• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.707-712
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• 2015

Background: To evaluate use of magnetic resonance imaging (MRI) and a logistic model including risk factors for lymph node metastasis for improved diagnosis. Materials and Methods: The subjects were 176 patients with rectal cancer who underwent preoperative MRI. The longest lymph node diameter was measured and a cut-off value for positive lymph node metastasis was established based on a receiver operating characteristic (ROC) curve. A logistic model was constructed based on MRI findings and risk factors for lymph node metastasis extracted from logistic-regression analysis. The diagnostic capabilities of MRI alone and those of the logistic model were compared using the area under the curve (AUC) of the ROC curve. Results: The cut-off value was a diameter of 5.47 mm. Diagnosis using MRI had an accuracy of 65.9%, sensitivity 73.5%, specificity 61.3%, positive predictive value (PPV) 62.9%, and negative predictive value (NPV) 72.2% [AUC: 0.6739 (95%CI: 0.6016-0.7388)]. Age (<59) (p=0.0163), pT (T3+T4) (p=0.0001), and BMI (<23.5) (p=0.0003) were extracted as independent risk factors for lymph node metastasis. Diagnosis using MRI with the logistic model had an accuracy of 75.0%, sensitivity 72.3%, specificity 77.4%, PPV 74.1%, and NPV 75.8% [AUC: 0.7853 (95%CI: 0.7098-0.8454)], showing a significantly improved diagnostic capacity using the logistic model (p=0.0002). Conclusions: A logistic model including risk factors for lymph node metastasis can improve the accuracy of MRI diagnosis of rectal cancer.

• Genomics & Informatics
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• 제17권1호
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• pp.8.1-8.10
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• 2019

Alveolar type II cells constitute a small fraction of the total lung cell mass. However, they play an important role in many cellular processes including trans-differentiation into type I cells as well as repair of lung injury in response to toxic chemicals and respiratory pathogens. Transcription factors are the regulatory proteins dynamically modulating DNA structure and gene expression. Transcription factor profiling in microarray datasets revealed that several members of AP1, ATF, $NF-{\kappa}B$, and C/EBP families involved in diverse responses were expressed in mouse lung type II cells. A transcriptional factor signature consisting of Cebpa, Srebf1, Stat3, Klf5, and Elf3 was identified in lung type II cells, Sox9+ pluripotent lung stem cells as well as in mouse lung development. Identification of the transcription factor profile in mouse lung type II cells will serve as a useful resource and facilitate the integrated analysis of signal transduction pathways and specific gene targets in a variety of physiological conditions.

• 동의신경정신과학회지
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• 제23권1호
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• pp.83-92
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• 2012

Objectives: The purpose of this study was to examine the psychological factors of Sasang constitutions which are classified by QSCC II(Questionnaire for Sasang Constitution Classification II) using major personality tests which are based on western psychological theory. Methods: 151 college students completed the MMPI-2, MBTI, NEO-PI-R, TCI-RS, and QSCC II. The data were analyzed by ANOVA and post hoc testing to find which personality scale significantly differentiated each Sasang constitution style. Results: MMPI-2, scale 2(D), 5(Mf), 7(Pt), 0(Si) and introversion scale(INTR) showed significant differences between Soeumin and Soyangin. Also, on the dimension of introversion-extraversion in MBTI, and neuroticism(N) and extraversion(E) in NEO-PI-R, there were differences between Soeumin and the other two constitutions(Soyangin and Taeeumin). Finally, in TCI-RS, there were differences between Soeumin and Soyangin on the scale of novelty seeking(NS) and reward dependence(RD), and with regards to the harm avoidance scale(HA), Soeumin received a higher score than any other constitutions. Conclusions: The analysis demonstrates that the classification of QSCC II is most consistent between Soeumin and Soyangin across 4 major personality tests.

• 대한불안의학회지
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• 제11권1호
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• pp.3-11
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• 2015

Objective : The aim of this study was to find associations between specific symptoms and suicidal behavior by using global severity on depression scales. Methods : Data were obtained from 1,183 patients of CRESCEND study. Factor analysis of the 17-item Hamilton Rating Scale for Depression (HAM-D) and the Beck Depression Inventory-II (BDI-II) was used to compare symptom clusters between the past suicide attempters and the non-suicide attempters, among the patients with depressive disorders. Results : Factor analyses of HAM-D and BDI-II extracted three factors. Suicide attempters had significantly higher scores on core factor of HAM-D, including depressed mood, feeling of guilt, suicide, work, and activities. The higher scores on all factors of BDI-II or scores correlated with a total of 7 suicide attempts and with known risk factors for suicidal behavior. Conclusion : These findings suggest that the suicide attempters complained of more cognitive, affective, somatic symptoms on BDI-II, but the core factor on HAM-D was the only differentiated factor between the two groups. Clinician-rated scales as well as self-reported questionnaires were valid in measuring suicidal attempts, and the clinical profile may help in guiding the studies of biological correlates and the treatments to reduce suicide risk.

