• Title/Summary/Keyword: $K^{+}$ channels

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Analyzing fashion item purchase patterns and channel transition patterns using association rules and brand loyalty in big data (빅데이터의 연관규칙과 브랜드 충성도를 활용한 패션품목 구매패턴과 구매채널 전환패턴 분석)

  • Ki Yong Kwon
    • The Research Journal of the Costume Culture
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    • v.32 no.2
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    • pp.199-214
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    • 2024
  • Until now, research on consumers' purchasing behavior has primarily focused on psychological aspects or depended on consumer surveys. However, there may be a gap between consumers' self-reported perceptions and their observable actions. In response, this study aimed to investigate consumer purchasing behavior utilizing a big data approach. To this end, this study investigated the purchasing patterns of fashion items, both online and in retail stores, from a data-driven perspective. We also investigated whether individual consumers switched between online websites and retail establishments for making purchases. Data on 516,474 purchases were obtained from fashion companies. We used association rule analysis and K-means clustering to identify purchase patterns that were influenced by customer loyalty. Furthermore, sequential pattern analysis was applied to investigate the usage patterns of online and offline channels by consumers. The results showed that high-loyalty consumers mainly purchased infrequently bought items in the brand line, as well as high-priced items, and that these purchase patterns were similar both online and in stores. In contrast, the low-loyalty group showed different purchasing behaviors for online versus in-store purchases. In physical environments, the low-loyalty consumers tended to purchase less popular or more expensive items from the brand line, whereas in online environments, their purchases centered around items with relatively high sales volumes. Finally, we found that both high and low loyalty groups exclusively used a single preferred channel, either online or in-store. The findings help companies better understand consumer purchase patterns and build future marketing strategies around items with high brand centrality.

Enhanced Expression of TREK-1 Is Related with Chronic Constriction Injury of Neuropathic Pain Mouse Model in Dorsal Root Ganglion

  • Han, Hyo Jo;Lee, Seung Wook;Kim, Gyu-Tae;Kim, Eun-Jin;Kwon, Byeonghun;Kang, Dawon;Kim, Hyun Jeong;Seo, Kwang-Suk
    • Biomolecules & Therapeutics
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    • v.24 no.3
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    • pp.252-259
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    • 2016
  • Neuropathic pain is a complex state showing increased pain response with dysfunctional inhibitory neurotransmission. The TREK family, one of the two pore domain $K^+$ (K2P) channel subgroups were focused among various mechanisms of neuropathic pain. These channels influence neuronal excitability and are thought to be related in mechano/thermosensation. However, only a little is known about the expression and role of TREK-1 and TREK-2, in neuropathic pain. It is performed to know whether TREK-1 and/or 2 are positively related in dorsal root ganglion (DRG) of a mouse neuropathic pain model, the chronic constriction injury (CCI) model. Following this purpose, Reverse Transcription Polymerase Chain Reaction (RT-PCR) and western blot analyses were performed using mouse DRG of CCI model and compared to the sham surgery group. Immunofluorescence staining of isolectin-B4 (IB4) and TREK were performed. Electrophysiological recordings of single channel currents were analyzed to obtain the information about the channel. Interactions with known TREK activators were tested to confirm the expression. While both TREK-1 and TREK-2 mRNA were significantly overexpressed in DRG of CCI mice, only TREK-1 showed significant increase (~9 fold) in western blot analysis. The TREK-1-like channel recorded in DRG neurons of the CCI mouse showed similar current-voltage relationship and conductance to TREK-1. It was easily activated by low pH solution (pH 6.3), negative pressure, and riluzole. Immunofluorescence images showed the expression of TREK-1 was stronger compared to TREK-2 on IB4 positive neurons. These results suggest that modulation of the TREK-1 channel may have beneficial analgesic effects in neuropathic pain patients.

Estimation of Oceanic Total Precipitable Water from HALE UAV (고고도 장기체공무인기 운영고도에서 해양 총가강수량 추정)

