• BMB Reports
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• 제54권10호
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• pp.522-527
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• 2021

Lysine-specific demethylase 1 (LSD1) is an epigenetic regulator that modulates the chromatin status, contributing to gene activation or repression. The post-translational modification of LSD1 is critical for the regulation of many of its biological processes. Phosphorylation of serine 112 of LSD1 by protein kinase C alpha (PKCα) is crucial for regulating inflammation, but its physiological significance is not fully understood. This study aimed to investigate the role of Lsd1-S112A, a phosphorylation defective mutant, in the cigarette smoke extract/LPS-induced chronic obstructive pulmonary disease (COPD) model using Lsd1^SA/SA mice and to explore the potential mechanism underpinning the development of COPD. We found that Lsd1^SA/SA mice exhibited increased susceptibility to CSE/LPS-induced COPD, including high inflammatory cell influx into the bronchoalveolar lavage fluid and airspace enlargement. Additionally, the high gene expression associated with the inflammatory response and oxidative stress was observed in cells and mice containing Lsd1-S112A. Similar results were obtained from the mouse embryonic fibroblasts exposed to a PKCα inhibitor, Go6976. Thus, the lack of LSD1 phosphorylation exacerbates CSE/LPS-induced COPD by elevating inflammation and oxidative stress.

• The Journal of Asian Finance, Economics and Business
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• 제8권12호
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• pp.443-453
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• 2021

Gen Z is a special generation that was born with technology, converging the best development conditions making them an important part of the future development of Vietnam's economy. Gen Z is an important part of the future development of Vietnam's economy. The purpose of this study is to identify and measure the impact of various factors affecting the business intentions of Gen Z in Vietnam during the Covid pandemic. The study did not go into the details of entrepreneurship, instead focused on explaining the impact of factors such as risk-taking, market economic trends, influencers, confidence, and family business traditions on the business intentions of Gen Z. The study was carried out using quantitative and qualitative methods with 335 data points collected online via survey links. The methods used to test the scale such as Cronbach alpha, CFA, SEM are used to examine the correlation between factors affecting the business intention of Gen Z in Vietnam. The results showed that the business intention of Gen Z in Vietnam is positively correlated and significantly influenced by confidence and risk-taking. Furthermore, the study reveals a difference in entrepreneurship of Gen Z Vietnam based on gender and education level.

• 전자통신동향분석
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• 제34권4호
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• pp.23-31
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• 2019

Deep learning is a hot topic in both academic and industrial fields. Deep learning applications can be categorized into two areas. The first category involves applications such as Google Alpha Go using interfaces with human operators to run complicated inference engines in high-performance servers. The second category includes embedded applications for mobile Internet-of-Things devices, automotive vehicles, etc. Owing to the characteristics of the deployment environment, applications in the second category should be bounded by certain H/W and S/W restrictions depending on their running environment. For example, image recognition in an autonomous vehicle requires low latency, while that on a mobile device requires low power consumption. In this paper, we describe issues faced by embedded applications and review popular inference engines. We also introduce a project that is being development to satisfy the H/W and S/W requirements.

• The Journal of Asian Finance, Economics and Business
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• 제9권1호
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• pp.363-372
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• 2022

Entrepreneurs are valuable assets for any country. Rather than being confronted with new obstacles, they should be fostered and nurtured. Entrepreneurial firms have the power to influence how we live and work, in addition to producing jobs and contributing to economic progress. Entrepreneurs have the ability to change the world by creating diversified skill sets and profitable businesses that are vital to the advancement of our economies. How does one go about being a successful business, though? More resources are believed to be needed to create entrepreneurial environments in higher education that foster progressive ideas and innovation while also providing students with the practical knowledge and skills they need to navigate the troublesome, difficult, and uncertain situations that come with owning a business. This article will outline the scales of components from which to measure variables impacting universities' ability to encourage entrepreneurial behavior among students, based on the aforementioned significance of universities. This article is based on a survey of 507 students from different universities and backgrounds in Vietnam. The research methods used are Cronbach's alpha test and Structural Equation Modeling. From the research results, it can be seen that the university's environment plays a significant role in fostering entrepreneurial behavior among students.

