• Korean Journal of Materials Research
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• v.2 no.4
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• pp.257-262
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• 1992

The cure kinetics of a diglycidyl ether of bisphenol A (DGEBA) with 4, 4'-methylene dianiline (MDA) added succinonitrile was studied through the dynamic run method by applying the data to the Kissinger equation which analyses the effect of the heating rate on the temperature at maximum reaction rate using Differential Scanning Calorimetry (DSC) analyzer in the range of 3$0^{\circ}C$-35$0^{\circ}C$. In the DGEBA/MDA system with SN, the activation energy ($E_a$) and the pre-exponential factor (A) were calculated. From these results, the rate constants (k) were obtained according to the different SN contents.

• Natural Product Sciences
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• v.14 no.3
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• pp.206-213
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• 2008

This study was designed to investigate the anti-inflammatory effects of mangiferin isolated from the rhizome of Anemarrhena asphodeloides, a natural polyphenol, on lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. Mangiferin dose-dependently inhibited LPS-induced nitric oxide (NO) and prostaglandin $E_2\;(PGE_2)$ productions in RAW 264.7 macrophages and peritoneal macrophages isolated from C57BL/6 mice. Consistent with these data, mangiferin suppressed the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein and mRNA levels in a concentration-dependent manner, as determined by Western blotting and RT-PCR, respectively. In addition, the release of tumor necrosis $factor-{\alpha}$($TNF-{\alpha}$) and interleukin-6 (IL-6), and the mRNA expression levels of these cytokines were reduced by mangiferin in a dose-dependent manner. Moreover, mangiferin effectively inhibited the transcriptional activation of nuclear factor-kappa B $(NF-{\kappa}B)$. These results suggest that the anti-inflammatory properties of mangiferin are caused by iNOS, COX-2, $TNF-{\alpha}$, and IL-6 down-regulation due to $(NF-{\kappa}B)$ inhibition in RAW 264.7 macrophages.

• Journal of Power System Engineering
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• v.16 no.6
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• pp.30-37
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• 2012

Effect of rib heights is found as significant parameter to enhance convective heat transfer performance under laminar and low turbulent regime. Circular ribs with different ribheight to channel height ratios, e/H = 0.05, 0.1, 0.15, are fabricated over the copper substrate respectively in a rectangular duct having 7.5 cross sectional aspect ratio. Only one rib pitch to rib height ratio (P/e = 10) has been chosen for all different height ribs. The result shows that the arithmetic average of turbulence intensity decreases with decreasing roughness height calculated between two ribs under laminar and low turbulent region. It occurs because the area of recirculation and reattachment zone also decreases with decreasing rib height. Optimum thermal enhancement factor is derived by 0.1 rib height to channel height ratio under low turbulent region but 0.15 rib height to channel height ratio gives maximum subjected to laminar flow.

• Biomolecules & Therapeutics
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• v.26 no.1
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• pp.57-68
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• 2018

Nuclear factor E2-related factor 2 (NRF2) plays an important role in redox metabolism and antioxidant defense. Under normal conditions, NRF2 proteins are maintained at very low levels because of their ubiquitination and proteasomal degradation via binding to the kelch-like ECH associated protein 1 (KEAP1)-E3 ubiquitin ligase complex. However, oxidative and/or electrophilic stresses disrupt the KEAP1-NRF2 interaction, which leads to the accumulation and transactivation of NRF2. During recent decades, a growing body of evidence suggests that NRF2 is frequently activated in many types of cancer by multiple mechanisms, including the genetic mutations in the KEAP1-NRF2 pathway. This suggested that NRF2 inhibition is a promising strategy for cancer therapy. Recently, several NRF2 inhibitors have been reported with anti-tumor efficacy. Here, we review the mechanisms whereby NRF2 is dysregulated in cancer and its contribution to the tumor development and radiochemoresistance. In addition, among the NRF2 inhibitors reported so far, we summarize and discuss repurposed NRF2 inhibitors with their potential mechanisms and provide new insights to develop selective NRF2 inhibitors.

