• Title/Summary/Keyword: $CBr_4$

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Sex Ratio at Birth and Son Preference in China (중국의 출산시 성비와 남아선호)

  • Gu, Baochang;Li, Yongping
    • Korea journal of population studies
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    • v.17 no.2
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    • pp.116-135
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    • 1994
  • China's population and family planning program has heen successful. Women's fertility as measured by total fertility rate (TFR) has declined from 5.8 in 1970 to 2.3 in 1990, accordingly the annual crude birth rate(CBR) has declined from 34 per thousand in 1970 to 21 per thousand in 1989, and the annual natural growth rate from 2.6 percent in 1970 to 1.4 percent in 1989 (Coale and Chen, 1987; SSB, 1991; Gu, 1994). While this is indeed an astonishing achievement for a developing country to have its fertility down to replacement within a short period, some new issues emerging along with the rapid fertility decline require careful considerations. One of them is the uprising of the sex ratio at birth in China. The 1990 population census reported the sex ratio at birth in China of 113.8 in 1989, which is ohviously much higher than the acceptable level of normal ratio around 106. It has received since then a lot of tention in China and abroad, among demographic professionals and governmental agencies alike (Hull, 1990; Johansson and Nygren, 1991; Xuand Guo, 1991; Tu, 1993; Gu and Xu, 1994; among others). Based on the available demographic data and research results this paper will first have a review of the patterns and trends of sex ratio at birth in China, then turn to the immediate causes of abnormal sex ratio at birth and the determinants of the son preference, followed with a conceptual framework for understanding of the phenomenon, and finally the policy implications and recommendations will be discussed.

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Prevalence and Risk Factors of Dementia in the Community Elderly (지역사회 노인 치매 유병율과 위험인자)

  • Park, Nam-Hee;Lee, Youn-Mee;E, Lu-Rie
    • Research in Community and Public Health Nursing
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    • v.19 no.1
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    • pp.36-45
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    • 2008
  • Purpose: This study was to estimate the prevalence of dementia in order to estimate the associations of dementia with its risk factors in the community elderly. Methods: The multistage random cluster sampling method was used to select the subjects. The response rate was 94.3%. For the 1st stage screening survey, the Korean-version Mini-Mental State Examination (K-MMSE) and the Bathel Index of activities of daily living (ADL) and instrumental activities of daily living (IADL) were used as primary screening tools. At the 2nd stage. diagnoses were confirmed according to the Clinical Dementia Rating Scale (CBR) and Computer Tomogram (CT). Results: Age-sex adjusted prevalence (%) [95% CI] of dementia was 6.25% [4.47-7.83] (male 4.21% [2.40-6.02]; female 8.28% [5.71-10.85]). Four statistically significant risk factors of the dementia were identified: age 70-74 (OR=1.367), age 75-79 (OR=1.712), age 80-84 (OR=2.465), age 85 over (OR=7.363) illiteracy (OR=3.827); unconsciousness after head injury (OR=3.383), and no exercise (OR=2.188). Hosmer and Lemeshow goodness-of-fit index of dementia risk model was E (legit of dementia)= -4.337+$0.312^*Age(70{\sim}74)+0.538^*Age(75{\sim}79)+0.902^*Age(80{\sim}84)+1.996^*Age$(85over)+$1.342^*$Illiteracy+$1.219^*$Unconsciousness after head trauma+$0.783^*$No exercise. We confirmed that the overall prevalence of dementia in adults aged 65 and older was 94.3%. The risk factors of dementia were explained by age, illiteracy unconsciousness after head trauma and no exercise. Conclusion: These data have been used to estimate the incidence of dementia in elderly community population and to manage the possible role of risk factors as predictors of dementia.

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Efficacy of Exemestane After Nonsteroidal Aromatase inhibitor Use in Metastatic Breast Cancer Patients

