• Biomolecules & Therapeutics
• /
• v.9 no.4
• /
• pp.285-290
• /
• 2001

Bioequivalence of two acetyl-1-carnitine tablets, test product (Carnitile tablet: Hanmi Pharm. Co., Ltd.) and reference product (Nicetil $e^{R}$ tablet: Dong-A Pharm. Co., Ltd.), was evaluated according to the guide- lines of Korea Food and Drug Administration (KFDA). Twenty-six healthy volunteers were divided randomly into two groups and administered the drug orally at the dose of 500 mg as acetyl-1-carnitine in a 2$\times$2 crossover study. Blood samples were taken at predetermined time intervals for 12 hours and the plasma concentration of acetyl-1-carnitine was determined using HPLC by derivatization with p-bromophenacyl bromide. The pearmacokinetic parameters (AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$) were calculated and ANOVA was utilized for the statistical analysis of parameters. The apparent differences of these parameters between two drugs were less than 20% (i.e., 1.26,-5.08 and 8.59% for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, respectively). The powers (1-$\beta$) for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, and Tmax were over 0.9. Minimal detectable difference ($\Delta$) at $\alpha$=0.05, 1-$\beta$=0.8 were less than 20% (i.e.,7.31, 14.88 and 11.77% for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, respectively). The confidence intervals ($\delta$) for these parameters were also within $\pm$ 20% (i.e.,-3.03$\leq$$\delta$$\leq$5.54, -13.80$\leq$$\delta$$\leq$3.64 and 1.69$\leq$$\delta$$\leq$15.48 for AU $C_{0-}$12h/ $C_{max}$ and $T_{max}$, respectively). These results satisfied the criteria of KFDA guideline for bioequivalence, indicating Carnitile bioequivalent to Nicetil $e^{R}$ .TEX>$^{R}$ .> R/ . R/ .

• Applied Biological Chemistry
• /
• v.42 no.2
• /
• pp.134-139
• /
• 1999

The characteristics of anthocyanin pigments extracted from cherry(Prunus serrulata L. var. spontanea Max. Wils.) were investigated at the various conditions, such as light, temperature, organic acid, metal ion and pH. The pigments were fairly stable under the sunlight during the 20 days storage period at room temperature. The pigments covered with the Al-foil, as well as red, blue, green and yellow films, were very stable at pH 2.5. The high thermal stability (over the 64% at $115^{\circ}C$, 30 min) of the pigments in the dark at pH 2.5 was also found. In the presence of organic acid, the hyperchromic effect of red color was greatly increased in the dark at $25^{\circ}C$. Addition of metal ion, such as $Na^+,\;K^+,\;Mg^{2+},\;Ca^{2+}\;and\;Mn^{2+}$, was contributed on the stability in color at pH 2.5 throughout 20 days storage period in the dark at $25^{\circ}C$. However, $Cu^{2+}\;and\;Fe^{3+}$ caused the rapidly degradation of pigments, and $Al^{3+}$ converted red color to blueish violet. The hyperchromic effect of the red color increased, as pH decreased. Therefore, these results indicated that cherry anthocyanin pigments might be used as the potential sources of natural red colorant for foods.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.21 no.4
• /
• pp.679-687
• /
• 2017

In this paper, a microstrip-fed triple-band monopole antenna with DGS (Defected Ground Structure) for WLAN/WiMAX applications was proposed. The proposed antenna is based on a microstrip-fed structure, and composed of two strip lines and DGS structure and then designed in order to get triple band characteristics. We carried out simulation about parameters. Adjusted the position and length of the two strips and three slits, we get the optimized parameters. The proposed antenna is fabricated on an FR-4 substrate of which the dielectric constant is 4.4, and its overall size is $34mm(W_1){\times}34mm(L_1){\times}1.6mm(t)$, and its proposed antenna size is $17.0mm(W_6){\times}30.75mm(L_3+L_4+L_9)$. From the fabricated and measured results, return loss of the proposed antenna satisfied return loss -10dB bandwidth 360 MHz (2.335~2.695 GHz), 645 MHz (3.37~4.015 GHz) and 1,770 MHz (5.14~6.91 GHz). And measured results of gain and radiation patterns characteristics displayed for operating bands.

