• Title/Summary/Keyword: $K^{+}$ channels

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Influences of channel assessment on the usage levels of multi-channels by product category in decision making process for purchasing fashion products (패션상품 구매의사 결정과정에서의 상품유형별 채널평가가 멀티채널 이용도에 미치는 영향)

  • Park, Sung Ryul;Kim, Mi Sook
    • The Research Journal of the Costume Culture
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    • v.24 no.6
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    • pp.803-816
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    • 2016
  • The purposes of this study were to investigate the influences of channel assessments on the usage of multi-channels by product types, and the differences in the usage of multi-channels among product types in buying decision making process for fashion products. Data were collected from 510 consumers in their 20s to 50s with purchasing experiences through multi-channel distribution system and living in Seoul and Kyunggi province; 491 were analyzed after deleting incomplete questionnaires. Factor analysis, multiple regression analysis and one-way ANOVA were used for statistical analysis by using SPSS 18.0. The results were as follows: 5 factors were extracted for channel assessment: utility, accuracy, risk, price benefit and sharing information. Price benefits, utility and sharing information for online channel tended to influence positively on the usage of online channel and online+offline channels. Accuracy and low perceived risk of offline influenced positively on offline and on+offline channel usages. The usage levels of on-line and off-line channels for cosmetics were significantly lower than the usage levels for clothes and accessories on information search, evaluation of alternatives, and purchase stages. Significant differences were also found in the usage levels of multi-channels (on+off-line) on information search and evaluation of alternatives stages. The usage levels of the multi-channels for clothes were the highest followed by those of accessories and cosmetics in order.

MADF: Mobile-Assisted Data Forwarding for Wireless Data Networks

  • Xiaoxin;Gary, Shueng-Han;Biswanath;Bharat
    • Journal of Communications and Networks
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    • v.6 no.3
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    • pp.216-225
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    • 2004
  • In a cellular network, if there are too many data users in a cell, data may suffer long delay, and system's quality-of-service (QoS) will degrade. Some traditional schemes such as dynamic channel-allocation scheme (DCA) will assign more channels to hot (or overloaded) cells through a central control system (CC) and the throughput increase will be upper bounded by the number of new channels assigned to the cell. In mobile-assisted data forwarding (MADF), we add an ad-hoc overlay to the fixed cellular infrastructure and special channels-called forwarding channels- are used to connect mobile units in a hot cell and its surrounding cold cells without going through the hot cell's base station. Thus, mobile units in a hot cell can forward data to other cold cells to achieve load balancing. Most of the forwarding-channel management work in MADF is done by mobile units themselves in order to relieve the load from the CC. The traffic increase in a certain cell will not be upper bounded by the number of forwarding channels. It can be more if the users in hot cell are significantly far away from one another and these users can use the same forwarding channels to forward data to different cold neighboring cells without interference. We find that, in a system using MADF, under a certain delay requirement, the throughput in a certain cell or for the whole net-work can be greatly improved.

Taxifolin Glycoside Blocks Human ether-a-go-go Related Gene $K^+$ Channels

  • Yun, Jihyun;Bae, Hyemi;Choi, Sun Eun;Kim, Jung-Ha;Choi, Young Wook;Lim, Inja;Lee, Chung Soo;Lee, Min Won;Ko, Jae-Hong;Seo, Seong Jun;Bang, Hyoweon
    • The Korean Journal of Physiology and Pharmacology
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    • v.17 no.1
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    • pp.37-42
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    • 2013
  • Taxifolin glycoside is a new drug candidate for the treatment of atopic dermatitis (AD). Many drugs cause side effects such as long QT syndrome by blocking the human ether-a-go-go related gene (hERG) $K^+$ channels. To determine whether taxifolin glycoside would block hERG $K^+$ channels, we recorded hERG $K^+$ currents using a whole-cell patch clamp technique. We found that taxifolin glycoside directly blocked hERG $K^+$ current in a concentration-dependent manner ($EC_{50}=9.6{\pm}0.7{\mu}M$). The activation curve of hERG $K^+$ channels was negatively shifted by taxifolin glycoside. In addition, taxifolin glycoside accelerated the activation time constant and reduced the onset of the inactivation time constant. These results suggest that taxifolin glycoside blocks hERG $K^+$ channels that function by facilitating activation and inactivation process.