  • Kim, Sun-Hye;Park, In-Hae;Lee, Hye-Won;Lee, Keun-Seok;Nam, Byung-Ho;Ro, Jung-Sil
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.3
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    • pp.979-983
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    • 2012
  • Background : Previous studies have suggested a lack of complete cross-resistance between steroidal (exemestane) and non-steroidal aromatase inhibitors (nSAI). Methods : Eighty-eight metastatic breast cancer (MBC) patients who received 25 mg of exemestane orally once a day at the National Cancer Center, Korea, between 2003 and 2009, were reviewed retrospectively. All patients had received nSAI for metastatic disease prior to exemestane therapy. Results : The median age was 52 years (range, 33-79), and 13 (14.8%) patients were premenopausal who concomitantly received GnRH agonist. Exemestane was given as a second- (80.7%) or third-line (19.3%) hormone therapy. The clinical benefit (CB) rate (complete response + partial response + stable disease ${\geq}$ 24 weeks) was 30.7%, with a median CB duration of 10.0 months (range, 6.3-78.7). The median progression-free survival (PFS) was 3.0 months (95% confidence interval [CI], 1.99-4.01) and the overall survival (OS) 21.5 months (95% CI, 17.96-25.04), with a median followup of 50.3 months. Patients who achieved CB had longer OS than those patients who did not (29.6 vs 17.9 months; P=0.002). On univariate analysis of predictive factors, patients who had achieved CB from previous nSAI tended to show lower CB rate (24.6% vs 44.4%, respectively; P=0.063) and shorter PFS (2.8 vs 4.8 months, respectively; p=0.233) than patients who had not. Achieving CB from previous nSAI became independent predictive factor for CBR to exemestane on multivariable analysis (Odds ratio = 2.852, P = 0.040). Conclusions : Exemestane after nSAI failure was effective in prolonging CB duration. The drug's efficacy seemed to be inferior in patients who had benefit from previous nSAI use.

Crystal Structures and Magnetic Properties of Sparteinium Tetrahalocuprate Monohydrate Compounds

  • Lee, Yong-Min;Park, Sung-Min;Kang, Sung-Kwon;Kim, Young-Inn;Choi, Sung-Nak
    • Bulletin of the Korean Chemical Society
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    • v.25 no.6
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    • pp.823-828
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    • 2004
  • The crystal structures of sparteinium tetrachlorocuprate monohydrate $[(C_{15}H_{28}N_2)CuCl_4{\cdot}H_2O]$, 1 and sparteinium tetrabromocuprate monohydrate $[(C_{15}H_{28}N_2)CBr_4{\cdot}H_2O]$, 2, were determined. The structures of 1 [orthorhombic, $P2_12_12_1$, a = 8.3080(10) ${\AA}$, b = 14.6797(19) ${\AA}$ and c = 16.4731(17) ${\AA}$], and 2 [orthorhombic, $P2_12_12_1$, a = 8.4769(7) ${\AA}$, b = 15.166(3) ${\AA}$ and c = 16.679(3) ${\AA}$], are composed of a doubly protonated sparteinium cation, $[C_{15}H_{28}N_2]^{2+}$, a discrete $CuX_4^{2-}$ anion $(X=Cl^-\;or\;Br^-)$, and one water molecule. These monomeric compounds are stabilized through various types of hydrogen bonding interaction in their packing structures. Crystal 2 exhibits weak anti-ferromagnetism (J = -3.24 $cm^{-1}$) as opposed to the magnetically isolated paramagnetism observed for 1. The results of comparative magneto-structural investigations of 1 and 2 suggest that the pathway for the weak anti-ferromagnetic super-exchange in 2 might be through a Cu-Br${\cdots}$Br-Cu contact.

Crossed Cerebellar Diaschisis : Comparison of SPECT, MRI, and Clinical Sign (교차소뇌해리현상 : SPECT와 MRI 소견의 비교와 임상징후)

  • Sohn, Hyung Sun;Kim, Euy Neyng;Shin, Kwang Hyun;Rha, Hyung Kyun;Choi, Chang Rack
    • Journal of Korean Neurosurgical Society
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    • v.29 no.6
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    • pp.794-799
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    • 2000
  • Objectives : The purpose of our study was to compare findings of brain SPECT representing crossed cerebellar diaschisis(CCD) with brain MRI, to evaluate relation between CCD and location of lesions on MRI and to elucidate clinically apparent cerebellar sign in patients with CCD. Methods : The study population was 20 patients representing CCD on SPECT. Percentage differences(${\triangle}%$) of activity on each cerebellar hemisphere were obtained from ipsilateral and contralateral cerebellum[${\triangle}%cbll=(IL-CL)/IL{\times}100$] and from cerebrum [${\triangle}%cbr=(CL-IL)/CL{\times}100$]. From MR studies, the percentage differences of signal intensity were also calculated as the same method. We compared the degree of percentage differences with location of cerebral lesions and with clinical cerebellar signs of the patients. Results : Among those representing CCD, the parietal lesions were the most common. There was significant correlation of the percentage differences in cerebellum between SPECT($18.8{\pm}7.22$) and MRI($4.4{\pm}3.38$) (p<0.05) and in cerebrum between SPECT($28.7{\pm}15.35$) and MRI($42.8{\pm}10.94$) (p<0.05). Cerebellar signs were observed in 3 of the 20 patients. However, there was no statistically significance between degree of percentage differences of each cerebellar hemisphere on SPECT and clinical cerebellar sign(p>0.05). Conclusion : Using the percentage differences in the cerebellum, the CCD evaluation can be easily done. On MRI, the signal changes of cerebellum were not as definite as SPECT. Despite of our assumption, there was no significant correlation between clinical cerebellar signs and CCD on SPECT.