• Clinical and Experimental Reproductive Medicine
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• v.30 no.1
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• pp.65-75
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• 2003

Objectives: To investigate the role of TGF (Transforming growth factor-$\beta$) involved in the paracrinic communication during decidualization between UEC (uterine epithelial cells) and USC (uterine stromal cells), we have employed a co-culture system composed of human endometrial epithelial and stromal cells in defined hormonal conditions. Design: In the co-culture, endometrial epithelial cells cultured in the matrigel-coated cell culture insert are seeded on top of the endometrial stromal cells cultured within a collagen gel. The co-culture was maintained for 48 hours under the following hormonal conditions: progesterone dominant condition (100 nM P4 and 1 nM E2) or estrogen-dominant condition (100 nM E2 and 1 nM P4). 10 ng/ ml HGF and/or 10 ng/ml TGF-$\beta$1 are added. Methods: RT-PCR is utilized to detect mRNAs quantitatively. Enzyme-linked immunosorbent assay (ELISA) and immunohistochemical staining are utilized to detect proteins in the tissue. Results: Prolactin mRNA is expressed in the co-cultured stromal cells under the progesterone dominant condition. TGF-$\beta$1 and its receptors are expressed in both the co-cultured epithelial and stromal cells irrespective of the steroid present, which is in contrast with no or negligible expression of TGF-$\beta$1 or its receptor in cells separately cultured. Both estrogen and progesterone significantly elevate the concentration of hepatocyte growth factor (HGF) in the conditioned medium of the co-culture with the value of 4, 325 pg/ml in E2-dominant and 2, 000 pg/ml in P4-dominant condition compare to 150 pg/ml in no hormone. In separately cultured stromal cells, administration of HGF induces the expression of TGF receptor 1 in both hormonal conditions, but induction of TGF receptor 2 is only manifest in the P4-dominant condition. Administration of TGF-$\beta$ and HGF directly induce the decidualization marker prolactin mRNA in separately cultured stromal cells. Conclusion: It is likely that steroid hormones induces prolactin mRNA indirectly by promoting the cell to cell communication between the stromal and the epithelial cells. TGF-$\beta$ and HGF are two possible paracrine mediators in the human endometrial decidualization.

• Proceedings of the Korean Vacuum Society Conference
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• 2010.08a
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• pp.131-131
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• 2010

원자의 여기 및 천이에 의한 플라즈마에서의 빛 방출은 일차적으로 여기를 위한 특정 문턱값 이상의 에너지 공급이 전제 된다. 진공 플라즈마에서 대부분의 에너지 전달 과정은 전자와의 물리적 충돌에 의해 일어나므로 충돌 여기의 결과 발생한 광신호 세기는 전자 에너지 분포에 대한 정보를 내포하고 있다. 전자는 입자들 간의 에너지 전달 매개가 되는 동시에 플라즈마 구성 입자 중 가장 가벼워 빠르게 주변 환경 변화에 응답하여 열평형을 이루므로 EEDF는 플라즈마의 미세한 변동까지도 보여줄 수 있는 인자가 된다. 플라즈마의 열평형 이동에 관한 정보를 광신호로부터 EEDF의 형태로 추출해내기 위해 BEB (Binary - Encounter - Bethe) 모델을 근거로 충돌 반응 단면적을 함수로 나타내어 신호를 분석하였다. EEDF의 꼴을 $f(E)=AEexp(-E^b)$의 임의의 형태로 두고 아르곤의 427nm, 763nm 두 빛의 세기 비를 BEB 모델을 적용하여 전개한 결과 b factor 의 값을 구할 수 있었다. b factor 가 1인 경우는 Maxwellian, 2인 경우는 압력이 높은 조건에서 잦은 충돌에 의한 에너지 손실 때문에 고에너지 전자군이 현격하게 감소된 Druyvesteyn 분포를 의미하므로 광신호에 모델을 적용하여 얻은 b factor의 변화는 EEDF의 형태 자체의 변화가 감지되었음을 보여준다. 실제로 13.56MHz - 1kW ICP 장치에서 아르곤 플라즈마를 발생시켰을 때, 압력이 낮아 Maxwellian 분포가 예상되는 10mTorr 조건에서는 b=1.13, Druyvesteyn 분포에 가까워지는 100mTorr 조건에서는 b=1.502 로 관측되었다.

