• Journal of the Korean Chemical Society
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• v.35 no.6
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• pp.603-606
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• 1991

The crystal structure of Probenecid has been determined from 2574 independent reflections collected on an automatic ENRAF-NONIUS CAD-4 diffractometer using graphite-monochromated $Mo-K{\alpa}$ radiation. The crystal is triclinic, space group P$\bar{1}$ with unit cell dimensions a = 7.535(2)${\AA}$, b = 18.473 (5)${\AA}$, c = 5.317(9)${\AA}$, ${\alpha} = 92.00(5)^{\circ}$, ${\beta} = 99.02(5)^{\circ}$, ${\gamma} = 94.89(2)^{\circ}$, V = 727.4(2)${\AA}^3$, Z = 2, $D_m$ = 1.310, $D_x$ = $1.302 gcm^{-3}$, ${\mu}$ = $1.88 cm^{-1}$, F(000) = 304, and T = 298 K. Final R = 0.0676 and $R_w$ = O.0630 for 1209 reflections > 5${\sigma}(F_o)$. In the spacial arrangement about N(13), the sum of bond angles about nitrogen is 350.9° and the nitrogen lies only 0.268(6)${\AA}$ out of S(1)-C(14)-C(17) plane. The S(1)-C(4) distance is 1.792(6)${\AA}$ and the C(4)-S(1)-N(13) angle is $106.5(3)^{\circ}$. The overall conformation of the molecule is folded with respect to sulfur.

• Applied Biological Chemistry
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• v.43 no.2
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• pp.95-99
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• 2000

A series of hetero ring (X) substitued chalcone derivatives with farnesyl protein transferase (FPTase) inhibition activities $(pI_{50})$ values determined in vitro is analyzed by modified Free-Wilson (F-W) and Hansch method for quantitative structure activity relationship (QSARs). On the basis of F-W analysis on the FPTase inhibitory activity of a training set of the compounds, none of the (X)-substituents were not contribute the activity. But the net charge of ${\alpha}$ carbon atom is contribute the activity than that of ${\beta}$ carbon atom. And the relative orders of the (Y)-substituents on the activity are ortho>meta>para-substituents. According to Hansch approach, the activities would depend largely on the optimal, $(R_{opt.}=-0.35)$ resonance effect with ortho substituted $(I_o>0)$ electron donating group (R<0) and STERIMOL parameter, $B_1$ constant. The inhibition activity between hetro ring substituents have been a proportioned with each others and none substituent(H), 45 showed the highest FPTase inhibition $(pI_{50}=4.30)$ activity.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.2
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• pp.643-653
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• 2013

Recently, there are an increasing number of studies on the method of wrapping the outer wall of granular piles with geosynthetic fibers such as geotextile or geogrid that has a certain level of tensile strength as an alternative method for the ground improvement techniques. In this study, triaxial compression tests are performed on the sand and clay specimen encased with various textiles to evaluate the reinforcing effect with regard to the tensile strength of the textile. Furthermore, triaxial compression tests are performed on the clay specimen inserted by sand only and sand encased with geosynthetics to compare behavioral differences between the conventional sand compaction pile and geosynthetic encased sand pile with regard to the replacement ratio, ${\alpha}_s$ and the tensile strength of the geosynthetics. Based on the experimental results, the strength enhancement due to the textile is affected by the longitudinal tensile strength rather than the transverse one of the applied textile. The effect of the confinement by the textile encasement results in the large increase of the cohesions. The overall behaviors, such as shear strength, pore pressure parameter at failure and stress ratio, of the geosynthetic encased sand pile is quite different from those of the conventional sand compaction pile.

• Journal of Life Science
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• v.20 no.5
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• pp.775-781
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• 2010

The antioxidant activities of hot water extracts from fresh, red and black garlic processed in low temperatures were compared. The chromaticity value of browning garlic was between that of fresh and black garlic. Red garlic was similar in browning intensity to fresh garlic. Also, total phenol, flavonoids, total pyruvate and thiosulfate contents were similar between fresh and black garlic. DPPH, ABTs, NO radical scavenging activity and reducing power of red garlic were significantly higher than fresh garlic, but lower than those of black garlic. $\alpha$-Glucosidase inhibitory activity in red garlic was similar to that in black garlic. Antioxidant activities of red garlic were higher than fresh garlic but lower than black garlic, and it was confirmed that antioxidant activity by production of browning material through the thermal process was the main parameter of the biological activity in the aged red garlic.

• Earthquakes and Structures
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• v.13 no.1
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• pp.59-66
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• 2017

Modern seismic codes rely on performance-based seismic design methodology which requires that the structures withstand inelastic deformation. Many studies have focused on the inelastic deformation ratio evaluation (ratio between the inelastic and elastic maximum lateral displacement demands) for various inelastic spectra. This paper investigates the inelastic response spectra through the ductility demand ${\mu}$, the yield strength reduction factor $R_y$, and the inelastic deformation ratio. They depend on the vibration period T, the post-to-preyield stiffness ratio ${\alpha}$, the peak ground acceleration (PGA), and the normalized yield strength coefficient ${\eta}$ (ratio of yield strength coefficient divided by the PGA). A new inelastic deformation ratio $C_{\eta}$ is defined; it is related to the capacity curve (pushover curve) through the coefficient (${\eta}$) and the ratio (${\alpha}$) that are used as control parameters. A set of 140 real ground motions is selected. The structures are bilinear inelastic single degree of freedom systems (SDOF). The sensitivity of the resulting inelastic deformation ratio mean values is discussed for different levels of normalized yield strength coefficient. The influence of vibration period T, post-to-preyield stiffness ratio ${\alpha}$, normalized yield strength coefficient ${\eta}$, earthquake magnitude, ruptures distance (i.e., to fault rupture) and site conditions is also investigated. A regression analysis leads to simplified expressions of this inelastic deformation ratio. These simplified equations estimate the inelastic deformation ratio for structures, which is a key parameter for design or evaluation. The results show that, for a given level of normalized yield strength coefficient, these inelastic displacement ratios become non sensitive to none of the rupture distance, the earthquake magnitude or the site class. Furthermore, they show that the post-to-preyield stiffness has a negligible effect on the inelastic deformation ratio if the normalized yield strength coefficient is greater than unity.

