• The Korean Journal of Pain
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• v.27 no.3
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• pp.229-238
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• 2014

Background: A toxic dose of bupivacaine produces vasodilation in isolated aortas. The goal of this in vitro study was to investigate the cellular mechanism associated with bupivacaine-induced vasodilation in isolated endothelium-denuded rat aortas precontracted with phenylephrine. Methods: Isolated endothelium-denuded rat aortas were suspended for isometric tension recordings. The effects of nifedipine, verapamil, iberiotoxin, 4-aminopyridine, barium chloride, and glibenclamide on bupivacaine concentration-response curves were assessed in endothelium-denuded aortas precontracted with phenylephrine. The effect of phenylephrine and KCl used for precontraction on bupivacaine-induced concentration-response curves was assessed. The effects of verapamil on phenylephrine concentration-response curves were assessed. The effects of bupivacaine on the intracellular calcium concentration ($[Ca^{2+}]_i$) and tension in aortas precontracted with phenylephrine were measured simultaneously with the acetoxymethyl ester of a fura-2-loaded aortic strip. Results: Pretreatment with potassium channel inhibitors had no effect on bupivacaine-induced relaxation in the endothelium-denuded aortas precontracted with phenylephrine, whereas verapamil or nifedipine attenuated bupivacaine-induced relaxation. The magnitude of the bupivacaine-induced relaxation was enhanced in the 100mM KCl-induced precontracted aortas compared with the phenylephrine-induced precontracted aortas. Verapamil attenuated the phenylephrine-induced contraction. The magnitude of the bupivacaine-induced relaxation was higher than that of the bupivacaine-induced $[Ca^{2+}]_i$ decrease in the aortas precontracted with phenylephrine. Conclusions: Taken together, these results suggest that toxic-dose bupivacaine-induced vasodilation appears to be mediated by decreased calcium sensitization in endothelium-denuded aortas precontracted with phenylephrine. In addition, potassium channel inhibitors had no effect on bupivacaine-induced relaxation. Toxic-dose bupivacaine-induced vasodilation may be partially associated with the inhibitory effect of voltage-operated calcium channels.

• 한국문화재보존과학회:학술대회논문집
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• 2005.11a
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• pp.154-159
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• 2005

The most common conception of a work of art is as a unique object. In conservation the prevalent notion of authenticity is based on physical integrity, this guides judgements about loss. For the majority of traditional art objects, minimising change to the physical work means minimising loss, where loss is understood as compromising the (physical) integrity of a unique object, and this forms the focus of conservation. Fundamental to conservators' approach to the conservation of contemporary art is the notion that the artist's intent should guide conservators' practice. Since most of the artists creating installation art are living, it is possible to interview them about the details of the installation, attitudes to changing technology, parameters of acceptable change and their views about what aspects of the installation are essential to preserve. Conservation is no longer focused on intervening to repair the art object but has become concerned with documentation and determining what change is acceptable and managing those changes. In order to accurately install works in the future it is necessary to broaden our focus to include elements of an installation that affect the viewer's experience. This might mean documenting the space, the acoustics, the balance of the different channels of sound, the light levels and the way one enters and leaves the installation. These are as important as the more tangible or material elements in the conservation of the work. It is also necessary to work with industry and specialists outside the field of conservation to develop new skills to preserve and manage new types of objects in our care. We can also document the less tangible details of an installation such as the light levels, the character of the sound etc. This is a new area of conservation and as a profession our understanding and knowledge will deepen with time. All of these strategies work together to help to limit the risk of not being able to accurately install these works in the future. Deciding what can be changed and how to best care for any element of an installation will depend on its meaning and role. For both contemporary and traditional objects such decisions are documented by conservators and although the focus of the conservator may have moved away from the material object, the approach is still rooted in traditional notions of collection care.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.20 no.5
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• pp.493-502
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• 2009

In this paper, we compare the performance of initial timing acquisition in direct sequence ultra-wideband(DS-UWB) systems with different transmit pulse shaping filters through extensive computer simulations. Simulation results show that the timing acquisition performance of the DS-UWB system, whose chip rate is 1.32 Gchip/s, employing a rectangular transmit filter is similar to that employing a square root raised cosine(SRRC) filter with an interpolation factor of 4 in the realistic UWB channels(CM1 and CM3) as well as the additive white Gaussian noise(AWGN) channel. Additionally, we present both a 24-parallel digital correlator structure and a 24-parallel processing searcher operating at a 55 MHz system clock, and then briefly discuss the initial timing acquisition procedure. Because we can adopt an 1.32 Gsample/s digital-to-analog(D/A) converter and an 1.32 Gsample/s analog-to-digital(AID) converter in the DS-UWB system by employing the rectangular transmit filter, we have a realistic solution for the DS-UWB chipset development.

• Journal of Advanced Navigation Technology
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• v.11 no.4
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• pp.437-446
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• 2007

In this paper, we numerically induced the optimal values of optical phase conjugator (OPC) position and dispersion coefficients of fiber sections, which can improve the bit error rate (BER) and design the adaptive WDM transmission system, as a function of the extinction ratio (ER) of 10 dB and 20 dB in $16{\times}40$ Gb/s WDM transmission system. It is confirmed that these optimal parameter values for effectively compensating overall WDM channels are dependence on the extinction ratio of signals as well as modulation format, transmitted channel numbers, which were investigated in previous researches. It is also confirmed that ER of 20 dB has the advantage of designing flexible WDM systems using optimal parameters than ER of 10 dB.

