanics
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• 제62권6호
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• pp.663-674
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• 2017

This paper presents an approach for evaluating performance of prestressed concrete (PC) bridge girders exposed to fire. A finite element based numerical model for tracing the response of fire exposed T girders is developed in ANSYS. The analysis is carried out in three stages, namely, fire temperature calculation, cross sectional temperature evaluation, and then strength, deformation and effective prestress analysis on girders exposed to elevated temperatures. The applicability of the computer program in tracing the response of PC bridge girders from the initial preloading stage to failure stage, due to combined effects of fire and structure loading, is demonstrated through a case study, and validated by test data of a scaled PC box girder under ISO834 fire condition. Results from the case study show that fire severity has a significant influence on the fire resistance of PC T girders and hydrocarbon fire is most dangerous for the girder. The prestress loss caused by elevated temperature is about 10% under hydrocarbon fire till the girder failure, which can lead to the increase in deflection of the PC girder. The rate of deflection failure criterion is suggested to determine the failure of PC T girder under fire.

• Korean Journal of Acupuncture
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• 제32권3호
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• pp.136-143
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• 2015

This study was performed to comparative investigate the distribution of primary sensory and motor neurons associated with Cheonji(PC1) acupoint by using neural tracing technique. A total 4 SD rats were used in the present study. After anesthesia, the rats received microinjection of $6{\mu}l$ of cholera toxin B subunit(CTB) into the corresponding sites of the acupoints Cheonji(PC1) in the human body for observing the distribution of the related primary sensory neurons in dorsal root ganglia(DRGs) and motor neurons in the spinal cord(C3~T4) and sympathetic ganglia. Three days after the microinjection, the rats were anesthetized and transcardially perfused saline and 4% paraformaldehyde, followed by routine section of the DRGs, sympathetic chain ganglia(SCGs) and spinal cord. Labeled neurons and nerve fibers were detected by immunohistochemical method and observed by light microscope equipped with a digital camera. The labeled neurons were recorded and counted. From this research, the distribution of primary sensory and motor neurons associated with Cheonji(PC1) acupoints were concluded as follows. Muscle meridian related Cheonji(PC1) are controlled by spinal segments of C5~T1, C6~T4, respectively.

• 한국구조물진단유지관리공학회 논문집
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• 제12권6호
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• pp.71-80
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• 2008

본 연구에서 검토된 슬래브는 트러스 철근이 설치된 하프 프리캐스트 콘크리트(PC) 슬래브로서, 이러한 슬래브의 내력평가에 대한 몇몇 연구결과가 소개되었다. 하지만 합성슬래브의 내력평가에 대한 연구가 대부분이고 하프PC슬래브의 내력평가에 대한 연구는 적으며 특히, 트러스 높이에 따른 슬래브의 구조성능에 관한 연구는 매우 부족한 실정이다. 따라서 본 연구에서는, 트러스 철근이 설치된 하프PC슬래브의 구조성능을 검토하기 위하여 트러스 철근의 높이가 다른 세 종류의 슬래브를 제작하여 휨 실험을 실시하였다.

• 디지털융복합연구
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• 제11권3호
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• pp.115-126
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• 2013

이 연구의 목적은 정보시스템, PC 및 클라우드 컴퓨팅에 장착된 상용소프트웨어대비 공개소프트웨어 총소유비용 절감 정도가 어느 정도 되는지를 확인해 보는 것이었다. 이에 실제로 정부기관, 교육기관 및 민간업체의 정보시스템 분야 51개 업체, PC분야 18개 업체 그리고 클라우드 컴퓨팅 분야 6개 업체를 대상으로 정보시스템, PC 및 클라우드 컴퓨팅에 장착된 공개소프트웨어를 5년간 운영했을 때 소요되는 총소유비용 절감 비율을 전문가 서베이한 결과, (1)정보시스템 분야에서 DBMS, WAS, Web, OS 4개영역 평균 63.3%, (2)PC분야에서 OS, 문서프로그램, 백업 및 복구용, 스크린 캡쳐, 백신, 기타 6개 영역 평균 59.4%, (3)클라우드 컴퓨팅 분야에서 Virtualization, OS, WEM/WAS, DBMS, DFS, Cloud Management 6개 영역 평균 61.2%로 나타났다. 따라서 이 연구의 가장 큰 성과는 공개소프트웨어의 활용이 상용소프트웨어의 활용대비 총소유비용이 절감될 수 있음을 입증했다는 점이다. 그러나 이 연구의 결과는 공개소프트웨어의 활용이 회사 내부 인적 자산, 내부 프로세스의 효율성 향상, 경쟁력 강화 등 장점뿐만 아니라 진작 도움이 필요하거나 장애가 발생 시 기술지원을 받을 수 없다는 공개소프트웨어 이용에 대한 기술지원의 어려움 등 리스크도 동시에 내포하고 있음을 고려하여 해석해야 함을 잊어서는 안 될 것이다.