• Nuclear Engineering and Technology
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• v.51 no.7
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• pp.1835-1841
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• 2019

The mass attenuation coefficient ${\mu}_m$ for eight rock samples having different chemical composition was simulated using the MCNP 5 code in energy range($0.002MeV{\leq}E{\leq}10MeV$). Moreover, the ${\mu}_m$ for the studied rock samples was computed theoretically using XCOM database. The comparison between simulated and computed data for all selected rock samples showed a good agreement with differences varied between 0.01 and 8%. The highest ${\mu}_m$ was found for basalt rocks M2 and M1 and the lowest one is reported for limestone rocks Dike. The simulated values of the ${\mu}_m$ then were used to calculate other important shielding parameters such as the mean free path, effective electron density and effective atomic number. The exposure buildup factor EBF was also computed for the selected rocks with the contribution of G-P fitting parameters and the highest EBF attended by the basalt sample Sill and varied between 1.022 and 744 in the energy range between ($0.015MeV{\leq}E{\leq}15MeV$) but the lowest EBF achieved by basalt sample M2 and varied between 1.017 and 491 in the same energy range.

• Korean Journal of Soil Science and Fertilizer
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• v.47 no.6
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• pp.518-524
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• 2014

Heavy metal pollution in agricultural field near at the abandoned metal mines has been a critical issue in Korea. In particular, bioaccumulation in plants can have detrimental effect on human health. Main objective of this research was to examine arsenic (As) concentration in soil with varied extraction methods and to determine bioaccumulation and biological transfer factor in different crops. Results showed that bioaccumulation ratio of As for total contents in soil was ordered leafy and stem vegetables (1.19%) > fruit bearing vegetables (0.79%) > pulses (0.40%) > root vegetables (0.36%) with different crop species. Among 6 different extraction methods, all of extraction methods showed high correlation ($R^2=0.87-0.97$) except DTPA ($R^2=0.25$) when comparing As concentration in soil extracted with different extractants and As concentration in each crops. Calculated biological transfer factor was ranged 0.002-0.018 depending on crop species. Overall, concentration of As in crops can be varied and best management practice for minimizing bioaccumulation of As should be considered depending on crop species.

• Journal of Distribution Science
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• v.21 no.6
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• pp.1-11
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• 2023

Purpose: As a modern distribution channel, the growth of e-commerce has brought more competitive pressures on e-marketplace, making trust and loyalty become top priority. As one of many sources of trust and loyalty issues, understanding the effect of careless marketing communications on consumers' perception is critical. This study examines the effect of careless marketing communications (e.g. misspellings, incomplete information) in website on consumers' trust toward and confidence in purchasing a product from an e-commerce. Research design and methodology: An experimental research design (with two experimental studies) was used in to test the hypotheses. Study 1 employs a single-factor design and study 2 employs a 2x2, full-factorial, between-subjects design. Results: Results of the two experimental studies (Study 1, n = 60; Study 2, n = 140) demonstrate that simple mistakes significantly decrease consumers' trust toward an e-commerce and their confidence to purchase from the e-commerce. The effect is found to be significant in the case of high-involvement products; whereas no effect is found in low-involvement products. Conclusions: E-commerce relies heavily on carefully crafted marketing communications to establish consumers' trust and confidence. These studies confirm the equal importance of distribution and communication in maintaining consumers' trust and sustainability of the business.

• Journal of Microbiology and Biotechnology
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• v.16 no.2
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• pp.299-302
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• 2006

A combinatorial library of artificial transcription factors (ATFs) was introduced into the bacterial cells that expressed the Akt1-GFP fusion protein. By measuring the level of fluorescence generated by the transformed E. coli cells, we were able to obtain clones in which ATFs increased the solubility of the Akt1. Our results show that ATF library is a useful tool for increasing the solubility of selected recombinant proteins in E. coli.