• Bulletin of the Korean Chemical Society
• /
• v.33 no.5
• /
• pp.1470-1474
• /
• 2012

The pharmacokinetics of prunasin after oral administration of amygdalin or a decoction of peach seeds was determined and compared in rats. A $C_{18}$ column was used for separation at a column temperature of $25^{\circ}C$. The mobile phase consisted of 20% aqueous acetonitrile, and the flow rate was 0.5 mL/min. After oral administration of a decoction of peach seeds, prunasin was absorbed rapidly, reaching a maximum plasma concentration ($C_{max}$) of 62.1 mg/L within 45 min. After oral administration of amygdalin, the absorption of prunasin was delayed. The $C_{max}$ of prunasin was 42.9 mg/L and was reached at 60 min. Values for the pharmacokinetic parameters of prunasin, including $T_{max}$, $C_{max}$, AUC, $T_{1/2}$, CL/F, and V1/F, were significantly different for the oral administration of amygdalin compared with that of a decoction of peach seeds.

• Journal of Nutrition and Health
• /
• v.35 no.2
• /
• pp.223-228
• /
• 2002

The purpose of this study was to investigate the relationship between iron deficiency without anemia and physical performance in healthy women aged 20-21 yrs. Ten subjects with normal iron stores (serum ferritin $\geq$ 12$\mu\textrm{g}$/L: iron-sufficient group) and 11 subjects with iron depletion without anemia (serum ferritin < 12 $\mu\textrm{g}$/L and serum hemoglobin > 120 g/L: iron-depleted group) were chosen from a group of 50 women and were given physical-performance tests, including determinations of maximum oxygen consumption (VO$_2$ max) and ventilatory threshold. Iron status assessment included determination of hemoglobin, hematocrit, seam ferritin, total iron-binding rapacity, serum iron and transferrin saturation values. Dietary iron intake was assessed based on seven-day food intake records written by the subjects. Physical activity level was estimated by frequency questionnaires and two-week physical activity records were compiled daily by the subjects. Blood ferritin concentration was significantly lower in the iron-depleted group than in the iron-sufficient group (p < 0.05). However, other variables showing iron status was not different between the groups. There were no significant differences in body size, body composition and physical activity levels between the groups. Daily dietary iron, total protein and animal protein intakes of the iron-sufficient group were significantly higher than those of the iron depleted group. However, no differences were found in the amount of dietary vitamin C and fiber between the groups. The values for VO$_2$max and VO$_2$max corrected with weight or fat-free mass were not different between the groups. However, the ventilatory threshold was significantly higher in the iron sufficient group than in the iron-depleted group. The lower ventilatory threshold in the iron-depleted group suggests that iron depletion without anemia could diminish aerobic physical performance in young women. In addition, a significant correlation of physical performance to serum fferritin level was shown only in the iron depleted group.

• Journal of Korean Society on Water Environment
• /
• v.24 no.5
• /
• pp.550-555
• /
• 2008

This study was conducted to assess the growth characteristics of phytoplankton and to understand seasonal dynamics of phytoplankton in response to limiting nutrients in an agricultural reservoir from November 2002 to December 2003. Marked increase of chl.a concentration observed in July ($99.0{\mu}g/L$) and November ($109.7{\mu}g/L$) after heavy rainfall. TP concentration ranged $48.0{\sim}126.6{\mu}g/L$, and its the temporal variation was similar to that of chl.a concentration. Microcystis spp., dominant phytoplankton species were used for the growth kinetics experiment, except for the season when Aulacoseira spp. (March, April) and Aphanocapsa sp. (May) dominated. In the temperature range between $10{\sim}25^{\circ}C$, the rate of growth increase per $10^{\circ}C$ was almost two folds. The highest maximum growth rate (${\mu}_{max}=1.09day^{-1}$) of phytoplankton observed September, and ${\mu}_{max}$ was lowest ($0.34day^{-1}$) in March when Aulacoseira spp. dominated. The ${\mu}_{max}$ ($0.78{\pm}0.20day^{-1}$) was relatively high in the summer season when water temperature is above $20^{\circ}C$ and cyanobacteria dominated compared to the spring when diatoms dominated ($0.43{\pm}0.08day^{-1}$). The maximum growth rate ($0.55{\pm}0.12day^{-1}$) and the half saturation concentration ($K_s=0.73{\pm}0.15{\mu}M$) of cyanobacteria during winter season (November, December) was higher than those of diatoms. However, the ${\mu}_{max}$ and $K_s$ of cyanobacteria in December was similar to those of diatom, reflecting that diatom cell quota (Mean 48.4 pgP/cell) was greater than cyanobacteria (34.0 pgP/cell) during this time.

