[KSCI] Korea Science Citation Index Service

http://dx.doi.org/10.5012/bkcs.2013.34.8.2436

Facile Synthetic Routes to Prepare α-Muricholic Acid, Hyocholic Acid, and Their Taurine Conjugates

Kang, Dong Wook (Department of Pharmaceutical Science and Technology, Catholic University of Daegu)
Luecke, Hans F. (Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health)

Publication Information

Bulletin of the Korean Chemical Society / v.34, no.8, 2013 , pp. 2436-2440 More about this Journal

Abstract

${\alpha}$ -Muricholic acid was synthesized through 9 steps from chenodeoxycholic acid with 26% overall yield. Hyocholic acid was synthesized through 8 steps from the same starting material with 63% overall yield. Taurine conjugates of ${\alpha}$ -muricholic acid and hyocholic acid were also prepared via their pentafluorophenyl ester.

Keywords

Bile acids; ${\alpha}$ -Muricholic acid; Hyocholic acid; Taurine conjugates; Metabolites;

Citations & Related Records

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