• Proceedings of the KIEE Conference
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• 1999.07d
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• pp.1855-1857
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• 1999

$Mn_{1-x}Fe_{2+x}O_4$, $Mg_{1-x}Fe_{2+x}O_4$ (x=0.0, 0.025, 0.1, 0.2) for negative temperature coefficient (NTC) thermistor were prepared by calcining at $800^{\circ}C$ and sintering from 1100 to $1250^{\circ}C$ with $50^{\circ}C$ intervals. The best linear property was obtained in the Mn-based sample sintered at $1200^{\circ}C$ with x=0.0 composition. Temperature coefficient of resistance, $\alpha$, was -3.0 %/$^{\circ}C$ in the Mg-based sample at $25^{\circ}C$. Thermistor parameter, B, was in the range of 2500 [K] $\sim$7400 [K]. The results show the possibility that Mn-Ni-Co based thermistor could be substituted by the composition used in this study.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.10
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• pp.1374-1377
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• 2004

The present study was conducted to explore the possibilities of estrus induction and superovulation in a native Indian breed of goats called 'Black Bengal'. Forty-two adult non-pregnant females were divided in two groups, of which 18 goats were subjected to a superovulatory treatment comprising of equine chorionic gonadotropin (eCG), Prostaglandin (PGF2$\alpha$) and human chorionic gonadotropin (hCG) to induce superovulation. The remaining 24 goats received no treatment and served as controls for the parameter under study as well as recipients for embryo transfer studies. The average duration of estrus was found to be significantly increased in treated goats (34.2${\pm}$3.4 h) compared to controls 3.0${\pm}$2.4 h). The average duration between PGF administration and occurrence of estrus was 2.0${\pm}$5.2 h. After mid ventral laparotomy, superovulatory responses indicated a significant increase in the number of follicles, which was 8.27${\pm}$0.37 in the treatment group compared to 4.16${\pm}$0.17 in the control group. The number of corpora lutea was also significantly increased in treated animals compared to control (2.90${\pm}$0.86 vs. 0.74${\pm}$0.04) respectively per ovary per goat.

• Journal of Internet Computing and Services
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• v.17 no.5
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• pp.51-58
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• 2016

The unprecedented power of cloud computing (CC) that enables free sharing of confidential data records for further analysis and mining has prompted various security threats. Thus, supreme cyberspace security and mitigation against adversaries attack during data mining became inevitable. So, privacy preserving data mining is emerged as a precise and efficient solution, where various algorithms are developed to anonymize the data to be mined. Despite the wide use of generalized K-anonymizing approach its protection and truthfulness potency remains limited to tiny output space with unacceptable utility loss. By combining L-diversity and (${\alpha}$,k)-anonymity, we proposed a hybrid K-anonymity data relocation algorithm to surmount such limitation. The data relocation being a tradeoff between trustfulness and utility acted as a control input parameter. The performance of each K-anonymity's iteration is measured for data relocation. Data rows are changed into small groups of indistinguishable tuples to create anonymizations of finer granularity with assured privacy standard. Experimental results demonstrated considerable utility enhancement for relatively small number of group relocations.

• Journal of Biomedical Engineering Research
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• v.25 no.3
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• pp.217-225
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• 2004

In this paper, a new automatic classification method for the normal EEC and schizophrenia EEC using hidden Markov model(HMM) is proposed. We used the feature parameters which are the variance for statistical stationary interval of the EEC and power spectrum ratio of the alpha, beta, and theta wave. The results were shown that high classification accuracy of 90.9％ in the case of normal person, and 90.5％ in the case of schizophrenia patient. It seems that proposed classification system is more efficient than the system using complicate signal processing process. Hence, the proposed method can be used at analysis and classification for complicated biosignal such as EEC and is expected to give considerable assistance to clinical diagnosis.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.23 no.6 s.165
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• pp.1026-1038
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• 1999

Interlaminar fracture toughness of carbon/epoxy composite materials has been studied under tensile and flexural loading by the use of width tapered double cantilever beam(WTDCB) and end notched flexure(ENF) specimens. This study has significantly examined the effect of various interfacial ply orientation, ${\alpha}(0^{\circ},\;45^{\circ}\;and\;90^{\circ})$ and crack propagation direction, ${\theta}(0^{\circ},\;15^{\circ},\;30^{\circ}\;and\;45^{\circ})$ in terms of critical strain energy release rate through experiments. Twelve differently layered laminates were investigated. The data reduction for evaluating the fracture energy is based on compliance method and beam theory. Beam theory is used to analyze the effect of crack propagation direction. The geometry and lay-up sequence of specimens are considered various conditions such as skewness parameter, beam volume, and so on. The results show that the fiber bridging occurred due to the non-midplane crack propagation and causes the difference of fracture energy evaluated by both methods. For safer and more reliable composite structures, we obtain the optimal stacking sequence from initial fracture energy in each mode.