• The Journal of the Korean bone and joint tumor society
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• v.12 no.2
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• pp.131-135
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• 2006

Chondrosarcoma can be divided into grade I, II and III by histological finding and a relationship between the prognosis and the histological grading has been identified. Although the surgical treatment of grade II and III chondrosarcoma necessitates wide resection margin, there has been controversy about curettage versus wide resection in case of grade I chondrosarcoma. The authors report a case of grade I chondrosarcoma of proximal humerus and grade II chondrosarcoma of distal humerus with good oncological and functional result through curettage and wide resection respectively.

• Ocean Science Journal
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• v.41 no.2
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• pp.105-111
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• 2006

In this paper, the lines of investigation on a problem of the development of remote acoustic sensing methods in oceanology are formulated. This paper summarizes the results of investigations into the possibilities for monitoring temperature and flow fields in shallow seas. In the discussed experiments, the instrumentation being constituents of the complex for long-duration remote monitoring of marine medium climatic variability and that of the acoustic tomography of shallow sea dynamic processes is used. The acoustic instruments were located on the POI FEB RAS acousto-hydrophysical polygon (Pacific Oceanological Institute, Far Eastern Branch of the Russian Academy of Sciences) near the Gamov Peninsula. Acoustic receiving and transmitting systems operating with multiplex phase-manipulated signals (of M-codes) at frequency range 250-2500 Hz form the basis for this complex.

• Bulletin of the Korean Chemical Society
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• v.25 no.8
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• pp.1147-1150
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• 2004

Hypericin (1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione), an antidepressant which is also known to be a potent protein kinase C (PKC) inhibitor was synthesized as a precursor for radioiodine labeling via two step reactions. Malignant glioma cells express higher PKC activity compared to untransformed glial cell. Here we report the synthesis and radioiodine labeling of hypericin as a potential brain tumor imaging radiopharmaceutical. The reference compound, 2-iodohypericin, and its radiolabelled analogues, 2-[$^{123}I$]iodohypericin and 2-[$^{124}I$]iodohypericin have been prepared by the reaction of hypericin with NaI or [$^{123}I$]NaI or [$^{124}I$]NaI. The labeling yield was 60-65% for each analogue and the optimal reaction time was 10 min. The purification and isolation of the labelled products were achieved by a reversed-phase HPLC.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.6
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• pp.19-25
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• 2017

This paper deals with integer factorization of two prime p,q of SHA-256 secure hash value n for Bit coin mining. This paper proposes an algorithm that greatly reduces the execution time of Pollard's rho integer factorization algorithm. Rho(${\rho}$) algorithm computes $x_i=x^2_{i-1}+1(mod\;n)$ and $y_i=[(y^2_{i-1}+1)^2+1](mod\;n)$ for intial values $(x_0,y_0)=(2,2)$ to find the factor 1 < $gcd({\mid}x_i-y_i{\mid},n)$ < n. It however fails to factorize some particular composite numbers. The algorithm proposed in this paper applies multiple initial values $(x_0,y_0)=(2^k,2^k)$ and ($2^k,2$), $2{\leq}k{\leq}10$ to the existing Pollard's Rho algorithm. As a results, the proposed algorithm achieves both the factorization of all the composite numbers and the reduction of the execution time of Pollard's Rho by 67.94%.

• Tuberculosis and Respiratory Diseases
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• v.50 no.5
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• pp.549-556
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• 2001

Background : IGF-I is an important mitogen in many types of malignancies. Tumors also express many IGF binding proteins, which modulate IGF action. The propose of this study was to evaluate the effect of IGF-I and IGFBP on cell proliferation in mouse lung cancer cells (3LL). Methods : The cellular proliferation of 3LL with the treatment of growth factors was evaluated using MTT assay. Western ligand blot was performed in order to determine whether 3LL cells secrete IGFBPs and we evaluated the effect of IGFBP on cellular proliferation. Results : The treatment of 3LL cells with IGF-I increased cellular proliferation in a serum free media. Western ligand blot of conditioned medium of 3LL with $^{125}I$-IGF-I demonstrated one single major band with an estimated molecular mass of 24 kDa. This band was identified as IGFBP-4 with immunoblot analysis using antisera. The addition of anti-IGFBP-4 antibody to abrogate the effect of IGFBP-4 resulted in increased cellular proliferation suggesting that IGFBP-4 inhibits cell growth. Conclusion : IGF-I increases cellular proliferation, however the secreted IGFBP-4 has an inhibitory function on cell growth in 3LL. These findings suggest that IGF-I and IGFBP are involved in the cell proliferation.

• Honam Mathematical Journal
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• v.36 no.2
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• pp.417-424
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• 2014

Let A be an abelian variety defined over a number field K and p be a prime. Define ${\varphi}_i=(x^{p^i}-1)/(x^{p^{i-1}}-1)$. Let $A_{{\varphi}i}$ be the abelian variety defined over K associated to the polynomial ${\varphi}i$ and let Ш($A_{{\varphi}i}$) denote the Tate-Shafarevich groups of $A_{{\varphi}i}$ over K. In this paper assuming Ш(A/F) is finite, we compute [Ш($A_{{\varphi}1}$)][Ш($A_{{\varphi}2}$)]/[Ш($A_{{\varphi}1{\varphi}2}$)] in terms of K-rational points of $A_{{\varphi}i}$, $A_{{\varphi}1{\varphi}2}$ and their dual varieties, where [X] is the order of a finite abelian group X.

