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The Immunological Effect of Mistletoe Extract on Gastric Cancer Patients (미슬토 추출물(Mistletoe Extract)이 위암환자의 수술 후 면역기능에 미치는 효과)

  • Yang, Sung-Woo;Shin, Dong-Gue;Kim, Il-Myung;Yoon, Seong-Min;Lee, Yong-Jik;Heo, Su-Hak;Kim, Tae-Hee
    • Journal of Gastric Cancer
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    • v.7 no.3
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    • pp.167-173
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    • 2007
  • Purpose: Mistletoe (Viscum album L.) extract is one of the most widely used agents in alternative cancer therapeutic regimens in Europe. This study was conducted to determine the effect of mistletoe extract on immune function in gastric cancer patients. Materials and Methods: Ten patients that had undergone a curative gastrectomy were enrolled in the prospective study. ABNOBAviscum $Q^{(R)}$ was injected subcutaneously three times a week from postoperative-day 7 to week 16 with an increasing dose. All of the patients simultaneously received chemotheraphy with mitomycin, oral 5-FU and a cisplatin regimen. The WBC count, differential count, lymphocyte/WBC ratio and the level of cytokines (IL-$1{\beta}$, IL-2, IL-6, IFN-$\gamma$, TNF-$\alpha$) were checked in the peripheral blood preoperatively, at postoperative week 8 and at postoperative week 16. Results: The WBC and neutrophil counts significantly decreased after treatment on week 8 and week 16 (P=0.001), but the total eosinophil count was slightly increased (P=0.15). The total lymphocyte count also decreased during treatment but the lymphocyte/WBC ratio was slightly increased without statistical significance (P=0.91). The cytokine levels did not significantly change during treatment. Conclusion: It is somewhat difficult to determine the direct effect of mistletoe therapy on immune function as the effect may be compromised by the concurrent chemotherapy. It can be assumed that the slightly increased lymphocyte/WBC ratio and eosinophil count may be a result of the immunomodulatory effect of the mistletoe extract.

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A Study on the Representations of an Bell Chamber in Namhansansung (남한산성 종(鐘)과 종각(鐘閣) 복원을 위한 연구)

  • Lee, Jin-Hyang;Kim, Dae-Ho;Lee, Jae-Keun
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.28 no.4
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    • pp.120-126
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    • 2010
  • As the importance of an historical area is getting increased in these days, the reconstruction of an bell chamber in Namhansansung has significant historial, educational and cultural meaning. The purpose of this study, as a study on an bell chamber in Namhansansung, is to assume an original location of the bell chamber and identify the size and shape of the original bell chamber through literature study, site inspection, and analysis on old maps. In addition, this study could provide useful information when new bell chamber is constructed. According to the literature study, site inspections(5 times) and analysis on old maps, the original bell chamber is assumed to locate near current Oroji tea house at the rotary, where was in the area of Hanggung. With regard to the traffic system, it is assume that there was an old road along with the current local road No.342 connecting the South Gate with North Gate and a Y or T shape intersection connecting the site of old bell chamber with the north. In addition, there was a government office street from the old bell chamber to Hanggung. The shape of old bell chamber is assumed to have Paljak or Woojingak roof. Samo roof was not found in all the five maps. Regarding the direction of bell chamber, three maps indicate that it faces the East and two maps show that it faces the South. Therefore, it is assumed that the length and width of the roof have similar size. However, a new bell chamber should face the East, which is the same direction with Hanggung. As there is a record which states that a bell in the Cheonheoungsa, Seonggeosan, Cheonan was used as a Namhansansung's bell when the Cheonheoungsa was closed, this study suggests that new Namansansung's bell should be built, considering histroical value and artistry of Cheonheoungsa's bell. This study is a basic research for the reconstruction of Namhansansung in 2009. However, as reconstruction of historical assets should be based on thorough historical evidences. Therefore, more detail researches by a indicator analysis are left for the topic of future studies.

Investigation of Rock Slope Failures based on Physical Model Study (모형실험을 통한 암반사면의 파괴거동에 대한 연구)