  • Cho, Young-Jun;Jang, Hyun-Sung;Ha, Jong-Chul;Choi, Reno K.Y.;Kim, Ki-Hoon;Lim, Eunha;Yun, Jong-Hwan;Lee, Jae-Il;Seong, Ji-In
    • Atmosphere
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    • v.27 no.3
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    • pp.359-370
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    • 2017
  • In this study, the oceanic Total Precipitable Water (TPW) retrieval algorithm at 16 km altitude of High Altitude Long Endurance Unmanned Aerial Vehicle (HALE UAV) is described. Empirical equation based on Wentz method (1995) that uses the 18.7 and 22.235 GHz channels is developed using the simulated brightness temperature and SeeBor training dataset. To do radiative simulation, Satellite Data Simulator Unit (SDSU) Radiative Transfer Model (RTM) is used. The data of 60% (523) and 40% (349) in the SeeBor training dataset are used to develop and validate the TPW retrieval algorithm, respectively. The range of coefficients for the TPW retrieval at the altitude of 3~18 km with 3 km interval were 153.69~199.87 (${\alpha}$), 54.330~58.468 (${\beta}$), and 84.519~93.484 (${\gamma}$). The bias and RMSE at each altitude were found to be about $-0.81kg\;m^{-2}$ and $2.17kg\;m^{-2}$, respectively. Correlation coefficients were more than 0.9. Radiosonde observation has been generally operated over land. To validate the accuracy of the oceanic TPW retrieval algorithm, observation data from the Korea Meteorological Administration (KMA) Gisang 1 research vessel about six clear sky cases representing spring, autumn, and summer season is used. Difference between retrieved and observed TPW at 16 km altitude were in the range of $0.53{\sim}1.87kg\;m^{-2}$, which is reasonable for most applications. Difference in TPW between retrieval and observation at each altitude (3~15 km) is also presented. Differences of TPW at altitudes more than 6 km were $0.3{\sim}1.9kg\;m^{-2}$. Retrieved TPW at 3 km altitude was smaller than upper level with a difference of $-0.25{\sim}0.75kg\;m^{-2}$ compared to the observed TPW.

Inhibitory Effects of Ginsenoside Metabolites, Compound K and Protopanaxatriol, on $GABA_C$ Receptor-Mediated Ion Currents

  • Lee, Byung-Hwan;Hwang, Sung-Hee;Choi, Sun-Hye;Kim, Hyeon-Joong;Lee, Joon-Hee;Lee, Sang-Mok;Ahn, Yun Gyong;Nah, Seung-Yeol
    • The Korean Journal of Physiology and Pharmacology
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    • v.17 no.2
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    • pp.127-132
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    • 2013
  • Ginsenosides, one of the active ingredients of Panax ginseng, show various pharmacological and physiological effects, and they are converted into compound K (CK) or protopanaxatriol (M4) by intestinal microorganisms. CK is a metabolite derived from protopanaxadiol (PD) ginsenosides, whereas M4 is a metabolite derived from protopanaxatriol (PT) ginsenosides. The ${\gamma}$-aminobutyric acid $receptor_C$ ($GABA_C$) is primarily expressed in retinal bipolar cells and several regions of the brain. However, little is known of the effects of ginsenoside metabolites on $GABA_C$ receptor channel activity. In the present study, we examined the effects of CK and M4 on the activity of human recombinant $GABA_C$ receptor (${\rho}$ 1) channels expressed in Xenopus oocytes by using a 2-electrode voltage clamp technique. In oocytes expressing $GABA_C$ receptor cRNA, we found that CK or M4 alone had no effect in oocytes. However, co-application of either CK or M4 with GABA inhibited the GABA-induced inward peak current ($I_{GABA}$). Interestingly, pre-application of M4 inhibited $I_{GABA}$ more potently than CK in a dose- dependent and reversible manner. The half-inhibitory concentration ($IC_{50}$) values of CK and M4 were $52.1{\pm}2.3$ and $45.7{\pm}3.9{\mu}M$, respectively. Inhibition of $I_{GABA}$ by CK and M4 was voltage-independent and non-competitive. This study implies that ginsenoside metabolites may regulate $GABA_C$ receptor channel activity in the brain, including in the eyes.

Vascular Relaxation Induced by the Water Soluble Fraction of the Seeds from Oenothera Odorata (월견자 물 분획층을 이용한 혈관이완 기전에 관한 연구)

  • Kim, Hye Yoom;Lee, Yun Jung;Yoon, Jung Joo;Kho, Min Chol;Han, Byung Hyuk;Choi, Eun Sik;Park, Ji Hun;Kang, Dae Gill;Lee, Ho Sub
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.29 no.6
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    • pp.492-497
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    • 2015
  • In the present study, vasorelaxant effect of the extract of seeds of Oenothera odorata (SOO) and its possible mechanism responsible for this effect were examined in vascular tissues isolated from rats. Changes in vascular tension, 3',5'-cyclic monophosphate (cGMP) levels were measured in thoracic aorta rings from rats. Methanol extract of seeds of Oenothera odorata relaxed endothelium-intact thoracic aorta in a dose-dependent manner. A dose-dependent vascular relaxation was also revealed by treatment of ethylacetate, n-butanol, and H2O (aqua extract of seeds of Oenothera odorata , ASOO) extracts partitioned from methanol, but not by hexane extract. However, the vascular relaxation induced by ASOO were abolished by removal of endothelium of aortic tissues. Pretreatment of the endothelium-intact vascular tissues with NG-nitro-L-arginine methyl ester (L-NAME) or 1H-[1,2,4]-oxadiazole-[4,3-α]-quinoxalin-1- one (ODQ) significantly inhibited vascular relaxation induced by ASOO. Moreover, incubation of endothelium-intact aortic rings with ASOO increased the production of cGMP. However, ASOO-induced increases in cGMP production were blocked by pretreatment with L-NAME or ODQ. The vasorelaxant effect of ASOO was attenuated by tetraethylammonium (TEA), 4-aminopyridine, and glibenclamide attenuated. On the other hand, the ASOO-induced vasorelaxation was not blocked by verapamil, and diltiazem. Taken together, the present study demonstrates that ASOO dilate vascular smooth muscle via endothelium-dependent NO-cGMP signaling pathway, which may be closely related with the function of K+ channels.

