• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.2
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• pp.118-122
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• 2016

Integrin ${\alpha}_v{\beta}_3$ plays an important role in the tumor metastases and angiogenesis. Arginine-glycine-aspartate (RGD) peptide motif binds to the integrin ${\alpha}_v{\beta}_3$. General $^{68}Ga$-labeled cyclic RGD peptides was rapidly eliminated from the circulatory system by renal excretion because of its hydrophilic property. The purpose of this study was to develop a novel $^{68}Ga$-labeled cyclic RGD peptides, which could acquire enhanced PET tumor images with improved pharmacokinetics by adopting biphenyl group between chelator and RGD peptides. $^{68}Ga$-DOTA-2P-c(RGDyK) was demonstrated a 12% higher lipophilicity level than $^{68}Ga$-DOTA-c(RGDyK) as a reference compound. In the animal PET, $^{68}Ga$-DOTA-2P-c(RGDyK) represented relatively lower blood-clearance, and an increased signal to noise ratio compared to $^{68}Ga$-DOTA-c(RGDyK). From these perspective, $^{68}Ga$-DOTA-2P-c(RGDyK) could be a good candidate for in integrin ${\alpha}_v{\beta}_3$-expressed tumor imaging.

• ETRI Journal
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• v.31 no.6
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• pp.732-740
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• 2009

This paper describes the implementation of a digital audio effect system-on-a-chip (SoC), which integrates an embedded digital signal processor (DSP) core, audio codec intellectual property, a number of peripheral blocks, and various audio effect algorithms. The audio effect SoC is developed using a software and hardware co-design method. In the design of the SoC, the embedded DSP and some dedicated hardware blocks are developed as a hardware design, while the audio effect algorithms are realized using a software centric method. Most of the audio effect algorithms are implemented using a C code with primitive functions that run on the embedded DSP, while the equalization effect, which requires a large amount of computation, is implemented using a dedicated hardware block with high flexibility. For the optimized implementation of audio effects, we exploit the primitive functions of the embedded DSP compiler, which is a very efficient way to reduce the code size and computation. The audio effect SoC was fabricated using a 0.18 ${\mu}m$ CMOS process and evaluated successfully on a real-time test board.

• Journal of the Korea Institute of Military Science and Technology
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• v.25 no.2
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• pp.125-134
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• 2022

Recently, there are an increased the number of reports on the misuse or malicious use of an UAS. Thus, many researchers are studying on defense schemes for UAS by developing or improving C-UAS sensor technology. However, the wrong placement of sensors may lead to a defense failure since the proper placement of sensors is critical for UAS defense. In this study, a multi-object optimization model for C-UAS sensor placement in an air base is proposed. To address the issue, we define two objective functions: the intersection ratio of interested area and the minimum detection range and try to find the optimized placement of sensors that maximizes the two functions. C-UAS placement model is designed using a NSGA-II algorithm, and through experiments and analyses the possibility of its optimization is verified.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.06a
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• pp.16-16
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• 2009

