• EDISON SW 활용 경진대회 논문집
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• 제3회(2014년)
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• pp.237-249
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• 2014

Deposition of amyloid-${\beta}$ ($A{\beta}$) proteins is the conventional pathological hallmark of Alzheimer's disease (AD). The $A{\beta}$ protein formed from the amyloid precursor protein is predominated by the 40 residue protein ($A{\beta}40$) and by the 42 residue protein ($A{\beta}42$). While $A{\beta}40$ and $A{\beta}42$ differ in only two amino acid residues at the C-terminal end, $A{\beta}42$ is much more prone to aggregate and exhibits more neurotoxicity than $A{\beta}40$. Here, we investigate the molecular origin of the difference in the aggregation propensity of these two proteins by performing fully atomistic, explicit-water molecular dynamics simulations. Then, it is followed by the solvation thermodynamic analysis based on the integral-equation theory of liquids. We find that $A{\beta}42$ displays higher tendency to adopt ${\beta}$-sheet conformations than $A{\beta}40$, which would consequently facilitate the conversion to the ${\beta}$-sheet rich fibril structure. Furthermore, the solvation thermodynamic analysis on the simulated protein conformations indicates that $A{\beta}42$ is more hydrophobic than $A{\beta}40$, implying that the surrounding water imparts a larger thermodynamic driving force for the self-assembly of $A{\beta}42$. Taken together, our results provide structural and thermodynamic grounds on why $A{\beta}42$ is more aggregation-prone than $A{\beta}40$ in aqueous environments.

• 생물환경조절학회지
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• 제4권2호
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• pp.131-135
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• 1995

겨울철 대부분의 시설재배 채소는 야간 온도가 떨어지기 매문에 많은 열 에너지를 공급함으로써 야온을 높여 생장시키기 때문에 에너지 손실이 많다. 본 실험은 수박의 경제적 출하를 목적으로 야온에 대한 생장 효과를 조사하였다. 낮의 온도를 $25^{\circ}C$와 3$0^{\circ}C$로 하고 야간의 온도는 2$0^{\circ}C$에서 3$0^{\circ}C$로 5$^{\circ}C$ 간격을 두고 처리하였다. 두 품종 수박(빛나, 감로) 모두 30/3$0^{\circ}C$ 처리에서 엽면적, 개화수 및 엽수가 가장 많았다. 30(14h)/25(10h) $^{\circ}C$과 30(12h)/25(12h) $^{\circ}C$ 처리구에서는 발아율 및 건중과 엽록소의 함량이 야온을 높인 30/3$0^{\circ}C$ 처리구 보다 높은 경향을 보였다. 25/$25^{\circ}C$와 30/2$0^{\circ}C$는 평균 온도가 같을지라도 수박의 생장에 있어서는 30/2$0^{\circ}C$ 처리구가 25/$25^{\circ}C$에 비하여 생장이 우수하였다. 빛나는 동일 조건에서 감로보다 생장이 우수하였다. 건중 엽면적율은 30/3$0^{\circ}C$와 30/2$0^{\circ}C$ 사이의 온도에서 DIF가 증가함에 따라 감소되었으나, 건중 엽중율은 증가되었다. 시설내 야온을 적절히 낮추어 재배하는 방법이 겨울철 에너지 소모 방지와 수박의 생장에 도움을 줄 것으로 기대된다.

• KIEE International Transaction on Systems and Control
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• 제2D권2호
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• pp.78-91
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• 2002

In the thermal power plant, there are six manipulated variables: main steam flow, feedwater flow, fuel flow, air flow, spray flow, and gas recirculation flow. There are five controlled variables: generator output, main steam pressure, main steam temperature, exhaust gas density, and reheater steam temperature. Therefore, the thermal power plant control system is a multinput and output system. In the control system, the main steam temperature is typically regulated by the fuel flow rate and the spray flow rate, and the reheater steam temperature is regulated by the gas recirculation flow rate. However, strict control of the steam temperature must be maintained to avoid thermal stress. Maintaining the steam temperature can be difficult due to heating value variation to the fuel source, time delay changes in the main steam temperature versus changes in fuel flow rate, difficulty of control of the main steam temperature control and the reheater steam temperature control system owing to the dynamic response characteristics of changes in steam temperature and the reheater steam temperature, and the fluctuation of inner fluid water and steam flow rates during the load-following operation. Up to the present time, the Proportional-Integral-Derivative Controller has been used to operate this system. However, it is very difficult to achieve an optimal PID gain with no experience, since the gain of the PID controller has to be manually tuned by trial and error. This paper focuses on the characteristic comparison of the PID controller and the modified 2-DOF PID Controller (Two-Degrees-Freedom Proportional-Integral-Derivative) on the DCS (Distributed Control System). The method is to design an optimal controller that can be operated on the thermal generating plant in Seoul, Korea. The modified 2-DOF PID controller is designed to enable parameters to fit into the thermal plant during disturbances. To attain an optimal control method, transfer function and operating data from start-up, running, and stop procedures of the thermal plant have been acquired. Through this research, the stable range of a 2-DOF parameter for only this system could be found for the start-up procedure and this parameter could be used for the tuning problem. Also, this paper addressed whether an intelligent tuning method based on immune network algorithms can be used effectively in tuning these controllers.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2009년도 제38회 동계학술대회 초록집
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• pp.74-74
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• 2010

