• E2M - 전기 전자와 첨단 소재
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• 제5권3호
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• pp.329-336
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• 1992

본 논문은 이방성 Sr.페라이트의 자기특성의 개선에 관하여 연구한 것이다. 시편은 SrO.nFe$_{2}$O$_{3}$의 기본조성으로서 비화학양론적 영역인 n=5.9를 택하였다. 그리고 보자력을 증가시키기 위하여 기본첨가제로서 0.7wt% CaCO$_{3}$와 0.3% wt% SiO$_{2}$를 첨가하여 하소시킨 다음 $Na_{2}$SiO$_{3}$의 량을 변화시키면서 복합첨가하였다. 한편, 위의 시료(기본첨가제와 0.5wt% $Na_{2}$SiO$_{3}$)에 Cr$_{2}$O$_{3}$ 및 $Al_{2}$O$_{3}$를 단독 및 복합첨가한 결과, 0.5wt% $Al_{2}$O$_{3}$가 단독첨가되었을 경우, 좋은 자기특성을 나타내었다. 본 연구에서 시행한 복합첨가방식에 의한 Sr.페라이트의 자기특성의 조사를 통하여 등방성의 경우, 기본조성과 기본첨가제와 0.5wt% $Na_{2}$SiO$_{3}$와 0.5wt% $Al_{2}$O$_{3}$조성에서 (BH)$_{max}$=1.15MGOe, 그리고 이방성의 경우, (BH)$_{max}$=3.23MGOe를 얻었으며 시료를 이방성화하므로서 자기특성면에서 등방성인 경우의 2~3배의 개선효과를 얻었다. 그리고 소결온도는 1210.deg.C에서 가장 좋은 특성을 나타내었으며 큐리온도는 등방성의 경우 T$_{c}$=410~420.deg.C에서 이방성의 경우 T$_{c}$=439~445.deg.C로서 약 30.deg.C가 향상되었다.

• 한국환경성돌연변이발암원학회지
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• 제21권1호
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• pp.1-8
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• 2001

We have synthesized $^{99m}$Tc-mercaptoacetyltriglycine (MAG3)-biocytin as a new imaging agent for hepatobiliary scintigraphy. The aim of this study was to evaluate the usefulness of $^{99m}$Tc-MAG3-biocytin scintigraphy in differentiating carbon tetrachloride ( $CCl_4$)-induced hepatotoxicity from $\alpha$-naphthylisothiocyanate (ANIT)-induced cholestasis in mice, which reflecting the differential diagnosis of neonatal jaundice caused by neonatal hepatitis from congenital biliary atresia in humans. Methods: Balb/c mice (female, 20 g, n=4-6) were pretreated with $CCl_4$(0.5 or $1.0m\ell$/kg) and ANIT ($150 or 300 m\ell$/kg) 18 h before scintigraphy. Biochemical and histopathological examinations showed a pattern of typical acute hepatitis (increase of transaminases and hepatocellular necnsis) in $CCl_4$-treated mice and cholestasis (increase of alkaline phosphatase and ${\gamma}$-glutamyltransferase, and biliary hyperplasia) in ANIT-treated mice, respectively, Mice were fasted at least 4 hr prior to the intravenous injection of $^{99m}$Tc-MAG3-biocytin (18.5 MBq/20$\mu\textrm{g}$) in 2% human serum albumin in saline. Scintigraphy was performed with a ${\gamma}$-camera equipped with a 1-mm diameter pin-hole collimator for 30 min and images were acquired every 15 s. We compared the values of physical parameters, such as peak liver/heart ratio ($${\gamma}$_{max}$) and peak ratio time ($t_{max}$) far $^{99m}$Tc-MAG3-biocytin scintigraphy. Results: Scintigraphic parameters of the $CCl_4$-pretreated (0.5 $m\ell$/kg) group showed a 81.9% decrease of r$_{max}$, and 42.2% decrease of $t_{max}$, whereas the ANIT-pretreated ( $150m\ell$/kg) group showed a 53% decrease of $r_{max}$, and 2.36-fold increase of $t_{max}$, (P<0.05). These results demonstrate that the decrease of $r_{max}$ and the shortening of $t_{max}$ are characteristic features for hepatotoxicity, in contrast to the increase of $t_{max}$ and decrease of $r_{max}$ for biliary hyperplasia. Conclusion: $^{99m}$Tc-MAG3-biocytin hepatobiliary scintigraphy can distinguish hepatitis from cholestasis in mice model and may be similarly useful in humans which differentiating the cause of neonatal jaundice in clinical study.cal study.cal study.cal study.