• Bulletin of the Korean Mathematical Society
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• v.45 no.3
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• pp.587-600
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• 2008

In this paper we establish the general solution and investigate the Hyers-Ulam-Rassias stability of the following functional equation in quasi-Banach spaces. $${\sum\limits_{{{1{\leq}i<j{\leq}4}\limits_{1{\leq}k<l{\leq}4}}\limits_{k,l{\in}I_{ij}}}\;f(x_i+x_j-x_k-x_l)=2\;\sum\limits_{1{\leq}i<j{\leq}4}}\;f(x_i-x_j)$$ where $I_{ij}$={1, 2, 3, 4}\backslash${i, j} for all $1{\leq}i<j{\leq}4$. The concept of Hyers-Ulam-Rassias stability originated from Th. M. Rassias' stability theorem that appeared in his paper: On the stability of the linear mapping in Banach spaces, Proc. Amer. Math. Soc.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.11
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• pp.3498-3506
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• 1996

A loading device to be used in fracture experiment is presented. It's loading angle can be adjusted from $-45^{\circ}$ to $105^{\circ}$ at intervals of $15^{\circ}$ for a CTS ( compact tension-shear) specimen, so that it is to be useful to measure mixed mode toughness. The equations to give the $K_ I$, $K_ I1$ and J-integral for the experiment are evluated though finite elemetn analysis in which the loading procedure is simulated and the behaviors of the specimen such as load-displacement curve are estimated. In the course of the evaluation the values $K_ I$, $K_ I1$ and J-integral calculated through recentrly released numerical methods are employed as the reference ones.

• Journal of the Korean Magnetic Resonance Society
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• v.2 no.2
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• pp.141-151
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• 1998

Human annexin I is a member of annexin family of calcium dependent phospholipid binding proteins, which have been implicated in various physiological roles including phospholipase A2(PLA2) inhibition, membrane fusion and calcium channel activity. In this work, the structure of N-terminally truncated human annexin I ({{{{ DELTA }}-annexin I) and its interactions with Ca2+, ATP and cAMP were studied at atomic level by using nuclear magnetic resonance (NMR) spectroscopy. The effect of Ca2+ binding on the structure of {{{{ DELTA }}-annexin I was investigated. The addition of Ca2+ to {{{{ DELTA }}-annexin I caused some changes in 13C NMR spectra. Carbonyl carbon resonances of some histidines were significantly broadened by Ca2+ binding. However, in the case of methionine, phenylalanine, and tyrosin, small changes could be observed. We found that ATP and cAMP bind {{{{ DELTA }}-annexin I, and the binding ratio of ATP to {{{{ DELTA }}-annexin I is 1. These results are well consistent with the report that cAMP and ATP interact with annexin I, and affect the calcium channels formed by annexin I. Because {{{{ DELTA }}-annexin I is a large protein with 35 kDa molecular weight, site-specific (carbonyl-13C) labeling technique was used to study the interaction sites of {{{{ DELTA }}-annexin I with Ca2+. NMR study was focused on the carbonyl carbon resonances of tyrosine, phenylalanine, methionine and histidine residues of {{{{ DELTA }}-annexin I because the number of these amino acids is small in the amino acid sequence of {{{{ DELTA }}-annexin I.

• The Korean Journal of Physiology and Pharmacology
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• v.7 no.2
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• pp.53-57
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• 2003

The glutamate receptors (GluRs) are key receptors for modulatory synaptic events in the central nervous system. It has been reported that glutamate increases the intracellular $Ca^{2+}$ concentration ($[Ca^{2+}]_i$) and induces cytotoxicity. In the present study, we investigated whether the glutamate-induced $[Ca^{2+}]_i$ increase was associated with the activation of ionotropic (iGluR) and metabotropic GluRs (mGluR) in substantia gelatinosa neurons, using spinal cord slice of juvenile rats (10${\sim}21 day). $[Ca^{2+}]_i$ was measured using conventional imaging techniques, which was combined with whole-cell patch clamp recording by incorporating fura-2 in the patch pipette. At physiological concentration of extracellular $Ca^{2+}$, the inward current and $[Ca^{2+}]_i$ increase were induced by membrane depolarization and application of glutamate. Dose-response relationship with glutamate was observed in both $Ca^{2+}$ signal and inward current. The glutamate-induced $[Ca^{2+}]_i$ increase at holding potential of -70 mV was blocked by CNQX, an AMPA receptor blocker, but not by AP-5, a NMDA receptor blocker. The glutamate-induced $[Ca^{2+}]_i$ increase in $Ca^{2+}$ free condition was not affected by iGluR blockers. A selective mGluR (group I) agonist, RS-3,5-dihydroxyphenylglycine (DHPG), induced $[Ca^{2+}]_i$ increase at holding potential of -70 mV in SG neurons. These findings suggest that the glutamate-induced $[Ca^{2+}]_i$ increase is associated with AMPA-sensitive iGluR and group I mGluR in SG neurons of rats.