• Asian Pacific Journal of Cancer Prevention
• /
• 제13권10호
• /
• pp.5097-5099
• /
• 2012

Objective: To assess associations of Type II DM with hepatocellular carcinoma occurrence in Nepal. Materials and Methods: This case control study was carried out using data retrieved from the register maintained in the Department of Biochemistry of Nepalese Army Institute of Health Sciences between 1st January, 2012, and 31st August, 2012. The variables collected were age, gender, HbA1c. All biochemical parameters were analyzed in the Central Laboratory of our hospital by standard validated methods. One way ANOVA was used to examine the statistical significant difference between groups with the LSD post-hoc test for comparison of means of case groups. Odds ratios (OR) were calculated using simple logistic-regression analysis. Results: Etiological factors for HCC were HBV, HCV, alcohol and cryptogenic cirrhosis. The highest age group belonged to the etiological category of HCV with a mean of $71.9{\pm}3.6$ (CI 69.3, 74.5) years and the lowest age group to the etiological category of HBV with $61.7{\pm}5.3$(CI 57.9, 65.5) years. The main imperative basis of HCC in present study was HCV (39.5%) and second most significant cause of HCC was alcohol (26%). Glycated hemoglobin was found to be more in males with HCC (7.9%) as compared to females (7.3%). The percentage of Type II diabetes mellitus was greater in HCC patients when compared to controls. This difference was statistically significant with an odd ratio of 4.63 (p<0.001). Conclusion: Type II DM influences incidence, risk of recurrence, overall survival, and treatment-related complications in HCC patients.

• BMB Reports
• /
• 제39권3호
• /
• pp.311-318
• /
• 2006

One of the biggest group of proteins influenced by protein kinase CK2 is formed by factors engaged in gene expression. Here we have reported recently identified yeast transcription elongation factor Elf1 as a new substrate for both monomeric and tetrameric forms of CK2. Elf1 serves as a substrate for both the recombinant CK2$\alpha$' ($K_m$ 0.38 ${\mu}M$) and holoenzyme ($K_m$ $0.13\;{\mu}M$). By MALDI-MS we identified the two serine residues at positions 95 and 117 as the most probable in vitro phosphorylation sites. Co-immunoprecypitation experiments show that Elf1 interacts with catalytic ($\alpha$ and $\alpha$') as well as regulatory ($\beta$ and $\beta$') subunits of CK2. These data may help to elucidate the role of protein kinase CK2 and Elf1 in the regulation of transcription elongation.

• Journal of Periodontal and Implant Science
• /
• 제27권1호
• /
• pp.217-234
• /
• 1997

The purpose of present study is to compare the effect of treatment using $Guidor^{(R)}$ as a barrier membrane in conjunction with platelet-derived growth factor and insulin like growth factors on experimental dehiscence defects. Following the resection of premolar crowns, roots were submerged. After 12 weeks of healing period, experimental dehiscence defects of 4mm in height and 4mm in width were surgically created on the mid-facial aspect of the lower premolar roots in each of 4 adult dogs. After root planning and demineralization of the root surface with citric acid, the control groups received 4% methylcellulose gel only, the test group I received 4% methylcellulose gel and were covered by $Guidor^{(R)}$ and the test group II were treated with PDGF and IGF and 4% methylcellulose gel with $Guidor^{(R)}$ coverage. Histological and histomorphometric analysis following 8 weeks of healing revealed the following results. 1. The new bone formation showed no statistically significant difference in all groups with $0.59{\pm}0.82mm$($14.03{\pm}19.60%$) for control, $0.70{\pm}0.39mm$($16.30{\pm}9.01%$) for group I, $0.87{\pm}0.76mm$($18.74{\pm}16.03%$) for group II. 2. The new cementum formation showed no statistically significant difference in all groups with $0.54{\pm}0.48mm$($l6.38{\pm}14.57%$) for control, $0.95{\pm}0.38mm$($23.43{\pm}9.30%$) for group I, $1.01{\pm}0.75mm$($22.10{\pm}16.ll%$) for gorup II. 3. The root resorption showed statistically significant differences betweenthe control group and all test groups(p<0.05) with $2.11{\pm}0.53mm$($52.93{\pm}12.32%$) for control, $0.63{\pm}0.27mm$($15.32{\pm}7.05%$) for group I, $0.89{\pm}0.33mm$ ($19.26{\pm}7.11%$) for group II. On the bases of these results, there were no statistically difference between treatment using resorbable membrane and resorbable membrane in conjunction with PDGF and IGF in the dehiscence defects, where it was difficult to maintain space. The use of membrane seemed to be more effective in the inhibition of root resorption.

