• Asian Pacific Journal of Cancer Prevention
• /
• v.16 no.2
• /
• pp.707-712
• /
• 2015

Background: To evaluate use of magnetic resonance imaging (MRI) and a logistic model including risk factors for lymph node metastasis for improved diagnosis. Materials and Methods: The subjects were 176 patients with rectal cancer who underwent preoperative MRI. The longest lymph node diameter was measured and a cut-off value for positive lymph node metastasis was established based on a receiver operating characteristic (ROC) curve. A logistic model was constructed based on MRI findings and risk factors for lymph node metastasis extracted from logistic-regression analysis. The diagnostic capabilities of MRI alone and those of the logistic model were compared using the area under the curve (AUC) of the ROC curve. Results: The cut-off value was a diameter of 5.47 mm. Diagnosis using MRI had an accuracy of 65.9%, sensitivity 73.5%, specificity 61.3%, positive predictive value (PPV) 62.9%, and negative predictive value (NPV) 72.2% [AUC: 0.6739 (95%CI: 0.6016-0.7388)]. Age (<59) (p=0.0163), pT (T3+T4) (p=0.0001), and BMI (<23.5) (p=0.0003) were extracted as independent risk factors for lymph node metastasis. Diagnosis using MRI with the logistic model had an accuracy of 75.0%, sensitivity 72.3%, specificity 77.4%, PPV 74.1%, and NPV 75.8% [AUC: 0.7853 (95%CI: 0.7098-0.8454)], showing a significantly improved diagnostic capacity using the logistic model (p=0.0002). Conclusions: A logistic model including risk factors for lymph node metastasis can improve the accuracy of MRI diagnosis of rectal cancer.

• Genomics & Informatics
• /
• v.17 no.1
• /
• pp.8.1-8.10
• /
• 2019

Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. Transcription factor profiling in microarray datasets revealed that several members of AP1, ATF, $NF-{\kappa}B$, and C/EBP families involved in diverse responses were expressed in mouse lung type II cells. A transcriptional factor signature consisting of Cebpa, Srebf1, Stat3, Klf5, and Elf3 was identified in lung type II cells, Sox9+ pluripotent lung stem cells as well as in mouse lung development. Identification of the transcription factor profile in mouse lung type II cells will serve as a useful resource and facilitate the integrated analysis of signal transduction pathways and specific gene targets in a variety of physiological conditions.

• Journal of Oriental Neuropsychiatry
• /
• v.23 no.1
• /
• pp.83-92
• /
• 2012

Objectives: The purpose of this study was to examine the psychological factors of Sasang constitutions which are classified by QSCC II(Questionnaire for Sasang Constitution Classification II) using major personality tests which are based on western psychological theory. Methods: 151 college students completed the MMPI-2, MBTI, NEO-PI-R, TCI-RS, and QSCC II. The data were analyzed by ANOVA and post hoc testing to find which personality scale significantly differentiated each Sasang constitution style. Results: MMPI-2, scale 2(D), 5(Mf), 7(Pt), 0(Si) and introversion scale(INTR) showed significant differences between Soeumin and Soyangin. Also, on the dimension of introversion-extraversion in MBTI, and neuroticism(N) and extraversion(E) in NEO-PI-R, there were differences between Soeumin and the other two constitutions(Soyangin and Taeeumin). Finally, in TCI-RS, there were differences between Soeumin and Soyangin on the scale of novelty seeking(NS) and reward dependence(RD), and with regards to the harm avoidance scale(HA), Soeumin received a higher score than any other constitutions. Conclusions: The analysis demonstrates that the classification of QSCC II is most consistent between Soeumin and Soyangin across 4 major personality tests.

• Anxiety and mood
• /
• v.11 no.1
• /
• pp.3-11
• /
• 2015

Objective : The aim of this study was to find associations between specific symptoms and suicidal behavior by using global severity on depression scales. Methods : Data were obtained from 1,183 patients of CRESCEND study. Factor analysis of the 17-item Hamilton Rating Scale for Depression (HAM-D) and the Beck Depression Inventory-II (BDI-II) was used to compare symptom clusters between the past suicide attempters and the non-suicide attempters, among the patients with depressive disorders. Results : Factor analyses of HAM-D and BDI-II extracted three factors. Suicide attempters had significantly higher scores on core factor of HAM-D, including depressed mood, feeling of guilt, suicide, work, and activities. The higher scores on all factors of BDI-II or scores correlated with a total of 7 suicide attempts and with known risk factors for suicidal behavior. Conclusion : These findings suggest that the suicide attempters complained of more cognitive, affective, somatic symptoms on BDI-II, but the core factor on HAM-D was the only differentiated factor between the two groups. Clinician-rated scales as well as self-reported questionnaires were valid in measuring suicidal attempts, and the clinical profile may help in guiding the studies of biological correlates and the treatments to reduce suicide risk.