• Journal of Forest and Environmental Science
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• 제18권1호
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• pp.7-14
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• 2001

본 연구는 집중호우로 인하여 절토사면의 붕괴가 발생한 임도를 대상으로 수량화이론(II)을 이용하여 붕괴요인을 평가하였다. 그 결과는 다음과 같다. 임도 절토사면의 붕괴발생에 미치는 요인의 영향은 절토사면길이, 겉보기 토질, 사면방위, 절토사변경사, 산지경사 등 5개 요인이 가장 크게 나타났다. 특히, 절토사면길이는 8m 이상, 겉보기 토질은 토사, 사면방위는 북사면, 절토사변경사는 $60^{\circ}$이상, 산지경사는 $35{\sim}40^{\circ}$ 사이에서 사면붕괴에 기여도가 가장 크게 나타났다.

• 대한토목학회논문집
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• 제11권1호
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• pp.17-27
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• 1991

본 논문에서는 구조물의 응력확대 계수를 균열선단주위에서 정의되는 표면적분법에 의하여 구하는 방법을 연구하였다. 통상의 J적분법을 변형시켜 표면 적분법을 유도하였으며 물체력을 고려하는 경우도 포함시켰다. 유한요소 해석결과를 입력변수로 받아들여 표면적분법으로 응력확대계수 $K_I$과 $K_{II}$를 구하는 프로그램을 작성하였다. 형상비(요소길이/균열길이)가 25% 정도인 요소망에서 본 논문에서 제안한 포물선형태의 평활곡선함수를 사용한 결과, 외측적분반경이 균열길이의 1/3~1 되는 구간에서 비교적 정확한 응력확대 계수가 얻어지는 것을 알수 있었다.

• BMB Reports
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• 제32권4호
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• pp.405-408
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• 1999

The transactivation potential of HIV-1 Vpu was identified from the yeast two-hybrid screening process. The helix II domain of HIV-1 Vpu protein and mutant Vpu protein lacking the transmembrane domain exhibited transactivation of the LacZ and Leu2 reporter genes carrying LexA upstream activating sequences, but full-length HIV-1 Vpu and the helix I domain of HIV-1 Vpu did not. The helix II domain of HIV-1 Vpu consists of a number of acidic amino acids, and is especially rich in glutamic acid, a characteristic of many transcription factors. This result suggests that protein-protein interaction may occur through the acidic helix II domain of HIV-1 Vpu.

• 대한수학회보
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• 제47권5호
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• pp.997-1000
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• 2010

We prove that the reduced free product of $k\;{\times}\;k$ matrix algebras over abelian $C^*$-algebras is not the minimal tensor product of reduced free products of $k\;{\times}\;k$ matrix algebras over abelian $C^*$-algebras. It is shown that the reduced group $C^*$-algebra associated with a group having the property T of Kazhdan is not isomorphic to a reduced free product of abelian $C^*$-algebras or the minimal tensor product of such reduced free products. The infinite tensor product of reduced free products of abelian $C^*$-algebras is not isomorphic to the tensor product of a nuclear $C^*$-algebra and a reduced free product of abelian $C^*$-algebra. We discuss the freeness of free product $II_1$-factors and solidity of free product $II_1$-factors weaker than that of Ozawa. We show that the freeness in a free product is related to the existence of Cartan subalgebras in free product $II_1$-factors. Finally, we give a free product factor which is not solid in the weak sense.

• Journal of Gastric Cancer
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• 제20권1호
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• pp.81-94
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• 2020

Purpose: Duodenal stump leakage (DSL) is a potentially fatal complication that can occur after gastrectomy, but its underlying risk factors are unclear. This study aimed to investigate the risk factors and management of DSL after laparoscopic radical gastrectomy for gastric cancer (GC). Materials and Methods: Relevant data were collected from several prospective databases to retrospectively analyze the data of GC patients who underwent Billroth II (B-II) or Rouxen-Y (R-Y) reconstruction after laparoscopic gastrectomy from 2 institutions (Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, and HwaMei Hospital, University of Chinese Academy of Sciences). The DSL risk factors were analyzed using univariate and multivariate analysis regression. Results: A total of 810 patients were eligible for our analysis (426 with R-Y, 384 with B-II with Braun). Eleven patients had DSL (1.36%). Body mass index (BMI), elevated preoperative C-reactive protein (CRP) level, and unreinforced duodenal stump were the independent risk factors for DSL. DSL was diagnosed in 2-12 days, with a median of 8 days. Seven patients received conservative treatment, 3 patients received puncture treatment, and only 1 patient required reoperation. All patients recovered successfully after treatment. Conclusions: The risk factors of DSL were BMI ≥24 kg/㎡, elevated preoperative CRP level, and unreinforced duodenal stump. Nonsurgical treatments for DSL are preferred.

• 한국보건간호학회지
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• 제10권1호
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• pp.23-30
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• 1996

The purpose of study is to find out common factors and variables that affect common factors in level of right knowledge. attitude behavior with respect to AIDS. During the period form Apr.1. 1995 to Jun. 30. guestionnaires, written both in Korean and English. were distributed to Korean Malaysion employees woring at a certain Korean Video companies. and results of replies. given by 80 workers by country. were used as the research matrials. The gathered marials were analyzed through the SPSS package t-test. ANOVA. factor analysis. and the following results were obtained. The 4 extracted common factors could be named 'general publicity', 'transmissive knowledge', 'diagnosis. prevention'. and 'limitted publicity'. The means of trasimssive knowledge. diagnosos. prevention. limtted publicity factors showed higher means in groups who had beyond university level of education than in showed higher means in groups who beyond university level of education than in groups who had below high school level of education. There was a significant relationship between general publicity factor and econmic state. and between limitted publicity factor and preventive education