• Title/Summary/Keyword: $P^+$ region

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Advanced P-Channel Poly-Si TFTs for SOG

  • Park, Seong-Jin;Kang, Sang-Hoon;Ku, Yu-Mi;Choi, Jong-Hyun;Jang, Jin
    • 한국정보디스플레이학회:학술대회논문집
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    • 2004.08a
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    • pp.1019-1022
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    • 2004
  • High performance p-ch poly-Si TFTs with excellent stability were developed. By using a frequency doubled DPSS CW laser, the a-Si on glass could be crystallized into one dimensional single crystalline silicon named as a sequential lateral crystallization (SLC) region. We fabricated p-ch TFTs on SLC region and the typical characteristic values of the TFTs were $u_{fe}$ = 180 $cm^2$/Vs, $V_{th}$ = -3 V, S.S. = 0.5 V/dec, and $I_{off}$ = 1 pA/um@ $V_d$ = -10V. It is found that the TFTs are very stable after bias stresses such as negative and positive gate biases, hot carrier bias and high current bias. These results indicate that the poly-Si in SLC region is suitable for system on glass (SOG) application.

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Choice of Capecitabine or S1 in Combination with Oxaliplatin based on Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase Expression Status in Patients with Advanced Gastric Cancer

  • Xu, Rong;He, Xiaolei;Wufuli, Reyina;Su, Ying;Ma, Lili;Chen, Ru;Han, Zhongcheng;Wang, Fang;Liu, Jiang
    • Journal of Gastric Cancer
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    • v.19 no.4
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    • pp.408-416
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    • 2019
  • Purpose: To study the efficacy of capecitabine or S-1 plus oxaliplatin (CAPOX or SOX) for treating thymidine phosphorylase (TP)- or dihydropyrimidine dehydrogenase (DPD)-positive advanced gastric cancer. Materials and Methods: Eighty-six patients with stage IIIC to IV gastric cancer were assessed for TP and DPD expression by immunohistochemistry. The association between CAPOX or SOX efficacy and TP/DPD expression was retrospectively analyzed. Results: There were no significant differences in the objective remission rate (ORR, 52.27% vs. 47.62%; P>0.05), disease control rate (72.73% vs. 73.81%, P>0.05), progression-free survival (hazard ratio [HR], 1.119; 95% confidence interval [CI], 0.739-1.741; P=0.586), and overall survival (OS; HR, 0.855; 95% CI, 0.481-1.511; P=0.588) between CAPOX and SOX. A higher number of stage IV patients showed TP positivity, while DPD-positive patients predominantly showed intestinal type of gastric cancer. In TP-positive patients, the ORRs associated with CAPOX and SOX treatments were 57.14% and 38.10%, respectively; OS was better with CAPOX than with SOX (HR, 0.447; 95% CI, 0.179-0.978; P=0.046). Among DPD-positive patients, the SOX treatment-associated ORR (60.87%) was significantly higher than the CAPOX treatment-associated ORR (43.48%). Furthermore, SOX treatment resulted in better OS than did CAPOX treatment (HR, 2.020; 95% CI, 1.019-4.837; P=0.049). Conclusions: No significant difference in clinical efficacy was found between CAPOX and SOX. TP-positive patients might respond better to CAPOX while DPD-positive patients may respond better to SOX. Our findings might serve as a guide for personalized chemotherapy for gastric cancer.

Phylogenetic Analysis of Mitochondrial DNA Control Region in the Swimming Crab, Portunus trituberculatus