Feasibility about the Direct Measurement of 226Ra Using the Gamma-Ray Spectrometry (감마분광분석을 이용한 226Ra의 직접 측정방법에 대한 적용성 평가)

  • Ji, Young-Yong;Chung, Kun Ho;Lim, Jong-Myoung;Kim, Change-Jong;Jang, Mee;Kang, Mun Ja;Park, Sang Tae;Woo, Zuhee;Koo, Boncheol;Seo, Bokyun
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.12 no.2
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    • pp.97-105
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    • 2014
  • In the case of the direct measurement of $^{226}Ra$ using a HPGe gamma-ray spectrometer, the interference between gammarays with 186.21 keV of $^{226}Ra$ and 185.7 keV of $^{235}U$ should be corrected to calculate the net peak area in the energy spectrum. In general, it is very difficult to conduct peaks stripping with difference of about 0.5 keV, although a HPGe with the superior resolution is applied and the maximum channels is applied to the spectrometer. In this study, several interference correction techniques in the direct measurement were surveyed to evaluate the feasibility for the measurement of $^{226}Ra$ using the gamma-ray spectrometery. Applying the interference corrections to the analysis of raw materials and by-products, the method validation for the direct measurement of $^{226}Ra$ was conducted by evaluating the measurement uncertainty, linearity, and range. As a result, the optimum method of the interference correction was selected by comparing with the indirect measurement of which progenies of $^{226}Ra$, such as $^{214}Pb$ and $^{214}Bi$, were analyzed in the secular equilibrium state.

Effects of Cordyceps Militaris Mycelia(CMM) oral administration and Herbal Acupuncture at Shinsu(BL23), Tae-gye(K3) on Expression of Aquaporin-2 Protein Water Channels in the Kidney and the Renal Function in Rats with Renal Failure by Uninephrectomy (신유(腎兪),태계(太谿)의 동충하초(冬蟲夏草) 약침(藥鍼)과 경구(經口) 투여(投與)가 좌측 신장(腎臟) 제거 백서(白鼠)에 대한 신장(腎臟) Aquaporin-2 단백(蛋白) 발현(發現)과 신장기능(腎臟機能)에 미치는 영향(影響))

  • Kim, Jae-hong;Yoon, Dae-hwan;Na, Chang-su;Cho, Myung-rae;Yoon, Yeo-choong;Chae, Wu-suk
    • Journal of Acupuncture Research
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    • v.22 no.1
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    • pp.61-75
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    • 2005
  • Objective : The purpose of this study is to arrange the literature about a acupuncture therapy on the knee rheumatoid arthritis. Methods : We arrange fifty kinds of literature about a acupuncture therapy of knee joint, knee arthritis, Results : Acupucture point at G30, G34, S36, LI11, B4O, G39, G38, LI4 used freaquently for the acupuncture therapy Conclusion : B, G, S, Sp of merdians used frequently for the acupuncture therapy.

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Ecological Analysis and Environmental Evaluation of Aquatic Insects in Agricultural Ecosystem (농업생태계 내 수서곤충류의 생태분석 및 환경평가)

  • Kim, Jong-Gill;Choi, Young-Cheol;Choi, Ji-Young;Sim, Ha-Sik;Park, Hae-Chul;Kim, Won-Tae;Park, Byung-Do;Lee, Jong-Eun;Kang, Ki-Kyung;Lee, Duck-Bae
    • Korean journal of applied entomology
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    • v.46 no.3
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    • pp.335-341
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    • 2007
  • The main habitats of diving beetles in agricultural ecosystems were identified as ponds, irrigation channels, and reservoirs, where the water system is maintained throughout the year. Four species, Cybister japonicus, Cybister brevis, Hyphydrus japonicus and Noterus angustulus, were selected as biological indicators which can be used to evaluate the healthiness of the agricultural ecosystem. The species number of 4 indicator species, the species number of diving beetle species, and the diversity index were used as factors for environmental evaluation. The evaluation was classified into grades $I{\sim}IV$. The non-fertilizer and non-pesticide agricultural practicing area and the sustainable agricultural practicing area were evaluated as grades $I{\sim}II$, and the general agricultural area to be relatively fine with a grade II. However, the analysis indicated the agricultural areas near a residential area and an industrial complex to be poor with a grade of IV, suggesting that immediate improvement in the agricultural environment is needed.