• 대한환경공학회지
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• 제29권7호
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• pp.839-845
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• 2007

용해성 glucose를 기질로 하여 혐기성 산발효조에서 동역학정수에 대한 온도의존성을 검토하였다. 온도범위는 $15^{\circ}C$에서 $30^{\circ}C$이며, 포화정수$(K_s\upsilon)$와 증식수율(Y)은 온도의 상승에 따라 감소하였지만, 최대비기질소비속도$(\upsilon_{max})$는 증가하였다. 기질소비속도와 균체 증식속도의 온도보정인자$(Q_{10})$ 값은 각각 1.3에서 2.2, 1.5에서 2.2의 범위를 보였다. 최대비기질소비속도$(\upsilon_{max})$가 증식수율(Y) 보다 온도의 변화에 대하여 더 민감하였다. $20^{\circ}C$에서 $30^{\circ}C$까지의 온도영역에서 체류시간과 기질농도의 관계에 대한 시물레이션 모델은 $1/SRT={(6.53){\cdot}(1.038)^{T-20}{\cdot}(S/X)}/{(1.38){\cdot}(0.983)^{T-20}+(S/X)}$이다.

• 약학회지
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• 제37권3호
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• pp.235-242
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• 1993

8-Fluorociprofloxacin(8-FCP) is an investigational quinolone derivative that is substituted with fluorine at the C-8 position of ciprofloxacin(CP). It was found that the in vitro activity of 8-FCP against Gram(+) bacteria was more potent that of CP, but the opposite against Gram(-) bacteria was true. However, 8-FCP showed better in vivo efficacy than CP against representative Gram(-) organisms, E. coli and K pneumoniae. In an attempt to seek for factors causing this discrepancy in the antibacterial activities, a comparative pharmacokinetic study of 8-FCP and CP was conducted in mice and rats treated either intravenously or orally at a single dose of 30 mg/kg. The pharmacokinetic parameters in mice were as follows; the mean peak serum concentrations(C$_{max}$) following i.v. and oral doses were 12.4 and 5.3 $\mu\textrm{g}$/ml for 8-FCP, and 9.5 and 2.5 $\mu\textrm{g}$/ml for CP, respectively. The terminal half-life(t$_{1/2\beta}$) was 72.9 min for 8-FCP, and 98.2 min for CP, and the oral bioavailability(F) was 89.9% for 8-FCP, and 50.5% for CP. In rats, the mean ($\pm$SD) $C_{max}$ after i.v. administration were 11.6$\pm$1.6 $\mu\textrm{g}$/ml for 8-FCP, and 10.2$\pm$1.3 $\mu\textrm{g}$/ml for CP, whereas oral administration produced $C_{max}$ of 5.9$\pm$1.8 $\mu\textrm{g}$/ml for 8-FCP and 1.1$\pm$0.9 $\mu\textrm{g}$/ml for CP, respectively. The t$_{1/2\beta}$ was 67.9$\pm$8.4 min for 8-FCP, and 76.4$\pm$7.2 min for CP. The F was 88.6$\pm$6.3% for 8-FCP, and 40.7$\pm$6.5% for CP. Marked differences were observed between the two quinolones in the $C_{max}$ and the area under the concentration-time curve obtained after oral administration in mice and rats. The extent of 8-FCP absorption in both mice and rats was approximately 2-fold higher than that of CP, suggesting that the fluorine atom attached to C-8 plays an important role in facilitating oral absorption from the gastrointestinal tract.

• 한국안전학회지
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• 제17권1호
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• pp.18-24
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• 2002

This study verified the relationship between fracture mechanics parameters(${\Delta}K,\;K_{max}$) and X-ray parameters ($(\sigma}_r,;B$) for G365 steel at elevated temperature up to $300{\circ}C$. The fatigue crack propagation test were carried out and X-ray diffraction technique according to crack length direction was applied to fatigue fractured surface. The residual stress on the fracture surface was found to increase in low ${\Delta}K$ region, reach to a maximum value at a certain value of $K_{max}$ or ${\Delta}K$ and then decrease. Residual stress was independent on stress ratio by arrangement of ${\Delta}K$ and half value breadth was independent by the arrangement of $K_{max}$. The equation of ${\sigma}_r-{\Delta}K$ was established by the experimental data. Therefore, fracture mechanics parameters could be estimated by the measurement of X-ray parameters.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 B
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• pp.976-978
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• 1999