One-dimensional nanosturctures such as nanowires and nanotube have been mainly proposed as important components of nano-electronic devices and are expected to play an integral part in design and construction of these devices. Silicon carbide(SiC) is one of a promising wide bandgap semiconductor that exhibits extraordinary properties, such as higher thermal conductivity, mechanical and chemical stability than silicon. Therefore, the synthesis of SiC-based nanowires(NWs) open a possibility for developing a potential application in nano-electronic devices which have to work under harsh environment. In this study, one-dimensional nanowires(NWs) of cubic phase silicon carbide($\beta$-SiC) were efficiently produced by thermal chemical vapor deposition(T-CVD) synthesis of mixtures containing Si powders and hydrocarbon in a alumina boat about $T\;=\;1400^{\circ}C$ SEM images are shown that the temperature below $1300^{\circ}C$ is not enough to synthesis the SiC NWs due to insufficient thermal energy for melting of Si Powder and decomposition of methane gas. However, the SiC NWs are produced over $1300^{\circ}C$ and the most efficient temperature for growth of SiC NWs is about $1400^{\circ}C$ with an average diameter range between 50 ~ 150 nm. Raman spectra revealed the crystal form of the synthesized SiC NWs is a cubic phase. Two distinct peaks at 795 and $970\;cm^{-1}$ over $1400^{\circ}C$ represent the TO and LO mode of the bulk $\beta$-SiC, respectively. In XRD spectra, this result was also verified with the strongest (111) peaks at $2{\theta}=35.7^{\circ}$, which is very close to (111) plane peak position of 3C-SiC over $1400 ^{\circ}C$ TEM images are represented to two typical $\beta$-SiC NWs structures. One is shown the defect-free $\beta$-SiC nanowire with a (111) interplane distance with 0.25 nm, and the other is the stacking-faulted $\beta$-SiC nanowire. Two SiC nanowires are covered with $SiO_2$ layer with a thickness of less 2 nm. Moreover, by changing the flow rate of methane gas, the 300 sccm is the optimal condition for synthesis of a large amount of $\beta$-SiC NWs.

• Journal of Positioning, Navigation, and Timing
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• 제2권1호
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• pp.75-80
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• 2013

This article presents the design of long range navigation (LORAN)-disciplined oscillator (LDO), employing the timing information of the LORAN system, which was developed as a backup system that corrects the vulnerability of the global positioning system (GPS)-based timing information utilization. The LDO designed on the basis of hardware generates a timing source synchronized with reference to the timing information of the LORAN-C receiver. As for the LDO-based timing information measurement, the Kalman filter was applied to estimate the measurement of which variance was minimized so that the stability performance could be improved. The oven-controlled crystal oscillator (OCXO) was employed as the local oscillator of the LDO. The controller was operated by digital proportional-integral-derivative (PID) controlling method. The LDO performance evaluation environment that takes into account the additional secondary factor (ASF) of the LORAN signals allows for the relative ASF observation and data collection using the coordinated universal time (UTC). The collected observation data are used to analyze the effect of ASF on propagation delay. The LDO stability performance was presented by the results of the LDO frequency measurements from which the ASF was excluded.

• Computers and Concrete
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• 제25권6호
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• pp.551-563
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• 2020

This paper investigates the artificial neural network (ANN) to predict the dimensionless parameters for the maximum contact pressures and contact areas of a contact problem. Firstly, the problem is formulated and solved theoretically by using Theory of Elasticity and Integral Transform Technique. Secondly, the contact problem has been extended based on the ANN. The multilayer perceptron (MLP) with three-layer was used to calculate the contact distances. External load, distance between the two quarter planes, layer heights and material properties were created by giving examples of different values were used at the training and test stages of ANN. Program code was rewritten in C++. Different types of network structures were used in the training process. The accuracy of the trained neural networks for the case was tested using 173 new data which were generated via theoretical solutions so as to determine the best network model. As a result, minimum deviation value (difference between theoretical and C++ ANN results) of was obtained for the network model. Theoretical results were compared with artificial neural network results and well agreements between them were achieved.