  • Cho, Eun-Min;Min, Gi-Sik;Kanwal, Sumaira;Hyun, Young-Se;Park, Sun-Wha;Chung, Ki-Wha
    • Animal cells and systems
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    • v.13 no.3
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    • pp.305-314
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    • 2009
  • The control region of mitochondrial DNA (13516-14619) is located between srRNA and $tRNA^{lle}$ gene in swimming crab, Portunus trituberculatus. The present study was investigated the genetic polymorph isms of the control region in samples of P. trituberculatus collected at coastal waters of the Yellow Sea in Korea. A total of 300 substitution and indel polymorphic sites were identified. In addition to SNPs and indel variation, a hypervariable microsatellite motif was also identified at position from 14358 to 14391, which exhibited 10 alleles including 53 different suballeles. When the hypervariable microsatellite motif was removed from the alignment, 95 haplotypes were identified (93 unique haplotypes). The nucleotide and haplotype diversities were ranged from 0.024 to 0.028 and from 0.952 to 1.000, respectively. The statistically significant evidence for geographical structure was not detected from the analyses of neighbor-joining tree and minimum-spanning network, neither. This result suggest that population of P. trituberculatus are capable of extensive gene flow among populations. We believed that the polymorph isms of the control region will be used for informative markers to study phylogenetic relationships of P. trituberculatus.

New Approach to Low NOx Combustion by Changing Combustor Pressure (연소실 압력변동을 이용한 저 NOx 연소의 새로운 접근)

  • Kim Jong Ryul;Choi Gyung-Min;Kim Duck-Jool
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.29 no.10 s.241
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    • pp.1148-1155
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    • 2005
  • In this study, the influence of changing combustor pressure on nitric oxide emission was investigated. Expansion of reaction region was more clear in the P$^{*}$ <1 conditions compared to the P$^{*}\geq1$ conditions, and it could be observed that flames are distinct in the P$^{*}\geq1$ conditions and that brightness is relative low and wide distribution is shown in the P$^{*}$ <1 conditions. In the respect of temperature distribution, narrow and high-temperature region was shown in the P$^{*}\geq1$ conditions. On the other hands, overall uniform temperature distributions were shown in the P$^{*}$ <1 conditions. Nitric oxide emission decreased with decreasing combustor pressure. This tendency was explained by the mean flame temperature distribution. Low NOx combustion is ascribed to wide-spread reaction region in the low combustor Pressure and oscillation were shown P$^{*}\leq0.97$, and strength and sizes of oscillation were more increased with lower pressure index. These results demonstrate that flame shape and nitric oxide emission can be controlled with changing combustor pressure.

Phylogenetic Analysis of Pines Based on Chloroplast trnT-trnL Intergenic Spacer DNA Sequences

  • Um, Yurry;Park, Won-Kyu;Jo, Nam-Su;Han, Sim-Hee;Lee, Yi
    • Journal of Forest and Environmental Science
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    • v.30 no.3
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    • pp.307-313
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    • 2014
  • This study was conducted to distinguish the pines that are too similar to differentiate using conventional methods. Pinus densiflora and Pinus sylvestris have similar anatomical structure. They both have window-like pits and dentate ray tracheids, so it is not easy to distinguish the plants. We tried to find molecular markers by comparing chloroplast DNA sequences to differentiate the pines growing in Korea. We used P. densiflora, P. densiflora for. multicaulis, P. sylvestris, P. rigida, P. rigitaeda, P. koraiensis, and P. bungeana for this study. We found that the non-coding intergenic region of trnT(UGU) and trnL(UAA) genes have differences among the species. We designed a primer set to amplify the region efficiently and compared the PCR product sequences using CLC Workbench programs to find the polymorphism. We could distinguish the species using the sequences of the amplified region and the sequences were reproducible from the pines collected in Korea.

Cloning, Base Sequence Determination and Homology Analysis of Replication Controlling cop Gene of R-plasmid pSBK203 Isolated from Staphylococcus aureus DHI (Staphylococcus aureus DH1에서 분리된 R-plasmid pSBK203의 복제조절 유전자 cop의 Cloning, 염기서열 결정 및 상동성 분석)

  • Park, Seung-Moon;Byeon, Woo-Hyeon
    • Korean Journal of Microbiology
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    • v.32 no.2
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    • pp.115-119
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    • 1994
  • Replication control region of pSBK203, a chloramphenicol acetyltransferase conferring plasmid from Staphylococus aureus was cloned and its nucleotide sequence has been determined. Base sequence homology of this copy control region with those of plasmids belonging to pT181 family was obtained and analyzed. Copy number of four copy mutants derived by addtion or deletion of nucleotides in unique XbaI recognition site in copy control region of pSBK203 was also determined.

