• 제목/요약/키워드: $Ca^{2+}$ nutrition

검색결과 1,191건 처리시간 0.024초

Caffeic Acid의 항산화 활성 및 Amyloid beta와 LPS에 의한 C6 Glial 세포의 산화적 스트레스 보호 효과 (Antioxidant Activity and Protective Effect of Caffeic Acid against Oxidative Stress Induced by Amyloid Beta and LPS in C6 Glial Cells)

  • 김지현;왕천;이상현;조은주
    • 생약학회지
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    • 제46권2호
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    • pp.109-115
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    • 2015
  • This study was investigated the radical scavenging effect and the protective activity of caffeic acid (CA) against oxidative stress. CA showed strong 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and hydroxyl radical ( OH) scavenging activity, showing 42.00% and 87.22% at 5 μM concentration of DPPH and ·OH scavenging activity, respectively. Furthermore, we studied protective activity of CA from amyloid beta (A${\beta}$25-35) and lipopolysaccharide (LPS) induced neuronal cell damage and neuronal inflammation using C6 glial cells. The treatment of A${\beta}$25-35 to C6 glial cell showed declines in cell viability and high generation levels of reactive oxygen species (ROS). However, the treatment of CA increased cell viability. The treatment of 5 ${{\mu}M}$ CA led to the elevation of cell viability from 59.28% to 81.22%. In addition, the production of ROS decreased cellular levels of ROS by the treatment of CA. The treatment of LPS to C6 glial cells increased significant elevation of nitric oxide (NO) production, while CA decreased NO production significantly. The production of NO increased by the treatment of LPS to 131.08%, while CA at the concentration of 1 ${{\mu}M}$ declined the NO production to 104.86%. The present study indicated thatCA attenuated A${\beta}$25-35-induced neuronal oxidative stress and inflammation by LPS, suggesting as a promising agent for the neurodegenerative diseases.

돌외차(Gynostemma pentaphyllum Makino)의 무기성분에 관한 연구 (A Study on the Mineral Contents of Dolwoe Tea(Gynostemma pentaphyllum Makino))

  • 박영희;홍윤호;박원기
    • 한국식품영양과학회지
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    • 제16권2호
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    • pp.105-109
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    • 1987
  • 돌외를 채취해서 잎과 줄기로 나누어 각자 실험실에서 차로 제조한 것과 제품으로 시판되고 있는 국산품과 일본산 제품 및 국산품 볶은것에 대해 무기성분의 함량을 측정하고 비교하였다. 돌외차에 함유된 무기성분은 잎에서 Mg, Mn, Ca 및 Cu의 함량이 많았고 줄기에서 K, Na 및 Fe이 많이 함유되어 있었으며 특히 줄기중 총회분의 K의 함량이 33.4%로서 가장 높았다. 제조된 돌외차와 시판제품에서 차 4g을 $1{\ell}$의 끓는물에 넣어 5분간 우려냈을 때 무기성분의 침출율은 K이 $83.2{\sim}96.3%$로 가장 높았으며 다음 Mg이$44.8{\sim}62.2%$ 이었고 Ca은 $23.1{\sim}64.4%$, Na은 $6.3{\sim}55.6%$ 순이었으나 Mn, Fe 및 Cu등은 극히 미량만 침출되었다.

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Prevalence of osteoporosis according to nutrient and food group intake levels in Korean postmenopausal women: using the 2010 Korea National Health and Nutrition Examination Survey Data

  • Lim, Young-Suk;Lee, Sang-Wha;Tserendejid, Zuunnast;Jeong, So-Yeon;Go, Gyeongah;Park, Hae-Ryun
    • Nutrition Research and Practice
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    • 제9권5호
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    • pp.539-546
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    • 2015
  • BACKGROUND/OBJECTIVES: Women's bone health status is closely related with environmental factors and lifestyle factors. The purpose of this study is to evaluate the dietary risks of osteoporosis and osteopenia for Korean postmenopausal women. SUBJECTS/METHODS: The data from 1,433 subjects from the 2010 KNHANES were used and divided into three groups: normal, osteopenia, and osteoporosis group using bone mineral density (BMD). Nutrient intakes and food intake frequency were evaluated. Logistic regression analysis was applied to determine the odds ratios for osteoporosis and osteopenia. RESULTS: The RNI percentage of each nutrient and food intake frequency from 12 food groups decreased as bone mineral density status deteriorated. Risk for osteoporosis of low calcium (Ca) intake, under the EAR, showed an odds ratio of 2.13(95% CI; 1.26-3.61, P < 0.05). Higher intake frequency showed preventive effect from osteoporosis compared to lower intake frequency in such food group as dairy products (ORs 0.40, CI 0.21-0.75), beans (ORs 0.49, CI 0.29-0.83), seaweeds (ORs 0.55, CI 0.32-0.94), fish (ORs 0.56, CI 0.32-0.98), and fruits (ORs 0.42, CI 0.23-0.79) after adjusting for age. CONCLUSION: To prevent osteoporosis in later life, sufficient Ca intake and more frequent intakes of foods containing Ca such as dairy products, beans, fish, seaweeds, and fruits, which help in Ca absorption, should be stressed for Korean postmenopausal women.

