• Korean Journal of Clinical Laboratory Science
• /
• v.54 no.2
• /
• pp.110-118
• /
• 2022

Candidemia is a major cause of nosocomial infections resulting in increased morbidity and mortality. It remains a serious risk in inpatients and increases medical treatment costs. From 2009 to 2018, Candida strains (3,533) isolated from blood culture tests at the S Hospital were analyzed according to the period, year, sex, age, ward, etc. During the entire period, 54,739 of 717,996 blood culture tests showed a positive rate (7.6%) and the Candida isolation rate was 3,533 (6.4%) out of 1,036 patients. Among the Candida isolates, C. albicans was most common (33.8%), followed by C. tropicalis (28.6%), C. glabrata (19.8%), C. parapsilosis (7.8%), and C. krusei (4.0%). In early (2009~2013)/late (2014~2018) isolation, C. tropicalis decreased by 3.8% and C. glabrata increased by 3.4%. After 50 years of age, the higher the separation frequency. C. parapsilosis (31.3%) in 1~10s, C. tropicalis (30.3%) and C. glabrata (27.6%) in 41~50s, and C. tropicalis (28.6%) in 80s are relatively frequent. has been separated C. krusei was isolated in a relatively high proportion from females (60.9%). Therefore, a systematic and continuous nosocomial infection control system should be established for appropriate treatment as per antifungal treatment guidelines. The system should continuously monitor the distribution of Candida species and provide rapid identification results.

• Bulletin of the Korean Chemical Society
• /
• v.14 no.1
• /
• pp.113-117
• /
• 1993

Good yield synthetic routes for the production of new B-alkyl-dithiaborane clusters are reported. The syntheses of the B-alkyl-dithiaboranes are based on the use of Fischer-type carbene reagents to activate the B-H bonds of dithiaborane for alkyl-addition reactions and are the first examples of transition-mediated reactions of dithiaborane to be reported. Thus, reactions employing arachno-$S_2B_7H_8$- and $(CO)_5M{C(R_1)R_2}$ (M = Cr, W; $R_1 = CH_3,\;C_6H_5;\; R_2 = OCH_3,\;SC_6H_5)$ were found to yield the intermidiate anions I, $[(CO)_5M{C(R_1)R_2S_2B_7H_8}]^-$, which upon protonation gave the corresponding neutral, air-sensitive cluster arachno-4-$RCH_2-6,8-S_2B_7H_8(R=CH_3,\;IIa;\;C_6H_5,\;IIb)$ range from 30 to 35% yield. Complexes IIa and IIb are isoelectronic with arachno-6,8-$S_2B_7H_9$ and, on the basis of the spectroscopic data, are proposed to adopt a similar arachno cage geometry in which an $RCH_2$ units are substituted to 4 position boron atom of the arachno-6,8-$S_2B_7H_9$.

• Journal of Wetlands Research
• /
• v.13 no.3
• /
• pp.385-394
• /
• 2011

In this study, optimal parameters of diffusion-analogy GIUH were calculated by separating channel and hillslope from drainage structures in the basin. Parameters of the model were composed of channel and hillslope, each velocity($u_c$, $u_h$) and diffusion coefficient($D_c$, $D_h$). Tanbu subwatershed in Bocheong river basin as a target basin was classified as 4th rivers by Strahler's ordering scheme. The optimization technique was applied to the SCE-UA, the estimated optimal parameters are as follows. $u_c$ : 0.589 m/s, $u_h$ : 0.021 m/s, $D_c$ : $34.469m^2/s$, $D_h$ : $0.1333m^2/s$. As a verification for the estimated parameters, the error of average peak flow was about 11 % and the error of peaktime was 0.3 hr. By examining the variability of parameters, the channel diffusion coefficient didn't have significant effect on hydrological response function. by considering these results, the model is expected to be simplified in the future.