• Journal of the Korean Society for Industrial and Applied Mathematics
• /
• v.12 no.3
• /
• pp.161-169
• /
• 2008

We investigate the existence of solutions u(x, t) for perturbations of the elliptic system with Dirichlet boundary condition $$\array {L{\xi}+{\mu}g({\xi}+2{\eta})=f\;in\;{\Omega}}\\{L{\eta}+{\nu}g({\xi}+2{\eta})=f\;in\;{\Omega}}$$ (0.1) where $g(u)=Bu^+-Au^-$, $u^+=max\{u,\;0\}$, $u^-=max\{-u,\;0\}$, ${\mu}$, ${\nu}$ are nonzero constants and the nonlinearity $({\mu}+2{\nu})g(u)$ crosses the eigenvalues of the elliptic operator L.

• Proceedings of the Plant Resources Society of Korea Conference
• /
• 2018.10a
• /
• pp.127-127
• /
• 2018

Probiotics are microorganisms that have beneficial effects on the health of the host. The health promoting effect by probiotics influences suppressing harmful bacteria, prevention of constipation, blood cholesterol reduction and regulation of blood pressure. Prebiotics are used to promote the growth or activity of microorganisms. Synbiotics, which are a mixture of probiotics and prebiotics, synergize in the intestines by complementing each other. Synbiotics not only improves the viability of the probiotics while passing through the gastrointestinal tract, maintain intestinal homeostasis, but also regulate balance of harmful and useful bacterial growth. Glycine max Merr (GMM) has been widely used in Asian countries to treat cancer, obesity, oxidative stress and imbalanced immune diseases. In addition, it has been reported that dietary fiber-rich grains promote bowel movements and prevent constipation. In this study, we investigated the viability of LactobacillIus buchneri (L.buchneri) strains, known as lactic acid bacteria under conditions of gastric fluid and intestinal fluid to determine the suitability of L.buchneri as probiotics. The adhesion ability of L.buchneri to caco-2 cells was also confirmed. The present studies showed that GMM extract promoted the growth and activity of L.buchneri strains as prebiotics. Also, this results suggested that the mixture of L.buchneri and GMM extract can helps maintain intestinal health and healthy body as synbiotics and health functional food material.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.38 no.6
• /
• pp.750-756
• /
• 2009

Cherry powder (obtained from ground fruit of Prunus serrulata L. var. spontanea Max. wils.), which is a natural functional material, was used in muffin manufacturing at different concentrations from 0, 3, 5, 7, and 10% (w/w). Muffin was evaluated for their sensory property and physical quality. The antioxidative activity measured by DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity of muffin increased as the concentrations of cherry powder increased. As the concentration of cherry powder increased, the mechanical characteristics of the muffin, such as hardness increased, but gumminess and chewiness decreased. Lightness (L) and yellowness (b) of muffin decreased as the concentration of cherry powder increased, whereas the redness (a) increased. The muffins containing 3, 5, 7, and 10% cherry powder had acceptable sensory properties, such as color, flavor, taste, softness, moisture, and overall acceptability. The results exhibited that adding the cherry powder into the muffin increased antioxidant activity. The highest quality improvement was obtained by incorporating 5% (w/w) of cherry powder into the muffin formula.

• Proceedings of the Korean Society of Crop Science Conference
• /
• 2001.05a
• /
• pp.266-267
• /
• 2001