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Ontology Design of Semantic Case Based Reasoning System for the Share and Exchange of Sub-Cases (세부사례의 공유 및 교환을 위한 시맨틱 사례기반추론 시스템 온톨로지의 설계)

  • Park, Sangun;Kang, Juyoung
    • The Journal of Society for e-Business Studies
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    • v.18 no.4
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    • pp.195-214
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    • 2013
  • Case-based reasoning is a methodology for solving problems more quickly and efficiently by bringing the most similar case of a given problem from past cases and transforming it to fit the current situation. The most important performance indicator of case-based reasoning is the number of cases, so it is difficult to apply the methodology for the area which has not enough cases. In this paper, we proposed a method to exchange cases based on the Semantic Web in order to overcome the problems. Inparticular, we separated cases into sub-cases to make it possible creating new cases by combining the appropriate sub-cases even if there was no proper full case. In order to achieve that, we designed an ontology that connects a case and its sub-cases, represents detailed similarity rules that compare sub-cases, and represents the rules for the combination of sub-cases. Moreover, we designed and implemented a semantic distributed case-based reasoning framework where a case requester can request sub-cases via the Web from case providers and integrates sub-cases into a new case by using the ontology.

Decision Making Model using Multiple Matrix Analysis for Optimum Construction Method Selection (다중 매트릭스 분석 기법을 이용한 최적 건축공법 선정 의사결정지원 모델)

  • Lee, Jong-Sik;Lim, Myung-Kwan
    • Journal of the Korea Institute of Building Construction
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    • v.16 no.4
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    • pp.331-339
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    • 2016
  • According to high-rise, complexation, and enlargement of buildings, various construction methods are being developed, and the significance of construction method selection about main work types has emerged as a major interest. However, it has been pointed out that hand-on workers cannot consider project characteristics carefully, and they lack an objective standard or reference for main construction method selection. Hence, the selection is being made depending on hand-on workers' experience and intuition. To solve this problem, various studies have proceeded for construction method selection of main work types using Artificial Intelligence like Fuzzy, AHP and Case-based reasoning. It is difficult to apply many different kinds of construction method selection to every main work type with consideration for characteristics of work types and condition of a construction site when selecting construction method in the field. Accordingly, this study proposed the decision-making model which can apply to fields easily. Using matrix analysis and liner transformation, this study verified consistency of study models applied in the process of soil retaining selection with a case study.

Analysis of the Disaster Sites using Power-assisted Devices for Rescue (인명구조용 근력지원장치의 적용가능한 재난현장 분석)

  • Lee, Minsu;Park, Chan;Kim, Jingi;Lee, Dongeun
    • Journal of the Society of Disaster Information
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    • v.12 no.3
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    • pp.273-278
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    • 2016
  • In this study, we set the need, purpose, and the direction of developments in life-saving devices and analyzed the disaster sites where power-assisted devices are to be applied. For this purpose, we classified the disaster in accordance with the Basic Law for on Disaster and Safety Management and analyzed the common disaster sites where power-assisted devices are available. As a result, 13 disaster sites were classified into three categories. Firstly, 8 sites of social disaster accidents, fire(suppression), fire(rescue), collapse, traffic accidents, explosion, CBR(chemical, biological, and radiological), environment pollution, and other safety accidents, were defined. Secondly, 4 disaster accidents, earthquake, flood, typhoon and other natural disasters, were classified. Finally, other disaster sites were taken into account.

