• YAKHAK HOEJI
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• v.33 no.3
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• pp.206-210
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• 1989

Bromolactonization of 2-Substituted-1-cyclohexenyl-1-acetic acid (1) with 1,3-dibromo-5,5-dimethylhydantoin (dibromantin) in N,N-dimethylformamide gave the corresponding ${\gamma}-bromo-{\beta}-lactone$ (2) and ${\beta}-bromo-{\gamma}-lactone$ (3). The effect of the substituents, the reaction temperature, and the solvent on the regioselectivity was discussed.

• Archives of Pharmacal Research
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• v.4 no.2
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• pp.133-135
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• 1981

Reaction of unsaturated acids with 3-bromo-5, 5-dimenthylhydantoin in dry DMF at room temperature gives bromolactones in 58-91 % yields.