Recently PWM invertor is broadly used for control of induction motor. The invertor is able to generate sin wave current from high speed switching power device such as IGBT. However the invertor is disturbed by dead time inevitably needed to prevent a short of the DC link voltage, and the dead time mainly causes distortions of the output current. In this Paper the dead time compensation method which corrects the voltage error from dead time, and Min Max algorithm enlarging the operating voltage of PWM were Proposed. This method can be implemented by software programming without any additional hardware circuit. The proposed algorithms were implemented by DSP(TMS320C31, 40MHz) and FPGA(QL2007, Quick Logic) described in VHDL. and applied to 3 phase induction motor(2.2 KW) to show the superior performance

• Advances in Traditional Medicine
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• 제4권4호
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• pp.227-234
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• 2004

An ${\alpha}-Amylase$ was purified to apparent homogeneity from germinating soybean seeds (Glycine max). Enzyme showed high specificity for starch. ${\alpha}-Amylase$ from soybean has optimum pH at 7.6 in the pH range 4.0-10.6. At this pH, the $K_m$ of starch was 2.63 mg/ml and the $V_{max}$ was equal to 52.6 mg/ml/min protein. Optimum temperature of the enzyme was found to be $55^{\circ}C,\;Q_{10}$ equal to 1.85 and energy of activation equal to 12 kcal/mol. Additives like, EDTA reduced the activity of ${\alpha}-amylase$ whereas PMSF enhanced the activity. ${\alpha}-Amylase$ was inhibited by several heavy metal ions.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 춘계학술대회
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• pp.161-163
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• 1996

The correlation coefficients among hepatic extraction fraction(HEF), DISIDA-K, and ICG Rmax methods were found using two normal rabbits and four rabbits with damaged liver. The correlation coefficient between HEF and ICG R-max which is a standard technique in evaluating liver function was found to be 0.93. Therefore HEF is a valuable diagnostic method since it is not only accurate, but possible to estimate remaining liver function after surgical of cancerous hepatic tissue.

• 한국재료학회지
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• 제28권9호
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• pp.489-494
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• 2018

Lead free $(1-x)(0.675BiFeO_3-0.325BaTiO_3)-xLiTaO_3$ (BFBTLT, x = 0, 0.01, 0.02, and 0.03, with 0.6 mol% $MnO_2$ and 0.4 mol% CuO) were prepared by a solid state reaction method, followed by air quenching and their crystalline phase, morphology, dielectric, ferroelectric and piezoelectric properties were explored. An X-ray diffraction study indicates that lithium (Li) and tantalum (Ta) were fully incorporated in the BFBT materials with the absence of any secondary phases. Dense ceramic samples (> 92 %) with a wide range of grain sizes from $3.70{\mu}m$ to $1.82{\mu}m$ were obtained in the selected compositions ($0{\leq}x{\leq}0.03$) of BFBTLT system. The maximum temperatures ($T_{max}$) were mostly higher than $420^{\circ}C$ in the studied composition range. The maximum values of maximum polarization ($P_{max}{\approx}31.01{\mu}C/cm^2$), remnant polarization ($P_{rem}{\approx}22.82{\mu}C/cm^2$) and static piezoelectric constant ($d_{33}{\approx}145pC/N$) were obtained at BFBT-0.01LT composition with 0.6 mol% $MnO_2$ and 0.4 mol% CuO. This study demonstrates that the high $T_{max}$ and $d_{33}$ for BFBTLT ceramics are favorable for industrial applications.

• 한국환경복원기술학회지
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• 제19권2호
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• pp.83-93
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• 2016

This study purposed to examine the water retention capacity of floor litter in deciduous forests. Water holding capacity(WHC) and interception storage capacity of Alnus hirsuta Turcz. ex Rupr., Quercus acutissima, Quercus mongolica litters were experimentally estimated. Physical characteristics of litters were also obtained to understand the relationships between water-retention capacity and litter characteristics. Experiments showed that WHC increases with specific volume of litter, varying 244.4% to 416.8% of its dry mass. Interception storage have estimated with rainfall simulation experiments. Maximum interception storage ($C_{max}$) and minimum interception storage ($C_{min}$) of litters were 220% and 138% of dry mass in Alnus hirsuta Turcz. ex Rupr., 218% and 137% in Quercus acutissima, and 240% and 156% in Quercus mongolica. Both $C_{max}$ and $C_{min}$ increased linearly with litter mass, and the values of $C_{min}$ in broadleaf litters have also linear relation to leaf area.