ZnO($Zn_{1+x}O$)는 n-type 반도성 세라믹스로 우수한 전기적, 광학적, 화학적 특성을 갖고 있어 바리스터, 투명 전도막, 화학 및 바이오 센서, UV light emitter 등 다양한 용도로 사용되고 있다. 또한 ZnO에 각종 천이 금속 산화물을 일정량 첨가함에 따라 발생하는 결함준위와 입계 특성의 변화에 대한 연구가 활발히 진행되고 있다. 다양한 천이 금속 산화물의 첨가에 따른 전기적 광학적 특성의 변화에 대한 결과들이 많이 보고되고 있지만 서로 상충되거나 해석상 다소 어려운 것으로 알려져 있다. 따라서 본 연구에서는 ZnO에 $Cr_2O_3$를 2.0 at% 첨가하여 Cr 첨가에 따른 ZnO의 결함준위와 입계 특성 변화에 대하여 각종 유전함수($Z^*$, $Y^*$, $M^*$, $\varepsilon^*$, and $tan{\delta}$)를 이용하여 고찰하였다 ZnO에 Cr을 첨가할 경우 결함 중 장범위 쿨롱 인력에 의한 결함(0.13~0.18 eV)이 ~100K 영역에서 나타났으며, ZnO 내 결함 중 대표적인 $Zn_j$와 $V_o$는 서로 겹쳐서 나타났다. 이들 중첩된 결함에 대하여 각종 유전함수를 이용할 경우 서로 분리해 낼 수 있는 강점이 있음을 논하였다. 또한 각 결함준위가 강는 정전용랑(C)과 저항(R)을 impedance-modulus spectroscopy를 이용하여 구한 결과, 소결온도가 높아질수록 정전용량은 증가하였으며, 측정온도가 놓아질수록 높아지는 경향을 나타내었다. 입계의 정전용량은 소결온도가 높아질수록 높아 지지만 측정온도가 높아질수록 낮아지는 경향을 나타내었다. 각 저항값은 소결온도 및 측정온도가 높아질수록 지수적으로 감소하였다. 또한 분포함수를 이용하여 입계 안정성에 대하여 고찰하였다.

• Journal of Korea Foundry Society
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• v.33 no.2
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• pp.69-74
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• 2013

Silicon (Si) wafer was grown by using direct growth from Si melt and contaminations of wafer during the process were investigated. In our process, BN was coated inside of all graphite parts including crucible in system to prevent carbon contamination. In addition, coated BN layer enhance the wettability, which ensures the favorable shape of grown wafer by proper flow of Si melt in casting mold. As a result, polycrystalline silicon wafer with dimension of $156{\times}156$ mm and thickness of $300{\pm}20$ um was successively obtained. There were, however, severe contaminations such as BN and SiC on surface of the as-grown wafer. While BN powders were easily removed by brushing surface, SiC could not be eliminated. As a result of BN analysis, C source for SiC was from binder contained in BN slurry. Therefore, to eliminate those C sources, additional flushing process was carried out before Si was melted. By adding 3-times flushing processes, SiC was not detected on the surface of as-grown Si wafer. Polycrystalline Si wafer directly grown from Si melt in this study can be applied for the cost-effective Si solar cells.

• Molecules and Cells
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• v.45 no.6
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• pp.403-412
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• 2022

Hypoxia leads to significant cellular stress that has diverse pathological consequences such as cardiovascular diseases and cancers. MicroRNAs (miRNAs) are one of regulators of the adaptive pathway in hypoxia. We identified a hypoxia-induced miRNA, miR-34c, that was significantly upregulated in hypoxic human umbilical cord vein endothelial cells (HUVECs) and in murine blood vessels on day 3 of hindlimb ischemia (HLI). miR-34c directly inhibited BCL2 expression, acting as a toggle switch between apoptosis and autophagy in vitro and in vivo. BCL2 repression by miR-34c activated autophagy, which was evaluated by the expression of LC3-II. Overexpression of miR-34c inhibited apoptosis in HUVEC as well as in a murine model of HLI, and increased cell viability in HUVEC. Importantly, the number of viable cells in the blood vessels following HLI was increased by miR-34c overexpression. Collectively, our findings show that miR-34c plays a protective role in hypoxia, suggesting a novel therapeutic target for hypoxic and ischemic diseases in the blood vessels.

• Nuclear Engineering and Technology
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• v.42 no.2
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• pp.193-202
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• 2010

In order to study the cladding properties of zirconium after a loss-of-coolant accident (LOCA)-simulation oxidation and water quenching test, commercial Zircaloy-4 and two kinds of HANA claddings were oxidized at temperatures ranging from $900^{\circ}C$ to $1250^{\circ}C$ and exposed for 300 s, and then cooled to $700^{\circ}C$ before quenching. Microstructural observations were made to evaluate the matrix characteristics with the chemical compositions after the LOCA-simulation test. Ring compression testing was then performed to compare the ductile behaviour of the HANA and Zircaloy-4 claddings. An X-ray diffraction (XRD) analysis was carried out for temperatures ranging from room temperature to $1250^{\circ}C$ for the oxide layer to verify the oxide crystal structure at each oxidation temperature.