  • Cho, Tae-Chin;Suk, Jae-Uk;Lee, Sung-Am;Um, Jeong-Gi
    • The Journal of Engineering Geology
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    • v.18 no.4
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    • pp.447-457
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    • 2008
  • Laboratory tests for single plane sliding were conducted using the model rock slope to investigate the cut slope deformability and failure mechanism due to combined effect of engineering characteristics such as angle of sliding plane, water force, joint roughness and infillings. Also the possibility of prediction of slope failure through displacement monitoring was explored. The joint roughness was prepared in forms of saw-tooth type having different roughness specifications. The infillings was maintained between upper and lower roughness plane from zero to 1.2 times of the amplitude of the surface projections. Water force was expressed as the percent filling of tension crack from dry (0%) to full (100%), and constantly increased from 0% at the rate of 0.5%/min and 1%/min upto failure. Total of 50 tests were performed at sliding angles of $30^{\circ}$ and $35^{\circ}$ based on different combinations of joint roughness, infilling thickness and water force increment conditions. For smooth sliding plane, it was found that the linear type of deformability exhibited irrespective of the infilling thickness and water force conditions. For sliding planes having roughness, stepping or exponential types of deformability were predominant under condition that the infilling thickness is lower or higher than asperity height, respectively. These arise from the fact that, once the infilling thickness exceeds asperities, strength and deformability of the sliding plane is controlled by the engineering characteristics of the infilling materials. The results obtained in this study clearly show that the water force at failure was found to increase with increasing joint roughness, and to decrease with increasing filling thickness. It seems possible to estimate failure time using the inverse velocity method for sliding plane having exponential type of deformability. However, it is necessary to estimate failure time by trial and error basis to predict failure of the slope accurately.

Comparison of Foodservice Management Practices in the Employee Feeding Operations of Jeonnam and Chungchong Area (전남과 충청지역 사업체 급식소의 급식관리 실태 조사 비교연구)

  • 서희영;정복미
    • Korean Journal of Community Nutrition
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    • v.9 no.2
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    • pp.191-203
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    • 2004
  • This study was performed to compare the foodservice management practices in the employee feeding operations of Jeonnam and Chungchong area. Questionnaires were developed and mailed to 160 dietitians with management in employee foodservice of Jeonnam and Chungchong area. Completed questionnaires were received from 124 dietitians with a response rate of 77.5%. The results of this study can be summarized as follows:. Age, work experience, concurrent position and work time of dietitians were significantly higher in the Chungchong area than those in the Jeonnam area. Times of meals and amount of meals served per day in the Chungchong area were significantly higher than those in the Jeonnam area. The type of menu by foodservice operation was high non-selective menu in both areas, especially non-selective menu was high in self-operated place whereas selective menu was high in contract management. Period of cycle menu was 10-15 days in Jeonnam area, but that was 7 days in Chungchong area and so cycle menu of both areas was significantly different (p < 0.001). Most considerable factor in menu planning was preference in Jeonnam area and was cost in the Chungchong area. Food purchasing method was used mostly by automatic computerized order in the Jeonnam area whereas telephone or mail order was high in the Chungchong area.

Optimal Conditions for As(III) Removal by Filtration System Packed with Different Ratio of Iron-Coated Sand and Manganese-Coated Sand (철 및 망간코팅사 충전비를 달리한 여과시스템에서 3가 비소 제거의 최적 조건)

  • Chang, Yoon-Young;Kim, Kwang-Seob;Song, Ki-Hoon;Yang, Jae-Kyu
    • Journal of Korean Society of Environmental Engineers
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    • v.28 no.11
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    • pp.1186-1191
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    • 2006
  • Removal efficiency of As(III) through oxidation and adsorption in column reactors was investigated at different ratios of manganese-coated sand(MCS) and iron-coated sand(ICS) : MCS-alone, ICS-alone and both of ICS and MCS. The breakthrough of arsenic immediately occurred from a column reactor with MCS-alone. However, most of the arsenic present in the effluent was identified as As(V) due to the oxidation of As(III) by MCS. While five-times delayed breakthrough of arsenic was observed from a column reactor with ICS-alone. At a complete breakthrough of arsenic, the removed As(III) was 36.1 mg with 1 kg ICS. To find an optimum ratio of ICS and MCS in the column packed with both ICS and MCS, the removal efficiency of As(III) was investigated at three different ratios of ICS/MCS with a fixed amount of ICS. The breakthrough time of arsenic was quite similar in the different ratios ICS/MCS. However, much slower breakthrough of arsenic was observed as the ratio of ICS/MCS decreased. As the ratio of ICS/MCS decreased the concentration of As(III) in the effluent decreased and then showed below 50 ppb at an equal amount of ICS and MCS, suggesting more efficient oxidation of As(III) by greater amount of MCS. When a complete breakthrough of arsenic occurred, the removed total arsenic with an equal amount of ICS and MCS was 68.5 mg with 1 kg of filter material.