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Phylogenetic Relationships Among Pleurotus species Inferred from Sequence Data of PCR Amplified ITS II Region in Ribosomal DNA (rDNA의 ITS II 부위의 염기서열분석에 의한 느타리버섯 종간의 근연관계)

  • Bae, Shin-Churl;Seong, Ki-Young;Lee, Shin-Woo;Go, Seung-Joo;Eun, Moo-Young;Rhee, In-Koo
    • The Korean Journal of Mycology
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    • v.24 no.2 s.77
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    • pp.155-165
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    • 1996
  • This study was carried out to identify the phylogenetic relationship among several isolates of Pleurotus species by comparing ITS II region of ribosomal DNA(rDNA) repeat unit. Two primers from ribosomal DNA sequences were chosen to amplify the specific internal transcribed spacer (ITS) II region of Pleurotus spp. The exact ITS II region with an unique band from six species of Pleurotus genus could be amplified using the two primers taken from at the 3'-end of 5.8S rDNA and 5'-end of 28S rDNA. Six representative species of the Pleurotus genus were easily characterized according to the length differences of ITS II region. Furthermore, within P. ostreatus species, different sizes of ITS II region could be observed in the isolates of ASI 2025 and ASI 2095 although they were classified as P. ostreatus by the conventional observation. The nucleotide sequence analyses of PCR-amplified ITS II region indicated that the isolates ASI 2025 and ASI 2095 were different from other Pleurotus spp. When the nucleotide sequences of six Pleurotus species were compared, three typical ITS II regions were highly variable especially at both ends of this region. The phylogenetic tree obtained by the Neighbor program of Felsenstein PHYLIP package with all the nucleotide sequence of Pleurotus spp. indicated that P. ostreatus, P. florida, P. sajor-caju and P. eryngii were closely related to one phylogenetic branch and P. cystidious was related to other branch with P. cornucopiae. The isolates ASI 2025 and 2038, however, were not closely related to any other Pleurotus spp. and formed their own individual branches.

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Ecological Studies on the Bog in Changnyeung Area(1. Vegetation and Environmental Factors) (昌寧地域 濕原의 生態學的 硏究 1. 植生과 環境要因)

  • Ri, Chong Un;Woen Kim;Hee Cheon Park
    • The Korean Journal of Ecology
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    • v.8 no.3
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    • pp.171-176
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    • 1985
  • The structure of natural vegetation and soil condition in bog area of Woopo, Changnyeung, South Korea were observed. The vegetations in the investigated area could be classified into two groups; a typical bog vegetation with dominant species of Eleocharis mamillats, Acorus calamus and Persicaria hostatosagittata and the transitional vegetation of three neighboring areas. Interspecific correlation in the investigated area was very close. In the typical bog vegetatiion regions (region II, III, V, VI, VII, VIII and X) soil pH, field moisture capacity, available P content and exchangeable K were moderate. But, In the transitiional area I, with the highest humus content, field moisture capacity and exchangeable K Salix gracilistyla was dominant. In the region IV with the lowest humus and a ailable P content and with high soil pH Geophyta was a major component species. Also Acorus region IX with the lowest content of exchangeable K Therophyta was dominant and plant species was diverse due to weak water influence. The vegetation structure of the region IX was most different from that of the whole vegetation.