• 동의신경정신과학회지
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• 제21권3호
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• pp.45-64
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• 2010

Objectives : The purpose of this study was to examine the effects of auricular acupuncture at the Shinmun on patients with dementia by using power spectrum analysis. Electroencephalogram(EEG) power spectrum show site-specific and state-related differences in various frequency bands. Methods : Study was carried out in 38 subjects.(31 patients with dementia and 7 normal people, 27 females and 11 males ; mean age=75.9 years old). To know the effect of auricular acupuncture at the Shinmun in patients with dementia, we measured electroencephalogram(EEG) of normal people and patients with dementia about 'before', 'after' and 'after 15 minutes' giving auricular acupuncture at the Shinmun, and compared the brain wave($\alpha$, $\beta$, $\delta$, $\theta$) of EEG 30 channels. Results : In the case of patients with dementia, in the power values of $\alpha$(alpha) band at F4, FP2, FCZ, F8, FC4 channels (p<0.05) during the Shinmun-auricular acupuncture treatment increased significantly. In $\beta$(beta) band, the power values at T8 channel(p<0.05) during the Shinmun-auricular acupuncture treatment increased significantly. In $\delta$(delta) band, the power values at F7, FP1, FZ, FP2, FCZ, C4, FC4, CP4, T8, P7, P3, O1, OZ, O2, P4, P8 channels(p<0.05) during the Shinmun-auricular acupuncture treatment decreased significantly. In $\Theta$(theta) band, the power values at O1, OZ, O2channel(p<0.05) during the Shinmun-auricular acupuncture treatment decreased significantly. Conclusions : Through these results, we concluded that auricular acupuncture at the Shinmun on patients with dementia could have effect the functional mechanism of the cerebral cortex.

• KSBB Journal
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• 제14권4호
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• pp.445-451
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• 1999

E. coli TGI/pDG7 $\alpha$ 와 빵효모의 혼합세포계에 의한 글루타치온 생산을 Aerated Slurry Bioreactor에서 수행하였다. 글루타치온 생산 효소는 34시간 동안 안정성을 보였으며, 글루타치온 수율은 4.6 mM을 유지함을 보였다. 고농도의 혼합세포를 이용한 Aerated Slurry Bioreactor에서 기질의 공급속도가 글루타치온 생산에 미치는 영향을 조사하였다. 세포가 회수되어 기질공급속도 5.2 mL/hr에서 글루타치온의 생산농도는 32시간에서 현탁반응보다 낮아짐을 보였고, 반면 세포가 회수되지 않은 기질공급속도 5.2 mL/hr에서는 22시간 동안 유지되었고 2.6 mL/hr에서는 42시간 동안 유지되었다. 글루타치온의 생산성은 기질공급속도가 10.4 mL/hr에서 25.7 mg/g wet $cell{\cdot}hr$이었으나, 2.6 mL/hr에서는 1.65 mg/g wet $cell{\cdot}hr$이었고 5.2mL/hr에서는 5.28 mg/g wet $cell{\cdot}hr$이었다. 계면활성제(Tween 80)을 사용한 경우, 글루타치온 생산시간을 25시간에서 45시간으로 연장되었다. 글루타치온 생산있어 산소가 세포계의 효소에 산소에 의해 영향을 미칠 것으로 판단되었고, 공기를 질소로 교체하여 글루타치온 생산시간을 40시간으로 연장시켰다.