• 셀메드
• /
• 제1권1호
• /
• pp.5.1-5.3
• /
• 2011

Molecular events that cause tumor formation enhance a number of HOX genes, called switch genes, coding for RNApolymeraseII transcription factors. Thus, in tumor cells, RNApolymeraseII is more active than in other somatic cells. Amanita phalloides contains amanitin which inhibits RNApolymeraseII. Partial inhibition with amanitin influences tumor cell - but not normal cell - activity. To widen the treatment spectrum, dilutions of Amanita phalloides, containing amanitin, are applied to a patient with mammary duct cancer. For monitoring tumormarkers, different doses of amanitin are applied. The former duplication time of tumor growth represented three months; however within a period of 18 months the patient can be stabilized without further growth of the tumor. There are also no severe symptoms, no liver damage and no continuous erythrocyte deprivation. This new principle of tumor therapy shows high potential to provide a medical treatment.

• 산업융합연구
• /
• 제1권2호
• /
• pp.205-216
• /
• 2003

CRM(Customer Relationship Management) is now moving to the center of corporate strategy because acquiring customers is usually much more expensive than keeping them. Some successful CRM cases of leading companies are surveyed and their critical success factors are discussed in this paper. For successful construction of CRM system, It must be considered some critical factors as follows (i) improvement of customer loyalty, (ii) higher customer profitability, (iii) reduced cost of sales.

• 대한치과교정학회지
• /
• 제27권4호
• /
• pp.523-538
• /
• 1997

서울대학교병원 치과 교정과에 내원한 6세 1개월에서 45세 8개월사이(평균 19세 6개월)의 부정교합자 205명(남 67명, 여 138명)을 대상으로 TMD 증상과 기여요인에 관한 설문조사와 Orthopantomogram, 경두개 방사선 사진(transcranial view)의 판독, 교정모형 검사 등을 시행하여 다음과 같은 결론을 얻었다. 1. Helkimo Anamnestic index는 Ai 0 $46.8\%$, Ai I $22.0\%$, Ai II $31.2\%$로 TND의 주관적 증상이 연령에 따라 증가하는 추세(p<0.001)를 보였으며 여성에서 높았다(p<0.05). 2. Orthopantomogram상 하악두의 이상소견은 flattening($4.4\%$)이 가장 많았으며 전체적으로 한가지 이상의 이상소견을 보인 경우는 $8.3\%$였다. 3. 목과 어깨의 동통(p<0.001) 이악물기, 입술을 깨무는 습관(이상 p<0.01). 두통(p<0.05)이 있는 경우 Ai가 높았다. 4. Angle II급에서 Orthopantomogram상 하악두 이상소견의 빈도가 높았고, 상악 대구치의 교모가 있을때 Ai가 높은 경향이 있었다(이상 p<0.05). 그외의 교합 요소는 TMD의 증상과 무관하였다. 5. 하악두 길이(Co'-Inc')와 하악지 길이(Co'-Go')가 짧고 하악두의 비율(Co'-Inc'/Co'-Go')이 낮을때, 그리고 좌우 하악지 길이 (Co'-Go'), 하악두 비율(Co'-Inc'/Co'-Go')이 다를때 Orthopantomogram상 하악두 이상소견이 많았다.

• Journal of Forest and Environmental Science
• /
• 제14권1호
• /
• pp.145-156
• /
• 1998

본 연구는 집중호우로 인하여 임도사면 붕괴가 발생한 강원도 춘천시 지역의 5개 임도(백양임도, 변가터임도, 사오랑임도, 부귀임도, 당림임도)를 대상으로 수량화이론(II)에 의한 절토사면의 붕괴위험 예측에 관하여 분석하였다. 그 결과는 다음과 같다. 임도 절토사면 붕괴는 주로 절토부 구조적인 요인과 식생, 지형적인 요인이 복합적으로 작용하여 발생하는 것으로 나타났다. 또한 편상관계수(partial correlation coefficient) 및 범위(range) 값에 의한 절토사면의 붕괴예측 결과는 절토길이 8m이상, 토심이 2.5m이상, 산지경사 $30^{\circ}{\sim}50^{\circ}$사이, 절토피복율이 무식생인 경우, 절토경사 $60^{\circ}$ 이상에서 붕괴위험도가 높게 나타났으며, 판별적중율은 90.1%이었다.