Nutritional Status and Bone Mineral Density of Elderly Women in Asan

  • Kim Ji Sun;Kwon Young Suk;Shin Yoon Jeong;Kim Min Kyung;Kim Hee Seon
    • Journal of Community Nutrition
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    • 제7권1호
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    • pp.49-57
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    • 2005
  • Nutrition factors play an important role in the pathogenesis of osteoporosis. The purpose of this study is to investigate the relationship between nutritional status and bone mineral density of elderly women. Three hundred thirty five elderly women (over 65 years) in Asan were divided into three age groups (group 1, less than 70 y ; group 2, from 70 to 75 y ; group 3, 75 y or more). Total alkaline phosphatase and serum calcium (Ca) were analyzed using spectrophotometric procedure. Data for food and nutrient intakes were obtained by a 24-hour recall method. Bone density was measured by broadband ultrasound attenuation (BUA) using QUS-2. Age differences were tested with the X 2 test for categorical variables and with ANOVA and Tukey's test for continuous variables. Correlation was conducted to test the association between bone density and nutrient intake. The subjects in age groups 1,2 and 3 were $36.7\%$, $32.8\%$ and $30.4\%$, respectively. Height and body weight of the subjects were significantly decreased with age. Average bone density of the subjects in group 3 was lower than the other age groups. Osteoporosis determined by t-score is $17.9\%$ for group 1, $24.5\%$ for group 2 and $55.9\%$ for group 3 (p < 0.001). The serum Ca level of the subjects in group 2 was significantly lower than that of group 1 although mean values in all age groups are within the normal range. Dietary Ca intake, nutrient adequacy ratio (NAR) and index of nutrient quality (INQ) were decreased with age. Bone density was negatively correlated with age (p < 0.001), while body mass index (p < 0.01) was positively related with bone density. Although partial correlation did not reveal the significant correlation of BMD and dietary calcium after controlling for age, since calcium intake was very poor compared to sodium and phosphorous intakes, recommendation of more calcium intake for elderly women especially those over 75 years must be continuously emphasized.

천연칼슘소재로서 개조개(Saxidomus purpuratus)와 바지락(Ruditapes philippinarum) 패각 및 소성분말의 특성 (Characteristics of the Shells and Calcined Powders from the Butter Clam Saxidomus purpuratus and Littleneck Clam Ruditapes philippinarum as a Natural Calcium Resource)

  • 김진수;정남영;장수정;이현지;박성환;김민주;허민수
    • 한국수산과학회지
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    • 제48권2호
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    • pp.168-177
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    • 2015
  • Shell waste from the butter clam Saxidomus purpuratus and littleneck clam Ruditapes philippinarum is a large by-product of shellfish aquaculture, and it is desirable to convert it into value-added products for industrial applications. In this study, calcium carbonate (CaC) polymorphs from butter clam (BCSP) and littleneck clam (LCSP) shell powders and commercial CaC were characterized using Fourier transmission infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). The results revealed that the optimal calcination conditions to eliminate organic substances and improve solubility for both BCSP and LCSP were $800^{\circ}C$ for 8 h in an electrical furnace. Calcination improved the white index of the butter clam (BCCP) and littleneck clam (LCCP) calcined powder compared with shell powders. The calcium content in BCCP (51.1%) was higher than that of LCCP (44.9%) or commercial calcium oxide (CaO, 44.7%). The XRD patterns of BCCP and LCCP were similar to that of CaO. Cubic-like crystals of CaC and irregular crystals of BCCP and LCCP were observed by SEM. The FT-IR and XRD analyses revealed the presence of calcite and aragonite in the BCSP and aragonite in the LCSP, whereas the CaC contained calcite. These results indicate that butter and littleneck clam shells are potential biomass resources for calcium carbonate and calcium oxide.

