• Journal of Ginseng Research
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• v.32 no.2
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• pp.89-98
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• 2008

There are increasing evidences in the literatures on the potential role of ginsenosides in treating cardiovascular diseases. In this article, current information about ginsenosides-mediated vascular relaxation are reviewed. From the published studies using isolated organs, cell culture systems and animal models, ginsenosides are shown to relax blood vessels and improve blood flow through diverse mechanisms, including nitric oxide release by activating eNOS phosphorylation via PI3K/Akt and/or ERK1/2 pathways in endothelial cells, induction of inducible nitric oxide synthase through activation of NF-${\kappa}$B, reducing the intracelluar Ca$^{2+}$ levels by activating Ca$^{2+}$-activated K$^{+}$ channels in vascular smooth muscle cells and reducing platelet aggregation by decreasing thromboxane A$_2$ formation and intracelluar Ca$^{2+}$in platelets. In addition, the relevant clinical trials regarding the effects of ginsenosides on the cardiovascular disease are summarized, particulary focusing on managing hypertension and improving thrombotic disorders. Finally, antagonistic effects of ginsenosides on the prostaglandin H$_2$ receptor and scavenging effects on the generation of oxygen-derived free radicals in spontaneously hypertensive rats (SHR) are discussed.

• Journal of Advanced Marine Engineering and Technology
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• v.33 no.1
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• pp.62-70
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• 2009

In this paper, the fluid flow behavior past a pair of rectangular cylinders placed in a two dimensional horizontal channel has been investigated using Lattice-Boltzmann Method(LBM). The LBM has built up on the D2Q9 model and the single relaxation time method called the Lattice-BGK(Bhatnagar-Gross-Krook)model. Streamlines, velocity, vorticity and pressure contours are provided to analyze the important characteristics of the flow field for a wide range of non dimensional parameters that present in our simulation. Special attention is paid to the effect of spacing(d) between two cylinders and the blockage ratio A(=h/H), where H is the channel height and h is the rectangular cylinder height. for different Reynolds numbers. The first cylinder is called upstream cylinder and the second one as downstream cylinder. The downstream fluid flow fields have been more influenced by its blockage ratios(A) and Reynolds numbers(Re) whereas the upstream flow patterns(in front of downstream cylinder) by the gap length(d) between two cylinders. Moreover, it is observed that after a certain gap, both upstream and downstream flow patterns are almost similar size and shape. The simulation result has been compared with analytical solution and it is found to be in excellent agreement.

• Journal of Korean Ophthalmic Optics Society
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• v.4 no.2
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• pp.105-111
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• 1999

This paper presents experimental results on the electrical properties of hydrogenated amorphous carbon films(a-C:H) prepared by PECVD. DC conductance of a-C:H was measured as a function of temperatures in the range of 100 to 423K. We studied two a-C:H films: one was well explained by the Mott's Variable Range Hopping(VRH) rule, but the other sample did not follow it. However, the conduction data of second sample were well fitted to Shimakawa's Multi-Phonon Hopping(MPH) model according to which conductivity is proportional to $T^M$ with m=15-17. but, in our samples, m was 10-12. Also a-C:H showed several bias effects like relaxation of conductance, bias-dependent conductance and the change of conductance slope in 1n(${\sigma}{\sqrt{T}}$) vs. $T^{1/4}$ plot. In this study we interpret these data by bias-dependent detrapping model.

• Applied Chemistry for Engineering
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• v.10 no.6
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• pp.876-880
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• 1999

The surfactant self-diffusion coefficients of mixed micellar solutions of ionic and nonionic surfactants have been measured by the NMR pulsed field gradient spin echo(FT-PGSE) method. In addition, the line widths of $^1H$ NMR signal have been monitored. The system investgated are $C_{12}EO_5/SDS/D_2O$, $C_{12}EO_5/DTAC/D_2O$, and $C_{12}EO_8/SDS/D_2O$. In the sample series, the molar ratios of $D_2O$ to surfactant(ionic+nonionic) were kept constant while the surfactant mixing ratio was varied. For the $C_{12}EO_5$ system, the surfactant self-diffusion coefficient indicates minimum when the surfactant mixing ratio is about 20% ionic surfactant. The observed decrease in self-diffusion coefficients as nonionic surfactant was replaced by ionic surfactant is interpreted to mainly be due to an increased micelle-micelle repulsion. The increase in self-diffusion coefficients occurring at higher fraction of ionic surfactant is shown to be due to a decrease in micelle size. For the $C_{12}EO_8$ system, the effect of the surfactant mixing ratio is much weaker which can be understood by considering the molecular geometry and large headgroup area. The proton NMR line widths correlate well with the self-diffusion coefficients and broadening of the alkyl chain methylene signals is found when the self-diffusion coefficients is low.