• 수면정신생리
• /
• 제28권1호
• /
• pp.34-42
• /
• 2021

Objectives: This study investigated sleep quality in female full-time homemakers and evaluated the relationship of sleep disturbance with psychological and socio-environmental factors. Methods: This cross-sectional study adopted a structured survey and sequential recruitment method for randomized participation of community-dwelling full-time female homemakers. Sleep quality and mental health were measured using the Korean version of the Pittsburgh Sleep Quality Index (K-PSQI), Korean version of the Beck Depression Inventory-II (K-BDI-II), Korean version of the Beck Anxiety Inventory (K-BAI), and Korean version of the Beck Hopelessness Scale (K-BHS). The willingness-to-pay (WTP) method was selected to measure the self-evaluated monetary value of household service work. The relationship among the main relevant factors was statistically analyzed through a mediation model. Results: A total of 166 participants were analyzed and classified having poor versus good sleep quality (poor : 24.1%, n = 40 ; good : 75.9%, n = 126 ; cut-off point = 9 on the K-PSQI). Significant between-group differences were observed in mental health status (K-BDI-II, p < 0.001 ; K-BAI, p < 0.001 ; K-BHS, p = 0.003). The moderated mediation model was verified, indicating that depression may mediate the association between nurturing burden and sleep disturbance. The path from nurturing burden to depression may be moderated by average monthly household income. Conclusion: A relatively high portion of full-time female homemakers may suffer from sleep disturbance and interactions between psychological and socio-environmental factors might determine sleep quality, suggesting the need for public health policies targeting improvement of sleep quality and mental health among full-time homemakers.

• 대한인간공학회지
• /
• 제30권1호
• /
• pp.87-98
• /
• 2011

In this study, we investigated and identified criterial human factors(errors), most of which lead to terrible ship accidents such as collisions, sinking, fire and explosions resulting both in human lives and physical damages to ships as well as surrounding environments. To this end, we went through the accident reports of 413 cases over 2005~2009 period and classified the human factors into 6 major factors with 19 sub ones which were constructed in hierarchical order. The relative importance of major factors was calculated and among others the lack of awareness turned out to be the most important factor with the weight of 0.391. The contributions of the results in the research are two fold: it will help (i) identify the root causes of ship accidents and prevent further potential ship related incidents, (ii) analyze the degree of the risk associated with the ship accidents, when risk analysis is performed.

• 대한치과보철학회지
• /
• 제25권1호
• /
• pp.269-279
• /
• 1987

The purpose of this study was to obtain basic data needed to clinical diagnosis and treatment by investigating the occlusal wear facets and those related factors. Sixty-six subjects, ranging from 24 to 26 years of age without symptoms of stomatognatic system, were selected from dental students in Chosun University. The area of occlusal wear facets was measured and twenty subjects were selected, and divided into two groups (Group I and Group II). The Group I had small facet areas, and the Group II had large facet areas. These two groups were investigated into right and left side wear facet areas, vertical overlaps, occlusion types of working side, masticatory muscle activities, and asymmetry of right and left side masticatory muscle function. The results were as follows: 1. The average wear facet areas of all subjects was $22.84{\pm}88.95mm^2$, and Group I and Group II were $96.12{\pm}32.00mm^2$ and $372.94{\pm}65.63mm^2$ respectively. 2. The right and left wear facet areas of Group I were $46.72{\pm}14.36mm^2$ and $49.40{\pm}21.46mm^2$ respectively. The right and left wear facet areas of Group II were $175.27{\pm}45.75mm^2$ and $185.69{\pm}45.37mm^2$ repsectively. 3. The vertical overlap of Group I and Group II was $3.88{\pm}0.81mm$ and $2.88{\pm}1.14mm $ respectively. 4. Most of the Group I had Canine protection occlusion (80%), and most of the Group II had Group function occlusion (80%). 5. The masticatory muscle activities at rest position, maximum bite, habitual chewing, right and left unilateral chewing were greater in Group II than in Group I, especially in the masseter muscle of working side at right and left unilateral chewing. (P<0.01). 6. The asymmetry of right and left wear facets and masticatory muscle activities were greater in Group II than in Group I. (P<0.01).