• Journal of Chest Surgery
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• v.50 no.3
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• pp.144-152
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• 2017

Background: The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the UPS. Nuclear factor kappa-light-chain-enhancer of activated B cells ($NF-{\kappa}B$) and androgen receptor (AR) have been reported to be mediators of CMP and heart failure. This study drew upon pathophysiologic studies and the analysis of $NF-{\kappa}B$ and AR to assess the cardioprotective effects of MG132 in a left ventricular hypertrophy (LVH) rat model. Methods: We constructed a transverse aortic constriction (TAC)-induced LVH rat model with 3 groups: sham (TAC-sham, n=10), control (TAC-cont, n=10), and MG132 administration (TAC-MG132, n=10). MG-132 (0.1 mg/kg) was injected for 4 weeks in the TAC-MG132 group. Pathophysiologic evaluations were performed and the expression of AR and $NF-{\kappa}B$ was measured in the left ventricle. Results: Fibrosis was prevalent in the pathologic examination of the TAC-cont model, and it was reduced in the TAC-MG132 group, although not significantly. Less expression of AR, but not $NF-{\kappa}B$, was found in the TAC-MG132 group than in the TAC-cont group (p<0.05). Conclusion: MG-132 was found to suppress AR in the TAC-CMP model by blocking the UPS, which reduced fibrosis. However, $NF-{\kappa}B$ expression levels were not related to UPS function.

• Nutritional Sciences
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• v.4 no.1
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• pp.20-25
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• 2001

The dietary vitamin $B_6$ intake of 218 Korean young women (aged 20-26y), who had no health problems, and their sources were estimated using a modified Korean vitamin $B_6$ database. The average daily vitamin $B_6$ intake was 0.987 mg for the subjects. About 87.2% of the subjects consumed less than the Korean Recommended Dietary Allowance (RDA) of vitamin $B_6$. The average ratio of vitamin $B_6$ intake to daily protein intake was 0.014 mg/g protein, and approximately 91% of subjects consumed 〈 0.02 mg/g protein. Vitamin $B_6$ intake was significantly (p〈.01 -p〈.001) positively correlated to the intakes of all other nutrients. Between animal and vegetable protein, animal protein had a stronger positive correlation with vitamin $B_6$. Major dietary sources of vitamin $B_6$, the top 10 foods provided nearly 64% of total vitamin $B_6$, and dietary contributors of vitamin $B_6$ for Koreans are less varied than those for Americans.

• Journal of the Korean Ceramic Society
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• v.50 no.3
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• pp.195-200
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• 2013

Here, we report preparation of cyan ceramic nano-pigment for inkjet printing and the Ni substitutional effects on the cyan color. $MgAl_2O_4$ was selected as the crystalline host network for the synthesis of nickel-based cyan ceramic nano-pigments. Various compositions of $Ni_xMg_{1-x}Al_2O_4$ ($0{\leq}x{\leq}1$) powders were prepared using the polymerized complex method. The powder was then preheated at $400^{\circ}C$ for 5 h and finally calcined at $1000^{\circ}C$ for 5 h. XRD patterns of $Ni_xMg_{1-x}Al_2O_4$ showed a single phase of the spinel structure in all the compositions. The particle sizes ranged from 20 to 50 nm in TEM observations. The characteristics of the color tones of $Ni_xMg_{1-x}Al_2O_4$ were analyzed by UV-Visible spectroscopy and CIE $L^*a^*b^*$ measurement. CIE $L^*a^*b^*$ measurement results indicate that the pigment color changes from light cyan to deep cyan due to the decrease of the $a^*$ and $b^*$ values with an increase of an Ni substitutional amount. In addition, the thermal stability and the binding nature of $Ni_xMg_{1-x}Al_2O_4$ are also discussed using TG-DSC and FT-IR results respectively.

