• Title/Summary/Keyword: $E_{vd}$

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Analysis of Bearing Capacity Change of Forest Roadbed by Opening Year (개설시기에 따른 임도 노반의 지지력 변화분석)

  • Chen, Hyeong-Uk;Kim, Dong-Hyeon;Lee, Kwan-Hee;Kim, Dong-Geun
    • Journal of Korean Society of Forest Science
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    • v.108 no.3
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    • pp.322-328
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    • 2019
  • The purpose of this study was to provide basic data for maintenance and repair of the forest road surfaces using the light drop weight test (LDWT), density test, and grain size analysis at four sites in Yeongyang-gun Mt. (2011y, 2014y, 2016y, and 2017y). In terms of the density test results, the opening density in 2011 was the highest at $2.0694g/cm^3$, and the opening density in 2017 was the lowest at $1.7443g/cm^3$. The grain size analysis showed that the proportion of large aggregates was highest at the opening in 2017, and the proportion of large aggregates decreased with the delay of opening date. From the LDWT results, $E_{vd}$ (the dynamic deformation coefficient) of the 2011y forest road was $35.7MN/m^2$, 2014y was $30.5MN/m^2$, 2016y was $28.6MN/m^2$, and 2017y was $23.5MN/m^2$. The $E_{vd}$ value for the oldest forests opened with the 2011y forest road was the highest, the average $E_{vd}$ value of the center portion was $21.45MN/m^2$, the average $E_{vd}$ value of the wheel portion of the banking part was $31.31MN/m^2$, and the average $E_{vd}$ value of the wheel portion of the cut part was $36.71MN/m^2$.

Optimization and production of protein hydrolysate containing antioxidant activity from tuna cooking juice concentrate by response surface methodology

  • Kiettiolarn, Mookdaporn;Kitsanayanyong, Lalitphan;Maneerote, Jirawan;Unajak, Sasimanas;Tepwong, Pramvadee
    • Fisheries and Aquatic Sciences
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    • v.25 no.6
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    • pp.335-349
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    • 2022
  • To optimize the hydrolysis conditions in the production of antioxidant hydrolysates from tuna cooking juice concentrate (TC) to maximize the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, TC containing 48.91% protein was hydrolyzed with Alcalase 2.4 L, and response surface methodology (RSM) was applied. The optimum hydrolysis conditions included a 2.2% (w/v) Alcalase concentration and 281 min hydrolysis time, resulting in the highest DPPH radical scavenging activity of 66.49% (0.98 µmol Trolox/mg protein). The analysis of variance for RSM showed that hydrolysis time was an important factor that significantly affected the process (p < 0.05). The effects of different drying methods (freeze drying, hot air drying, and vacuum drying) on the DPPH radical scavenging activity and amino acid (AA) profiles of TC hydrolysate (TCH) were evaluated. Vacuum-dried TCH (VD) exhibited an increase in DPPH radical scavenging activity of 81.28% (1.20 µmol Trolox/mg protein). The VD samples were further fractionated by ultrafiltration. The AA profiles and antioxidant activities in terms of the DPPH radical scavenging activity, 2,2'-azino-bis(3-ethylbenzthiazoline)-6-sulfonic acid (ABTS) radical scavenging activity, ferric reducing antioxidant power, and ferrous ion chelating activity were investigated. Glutamic acid, glycine, arginine, and cysteine were the major AAs found in the TCH fractions. The highest DPPH radical scavenging activity was found in the VD-1 fraction (< 5 kDa). The VD-3 fraction (> 10 kDa) exhibited the highest ABTS radical scavenging activity and ferric reducing antioxidant power. The ferrous ion chelating activity was the highest in VD-1 and VD-2 (5 to 10 kDa). In conclusion, this study provided the optimal conditions to obtain high antioxidant activities through TCH production, and these conditions could provide a basis for the future application of TCH as a functional food ingredient.

Contribution of van der Waals Interactions to the Adsorption Energy of $C_2H_2$, $C_2H_4$, and $C_6H_6$ on Si(100)

  • Kim, Seon-U;Lee, Jun-Ho;Jo, Jun-Hyeong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2013.02a
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    • pp.269-269
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    • 2013
  • Usingvan der Waals (vdW) energy-corrected density-functional theory without or with self-consistent screening (SCS) effects, we calculate the adsorption energy of acetylene, ethylene and benzene on Si(100). We find that vdW interactions without SCS effects increase the adsorption energy by 0.23, 0.30, and 0.64 eV for adsorbed $C_2H_2$, $C_2H_4$, and $C_6H_6$ on Si(100), respectively. However, if SCS effects are included, this increase of the adsorption energy is reduced as 0.19, 0.24, and 0.54 eV for the three adsorption systems, respectively. The resulting adsorption energy for each system is between the values computed using the local-density approximation and the generalized-gradient approximation.