• 한국추진공학회지
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• 제5권2호
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• pp.24-31
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• 2001

본 연구에서 축류형 터빈의 설계기술이 개발되었다. 설계를 위하여 우선적으로 기본형상에 대한 설계가 이루어졌으며 유선곡률법에 의하여 터빈 내부유로에서의 공기 물성치를 계산하였다. 계산된 여러 유로에서의 유동각들을 고려하여 익형의 형상을 설계하기 위한 설계변수들이 설정되었다. 설정된 형상변수로부터 정익은 C4 형상을 사용하여 설계되었으며 동익은 설계변수에 의하여 설계되었다. 정익은 일체형으로 제작되었으며 동익은 입사각의 변경에 따른 실험을 수행하기 위하여 분리형으로 제작하였다. 터빈입구에서의 공기력과 RPM에 따라서 터빈에서의 출력이 얻어졌으며 실험의 결과는 제작된 터빈이 반동터빈임에도 불구하고 입사각이 줄어드는 것에 비례하여 출력이 감소하는 현상을 보여주었으며 설계값에서 입사각이 7.5도 감소함에 따라 5%의 효율 감소가 발생되었다.

• 농촌계획
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• 제2권1호
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• pp.57-68
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• 1996

Village Renewal(Dorferneuerung) Policy Program in Germany, directly originated from Rural Beutification Movement between mid 18C and mid 19C, has several characteristics as follows. First, we can find out the planned approach in land use and settlement reorganization of Pillage Renewal Program. There are three ways to designate the planning area of the village rearrangement project in countryside. One is to designate the detailed B-plan district by urban plan for the village over some size defined legally. Another is to have a living space of settlement be contained in land allotment project area. In this case, residential areas of several villages related to agricultural land consolidation should be simultaneously designated as the project area. The last is only for the built environment focused on the living space. Second, the emphasis in German village encouragement program can be made on the integral approach through which sets of policy programs of the land allotment, the living environment improvement, the physical landscape management and the cultural resources conservation are intensively implemented together. Third, the bottom-up and community participation approach can be greatly stressed on the planning and implementation process, Community participation, subsidy application to local government by residents themselves, community consensus on architectural style and outdoor spatial form, etc. have been recognized as an effective strategy to accomplish the task of village activity promotion.

• 한국가스학회지
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• 제1권1호
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• pp.120-126
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• 1997

저밀도 폴리에틸렌 (LDPE)과 $25\%{\~}48\%$의 함염소 폴리에틸렌(CPE)에 대한 열분해상태를 20ml/min의 질소기류와 $4^{\circ}C{\~}20^{\circ}C$/min의 여러 가지 가열율에서 열중량분석으로 검토하였다. 반응의 열분해 활성화에너지값을 얻기 위하여 수학적인 방법으로는 미분법(Friedman)과 적분법(Ozawa)법이 사용되었다. 위의 방법으로 평가된 활성화에너지는 각각이 잘 일치하였고, 최고평균 활성화에너지는 71.72kcal/mol로 계산되었다. LDPE와 CPE의 열분해는 주쇄분해반응이고 실제 열분해곡선은 이론식과 잘 일치하는 것으로 사료된다.

• Wind and Structures
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• 제24권2호
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• pp.185-204
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• 2017

High-resolution wind measurements at 2.25 m in height were used to investigate the mean and turbulence properties of an extreme thunderstorm wind event in West Texas. These data were combined with single Doppler scans from the Texas Tech University Ka-band mobile Doppler radars systems (TTUKa) to provide meteorological context over the surface measurement stations for portions of the outflow. Several features characteristic of a severe wind event were noted in the radar data, including a bowing portion of the thunderstorm complex and a small circulation on the leading edge. These features were reflected in the surface wind time histories and provided natural separation between various regions of the outflow. These features also contributed to the peak 1-s gust at all measurement stations. The turbulence characteristics of each outflow region were also investigated and compared. Reduced values of running turbulence intensity and elevated values of longitudinal integral scales were noted during the period of peak wind speed. Larger scales of turbulence within the outflow were also suggested via spectral analysis.