• Journal of the Korean Society of Food Science and Nutrition
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• v.9 no.1
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• pp.39-44
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• 1980

The effect of dietary vegetable oils on the growth and blood glucose level of rabbit was examed. This study was carried out to observe the nutritive effect of feeding vegetable oils for a period of weeks. The experimental diets were prepared on the basis of isocaloric and isonitrogenous diet. The Experimental animals were fed on 5 kinds of diets such as control (Basal), group A(Basal + sesame oil), group B(Basal + perilla oil), group C(Basal + soybean oil), and group D(Basal + rice bran on diets for 4 weeks. The results obtained are summarized as follows: 1. The gain in body weight of rabbit was higher for perilla oil fed group than any other group gained. 2. Liver weight of the control group, group A, group B, group C, and group D were 30.35 or 37.35 or, 37.25 or, 38.25 gr, 31.05 gr, and 39.54 gr, respectively. The reletionship between liver and body weight were 3.25, 3.99, 4.33, 4,15, and 4.57, respectively. It showed that to liver weight of group D which was fed rice bran oil was heavier than any other group showed. 3. The content of total protein and glucase level in serum of animal blood were 5.72 mg% 40.34 mg%, 5.65 mg%: 22.37 mg%, 5.95 mg%: 77.0 mg%. 5.62 mg%: 28.60 mg%, and 5.63 mg%: 34.10 mg%, respectively. As shown above, the group B was the most heaviest one. 4. It may be concluded from the above results that linolenic acid which was included in vegetable oils have an effect on interconversion among three caloric elements such as cabohydrate, protein, and fats.

• Food Science and Preservation
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• v.9 no.4
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• pp.400-405
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• 2002

Herbs are widely used as a source of tea and otherwise such as botanical medicine, essential oil for perfumes, cosmetics, and food spices. This study was carried out to investigate the characteristics of herb tea prepared with lavender, rosemary, mint, thyme and sage cultivated in korea. Approximate composition were as follows : crude protein 1.4∼17.5%, crude fat 6.1∼15.8%, sugars 43.5∼61s%, crude ash 7.7∼10.7%. Minerals contents of Ca ranged 707∼1763mg%, P 234 ∼513mg%, K 2,391∼3,430mg%, and Mg 361∼573mg%. Vitamins were $\beta$ -Carotene 6.9∼27.7mg%, B$_1$, 0.34∼0.62mg%, B$_2$1.37 ∼2.52mg%, niacin 5.3∼8.8mg%, and C 102∼111mg%. The changes of chromaticity a and b, pH, and sugar content of the herb tea at the different temperatures were decreased 80$\^{C}$ and 100$\^{C}$ in comparison to 60$\^{C}$ but increased chromaticity L. In the result of sensory test of the processed herb tea was more preferred than the market goods.

• Korean Journal of Community Nutrition
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• v.8 no.5
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• pp.667-674
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• 2003

The paper examines the effect of physical exercise on blood lipid with young male students. Our analysis is based on the body measurement, food intake and blood lipid component for 70 male students of Kongju National University who either major in physical exercise (group A) or do not major in physical exercise (group B). The average weight of group A is 71.97 $\pm$ 10.79 kg while that of group B is 67.57 $\pm$ 8.66 kg. The former is significantly higher (p<0.05) than the latter. The SBP of group A (128.20 $\pm$ 11.40 mmHg) is significantly (p<0.001) higher than that of group B (136.27 $\pm$ 13.18 mmHg). In terms of the intake of total kcal, group A marks significantly higher than group B; group A goes with 2190.26 $\pm$ 581.96 kcal and group B goes with 2392.94 $\pm$ 769.03 kcal. The comparative analysis of the three nutrient intake shows that the intake proportions for group A are carbohydrate 55.08 $\pm$ 6.03%, protein 15.58 $\pm$ 2.75%, and lipid 29.34 $\pm$ 5.16% while the intake proportions for group B are carbohydrate 57.29 $\pm$ 8.09%, protein 15.62 $\pm$ 3.26%, and lipid 27.10 $\pm$ 6.90%. For group A, the vitamin B$_1$ intake amounts to 1.50 $\pm$ 0.5 mg which fulfills 100% of RDA, and the niacin intake amounts to 16.57 $\pm$ 5.54 mg N.E which is less than RDA. In contrast, both intakes for group B are more than the RDA. In the case with minerals except calcium, both group A and B mark more intake than RDA. Group A's calcium intake is 517.12 $\pm$ 200.63 mg and group B's is 409.56 mg. The total cholesterol intake for group A is 447.00 $\pm$ 245.08 mg which is significantly (p<0.05) higher than for group B with 352.35 $\pm$ 200.25 mg. The total cholesterol in the lipid of serum is 151.30 $\pm$ 12.92 mg/dl for group A and 182.30 mg/dl for group B, where the dominance of group B over group A is true at the level of significance 0.01. In the case with triglyceride, group A is 107.57 $\pm$ 31.60 mg/dl and group B is 108.07 $\pm$ 33.93 mg/dl so that the group difference is non-significant. The HDL-cholesterol for group A is 54.67 $\pm$ 6.49 mg/dl which is significantly higher (p<0.001) than for group B with 36.13 $\pm$ 4.64 mg/dl. We conclude that regular exercise may have an effect on blood lipid metabolism among young males.