• Journal of Forest and Environmental Science
• /
• v.18 no.1
• /
• pp.7-14
• /
• 2001

On the basis of data obtained from forest road collapsed due to a heavy rainfall, this study carried out to evaluate the cutting slope failure factors of forest road by using Quantification theory(II). The results were summarized as follows. The factors on cutting slope failure was ranked in the order of cutting slope length, soil type, aspect, cutting slope gradients and slope gradients. And the slope failure was mainly occurred under such conditions as cutting slope length longer than 8m, soil type with soil, aspect of N, cutting slope gradients steeper than 600 and slope gradients greater than $35{\sim}40^{\circ}$.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.11 no.1
• /
• pp.17-27
• /
• 1991

The determination of the stress intensity factors is investigated by means of a surface integral defined around the crack tip of the structure. It has been shown in this work that this integral is derived from the standard path integral J. The use of the surface integral has also been extended to the case where body forces act. Computer program obtaining the stress intensity factors $K_I$ and $K_{II}$ is developed, which prepares input variables from the result of the conventional finite element analysis. This paper provides a parabolic smooth curve function. By the use of the function and conventional element meshes in which the aspect ratio (element length/crack length)is about 25 percent, relatively correct $K_I$ and $K_{II}$ values can be obtained for the exterior radius ranging from 1/3 to 1 of the crack length.

• BMB Reports
• /
• v.32 no.4
• /
• pp.405-408
• /
• 1999

The transactivation potential of HIV-1 Vpu was identified from the yeast two-hybrid screening process. The helix II domain of HIV-1 Vpu protein and mutant Vpu protein lacking the transmembrane domain exhibited transactivation of the LacZ and Leu2 reporter genes carrying LexA upstream activating sequences, but full-length HIV-1 Vpu and the helix I domain of HIV-1 Vpu did not. The helix II domain of HIV-1 Vpu consists of a number of acidic amino acids, and is especially rich in glutamic acid, a characteristic of many transcription factors. This result suggests that protein-protein interaction may occur through the acidic helix II domain of HIV-1 Vpu.

• Bulletin of the Korean Mathematical Society
• /
• v.47 no.5
• /
• pp.997-1000
• /
• 2010

We prove that the reduced free product of $k\;{\times}\;k$ matrix algebras over abelian $C^*$-algebras is not the minimal tensor product of reduced free products of $k\;{\times}\;k$ matrix algebras over abelian $C^*$-algebras. It is shown that the reduced group $C^*$-algebra associated with a group having the property T of Kazhdan is not isomorphic to a reduced free product of abelian $C^*$-algebras or the minimal tensor product of such reduced free products. The infinite tensor product of reduced free products of abelian $C^*$-algebras is not isomorphic to the tensor product of a nuclear $C^*$-algebra and a reduced free product of abelian $C^*$-algebra. We discuss the freeness of free product $II_1$-factors and solidity of free product $II_1$-factors weaker than that of Ozawa. We show that the freeness in a free product is related to the existence of Cartan subalgebras in free product $II_1$-factors. Finally, we give a free product factor which is not solid in the weak sense.

• Journal of Gastric Cancer
• /
• v.20 no.1
• /
• pp.81-94
• /
• 2020

Purpose: Duodenal stump leakage (DSL) is a potentially fatal complication that can occur after gastrectomy, but its underlying risk factors are unclear. This study aimed to investigate the risk factors and management of DSL after laparoscopic radical gastrectomy for gastric cancer (GC). Materials and Methods: Relevant data were collected from several prospective databases to retrospectively analyze the data of GC patients who underwent Billroth II (B-II) or Rouxen-Y (R-Y) reconstruction after laparoscopic gastrectomy from 2 institutions (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, and HwaMei Hospital, University of Chinese Academy of Sciences). The DSL risk factors were analyzed using univariate and multivariate analysis regression. Results: A total of 810 patients were eligible for our analysis (426 with R-Y, 384 with B-II with Braun). Eleven patients had DSL (1.36%). Body mass index (BMI), elevated preoperative C-reactive protein (CRP) level, and unreinforced duodenal stump were the independent risk factors for DSL. DSL was diagnosed in 2-12 days, with a median of 8 days. Seven patients received conservative treatment, 3 patients received puncture treatment, and only 1 patient required reoperation. All patients recovered successfully after treatment. Conclusions: The risk factors of DSL were BMI ≥24 kg/㎡, elevated preoperative CRP level, and unreinforced duodenal stump. Nonsurgical treatments for DSL are preferred.

• Journal of Korean Public Health Nursing
• /
• v.10 no.1
• /
• pp.23-30
• /
• 1996

The purpose of study is to find out common factors and variables that affect common factors in level of right knowledge. attitude behavior with respect to AIDS. During the period form Apr.1. 1995 to Jun. 30. guestionnaires, written both in Korean and English. were distributed to Korean Malaysion employees woring at a certain Korean Video companies. and results of replies. given by 80 workers by country. were used as the research matrials. The gathered marials were analyzed through the SPSS package t-test. ANOVA. factor analysis. and the following results were obtained. The 4 extracted common factors could be named 'general publicity', 'transmissive knowledge', 'diagnosis. prevention'. and 'limitted publicity'. The means of trasimssive knowledge. diagnosos. prevention. limtted publicity factors showed higher means in groups who had beyond university level of education than in showed higher means in groups who beyond university level of education than in groups who had below high school level of education. There was a significant relationship between general publicity factor and econmic state. and between limitted publicity factor and preventive education