시판 이유식류 제품의 무기질 함량에 관한 연구 (Study on the Mineral Contents of Commercial Baby Foods)

  • 양혜란;김을상;김연천;한선희
    • 한국식품영양과학회지
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    • 제30권3호
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    • pp.388-394
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    • 2001
  • This study was conducted ton investigate the mineral contents of commercial baby foods. Samples were classified into 4 groups; powdered formula, baby juice product (domestic), juice and paste products (imported) and soymilk-based formula. We analyzed Ca, P, Mg, Na, K, Fe, Cu, Zn contents by atomic absorption spectrophotometer after dry-ashing. The difference of analyzed value versus labeled value and Ca/P ratio of analyzed value were calculated. The difference (%) of analyzed value on the labeled value was Ca: 98.6, P: 121.8, Mg: 146.1, Na: 87.4, K: 104.3, Fe: 104.8, Cu: 120.2, Zn: 109.8 in powdered formula, Mg showed the highest difference among the elements. The Ca/P ratio of powdered formula was 1.41 (1.70-1.99). Baby juice products (domestic) were fortified Ca, Fe and the difference (%) of analyzed value on labeled value of Ca and Fe contents was 131.8, 110.2, respectively. The Ca/P ratio of these was 2.36 (1.64-3.71). Differently the domestic products, imported juice and paste products were not fortified Ca, Fe and its Ca/P ratio was 0.38(0.14-0.59). The difference (%) of analyzed value on the labeled value was Ca: 110.2, Mg: 179.5, Na: 83.7, K: 87.8, Cu: 107.8, Fe: 219.8, Zn: 100.5, P: 126.6 in soymilk-based formula, Fe showed the highest difference among the elements. The Ca/P ratio of soymilk-based formula was 1.17 (1.04-0.39).

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아스파르트산 킬레이트 칼슘의 칼슘 결핍쥐에서의 생물학적 유용성 (Bioavailability of Aspartic Acid Chelated Calcium in Calcium Deficient Rats)

  • 박명규;하태열;신광순
    • Journal of Nutrition and Health
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    • 제44권6호
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    • pp.474-480
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    • 2011
  • Calcium (Ca) is an essential element to maintain body homeostasis. However, many factors disturb calcium absorption. Aspartic acid chelated calcium (AAC) was synthesized by new methods using calcium carbonate and aspartic acid. This study was carried out to investigate the bioavailability of AAC in Ca-deficient rats. The experimental groups were as follows: NC; normal diet control group, CD-C; untreated control group of Ca-deficient (CD) rats, CD-$CaCO_3$; $CaCO_3$ treated group of CD rats, CD-AAC; AAC treated group of CD rats, and CD-SWC; and seaweed-derived Ca treated group of CD rats. The Ca content of various types of Ca was held constant at 32 mg/day, and the four CD groups were fed for 7 days after randomized grouping. Ca content in serum, urine, and feces within feeding periods were analyzed to confirm Ca absorption. Serum Ca content was significantly higher in the CD-AAC (11.24 mg/dL) and CD-SWC (10.12 mg/dL) groups than that in the CD-C (8.6 mg/dL) group 2 hours following the first administration. The Ca content in feces was significantly lower in the CD-AAC (35.4 mg/3 days) and CD-SWC (71.1 mg/3 day) groups than that in the CD-$CaCO_3$ (98.7 mg/3 days) group (p > 0.05). AAC had a 2.3-fold higher absorption rate of Ca than that of SWC. No differences in fibula length were observed in the NC and CD groups. The fibula weights of the CD-AAC (0.33 g) and CD-SWC (0.33 g) groups increased compared to those in the CD-C (0.27 g) group; however, no significant difference was observed between the CD groups. We conclude that bioavailability of AAC is higher than that of seaweed-derived Ca or inorganic Ca. Thus, these findings suggest the AAC has potential as a functional food material related to Ca metabolism.

에어로빅 운동과 칼슘보충이 폐경이후 여성의 칼슘대사에 미치는 영향 (The Effect of Aerobic Dancing and Ca Supplementation on Ca Metabolism in Postmenopausal Women)