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VD탐방-이지메디컴 최재훈 대표

  • Korea Venture Business Association
    • Venture DIGEST
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    • s.90
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    • pp.12-13
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    • 2006
  • IT강국의 자존심을 살리며 의료시장에 전자상거래 시스템을 도입한 이지메디컴의 2006년 기상도는 한겨울을 무색하게 할 만큼 화창하다. 국내 의료시장의 체질을 개선하고자 e-비즈니스라는 처방전을 내린 이지메디컴은 끊임없는 개척정신으로 시장을 선도하고 있다.

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Identification of Genes Modulated by High Extracellular Calcium in Coculture of Mouse Osteoblasts and Bone Marrow Cells by Oligo Chip Assay

  • Kim, Hyung-Keun;Song, Mi-Na;Jun, Ji-Hae;Woo, Kyung-Mi;Kim, Gwan-Shik;Baek, Jeong-Hwa
    • International Journal of Oral Biology
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    • v.31 no.2
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    • pp.53-65
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    • 2006
  • Calcium concentration in the bone resorption lacunae is high and is in the mM concentration range. Both osteoblast and osteoclast have calcium sensing receptor in the cell surface, suggesting the regulatory role of high extracellular calcium in bone metabolism. In vitro, high extracellular calcium stimulated osteoclastogenesis in coculture of mouse osteoblasts and bone marrow cells. Therefore we examined the genes that were commonly regulated by both high extracellular calcium and $1,25(OH)_2vitaminD_3(VD3)$ by using mouse oligo 11 K gene chip. In the presence of 10 mM $[Ca^{2+}]e$ or 10 nM VD3, mouse calvarial osteoblasts and bone marrow cells were co-cultured for 4 days when tartrate resistant acid phosphatase-positive multinucleated cells start to appear. Of 11,000 genes examined, the genes commonly regulated both by high extracellular calcium and by VD3 were as follows; 1) the expression of genes which were osteoclast differentiation markers or were associated with osteoclastogenesis were up-regulated both by high extracellular calcium and by VD3; trap, mmp9, car2, ctsk, ckb, atp6b2, tm7sf4, rab7, 2) several chemokine and chemokine receptor genes such as sdf1, scya2, scyb5, scya6, scya8, scya9, and ccr1 were up-regulated both by high extracellular calcium and by VD3, 3) the genes such as mmp1b, mmp3 and c3 which possibly stimulate bone resorption by osteoclast, were commonly up-regulated, 4) the gene such as c1q and msr2 which were related with macrophage function, were commonly down-regulated, 5) the genes which possibly stimulate osteoblast differentiation and/or mineralization of extracellular matrix, were commonly down-regulated; slc8a1, admr, plod2, lox, fosb, 6) the genes which possibly suppress osteoblast differentiation and/or mineralization of extracellular matrix, were commonly up-regulated; s100a4, npr3, mme, 7) the genes such as calponin 1 and tgfbi which possibly suppress osteoblast differentiation and/or mineralization of extracellular matrix, were up-regulated by high extracellular calcium but were down-regulated by VD3. These results suggest that in coculture condition, both high extracellular calcium and VD3 commonly induce osteoclastogenesis but suppress osteoblast differentiation/mineralization by regulating the expression of related genes.

Expression of Human Papillomavirus Type 16, Prototype and Natural Variant E7 Proteins using Baculovirus Expression System

  • Han, Hee-Sung;Kee, Sun-Ho;Hwang, Soon-Bong;Kim, Hyung-Jun;Cho, Kyung-A;Kim, Yoon-Won;Cho, Min-Kee;Chang, Woo-Hyun
    • The Journal of Korean Society of Virology
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    • v.28 no.1
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    • pp.53-62
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    • 1998
  • Human papillomavirus (HPV) 16, E7 proteins derived from the prototype (Bac73) and natural variant (Bac101) E7 open reading frame were produced in Sf9 insect cells. The variant E7 gene occurred naturally by substitution mutation at the position of 88 nucleotide, resulting serine instead of asparagine. Using E7 specific monoclonal antibody (VD6), both E7 proteins were identified in recombinant baculovirus infected SF9 cells. Radiolabelling and immunoprecipitation analysis revealed that both E7 proteins were phosphoproteins. Immunostaining result showed that E7 proteins were mainly localized in the cytoplasm. Nuclear form of E7 proteins was also detected after a sequential fractionation procedure for removing chromatin structure. Considering that the VD6 recognition site in E7 protein is located within 10 amino acid at the N-terminus, this region appears to be blocked by the nuclear component. Western blot analysis revealed that nuclear form was more abundant than cytoplasmic E7 proteins. Time course immunostaining showed that the primary location of E7 protein was the nucleus and exported to the cytoplasm as proteins were accumulated. These events occurred similarly in both Bac73 and Bac101 infected Sf9 cells, suggesting that these two proteins may have similar biological functions.