Convenient Nucleic Acid Detection for Tomato spotted wilt virus: Virion Captured/RT-PCR (VC/RT-PCR) (Tomato spotted wilt virus를 위한 간편한 식물바이러스 핵산진단법: Virion Captured/RT-PCR (VC/RT-PCR))

  • Cho Jeom-Deog;Kim Jeong-Soo;Kim Hyun-Ran;Chung Bong-Nam;Ryu Ki-Hyun
    • Research in Plant Disease
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    • v.12 no.2
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    • pp.139-143
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    • 2006
  • Virion captured reverse transcription polymerase chain reaction (VC/RT-PCR) could detect plant virus quickly and accurately. In the VC/RT-PCR, no antibody is needed unlike immuno-captured RT-PCR (IC/RT-PCR) which had been improved method of RT-PCR for plant viruses, and virus nucleic acids can be obtained easily within 30minutes by property of polypropylene PCR tube which is hold and immobilized viral particles on its surface. For the virion capture of Tomato spotted wilt virus (TSWV), the extraction buffer was tested. The optimum macerating buffer for TSWV was 0.01M potassium phosphate buffer, pH 7.0, containing 0.5% sodium sulfite. The viral crude sap was incubated for 30 min at $4^{\circ}C$. The virions in the PCR tubes were washed two times with 0.01M PBS containing 0.05% Tween-20. The washed virions were treated at $95^{\circ}C$ immediately for 1 min containing RNase free water and chilled quickly in the ice. Disclosed virions' RNAs by heat treatment were used for RT-PCR. Dilution end point of $10^{-5}$ from plant's crude sap infected with TSWV showed relatively higher detection sensitivity for VC/RT-PCR. During multiple detection using two or more primers, interference was arisen by interactions between primer-primer and plant species. The result of multiplex RT-PCR was influenced by combinations of primers and the kind of plant, and the optimum extraction buffer for the multiplex detection by VC/RT-PCR should be developed.

Physicochemical Composition and Fermentation Conditions of Sliced, Dried Radish Kimchi with Flying Fish Roe (날치알을 첨가한 무말랭이 김치의 이화학적 성분 및 발효양상)

  • Jang, Mi-Soon;Park, Hee-Yeon;Nam, Ki-Ho;Kim, Min Jeong
    • Korean Journal of Food Science and Technology
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    • v.46 no.5
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    • pp.566-574
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    • 2014
  • This study was conducted to compare the physicochemical composition and fermentation conditions of sliced, dried radish kimchi with flying fish roe (DFFR). The levels of crude protein, crude lipid, and crude ash in DFFR were higher than those in sliced, dried radish kimchi without flying fish roe (control). DFFR also contained higher levels of Fe and Ca, compared to the control. The inosine monophosphate (IMP) content of DFFR and control was 5.63 and 2.64 mg/100 g, respectively. The polyunsaturated fatty acid and DHA contents in DFFR were approximately 5 and 23 times higher than those in the control, respectively. The major free amino acids contained in these samples were arginine, proline, alanine, leucine, and valine. The number of cells belonging to the Leuconostoc species in DFFR was higher than that in the control. In sensory evaluation studies, DFFR scored the highest in terms of appearance, flavor, taste, and texture.

Lipid Oxidation in Roasted fish Meat III. Changes in Heme Compounds in Roasted and/or Reheated Dark Muscled Fish (어육의 배소에 의한 지질산화에 관한 연구 III. 적색육어의 배소 및 재가열에 의한 heme 화합물의 변화)

  • CHO Ho-Sung;LEE Kang-Ho;JOO Dong-Sik;KIM Gyeong-Eup;LIM Sang-Sun;LEE Jong-Ho
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.31 no.4
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    • pp.483-488
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    • 1998
  • In order to elucidate the effect of heme compounds on lipid oxidation in roasted and/or reheated mackerel and pacific saury, changes in myoglobin, metmyoglobin, total iron, nonheme iron and heme iron content were measured. Throughout the steps of roasting, heating and reheating, myoglobin content was decteased more rapidly roasted at $180^{\circ}C$ for 20 min in fillet samples than those roasted at $200^{\circ}C$ for 15 min or $220^{\circ}C$ for 10 min. When the skinless samples were roasted at $180^{\circ}C$ for 20 min, about $38\%$ of myoglobin in raw meat were remained. The skinless fillet roasted at the lower temperature resulted the higher level of metmyoglobin due to the reduced myoglobin. Regardless of roasted temperature and time, total iron content was retained the level of raw meat throughout processing. 2 times of nonheme iron content was noted in the skinless fillet samples roasted at $180^{\circ}C$ for 20 min. All samples, heme iron content was decreased much lower by roasted temperature and in absence of skin on fillet. It was decreased about $33\%$ when roasted at $180^{\circ}C$ for 20 min in the skinless fillet in case of pacific saury.