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FINITE ELEMENT ANALYSIS OF MANDIBULAR STRESSES INDUCED BY OVERDENTURE WITH DIFFERENT DESIGNS OF ABUTMENT COPINGS (지대치 coping형태에 따른 overdenture하에서 하악 응력에 관한 유한요소법적 분석)

  • Park Hae-Kyoon;Chung Chae-Heon;Cho Kyu-Zong
    • The Journal of Korean Academy of Prosthodontics
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    • v.29 no.3
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    • pp.141-170
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    • 1991
  • This study was to analyze the displacement and the magnitude and mode of distribution of the stresses in the lower overdenture, the mucous membrane, the abutment teeth and the mandibular supporting bone when various abutment designs were subjected to different loading schemes. For this study, the two-dimensional finite element method was used. The models of overdenture and mandibe with the canine and the second premolar remaining, were fabricated. In the first design, a 1 mm space was prepared between the denture and the dome abutment with the height of 2 mm(OS). In the second design, a contact between the denture and the occlusal third of the dome abutment with the hight of 2 mm was prepared(OC). In the third design, a 0.5 mm space was prepared between the denture and 8 degree tapered cylindrical abutments with the height of 7 mm(TS). In the fourth design, a contact between the denture and the occlusal two thirds of the conical abutments with the height of 7 mm was prepared(TC). In order to represent the same physiological condition as the fixed areas of the mandible under loading schemes, the eight nodes which lie at the mandibular angle, the coronoid process and the mandibular condyle were assumed to be fixed. Each model was loaded with a magnitude of 10 Kgs on the first molar region (P1) and 7 Kgs on the central incisor region (P2) in a vertical direction. The force of 10 Kgs was then applied distributively from the first premolar to the second molar of each motel in a vertical direction (P3). The results were as follows: 1. The vertical load on the central incisor region(P2) produced the higher displacement and stress concentration than that on the posterior region(P1, P3). 2. The case of space between abutment and denture base produced higher displacement than that of contact, and the case of long abutment produced higher displacement than that of short abutment because of low rigidity of denture base. 3. The magnitude of the torque and vertical force to the abutment teeth and the stress distribution to the denture base was higher in the telescope coping than in the overdenture coping. 4. The vertical load on the central incisor region(P2) produced higher equivalent stress in the mandible than that on the posterior region(P1, P3). 5. The case of space between abutment and denture base produced better stress distribution to the farther abutment from the loading point than that of contact. 6. In case of sound abutment teeth, the type of telescope coping can be used, hilt in case of weak abutment, the type of overdenture coping is considered to be favorable generally.

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Comparison of Ranges of Motion in The Thoracolumbar Region for Clinical Diagnoses of Patients with Chronic Low Back Pain (만성요통 환자의 질환명에 따른 흉요추부의 관절가동범위 비교)

  • Lee, Sang-Wook;Kim, Suhn-Yeop
    • Journal of the Korean Society of Physical Medicine
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    • v.5 no.3
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    • pp.363-373
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    • 2010
  • Purpose : The purpose of this study was to compare differences in thoracolumbar ranges of motions by comparing ratios among 4 type diagnosis for patient with chronic low back pain. Methods : The subjects were 58 chronic low back pain patients. A motion analysis program (Global Postural System) was used after photography for posture measurement. To analyze differences in mobility percentages and ratios of thoracolumbar ranges of motion, one-way ANOVA was used. Results : Regional difference spinal posture and movement were found to diagnosis patients with chronic low back pain. Comparison of thoracolumbar ranges of motion revealed significant differences in the thoracic region during forward-bending of the trunk (p<.05). In the upper thoracic region, the herniated intervertebral lumbar disc (HILD) group was significantly larger than the spinal stenosis/herniated intervertebral lumbar disc (SS/HILD) group (p<.05). In the lower thoracic region, chronic sprains (CS) were significantly greater than in the spinal stenosis (SS) group and in the (SS/HJLD) group (p<.05). Comparative analysis of thoracic/lumbar mobility ratio showed the CS group's ratio during forward bending was largest: 1.66, while the HILD group's ratio was smallest: 84 a significant difference between the two groups (p<.01). Diagnosis was not associated with difference in thoracolumbar backward-bending range of motion (p>.05). Conclusion : Theses results indicate the clinical efficacy of diagnosing for chronic low back pain by evaluating spinal mobility.