• Nutrition Research and Practice
• /
• v.16 no.3
• /
• pp.392-404
• /
• 2022

BACKGROUND/OBJECTIVES: Numerous studies have examined the relationship between drinking behaviors and metabolic syndrome (MetS) for adults, but these include very few studies for young adults. This study therefore undertook to investigate the association between drinking behaviors and components of MetS among adult drinkers aged 20-30 years. SUBJECTS/METHODS: Using the 2016-2018 Korea National Health and Nutrition Examination Survey data, drinking behaviors of adults in the age group 20-30 years were divided into 4 groups: 1) group A, good drinking habits; 2) group B, frequent binge drinking but not frequent drinking; 3) group C, frequent drinking but not frequent binge drinking; 4) group D, frequent drinking and binge drinking. The association between MetS components and drinking behaviors was analyzed by applying multiple logistic regression analysis. RESULTS: We determined the prevalence risk compared to group A. In men, the prevalence risk of high triglyceride (TG) increased 2.051-fold in group C and 1.965-fold in group D. Moreover, in group D, the prevalence risk of low high density lipoprotein cholesterol (HDL-C) increased 0.668-fold, high blood pressure (BP) increased 2.147-fold, and MetS increased 1.567-fold. In women, there was an increased prevalence risk of low HDL-C (0.353-fold) and MetS (3.438-fold) in group C, whereas group D showed increased prevalence risk of abdominal obesity (2.959-fold), high TG (1.824-fold, and low HDL-C (0.424-fold). CONCLUSIONS: Our study indicates that frequent drinking increases the risk of high TG, whereas frequent and binge drinking increases the risk of high TG, low HDL-C, high BP, and prevalence of MetS in men. In women, frequent drinking without binge drinking increases the risk of low HDL-C and MetS, whereas frequent and binge drinking increases the risk of abdominal obesity, high TG, and low HDL-C. We propose that improvements in the drinking behaviors can reduce the prevalence of MetS.

• Biomolecules & Therapeutics
• /
• v.15 no.4
• /
• pp.266-272
• /
• 2007

A rapid analytical method was developed to quantify very long-chain fatty acids (VLCFAs, C22:0, C24:0, C26:0) in human plasma with good sensitivity and specificity using tert-butyldimethylsilyl (TBDMS) derivatization and stable isotope GC-MS selective ion monitoring (GC-MS/SIM). Two-hundred and fifty ${\mu}L$ of plasma was fortified with deuterated stable isotope internal standards (d3-C22:0, d3-C24:0, d3-C26:0) and standard mixtures of chloroform and methanol, and then extracted with hexane and acetonitrile. To upper layer of liquid-liquid-extraction, N-(t-Butyldimethylsilyl)-N-methyltrifluoroacetamide was added and then heated to $60^{\circ}C$ for 30 min to produce the TBDMS derivatives. Derivatives of VLCFAs were analyzed by GC-MS/SIM. Calibration curves showed a linear relationship for the target compounds in the concentration range of $10^{-4}{\sim}2{\times}10^3\;{\mu}g/mL$ with the correlation coefficient ranging from 0.996 to 0.999. The limit of quantification for the plasma was $10^{-4}{\sim}2{\times}10^{-4}\;{\mu}g/mL$ (S/N=3). When applied to the plasma specimens of patients with peroxisomal disorder, X-linked adrenoleucodystropy (ALD, Mckusick 202370), the method clearly differentiated normal subjects from ALD patients. The C24:0/C22:0 and C26:0/C22:0 ratios were significantly elevated in the plasma of patients with X-linked ALD compared to normal subjects. The new developed method might be useful for a rapid and sensitive diagnosis of X-linked ALD and other peroxisomal disorders.