• Bulletin of the Korean Chemical Society
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• 제20권6호
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• pp.701-704
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• 1999

Metallophthalocyanines [PcM, Pc: phthalocyanine, M: Fe 2+ , Co 2+ ] were reacted with α-isocyanonaphthalene( α-in) and α-isocyanoanthracene (α-ia) to form monomeric complexes. The synthesis and coordination behaviour of the isocyanides as a ligand (L) are discussed. All the products were characterized by spectroscopic methods and instrumental analysis. The electrical conductivities of these complexes, which were not treated with dopant, were attributed to the metal-ligand electron delocalization in the PcML2 complexes. The complexes have an enlarged macrocycle where the π-electron back donating ability of PcM is stronger than the σ-electron coordinating ability of the isonitrile ligands. Their electrical conductivities were measured as σRT = 2.1×10 -9 ~3×10 -10 S/cm. Also thermal stability was investigated in this study.

• 동의신경정신과학회지
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• 제20권1호
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• pp.21-42
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• 2009

Objectives : This Study was performed to assess the antioxidant and neuroprotective effect of Chunghyul-dan(Qingxuedan) in PC12 cells and primary rat mesencephalic dopaminergic neurons. Methods : The anioxidant effect was investigated using the DPPH radical and ABTS cation scavenging assays and total polyphenol amout of Chunghyul-dan(Qingxuedan). The neuroprotective effect of Chunghyul-dan(Qingxuedan) in PC12 cells was evaluated using MTT assay. The scavenging activity of Chunghyul-dan(Qingxuedan) on ROS production induced by 6-OHDA(6-hydroxydopamine) in PC12 cells was evaluated, as well as the attenuating effect on GSH reduction. Finally, we examined the neuroprotective effect of Chunghyul-dan(Qingxuedan) against 6-0HDA-induced toxicity in the primary culture of rat mesencephalic doperminergic neurons. Results : Chunghyul-dan(Qingxuedan) showed concentration-dependent scavenging activities in DPPH radical and ABTS cation scavenging assays and it was not cytotoxic to PC12 cells. In postand co-treatment, Chunghyul-dan(Qingxuedan) protected PC12 cells from the 6-OHDA induced toxicity at 50 and 100 ${\mu}$g/mL significantly. And Chunghyu!-dan(Qingxuedan) decreased the 6-OHDA induced ROS production at a dose dependent manner, while increaing the 6-OHDA induced GSH reduction at 50 and 100 ${\mu}$g/mL significantly. Finally, Chunghyul-dan(Qingxuedan) showed signicant protection of rat mescencephalic dopaminergic neurons from 6-OHDA at 1 ${\mu}$g/mL. Conclusions : These results demonstrate that Chunghyul-dan(Qingxuedan) has the antioxidant and neuroprotective effect against 6-0HDA induced cytotoxicity through decreasing ROS production and increasing GSH reduction.

• 대한본초학회지
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• 제23권3호
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• pp.19-25
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• 2008

Objectives : This study was performed to evaluate the neuroprotective effect of water extracts from Thujae Semen(TSW) in PC12 cells. Methods : We performed 2,2-diphenyl-2-picrylhydrazyl(DPPH) radical scavenging assay, 2,2-azinobis- (3-ethyl-benzothiazoline-6-sulfonic acid(ABTS) cation scavenging assay, and determination of total polyphenolic content to examine the antioxidant effects of TSW. We also carried out 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay(MTT), reactve oxygen species(ROS) assay, and nitric oxide(NO) assay to examine neuroprotective effects against 6-hydroxydopamine(6-OHDA) in PC12 cells. Results : TSW showed $IC_{50}$ values of 404.3 and 219.9 ${\mu}g/mL$ in DPPH and in ABTS assays, respectively. TSW showed 9.74 ${\mu}g/mL$ of total polyphenol contents. TSW incresed cell viability in a dose dependent manner and it showed protective effect against 6-OHDA neurotoxicity at the concentration of 25-200 ${\mu}g/mL$. Moreover, it recovered 6-OHDA induced cell death at the same concentrations. The extract showed a dose dependent reduction of ROS and NO generation by 6-OHDA. Conclusions : We concluded that TSW has neuroprotective effect against 6-OHDA-induced toxicity in PC12 cells through ROS and NO inhibition.