Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)

Korean Society for Clinical Laboratory Science (대한임상검사과학회)
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Frequency of Candida Strains Isolated from Candidiasis Patients at A Tertiary Hospital over the Last 10 Years

최근 10년 동안 일개 상급종합병원의 칸디다혈증 환자에서 분리된 칸디다 균종의 빈도

  • Hwang, Yu-Yean (Department of Laboratory Medicine, Samsung Medical Center) ;
  • Kang, On-Kyun (Department of Laboratory Medicine, Samsung Medical Center) ;
  • Park, Chang-Eun (Department of Biomedical Laboratory Science, Molecular Diagnostics Research Institute, Namseoul University) ;
  • Hong, Sung-No (Department of Clinical Laboratory Science, Dongnam Health University) ;
  • Kim, Young-Kwon (Department of Health Sciences, The Graduate School of Konyang University) ;
  • Huh, Hee-Jae (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Nam-Yong (Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 황유연 (삼성서울병원 진단검사의학과) ;
  • 강온균 (삼성서울병원 진단검사의학과) ;
  • 박창은 (남서울대학교 임상병리학과.분자진단연구소) ;
  • 홍성노 (동남보건대학교 임상병리과) ;
  • 김영권 (건양대학교 보건복지대학원 보건학과) ;
  • 허희재 (성균관대학교 의과대학 삼성서울병원 진단검사의학과) ;
  • 이남용 (성균관대학교 의과대학 삼성서울병원 진단검사의학과)
  • Received : 2022.04.06
  • Accepted : 2022.05.22
  • Published : 2022.06.30
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Abstract

Candidemia is a major cause of nosocomial infections resulting in increased morbidity and mortality. It remains a serious risk in inpatients and increases medical treatment costs. From 2009 to 2018, Candida strains (3,533) isolated from blood culture tests at the S Hospital were analyzed according to the period, year, sex, age, ward, etc. During the entire period, 54,739 of 717,996 blood culture tests showed a positive rate (7.6%) and the Candida isolation rate was 3,533 (6.4%) out of 1,036 patients. Among the Candida isolates, C. albicans was most common (33.8%), followed by C. tropicalis (28.6%), C. glabrata (19.8%), C. parapsilosis (7.8%), and C. krusei (4.0%). In early (2009~2013)/late (2014~2018) isolation, C. tropicalis decreased by 3.8% and C. glabrata increased by 3.4%. After 50 years of age, the higher the separation frequency. C. parapsilosis (31.3%) in 1~10s, C. tropicalis (30.3%) and C. glabrata (27.6%) in 41~50s, and C. tropicalis (28.6%) in 80s are relatively frequent. has been separated C. krusei was isolated in a relatively high proportion from females (60.9%). Therefore, a systematic and continuous nosocomial infection control system should be established for appropriate treatment as per antifungal treatment guidelines. The system should continuously monitor the distribution of Candida species and provide rapid identification results.

칸디다혈증(candidemia)은 이환율과 사망률을 높이는 주요 원인으로 입원 환자에서 심각한 위험으로 남아 있으며 의료비용을 증가시킨다. 2009년부터 2018년까지 S병원의 혈액배양 검사에서 분리된 칸디다 균주 3,533건을 대상으로 시기별 분리빈도, 연도, 성별, 나이, 병동 등에 따라 분석하였다. 전체 기간 중 혈액 배양 의뢰 건수 717,996 중에 54,739건이 배양 양성으로 7.6%의 양성율을 보였으며 칸디다 분리률은 1,036명의 환자에서 3,533건으로 6.4%였다. 균종의 분포는 C. albicans (33.8%), C. tropicalis (28.6%), C. glabrata (19.8%), C. parapsilosis (7.8%), C. krusei (4.0%) 이다. 전기/후기 분리에서는 C. tropicalis가 3.8% 감소하고 C. glabrata는 3.4% 증가하였다. 50세 이후 연령이 증가할수록 분리 빈도가 높았으며, 1~10대에서는 C. parapsilosis (31.3%), 41~50대에서는 C. tropicalis (30.3%), C. glabrata (27.6%) 순으로, 80대에서는 C. tropicalis (28.6%)가 상대적으로 자주 분리되었다. C. krusei 는 여성(60.9%)에서 상대적으로 높은 비율로 분리되었다. 따라서 Candida 균종의 분포를 지속적으로 감시하고 신속한 동정 결과를 제공하여 적절한 치료 및 항진균제 치료 지침을 위한 체계적이고 지속적인 병원감염관리 시스템이 이루어져야 할 것이다.

Keywords

Acknowledgement

This article is a revision of the first author's master's thesis from University.

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