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Influence of Steel-making Process and Heat-treatment Temperature on the Fatigue and Fracture Properties of Pressure Vessel Steels (제강 및 열처리 조건이 압력용기강의 피로 및 파괴특성에 미치는 영향)

  • Koh, S.K.;Na, E.G.;Baek, T.H.;Park, S.J.;Won, S.Y.;Lee, S.W.
    • Proceedings of the KSME Conference
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    • 2001.11a
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    • pp.87-92
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    • 2001
  • In this paper, high strength pressure vessel steels having the same chemical compositions were manufactured by the two different steel-making processes, such as vacuum degassing(VD) and electro-slag remelting(ESR) methods. After the steel-making process, they were normalized at $955^{\circ}C$, quenched at $843^{\circ}C$, and finally tempered at $550^{\circ}C$ or $450^{\circ}C$, resulting in tempered martensitic microstructures with different yielding strengths depending on the tempering conditions. Low-cycle fatigue(LCF) tests, fatigue crack growth rate(FCGR) tests, and fracture toughness tests were performed to investigate the fatigue and fracture behaviors of the pressure vessel steels. In contrast to very similar monotonic, LCF, and FCGR behaviors between VD and ESR steels, a quite difference was noticed in the fracture toughness. Fracture toughness of ESR steel was higher than that of VD steel, being attributed to the removal of impurities in steel-making process.

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Load transfer and energy absorption in transversely compressed multi-walled carbon nanotubes

  • Chen, Xiaoming;Ke, Changhong
    • Coupled systems mechanics
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    • v.6 no.3
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    • pp.273-286
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    • 2017
  • We present a simple and easy-to-implement lumped stiffness model to elucidate the load transfer mechanism among all individual tube shells and intertube van der Waals (vdW) interactions in transversely compressed multi-walled carbon nanotubes (CNTs). Our model essentially enables theoretical predictions to be made of the relevant transverse mechanical behaviors of multi-walled tubes based on the transverse stiffness properties of single-walled tubes. We demonstrate the validity and accuracy of our model and theoretical predictions through a quantitative study of the transverse deformability of double- and triple-walled CNTs by utilizing our recently reported nanomechanical measurement data. Using the lumped stiffness model, we further evaluate the contribution of each individual tube shell and intertube vdW interaction to the strain energy absorption in the whole tube. Our results show that the innermost tube shell absorbs more strain energy than any other individual tube shells and intertube vdW interactions. Nanotubes of smaller number of walls and outer diameters are found to possess higher strain energy absorption capacities on both a per-volume and a per-weight basis. The proposed model and findings on the load transfer and the energy absorption in multi-walled CNTs directly contribute to a better understanding of their structural and mechanical properties and applications, and are also useful to study the transverse mechanical properties of other one-dimensional tubular nanostructures (e.g., boron nitride nanotubes).

Modelling creep behavior of soft clay by incorporating updated volumetric and deviatoric strain-time equations

  • Chen Ge;Zhu Jungao;Li Jian;Wu Gang;Guo Wanli
    • Geomechanics and Engineering
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    • v.35 no.1
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    • pp.55-65
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    • 2023
  • Soft clay is widely spread in nature and encountered in geotechnical engineering applications. The creep property of soft clay greatly affects the long-term performance of its upper structures. Therefore, it is vital to establish a reasonable and practical creep constitutive model. In the study, two updated hyperbolic equations based on the volumetric creep and deviatoric creep are respectively proposed. Subsequently, three creep constitutive models based on different creep behavior, i.e., V-model (use volumetric creep equation), D-model (use deviatoric creep equation) and VD-model (use both volumetric and deviatoric creep equations) are developed and compared. From the aspect of prediction accuracy, both V-model and D-model show good agreements with experimental results, while the predictions of the VD-model are smaller than the experimental results. In terms of the parametric sensitivity, D-model and VD-model are lower sensitive to parameter M (the slope of the critical state line) than V-model. Therefore, the D-model which is developed by incorporating the updated deviatoric creep equation is suggested in engineering applications.

Dexamethasone, but Not Vitamin D or A, Dampens the Inflammatory Neutrophil Response to Protect At-risk COVID-19 Patients

  • Florianne M.J. Hafkamp;Sanne Mol;Iris Waque;Esther C. De Jong
    • IMMUNE NETWORK
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    • v.22 no.4
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    • pp.36.1-36.12
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    • 2022
  • Dexamethasone (DEX) was the first drug shown to save lives of critically ill coronavirus disease 2019 (COVID-19) patients suffering from respiratory distress. A hyperactivated state of neutrophils was found in COVID-19 patients compared to non-COVID pneumonia cases. Given the beneficial effects of DEX in COVID-19 patients, we investigated the effects of DEX and of other immunomodulatory drugs vitamin D3 (VD3) and retinoic acid (RA) on neutrophil function. DEX, but not VD3 or RA, significantly inhibited all tested aspects of neutrophil function, e.g., degranulation, intracellular ROS production, CXCL8 release and NETosis. Interestingly, RA displayed the opposite effect by significantly increasing both CXCL8 and NET release by neutrophils. Taken together, these data suggest that the lower COVID-19 mortality in DEX-treated patients may in part be due to the dampening effect of DEX on the inflammatory neutrophil response, which could prevent neutrophil plugs with NETS in the lungs and other inflamed organs of patients.