• 지능정보연구
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• 제23권1호
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• pp.95-108
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• 2017

최근 알파고의 등장으로 딥러닝 기술에 대한 관심이 고조되고 있다. 딥러닝은 향후 미래의 핵심 기술이 되어 일상생활의 많은 부분을 개선할 것이라는 기대를 받고 있지만, 주요한 성과들이 이미지 인식과 자연어처리 등에 국한되어 있고 전통적인 비즈니스 애널리틱스 문제에의 활용은 미비한 실정이다. 실제로 딥러닝 기술은 Convolutional Neural Network(CNN), Recurrent Neural Network(RNN), Deep Boltzmann Machine (DBM) 등 알고리즘들의 선택, Dropout 기법의 활용여부, 활성 함수의 선정 등 다양한 네트워크 설계 이슈들을 가지고 있다. 따라서 비즈니스 문제에서의 딥러닝 알고리즘 활용은 아직 탐구가 필요한 영역으로 남아있으며, 특히 딥러닝을 현실에 적용했을 때 발생할 수 있는 여러 가지 문제들은 미지수이다. 이에 따라 본 연구에서는 다이렉트 마케팅 응답모델, 고객이탈분석, 대출 위험 분석 등의 주요한 분류 문제인 이진분류에 딥러닝을 적용할 수 있을 것인지 그 가능성을 실험을 통해 확인하였다. 실험에는 어느 포르투갈 은행의 텔레마케팅 응답여부에 대한 데이터 집합을 사용하였으며, 전통적인 인공신경망인 Multi-Layer Perceptron, 딥러닝 알고리즘인 CNN과 RNN을 변형한 Long Short-Term Memory, 딥러닝 모형에 많이 활용되는 Dropout 기법 등을 이진 분류 문제에 활용했을 때의 성능을 비교하였다. 실험을 수행한 결과 CNN 알고리즘은 비즈니스 데이터의 이진분류 문제에서도 MLP 모형에 비해 향상된 성능을 보였다. 또한 MLP와 CNN 모두 Dropout을 적용한 모형이 적용하지 않은 모형보다 더 좋은 분류 성능을 보여줌에 따라, Dropout을 적용한 CNN 알고리즘이 이진분류 문제에도 활용될 수 있는 가능성을 확인하였다.

• 한국HCI학회논문지
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• 제12권4호
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• pp.27-35
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• 2017

본 연구는 증강현실 게임의 참여와 몰입 사이에 영향을 미치는 매개변인을 규명하는 데 목적이 있다. 참여로부터 형성되는 정서적 애착과 주의집중이 현존감에 대해 나타내는 매개효과와, 현존감이 몰입에 대해 나타내는 매개효과를 통해 참여와 몰입의 관계를 알아보았다. 연구가설의 검증을 위해 포켓몬 고 게임이용자를 대상으로 온라인 설문을 실시하였다. 증강현실몰입(Augmented Reality Immersion) 설문척도를 번역한 설문조사를 통해 총 200부의 설문응답을 수집하여 분석에 사용하였다. 분석에는 SPSS 23.0과 Mplus 7.0 프로그램을 사용하여 문항내적합치도 (Cronbach's ${\alpha}$) 계수를 통해 척도의 신뢰도를 확인하고 정규분포 충족 여부에 의해 모형 적합도를 확인한 후, 경로분석을 실시하여 각 변인 간 인과관계와 매개효과를 확인하였다. 연구결과, 참여와 몰입의 관계에서는 직접적 인과관계를 보이지 않았으나 증강현실 게임 참여가 현존감과 몰입에 도달하는 과정에서 정서적 애착과 주의집중이 매개가 되었을 때 인과관계가 뚜렷하게 나타났다. 결론적으로, 증강현실 게임의 참여에서 몰입으로 향하는 과정에 참여자의 정서적 애착과 주의 집중 상태가 주요한 요인으로 작용함을 체계적으로 설명함으로써 인간과 상호작용하는 증강현실 기술의 발전에 있어서 고려해야 할 요소를 밝혀낸 점에 본 연구의 의의가 있다.