• ETRI Journal
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• v.31 no.6
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• pp.795-802
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• 2009

This paper presents the design of an advanced terrestrial digital multimedia broadcasting (AT-DMB) baseband receiver SoC. The AT-DMB baseband is incorporated into a hierarchical modulation scheme consisting of high priority (HP) and low priority (LP) stream decoders. The advantages of the hierarchical modulation scheme are backward compatibility and an enhanced data rate. The structure of the HP stream is the same as that of the conventional T-DMB system; therefore, a conventional T-DMB service is possible by decoding multimedia data in an HP stream. An enhanced data rate can be achieved by using both HP and LP streams. In this paper, we also discuss a time deinterleaver that can deinterleave data for a time duration of 384 ms or 768 ms. The interleaving time duration is chosen using the LP symbol mapping scheme. Furthermore, instead of a Viterbi decoder, a turbo decoder is adopted as an inner error correction system to mitigate the performance degradation due to a smaller symbol distance in a hierarchically modulated LP symbol. The AT-DMB baseband receiver SoC is fabricated using 0.13 ${\mu}m$ technology and shows successful operation with a 50 mW power dissipation.

• Proceedings of the Korea Information Processing Society Conference
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• 2024.05a
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• pp.216-217
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• 2024

최근 클라우드 컴퓨팅 인프라 및 소프트웨어의 지속적인 발전으로 인한 복잡성 증가로 인해 신속한 확장성과 유연성에 대한 요구가 증가하고 있다. 이에 클라우드 네이티브 환경과의 호환성뿐만 아니라 개발과 운영의 효율성을 높이고자 코드로 인프라를 정의하여 자동화된 환경을 구축해 주는 코드형 인프라(Infrastructure as Code, IaC) 기술이 주목받고 있으며, AWS CloudFormation 은 대표적인 솔루션 중 하나이다. 그러나 IaC 형태로 배포되는 템플릿에 취약성이 존재할 경우, 인스턴스가 실행되기 전까지 보안 취약점을 미리 발견하기 어려워 DevOps 사이클에서의 보안 이슈를 야기할 수 있다. 이에 본 논문은 CloudFormation 템플릿의 보안 취약성 스캔이 가능하다고 알려진 오픈 소스 도구의 효율성을 평가하기 위한 사례 연구를 수행한다. 분석 결과를 바탕으로, DevSecOps 달성을 위한 IaC 기반 환경에서 취약성 사전 탐지의 필요성과 세분화된 접근 방식을 제시하고자 한다.

• Elastomers and Composites
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• v.50 no.2
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• pp.126-131
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• 2015

$C_{60}$ nanowhiskers were synthesized from $C_{60}$ by liquid-liquid interfacial precipitation (LLIP) using $C_{60}$-saturated toluene and isopropyl alcohol. The $WO_3$ nanoparticles were synthesized by adding $3.8{\times}10^{-4}$ mole amount of ammonium metatungstate hydrate ($H_{26}N_6O_{40}W_{12}{\cdot}H_2O$) to 500 ml of distilled water, and the resulting solution was heated on a hot plate for 4 h. The $C_{60}$ nanowhiskers/$WO_3$ nanocomposites were prepared with $C_{60}$ nanowhiskers and $WO_3$ nanoparticles in an electric furnace at $700^{\circ}C$ in an argon gas atmosphere for 2 h. The $C_{60}$ nanowhiskers/$WO_3$ nanocomposites were characterized by X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. UV-vis spectroscopy was used to evaluate the performance of the $C_{60}$ nanowhiskers/$WO_3$ nanocomposites as a photocatalyst in the degradation of organic dyes, such as methylene blue (MB) and brilliant green (BG) under ultraviolet light (254 nm).