Simulation of Pesticide Fate and Transport in Drainage Channels

  • Chung, Sang-Ok;Park, Ki-Jung;Christen, E.W.
    • Journal of The Korean Society of Agricultural Engineers
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    • v.47 no.7
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    • pp.49-56
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    • 2005
  • Contamination in the drainage channels and creeks with pesticides used in agriculture is of a major concern in many countries. In this study the stream pesticide model RIVWQ (chemical transport model for riverine environments) was assessed for its applicability in simulating pesticide fate in drainage channels. The model was successfully calibrated against field data collected on flows and pesticide concentrations for a drainage channel from a small catchment in the Murrumbidgee Irrigation Area of southwestern New South Wales. The effects of different pesticide loading scenarios from farm fields on channel water quality were analysed by the calibrated model. The model simulated the flow rates and the pesticide concentrations in the drainage channel well. The results of the model simulation suggest that the RIVWQ model can be effectively used for predicting pesticide fate in the drainage channels and exposure assessment of pesticide in the agricultural environment.

Spinal Gap Junction Channels in Neuropathic Pain

  • Jeon, Young Hoon;Youn, Dong Ho
    • The Korean Journal of Pain
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    • v.28 no.4
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    • pp.231-235
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    • 2015
  • Damage to peripheral nerves or the spinal cord is often accompanied by neuropathic pain, which is a complex, chronic pain state. Increasing evidence indicates that alterations in the expression and activity of gap junction channels in the spinal cord are involved in the development of neuropathic pain. Thus, this review briefly summarizes evidence that regulation of the expression, coupling, and activity of spinal gap junction channels modulates pain signals in neuropathic pain states induced by peripheral nerve or spinal cord injury. We particularly focus on connexin 43 and pannexin 1 because their regulation vastly attenuates symptoms of neuropathic pain. We hope that the study of gap junction channels eventually leads to the development of a suitable treatment tool for patients with neuropathic pain.

Fabrication of Porous RBSN Ceramics with Aligned Channels by an Ice-Templating Method

  • Kim, Dong-Seok;Go, Jae-Ung;Kim, Do-Gyeong
    • Proceedings of the Materials Research Society of Korea Conference
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    • 2012.05a
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    • pp.97.1-97.1
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    • 2012
  • Porous ceramics are widely used for applications such as catalysis supports, gas distributors and filters such as DPF. For these purpose, it is important to have proper porosity controlling pore structure while maintaining mechanical and thermal properties. In this work, we have prepared the porous ceramic structures made of reaction bonded silicon nitride with hierarchical pore structures. Uni-directionally aligned pore channels, which are mostly filled with ${\beta}$-Si3N4 whiskers, were achieved by an ice-templating method. The structures of the pore channels and the walls are controllable by the processing conditions, such as solid concentration, freezing rate of the slurry, and additives. We have investigated and characterized the influences of the conditions on the microstructures and the properties, such as porosity, pore size distribution, lamellar thickness, wavelength, and orientations. The compressive strength test and flow test was performed to determine the structural integrity and air permeability.

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Understanding the Consumer Experience in Retailing Channel Using Critical Incident Technique (결정적 사건기법(CIT)을 이용한 소비자의 유통채널 이용경험에 대한 연구)

  • Choi, A-Young;Rha, Ong-Youn
    • Korean Journal of Human Ecology
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    • v.20 no.6
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    • pp.1185-1198
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    • 2011
  • This research explores the consumers' experience in retailing channel(offline channel and online channel) using the critical incident technique. This research aims to clarify the common incidents within retailing channels which implies decisive factors over the channels, and to clarify the contrasts between channels to compare advantages and disadvantages. Therefore, the research is designed to collect the consumers' narrative of those who have used both channels in 3 months. Classifications are conducted with other researchers majoring consumer science. The results address how impressive experiences are constructed on each channel in three dimensions: product, information search, and the purchase-service dimension. These results are able to provide implications for offline and online retailers and directions for future research.

CONTRIBUTION OF DIFFERENT TYPES OF $Ca^{2+}$ CHANNELS TO CATECHOLAMINE SECRETION IN RAT CHROMAFFIN CELLS

  • Goo, Yong-Sook;Jina Roh;Lee, Jung-Hwa;Cha, Eun-Jong
    • Proceedings of the Korean Biophysical Society Conference
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    • 1996.07a
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    • pp.42-42
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    • 1996
  • Adrenal chromaffin cells secrete catecholamine in response to acetylcholine. The secretory response has absolute requirement for extracellular calcium, indicating that $Ca^{2+}$ influx through voltage operated $Ca^{2+}$ channels (VOCC) is the primary trigger of the secretion cascade. Although the existence of various types of $Ca^{2+}$ channels has been explore using patch clamp techique in adrenal chromaffin cells, the contribution of different types of $Ca^{2+}$ channels to catecholamine secretion remains to be establised. (omitted)omitted)

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