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The Comparison of Characteristics of Korean, Chinese and Japanese Traditional Flower Arts Used in Royal Court Ceremonies (한국과 중국 및 일본의 궁중 전통 꽃꽂이 특징비교)

  • Hong, Hoon Ki;Lee, Jong Suk
    • FLOWER RESEARCH JOURNAL
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    • v.18 no.2
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    • pp.125-135
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    • 2010
  • To discover the main characteristics of Korean traditional flower arrangement, they were compared with different articles and old paintings used in royal court ceremonies. The primary research involved principle of design. The times periods used were the Joseon Dynasty era of Korea, the Ming era of China, and the Edo eras of Japan. The result, which shows both the similarities and differences, of the research is summarized as follows. The similarities were that they all respect the features of nature, and their image expresses their creator's thinking. There was one technique, called 'Suje', in which a part of the stem is coming out from one branch. Also, each three eras preferred flowering trees and ornamental trees more than annuals or foliage plants. one of the differences was that korea used a simple number of materials. The work had volume and appeared mild by using a soft curved line which was repetitive and massive. The Joseon Dynasty era advanced a sense of beauty with artistic symmetry and balance. The work seemed soft and natural because of the little change in blank space, with almost no angle of line. The form had a characteristic preference of being taller than the typical Japanese arrangement. It appeared simple, calm, and rustic by using only one kind of material. In contrast, the Chinese style was gorgeous and displayed volume in a non-symmetrical tripodal form, which incorporated various colors and materials. Also, they avoided processing the materials in order to emphasize the original beauty of nature. Chinese flower arts did not become formalized because they did not consider the formality seriously the formal. The Japanese style was also gorgeous because it incorporated various materials and angles. It included an extreme technique in which an artificial line divided the blank space delicately. The line was both strong and delicate in an established form. The restriction of the main branch gave a light feeling, as well as more strain as in a balance sense. The Japanese eras emphasized more the use of line and a sense of blank space.

A Change Detection of Urban Vegetation of Seoul with Green Vegetation Index Extracted from Landsat Data (Landsat 녹색식생지수를 이용한 서울시 도시녹지 변화 조사)

  • 박종화
    • Korean Journal of Remote Sensing
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    • v.8 no.1
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    • pp.27-43
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    • 1992
  • The purpose of this study is to detect and evaluate the change of urban vegetation of Seoul during 1980s. Large areas covered with agricultural crops or forests were converted to residential and commercial areas, roads, schools, sports complexes, etc. There were also widespreas concerns on the deterioration of the quality of urban vegetation due to severe air pollution, overcrowding of nature parks, and idling of farm lands by land speculators. The image used for this study were MSS(Oct. 4, 1979) and TM(Apr. 26, 1990). The Green Vegetation Index of Kauth & Thomas(1976) was for the analysis. The GVI were resampled with 75$\times$75m grids and overlaid with the jurisdictional boundaries of 22 districts of Seoul. The results were reclassified to 6 classes, class 6 representing grids with the most vigorous vegetation or the best vegetation improvement in 1980s. The finding of this study can be summarized as follows : First, the most vigorous vigorous vegetation, in terms of GVI, of the 1979 image can be found at paddy fields located on alluvial near Han River. Broad-leaf forests located on hilly terrains have higher GVI than conifers located on the upper-parts of mountains. The average GVI of the northern part and southern part of Han River are 3.56 and 3.74, respectively. The main reason why the southern part has higher GVI is that there are more prime agricultural lands. Districts of Kangseo, Yangcheon, and Songpa have the highest percentage of grids of GVI class 6, and the percentages are 3.55 %, 3.47 %, and 2.69 %, respectively. Second, the most vigorous vegetation of the 1990 image can be found at the grass lands of the Yongsan golf club and the Sungsu horse racing track. The GVI of farm lands is lower than forest because most agricultural crops are at the early stage of growing season when the TM image was taken. The size of built-up area is much larger than of 1979. On the other hand, vegetation patches surrounded by developed area become smaller and have stronger contrast to surrounding area. The average GVI of the northern part and southern part of Han River are 3.57 and 3.51, respectively. The main reason why the southern part has lower GVI is the at more large-scale urban development projects were carried out in there during 1980s. Districts of Tobong, Nowon, and Seocho have the highest percentage of class 6, and the perecentages are 16.58 %, 10.14 %, and 8.50% respectively. Third, the change of urban vegetation in Seoul during 1980s are significant. Grids of GVI change classes 1 and 2, which represent severe vegetation loss, occupy 15.97% of Seoul. Three districts which lost the most vegetation are Yangcheon, Kangseo, and Songpa, where the percentages of GVI class 1 are 13.42%, 13.39% and 9.06%, respectively. The worst deterioration was mainly caused by residential developments. On the other hand, the vegetation of some part of Seoul improved in this period. Grids of GVI change classes 5 and 6 occupy 9.83 % of Seoul. Distircts of Jung, Yongsan, and Kangnam have the highest percentage of grids with GVI change classes 5 and 6, and their percentages are 22.31%, 19.17%, and 13.66%, respectively. The improvement of vegetation occurred in two areas. Forest vegetation is generally improving despite of concerns based on air pollution and heavy use by recreationists. Vegetation in open spaces established in riverside parks, large residential areas, and major public facilities are also improving.