• Membrane Journal
• /
• v.11 no.4
• /
• pp.143-151
• /
• 2001

We have fabricated mixed-ionic conducting membranes, L $a_{0.6}$S $r_{0.4}$ $Co_{0.2}$F $e_{0.8}$ $O_{3-}$$\delta$/ and L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ by the solid state method. Ceramic membranes consisted of perovskite-type structures and exhibited high relative density, >95%. Especially, dense L $a_{0.6}$S $r_{0.4}$Co $O_{3-}$$\delta$/ layer was coated on the L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ membranes by using screen printing technique in order to improve oxygen ion flux. We measured oxygen ion flux on uncoated L $a_{0.6}$S $r_{0.4}$ $Co_{0.2}$F $e_{0.8}$ $O_{3-}$$\delta$/, uncoated L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/, and coated L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ membranes. The L $a_{0.6}$S $r_{0.4}$ $Co_{0.2}$F $e_{0.8}$ $O_{3-}$$\delta$/ membranes showed the highest flux, 0.26 mL/min.$\textrm{cm}^2$ at 90$0^{\circ}C$, after steady state had been reached. The oxygen flux of coated L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ membranes showed higher value, 0.19 mL/min.$\textrm{cm}^2$ at 95$0^{\circ}C$. This flux was as much as 2 or 3 times higher than those of uncoated L $a_{0.7}$S $r_{0.3}$G $a_{0.6}$F $e_{0.4}$ $O_{3-}$$\delta$/ membranes. 3-$\delta$/ membranes.X> 3-$\delta$/ membranes.membranes.

• Bulletin of the Korean Chemical Society
• /
• v.34 no.3
• /
• pp.759-762
• /
• 2013

Four prominent features of Titan's haze are found within the '3.4-${\mu}m$' absorption to be uniform with recent vertically resolved Cassini/VIMS spectra. These are absorptions at 2998 $cm^{-1}$ (3.34 ${\mu}m$), 2968 $cm^{-1}$ (3.37 ${\mu}m$), 2927 $cm^{-1}$ (3.42 ${\mu}m$), and 2882 $cm^{-1}$ (3.47 ${\mu}m$). A detailed fitting suggests that the 2998 $cm^{-1}$ feature could originate from amorphous acetonitrile ($CH_3CN$) carrying about 25% of integrated optical depth; the remaining features, which account for 75% of the integrated optical depth, could arise from a distinct triplet (C-H stretching) structure of radiolyzed hydrocarbons. An additional feature was possibly evidenced at altitudes higher than 300 km and attributable to 'polymer-capped' methane ($CH_4$), significantly constraining the chemical composition of organic haze layers under Titan's active radiation field.

• Korean Journal of Clinical Laboratory Science
• /
• v.50 no.3
• /
• pp.354-358
• /
• 2018

When preparing for a blood transfusion, the presence and types of unexpected antibodies should be identified through screening tests. Using the DiaMed-ID system, antibody identification among unexpected antibody screening tests performed at a university hospital in Daejeon area for two years from January 2016 to December 2017 were limited to 55 patients and were predominantly women. A total of 36 patients (65.5%) belonged to the Rh group, 7 (12.7%) patients to the Lewis group, 4 (7.3%) patients to the Kidd and Duffy groups, 3 patients (5.5%) to the MNS group, and 1 (1.8%) to the Rh+Kidd combined group. In the Rh group, 19 (34.5%) patients had Anti-E single antibody, 5 (9.1%) patients had Anti-D single antibody, 4 (7.3%) patients had Anti-E/-c, 4 (7.3%) patients had Anti-C/-e, and 1 (1.8%) patient had $Anti-E/-c/-Jk^b$. In the Lewis group, three (5.5%) patients had both $Anti-Le^a$ and $Anti-Le^b$. In the Kidd group, one (1.8%) patient had $Anti-Jk^a$ and three (5.5%) patients had $Anti-Jk^b$. In the Duffy and MNS groups, only single antibody was found: one (1.8%) patient with $Anti-Fy^a$, three (5.5%) patients with $Anti-Fy^b$, two (3.6%) patients with Anti-M, and one (1.8%) patient with Anti-S. This study reflects the recent frequencies and distributions of unexpected antibodies in Daejeon, which would be helpful for the efficient preparation for transfusions.

• Journal of the Korean Chemical Society
• /
• v.18 no.5
• /
• pp.329-340
• /
• 1974