• Journal of the Korean association of regional geographers
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• v.21 no.3
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• pp.503-514
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• 2015

This study aims to analyze the relationship between transport infrastructure investment and rural development in Korea in a more systematic and empirical way. To do so, we formulate research framework to examine the multi-faceted relationship through extensive literature review and carry out a descriptive study on the spatial patterns of road investment and rural development in Korea. Finally, using the structural equation model, this study carries out the exploratory empirical analysis on the direct and indirect relationship between transport infrastructure investment and rural development. The study finds that the transport infrastructure investment in rural Korea impacts clearly on both the population base promotion and production and income growth through better accessibility. In addition, the investment has an indirect effects on the production and income growth through its influence on the population base promotion. This implies that the transport infrastructure investment in rural Korea so far exerts both long-term and short-term influences on rural development through various channels of impacts.

• Current Research on Agriculture and Life Sciences
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• v.1
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• pp.215-238
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• 1983

The study was conducted to indentify systematically current marketing structure and markeiing efficiency of major cash crops such as red peppers and garlics. That various data and information have been used to analyze the problems related, some of them have come from secondary sources, but major parts of real circum stances were primarily obtained from the scheduled field survey. Some of valuable facts and consequences stemmed from the research can be summarized as fellows: First of all, the commercial rates of peppers and garlics produced by sample farms were 87.5 percent and 69 percent, respectively. On the other hand, annual handling volumes per marketing firm of those two crops were on the average estimated into 51,000 kyun(about 600gr) for peppers and 20,000 hundred bulbs of garlic. As seen physical losses over the entire marketing channels of each crop, it was approximately calculated in 14.7 percent of peppers and 21.1 percent of garlic, respectively. Secondarily, it was found that marketing chanells of these crops are very diversified and complex. However, the five-staged chanell is typical: i.e., from producers to local consigners, to local carry-out merchants, to consigner-wholesales, and finally to retailers. Thirdly, it was also estimated that gross marketing margin, marketing cost and profit based on average grade of peppers were 56.1 percent, 22.6 and 33.5 percent, respectively, having 43.8 percent of farmer's share, and those of garlic 38.9, 17.1, 21.8 and 61.1 percent, separately. To the end, it seems that current collective bargaining power of farmers' cooperatives is virtually weak compared to free individual marketing firms in terms of bssiness volumes and quantity handled over the year.

• Journal of the Korean Society for information Management
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• v.29 no.3
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• pp.99-122
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• 2012

This study analyzed scientists information behaviors when they engage in solving specific research problems in various situations throughout the entire scientific R&D lifecycle process. In-depth interviews with a total of 24 scientists were conducted in their research laboratories, the scientists' everyday workplace and the contexts of scientific research. The theoretical and methodological frameworks employed for this study were Dervin's Sense-making, Savolainen's Everyday Life Information Seeking, and Engestrom's Activity Theory. The findings of this study informed context-specific research and information behaviors of the scientists in the 14 sub stages of the five-stage of R&D lifecycle. Specifically, the study revealed the research objectives and related information behaviors (e.g., information needs, information seeking, information sources and channels, information barriers, etc.) to achieve the objectives at each sub-stage. The study results provided essential information to re-design the information services and strategies that accommodate the scientific R&D lifecycle.

• The Journal of the Acoustical Society of Korea
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• v.34 no.5
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• pp.394-402
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• 2015

CMA (Constant Modulus Algorithm) is one of the well-known algorithms in blind acoustic channel equalization. Generally, CMA converges slowly and the speed of convergence is dependent on a step-size in the CMA procedure. Many researches have tried to speed up the convergence speed by applying a variable step-size to CMA, e.g. the orthogonal projection CMA and algebraic optimal step-size CMA. In this paper, we summarize these two algorithms, and we propose a new CMA with improved convergence performance. The improvement comes from the switching between the orthogonal projection CMA and algebraic optimal step-size CMA. In simulation results, we show the performance improvement in the time invariant channels as well as in time varying channel.

• The Journal of the Acoustical Society of Korea
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• v.39 no.6
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• pp.600-605
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• 2020

In this paper, we propose a sound event detection method using a multi-channel multi-scale neural networks for sound sensing home monitoring for the hearing impaired. In the proposed system, two channels with high signal quality are selected from several wireless microphone sensors in home. The three features (time difference of arrival, pitch range, and outputs obtained by applying multi-scale convolutional neural network to log mel spectrogram) extracted from the sensor signals are applied to a classifier based on a bidirectional gated recurrent neural network to further improve the performance of sound event detection. The detected sound event result is converted into text along with the sensor position of the selected channel and provided to the hearing impaired. The experimental results show that the sound event detection method of the proposed system is superior to the existing method and can effectively deliver sound information to the hearing impaired.

• The Journal of the Acoustical Society of Korea
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• v.39 no.6
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• pp.559-567
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• 2020

This paper proposes a noise cancelling algorithm to remove own-ship noise for a towed array sonar. Extra beamforming is performed using partial channels of the acoustic array to get a reference beam signal robust to the noise bearing. Frequency domain Adaptive Noise Cancelling (ANC) is applied based on Normalized Least Mean Square (NLMS) algorithm using the reference beam. The bearing of own-ship noise is estimated from the coherence between the reference beam and input beam signals. Own-ship noise level is calculated using a beampattern of the noise with estimated steering angle, which prevents loss of a target signal by determining whether to update a filter so that removed signal level does not exceed the estimated noise level. Simulation results show the proposed algorithm maintains its performance when the own-ship gets out off its bearing 40 % more than the conventional algorithm's limit and detects the target even when the frequency of the target signal is same with the frequency of the own-ship signal.