• Title/Summary/Keyword: ${\alpha}$-Muricholic acid

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Facile Synthetic Routes to Prepare α-Muricholic Acid, Hyocholic Acid, and Their Taurine Conjugates

  • Kang, Dong Wook;Luecke, Hans F.
    • Bulletin of the Korean Chemical Society
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    • v.34 no.8
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    • pp.2436-2440
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    • 2013
  • ${\alpha}$-Muricholic acid was synthesized through 9 steps from chenodeoxycholic acid with 26% overall yield. Hyocholic acid was synthesized through 8 steps from the same starting material with 63% overall yield. Taurine conjugates of ${\alpha}$-muricholic acid and hyocholic acid were also prepared via their pentafluorophenyl ester.