• 공업화학
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• 제29권5호
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• pp.533-540
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• 2018

그래핀은 표면 에너지가 낮고 원자단위의 얇은 물질로서 다양한 소재의 표면에 코팅시키거나 윤활제에 분산시켜 접착력과 마찰을 줄여주는 우수한 윤활유 첨가제로 보고되고 있다. 본 연구에서는 산화 그래핀 나노시트를 세 가지 종류의 염화알킬(butyl chloride, octyl chloride 및 tetradecyl chloride)을 이용하여 액체 윤활제 첨가제용 기능화 산화 그래핀(alkyl functionalized GO, FGO)을 제조하였다. 제조한 기능화 산화 그래핀의 화학적 및 구조적 특성은 Fourier transform infrared (FT-IR), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), Raman spectroscopy, scanning electron microscope (SEM), and transmission electron microscope (TEM)으로 분석하였다. 제조한 기능화 산화 그래핀은 PAO-0W40 오일에 0.02 wt%의 농도로 분산시켰으며, 트라이볼로지적 특성을 high frequency friction/wear tester로 분석한 결과, FGO-14이 첨가된 PAO-0W40 오일은 ball-on-disk의 직선왕복운동 하에서 기유에 비해 ~5.88%의 마찰계수와 ~3.8%의 마모 트랙 폭을 감소시킴으로써 내마모성이 향상됨을 확인하였다. 본 연구에서는 산화 그래핀의 성공적인 기능화와 더불어 다양한 탄화수소사슬 길이에 따른 분산 안정성 및 트라이볼로지적 특성의 향상을 입증하였다.

• Journal of Animal Science and Technology
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• 제63권4호
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• pp.934-953
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• 2021

Ciglitazone is a member of the thiazolidinedione family, and specifically binds to peroxisome proliferator-activated receptor-γ (PPARγ), thereby promoting adipocyte differentiation. We hypothesized that ciglitazone as a PPARγ ligand in the absence of an adipocyte differentiation cocktail would increase adiponectin and adipogenic gene expression in bovine satellite cells (BSC). Muscle-derived BSCs were isolated from six, 18-month-old Yanbian Yellow Cattle. The BSC were cultured for 96 h in differentiation medium containing 5 µM ciglitazone (CL), 10 µM ciglitazone (CM), or 20 µM ciglitazone (CH). Control (CON) BSC were cultured only in a differentiation medium (containing 2% horse serum). The presence of myogenin, desmin, and paired box 7 (Pax7) proteins was confirmed in the BSC by immunofluorescence staining. The CL, CM, and CH treatments produced higher concentrations of triacylglycerol and lipid droplet accumulation in myotubes than those of the CON treatment. Ciglitazone treatments significantly increased the relative expression of PPARγ, CCAAT/enhancer-binding protein alpha (C/EBPα), C/EBPβ, fatty acid synthase, stearoyl-CoA desaturase, and perilipin 2. Ciglitazone treatments increased gene expression of Pax3 and Pax7 and decreased expression of myogenic differentiation-1, myogenin, myogenic regulatory factor-5, and myogenin-4 (p < 0.01). Adiponectin concentration caused by ciglitazone treatments was significantly greater than CON (p < 0.01). RNA sequencing showed that 281 differentially expressed genes (DEGs) were found in the treatments of ciglitazone. DEGs gene ontology (GO) analysis showed that the top 10 GO enrichment significantly changed the biological processes such as protein trimerization, negative regulation of cell proliferation, adipocytes differentiation, and cellular response to external stimulus. Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that DEGs were involved in the p53 signaling pathway, PPAR signaling pathway, biosynthesis of amino acids, tumor necrosis factor signaling pathway, non-alcoholic fatty liver disease, PI3K-Akt signaling pathway, and Wnt signaling pathway. These results indicate that ciglitazone acts as PPARγ agonist, effectively increases the adiponectin concentration and adipogenic gene expression, and stimulates the conversion of BSC to adipocyte-like cells in the absence of adipocyte differentiation cocktail.