  • 배영란
    • Journal of Nutrition and Health
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    • 제24권2호
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    • pp.114-123
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    • 1991
  • This study was designed to investigate the effects of aerobic dancing and/or Ca supplemen-tation for six months on Ca metabolism in postmenopausal women. The subjects were healthy 29 women aged from 60 to 70 years old. They were divided into four groups ; placebo and Ca supplementation group with and without exercise. The amount of Ca supplemented was 500mg a day. The frequency of doing exercise was three times a week and it took 40 minutes to complete once all the course of aerobic dancing programmed for old women. The results were summarized as follows : 1) Bone density of the second lumbar spine and ward's triangle measured after experiment decreased significantly in control group as compared with pre-experimental level(P<0.05). On the contrary it showed a tendency to increase or maintained the pre-experimental level after experiment in other groups. 2) Urinary Ca/creatinine and P/creatinine ratios did not show any significant differences among groups before and after experiment. But urinary Ca/creatinine ration decreased signifi-cantly in Ca group after experiment(P<0.05) 3) Serum Ca and P levels did not show any significant differences among groups before and after experiment. But serum Ca level in creased significantly in Ca group after experiment(P<0.05) 3) Serum Ca and P levels did not show any significant differences among groups before and after experiment. But serum Ca level increased significantly in Ca group after experiment (P<0.05). 4) Serum PTH level also did not show any significant differences among groups before and after experiment. But serum calcitonin level decreased significantly in Ca group after experiment(P<0.05). The above results showed that it will be difficult to prevent degenerative bone loss without regular exercise and/or Ca supplementation in postmenopausal women having Korean usual diets.

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혈압조절에 있어서 Renin 활성도의 차이와 Ca, Na 섭취습관 그리고 호르몬 간의 관련성 (Renin Activity, Habitual Ca, Na Intake and Hormonal Effect on Hypertension)

  • 윤진숙
    • Journal of Nutrition and Health
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    • 제30권2호
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    • pp.170-176
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    • 1997
  • Twenty two hypertensive and thirty normotensive in-patients were participated in this study to investigate the relationship between plasma renin activity and metabolism of Ca and Na, Prior to pharmacological treatments, renin activity, aldosterone and parathyroid hormone(PTH) levels were measured from the fasting blood samles. Twenty four hour urine samples were collected to analyze urinary levels of creatinine, Ca, Na and K. Habitual intake of Na and Ca were also measured for hypertensive and normotensive patients. Hypertensive subjects were classified into higher reinin hypertensive (HH), medium renin hypertensive(MH) and low renin hypertensive (LH) group according to their renin activities. PTH level of LH group was the highest among three hypertensive groups. It appeared that aldosterone levels of HH group were significantly higher than LH or MH groups(p<0.05). However there were no significan시 differences in aldosterone level between LH group and normotensive group. Habitual intake of Na and Ca were highest in LH group but lowest in HH group, however, they were not statistically different. Positive correlations of systolic blood pressure with PTH(r=0.2597) and aldosterone(r=0.26480existed(p<0.05). Urinary Ca level was positively correlated with urinary Na(r=0.5619), K(r=0.4533) and habitual Na intake(r=0.3253). Above results suggested the possible relationships among renin activity, habitual Ca intake and Na intake and suggested a further study on the interrelationship between the hormonal control of Ca and Na metabolism and blood pressure in hypertension.

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장기간의 고.저단백식이섭취가 난소절제쥐의 Ca 및 골격대사에 미치는 영향 (A Study on the Long-Term Effects of Dietary Protein Level on Ca and Skeletal metabolism in Ovariectomized Rats)

  • 김화영
    • Journal of Nutrition and Health
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    • 제28권5호
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    • pp.415-425
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    • 1995
  • This study was performed to investigate the effect of dietary protein level on the metabolic changes of Ca and skeletons in postmenopausal women, using ovariecotomized rats as an animal model. The female rats of 200∼250g were fed either 8%(L) or 50%(H) casein diet for 15 weeks(1st experiment). At 15th week, the rats of each diet group were undergone ovariectomy or sham-operation and they were continued to feed the same experimantal diet for 9 more months(2nd experiment). Ca metabolism, kidney function and bone composition were determined at the end of 1st experiment, 3rd and 9th month of 2nd experiment. After 1st experiment, high protein group showed higher urinary Ca and protein excretion, however, there was no difference in GFR and urinary hydroxyproline excretion. The weights, ash and Ca content of femur, scapular and vertebra tended to be higher in high protein groups which tells that high protein promoted skeletal growth. In 2nd experiment, high protein group showed higher urinary Ca and protein excretion and lower Ca absorption and balance. GFR was not affected by dietary protein and ovariectomy but increased with time, as well as kidney weight which shows the continuous development of kidney at this age of 15 month in rats. There were no difference in urinary hydroxyproline, serum ALP, and PTH among experimental groups. The weights of femur, scapular, 4th vertebra increased with time, showing the skeleton continues to grow at this age in rats. However, Ca contents, Ca/wt, Ca/ash were decreased with time and tended to be lower in high protein group especially in femur. In conclusion, prolonged feeding of high protein diet deteriorated Ca metabolism and induced bone loss as time after menopause is extended.

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