DEVELOPMENT OF THE READOUT CONTROLLER FOR INFRARED ARRAY (적외선검출기 READOUT CONTROLLER 개발)

  • Cho, Seoung-Hyun;Jin, Ho;Nam, Uk-Won;Cha, Sang-Mok;Lee, Sung-Ho;Yuk, In-Soo;Park, Young-Sik;Pak, Soo-Jong;Han, Won-Yong;Kim, Sung-Soo
    • Publications of The Korean Astronomical Society
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    • v.21 no.2
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    • pp.67-74
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    • 2006
  • We have developed a control electronics system for an infrared detector array of KASINICS (KASI Near Infrared Camera System), which is a new ground-based instrument of the Korea Astronomy and Space science Institute (KASI). Equipped with a $512{\times}512$ InSb array (ALADDIN III Quadrant, manufactured by Raytheon) sensitive from 1 to $5{\mu}m$, KASINICS will be used at J, H, Ks, and L-bands. The controller consists of DSP(Digital Signal Processor), Bias, Clock, and Video boards which are installed on a single VME-bus backplane. TMS320C6713DSP, FPGA(Field Programmable Gate Array), and 384-MB SDRAM(Synchronous Dynamic Random Access Memory) are included in the DSP board. DSP board manages entire electronics system, generates digital clock patterns and communicates with a PC using USB 2.0 interface. The clock patterns are downloaded from a PC and stored on the FPGA. UART is used for the communication with peripherals. Video board has 4 channel ADC which converts video signal into 16-bit digital numbers. Two video boards are installed on the controller for ALADDIN array. The Bias board provides 16 dc bias voltages and the Clock board has 15 clock channels. We have also coded a DSP firmware and a test version of control software in C-language. The controller is flexible enough to operate a wide range of IR array and CCD. Operational tests of the controller have been successfully finished using a test ROIC (Read-Out Integrated Circuit).

The Role of New Information and Communication Technologies in the Internationalization of Firms: A Case Study of Haier (기업의 국제화와 신 정보통신기술의 역할: 중국 Haier 기업을 사례로)

  • Liu, Shuguang;Liu, Weidong
    • Journal of the Korean Geographical Society
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    • v.38 no.3
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    • pp.400-412
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    • 2003
  • It is now widely recognized that new Information and Communication Technologies (ICTs) have been changing the way tv which firms conduct their businesses. Examples are the application of enterprise resources planning (ERP) and business process reengineering (BPR) to increase the efficiency of internal resources management, adoption of Business-to-Business e-commerce (B2B e-com) to integrate supply chain, and invention of new marketing channels such as Business-to-Customer (B2C) e-com. These new ways of conducting businesses are believed to help firms to reduce transaction costs and increase productivity. As a result, new ICTs have played an important role in recent growth of many small firms into multi-functional and multi-product corporations and in their spatial expansion towards internationalization as well. This paper takes Haier in China as a case to study the role of new ICTs in the growth of firms and reveal how the new technologies have facilitated the expansion of Haier into a transnational corporation (TNC) by examining the internationalization process of the firm in relation to its adoption of new ICTs in the period from 1990 to 2002. The study reveals that the adoption of new Ins has helped Haier to integrate its functional units located in dozens of places across the world, which is essential to the internationalization of a firm, and to link closely together its worldwide suppliers and customers to achieve just-in-time (JIT) production and delivery. As such, the authors of the paper argue that, without the facilitation of new ICTS, Haier could not have developed into a TNC in less than ten years.It is now widely recognized that new Information and Communication Technologies (ICTs) have been changing the way tv which firms conduct their businesses. Examples are the application of enterprise resources planning (ERP) and business process reengineering (BPR) to increase the efficiency of internal resources management, adoption of Business-to-Business e-commerce (B2B e-com) to integrate supply chain, and invention of new marketing channels such as Business-to-Customer (B2C) e-com. These new ways of conducting businesses are believed to help firms to reduce transaction costs and increase productivity. As a result, new ICTs have played an important role in recent growth of many small firms into multi-functional and multi-product corporations and in their spatial expansion towards internationalization as well. This paper takes Haier in China as a case to study the role of new ICTs in the growth of firms and reveal how the new technologies have facilitated the expansion of Haier into a transnational corporation (TNC) by examining the internationalization process of the firm in relation to its adoption of new ICTs in the period from 1990 to 2002. The study reveals that the adoption of new Ins has helped Haier to integrate its functional units located in dozens of places across the world, which is essential to the internationalization of a firm, and to link closely together its worldwide suppliers and customers to achieve just-in-time (JIT) production and delivery. As such, the authors of the paper argue that, without the facilitation of new ICTS, Haier could not have developed into a TNC in less than ten years.