• The Korean Journal of Food And Nutrition
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• v.33 no.4
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• pp.390-398
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• 2020

The purpose of this study was to determine the contents of water-soluble vitamins B₁ (thiamine), B₂ (riboflavin), B₃ (niacin) and B₁₂ (cyanocobalamin) in seafood-based dishes by using the high-performance liquid chromatography with the ultra violet and fluorescence detector. The vitamin B₁, B₂, B₃ and B₁₂ contents were analyzed in 29 seafood-based dishes. The method validation was performed on the method to determine the linearity, accuracy, limits of quantification, limits of detection and precision for vitamin B₁, B₂, B₃ and B₁₂. An excellent linearity range (R²=0.999~1.000) in the calibration curve for the water-soluble vitamins was observed. All analytical methods for the water-soluble vitamins showed the acceptable accuracy (89.4~119.7% recovery) and the precision (0.6~4.8% repeatability and 1.0~4.2% reproducibility). The highest content of vitamin B₁ was 2.646 mg/100 g in the kkongchi-jorim, and the highest contents of vitamin B₂, B₃ and B₁₂ were 0.370 mg/100 g, 10.971 mg/100 g, and 17.193 ㎍/100 g, respectively, in the kkongchi-gui. Our results provide reliable data on the contents of the water-soluble vitamins of seafood-based dishes in Korea.

• Korean Journal of Food Science and Technology
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• v.18 no.5
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• pp.345-350
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• 1986

Crude saponins of soybean and Azuki bean (2.0 mg/plate)were most effective against Trp-p-2, and also all of legume saponins (2.0 mg/plate)were excellent effective against aflatoxin $B_1$. Crude saponins of taro, burdock and ginseng were remarkably effective at ranging from 1.0 mg to 2.0 mg per plate against MeIQ. Especially ginseng saponin was excellent effective and arrow root saponins was remarkably effective against MeIQ, respectively. Plant saponins of taro, lotus burdock, arrow root and ginseng except for dodok were most effective activities against aflatoxin $B_1$.

• Journal of the Korean Society of Food Science and Nutrition
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• v.25 no.4
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• pp.588-592
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• 1996

The flavonoids isolated from Oenanthe javanica were investigated on the antimutagenic effect againt aflatoxin $B_1(AEB_1).$ The 0.5 and 1.0mg/plate of isorhamnetin reduced the mutagenicity of $AFB_1about$ 33 and 59%, respectively. Persicarin showed the 40 and 47% inhibition rate at Previous concentration, respectively.

• Progress in Superconductivity
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• v.12 no.2
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• pp.75-81
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• 2011

We report on the progress that has been made in developing $MgB_2$ superconducting wires and tapes for commercialization and research efforts. A number of techniques have been developed to overcome the obstacle posed by the poor critical current density ($J_c$) of pristine $MgB_2$. Chemical doping has proved to be the effective way to modify and enhance the superconducting properties, such as the $J_c$ and the irreversibility field ($B_{irr}$). More than 100 different types of dopants have been investigated over the past 8 years. Among these, the most effective dopants have been identified to be SiC and malic acid ($C_4H_6O_5$). The best results, viz. a $B_{irr}$ of 22 T and $J_c$ of $30,000\;A{\cdot}cm^{-2}$ at 4.2 K and 10 T, were reported for malic acid doped $MgB_2$ wires, which matched the benchmark performance of commercial low temperature superconductor wires. In this work, we discuss the progress made in $MgB_2$ conductors over the past few years at the University of Wollongong, Hyper Tech Research, Inc., and Ohio State University.