Sulfadiazine, $C_{10}H_{10}N_4O_2S$, forms monoclinic crystals of space group $P21}c$ from a mixture of acetone and ethanol with $a=13.71{\pm}0.04,\;b=5.84{\pm}0.03,\;c=15.11{\pm}0.05{\AA},\;{\beta}=115.0{\pm}0.3^{\circ}$, and four molecules per cell. Three dimensional photographic data were collected with $CuK\alpha$ radiation. The structure was determined using Patterson and Fourier synthesis methods and refined by block diagonal least-squares methods with isotropic thermal parameter for all non-hydrogen atoms. The final R value was 0.15 for the 1517 observed independent reflections. The dihedral angle between the planes through the benzene ring and the pyrimidine ring is $76^{\circ}$. The conformational angle formed by the projection of the S-C(5) bond with that of N(1)-C(1) where the projection is taken along the S-N(1) bond is $77^{\circ}$. The imino nitrogen atom, N(1), and pyrimidine nitrogen atom, N(3), form intermolecular $N-H{\cdots}N$ hydrogen bond between the molecules related by center of symmetry. Amino nitrogen atom, N(4), forms two intermolecular $N-H{\cdots}O$ hydrogen bonds, with O(1) and O(2) atoms of different molecules separated by b. A two dimensional network of hydrogen bonds form infinite molecular sheets parallel to the (100) plane. Adjacent sheets are bound together by van der Waals forces.

• Proceedings of the Korea Water Resources Association Conference
• /
• 2017.05a
• /
• pp.29-29
• /
• 2017

유역의 물수지를 강수, 증발산, 토양수분저류, 유출 등 성분으로 구성하고, 토양수분저류 상태에 따라 증발산과 유출이 변화하는 식을 기본식으로 구성하였으며, 물수지를 개선하는 매개변수를 변수화하는 개념을 도입하여 다음 식의 모형을 개발하였다. 여기서, ETa는 실제증발산량, ETo는 잠재증발산량, Q는 유출량, S는 토양수분저류량이고, C1은 증발산, C2, ${\alpha}$는 유출반응, C3, C4는 매개변수 ${\alpha}$를 변수화시키는 데 관련한 매개변수이다. $$ETa(i)=(1-e^{-c1{\times}s(i)}){\times}ETo_{(i)}$$ $$Q_{(i)}=S_{(i)}{\times}(1-e^{-c2{\times}s(i)})^{[(c3+e^{-c4{\times}s(i)}){\times}a]}$$ 모형의 검증을 위해 Monte Calro 기법으로 최적 매개변수를 결정한 결과 수많은 매개변수 조합이 최적영역에 분포되는 것을 확인하였으며, 이를 바탕으로 매개변수 하나만 남겨 놓고 나머지 매개변수는 상수화시켜도 모의결과가 똑같다는 결과를 관찰하였으며, 이를 토대로 하나 매개변수만으로 일 유출 모의가 가능하다고 결론을 내렸다. 하나의 매개변수는 ${\alpha}$를 우선 추천하고, C1도 유역의 토지이용에 따라 증발산이 변화하기 때문에 의미있다고 판단하고 있다. 하나의 매개변수를 결정하는 방법은 유출 자료가 있으면 유출량으로, 없으면 유출률을 맞추는 방법이며, 일반화하기 쉽고 실용성이 매우 높은 것으로 평가된다. 유역면적 $209km^2$인 보령댐의 2007년부터 2009년까지 Monte Calro 기법으로 매개변수를 결정한 결과 C1=0.0196, C2=0.0023, C3=0.3230, C4=0.0051, ${\alpha}=2.3304$ 이었으며, 이 때 연평균 강우량 1221.2mm, 유출량 651.2mm, 유출률 53.3%이었으며, $R^2=0.833$, RMSE=2.073, NSE=0.831이었고, 관측 유출량 610.8mm, 유출률 50.0%였다. 매개변수 C1, C2, C3, C4를 고정시키고 유출률 50%에 이를 때 ${\alpha}$는 2.6946이었으며, 이 때 $R^2=0.831$, RMSE=2.102, NSE=0.826이었고, 매개변수 C2, C3, C4, ${\alpha}$를 고정시키고 유출률 50%에 이를 때 C1은 0.0255이었으며, 이 때 $R^2=0.833$, RMSE=2.083, NSE=0.829이었다. 한편 똑같은 자료로 탱크모형은 $R^2=0.79$, RMSE=2.43, NSE=0.77이었고, SWAT 모형은 $R^2=0.56$, RMSE=3.97, NSE=0.40으로 나타난 것과 비교할 때, 개발된 모형의 성능이 우수한 것이라 결론내릴 수 있었다.