The Effects of Community-Based Rehabilitation(CBR) on the Elderly with Mild Cognitive Impairment(MCI): A Systematic Review and Meta Analysis (경도인지장애가 있는 노인의 지역사회기반 재활의 효과: 체계적 고찰 및 메타분석)

  • Kim, EunJoo;Park, YoungJu
    • The Journal of the Korea Contents Association
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    • v.19 no.7
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    • pp.628-637
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    • 2019
  • The purpose of this study was to investigate the systematic review and meta analysis the effect of community based rehabilitation on elderly people with mild cognitive impairment by ICF factors. This study used PubMed MEDLINE, Cochrane CENTRAL database from January 2009 to January 2019. As a result, a total of 5 studies were selected. The ICF factor effect size of the community based rehabilitation was 4.77 for physical function and structure, and 6.17 for activity and participation. The results of this study showed that the effect of community based rehabilitation of the elderly with mild cognitive impairment is effective on physical function, structure, activities and participation.

A Study on the Prediction Model of Stock Price Index Trend based on GA-MSVM that Simultaneously Optimizes Feature and Instance Selection (입력변수 및 학습사례 선정을 동시에 최적화하는 GA-MSVM 기반 주가지수 추세 예측 모형에 관한 연구)

  • Lee, Jong-sik;Ahn, Hyunchul
    • Journal of Intelligence and Information Systems
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    • v.23 no.4
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    • pp.147-168
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    • 2017
  • There have been many studies on accurate stock market forecasting in academia for a long time, and now there are also various forecasting models using various techniques. Recently, many attempts have been made to predict the stock index using various machine learning methods including Deep Learning. Although the fundamental analysis and the technical analysis method are used for the analysis of the traditional stock investment transaction, the technical analysis method is more useful for the application of the short-term transaction prediction or statistical and mathematical techniques. Most of the studies that have been conducted using these technical indicators have studied the model of predicting stock prices by binary classification - rising or falling - of stock market fluctuations in the future market (usually next trading day). However, it is also true that this binary classification has many unfavorable aspects in predicting trends, identifying trading signals, or signaling portfolio rebalancing. In this study, we try to predict the stock index by expanding the stock index trend (upward trend, boxed, downward trend) to the multiple classification system in the existing binary index method. In order to solve this multi-classification problem, a technique such as Multinomial Logistic Regression Analysis (MLOGIT), Multiple Discriminant Analysis (MDA) or Artificial Neural Networks (ANN) we propose an optimization model using Genetic Algorithm as a wrapper for improving the performance of this model using Multi-classification Support Vector Machines (MSVM), which has proved to be superior in prediction performance. In particular, the proposed model named GA-MSVM is designed to maximize model performance by optimizing not only the kernel function parameters of MSVM, but also the optimal selection of input variables (feature selection) as well as instance selection. In order to verify the performance of the proposed model, we applied the proposed method to the real data. The results show that the proposed method is more effective than the conventional multivariate SVM, which has been known to show the best prediction performance up to now, as well as existing artificial intelligence / data mining techniques such as MDA, MLOGIT, CBR, and it is confirmed that the prediction performance is better than this. Especially, it has been confirmed that the 'instance selection' plays a very important role in predicting the stock index trend, and it is confirmed that the improvement effect of the model is more important than other factors. To verify the usefulness of GA-MSVM, we applied it to Korea's real KOSPI200 stock index trend forecast. Our research is primarily aimed at predicting trend segments to capture signal acquisition or short-term trend transition points. The experimental data set includes technical indicators such as the price and volatility index (2004 ~ 2017) and macroeconomic data (interest rate, exchange rate, S&P 500, etc.) of KOSPI200 stock index in Korea. Using a variety of statistical methods including one-way ANOVA and stepwise MDA, 15 indicators were selected as candidate independent variables. The dependent variable, trend classification, was classified into three states: 1 (upward trend), 0 (boxed), and -1 (downward trend). 70% of the total data for each class was used for training and the remaining 30% was used for verifying. To verify the performance of the proposed model, several comparative model experiments such as MDA, MLOGIT, CBR, ANN and MSVM were conducted. MSVM has adopted the One-Against-One (OAO) approach, which is known as the most accurate approach among the various MSVM approaches. Although there are some limitations, the final experimental results demonstrate that the proposed model, GA-MSVM, performs at a significantly higher level than all comparative models.