• Journal of Power System Engineering
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• v.4 no.4
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• pp.16-24
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• 2000

고체내의 열에너지의 전달을 분석하기 위하여 고전적인 Fourier 열전도 법칙과 에너지 보존식에서 유도되는 열전도 방정식을 사용해 왔다. 이러한 열전도 방정식은 열전도가 무한한 속도로 진행된다는 것을 의미하고 있다. 그러나 극저온상태에서나 매우 급속한 열전도과정 중 매우 짧은 시간의 상태에서 non-Fourier 모델에 기초를 둔 쌍곡선형 열전도 방정식이 도입되었다. 최근의 이에 관한 연구에서 열전도가 파장의 형태로 유한한 전파속도를 갖는다는 것이 실험적으로 증명되었고 이로부터 여러 가지 실험적인 해석과 이론 해석이 전개되었다. 본 논문에서는 열전파 속도의 유한한 성질을 나타내는 수정된 열전도 법칙을 이용하여 1차원 평판에 대하여 공간에 대한 finite Fourier 변환 방법과 Green 함수 방법으로 해석하여 열전도파의 파동 성질, 공진 현상 및 위상차를 고찰하고자 한다. 열전도파가 갖는 모달 주파수에 대해 임계값을 갖으며 이 임계값을 초과할 때 공진 현상과 위상차를 고찰할 수 있었다.

• Journal of the Korean Chemical Society
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• v.68 no.2
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• pp.74-81
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• 2024

A sulfonic acid-water-silanol system in SO₃H-functionalized MCM-41 was investigated using solid-state nuclear magnetic resonance techniques. The proton exchange rate between a water molecule and a silanol group in the S-PE-MCM-41 was determined by analyzing the 1D proton spectra, the proton EXSY spectrum, and ²H spin-lattice relaxation data under various hydration levels. Two kinds of water-bounding sites were found in the S-PE-MCM-41: weakly and strongly bound sites. Over several hours, water molecules bound to the weakly bound sites at the low hydration level migrated to the strongly bound sites. At high temperature, the S-PE-MCM-41 easily lost water molecules weakly bound to the silanol, while the strongly bound water molecules survived. Water molecules that participated in the hydration of the phenethyl sulfonate were involved in the hydrogenbonded silanol mechanism of proton conductivity. This phenomenon contributes higher proton conductivity to the S-PE-MCM-41 by the cooperation of sulfonyl and silanol groups in the proton transfer process, even at higher temperature.

• Herbal Formula Science
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• v.11 no.2
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• pp.125-134
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• 2003

We have examined the relaxational response to the water extract of Angelica gigas $N_{AKAI}$ (AG), Gingko biloba $L_{INNE}$ (GB), Acanthopanax senticosus $H_{ARMS}.$ (AP) and Augumented-Four-Substance Decoction (AG-FSD, GB-FSD, AP-FSD) in isolated thoracic aorta from sprague dawley(SD) rat. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, GB, AP and AG-FSD, GB-FSD, AP-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at $10^{-4}M$ were inhibited by 26.3%, 75.8%, 87.5% and 6.9%, 22.6%, 30.8% after addition of the 0.1 g/mL water extract of AG, GB, AP and AG-FSD, GB-FSD, AP-FSD. In conclusion, AG, GB, AP and AG-FSD, GB-FSD, AP-FSD induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AP-FSD has very potent vasodilation.

• Nuclear Engineering and Technology
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• v.28 no.1
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• pp.17-26
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• 1996

The in-reactor fuel rod support conditions against the fretting wear-induced damage can be evaluated by residual spacer grid spring deflection or rod-to-grid gap. In order to evaluate the impact of fuel design parameters on the fretting wear-induced damage, a simulation methodology of the in-reactor fuel rod supporting conditions as a function of burnup has been developed and implemented in the GRIDFORCE program. The simulation methodology takes into account cladding creep rate, initial spring deflection, initial spring force, and spring force relaxation rate as the key fuel design parameters affecting the in-reactor fuel rod supporting conditions. Based on the parametric studies on these key parameters, it is found that the initial spring deflection, the spring force relaxation rate and cladding creepdown rate are in the order of the impact on the in-reactor fuel rod supporting conditions. Application of this simulation methodology to the fretting wear-induced failure experienced in a commercial plant indicates that this methodology can be utilized as an effective tool in evaluating the capability of newly developed cladding materials and/or new spacer grid designs against the fretting wear-induced damage.

• Journal of the Korean Ceramic Society
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• v.37 no.2
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• pp.111-116
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• 2000

700nm red emission(3F3longrightarrow3H6) in Tm3+ ion with 800 nm(3H6longrightarrow3H4) excitation via upconversion process has been reported only in host materials which have low phonon energies such as halide crystals. However, we observed 700nm and 480nm(1G4longrightarrow3H6) upconverted emission with 800nm excitation in several oxide glasses which has never reported. With spectroscopic analyses and lifetime measurements of each nergy level of Tm3+ ion doped in various oxide glasses, following mechanisms are suggested. For red upconversion, upconversion mechanism changed with Tm3+ concentration. While direct excitation up to 3F3 level via anti-Stokes excitation was dominated at low concentration, two-step excitation via 3H6longrightarrow3H4 and 3F4longrightarrow3F3 transitions was dominated at high concentration. For blue upconversion, two step excitation mechanism up to 1G4 level was suggested as follows : electrons are exciated up to 3H5 with direct excitation with pumping light up to 3H4 followed by multiphonon relaxation, and then additional reabsorption of pumping light excites electrons up to 1G4.

• Bulletin of the Korean Chemical Society
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• v.27 no.7
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• pp.1038-1042
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• 2006

A new type of DTPA-bis-amides (L1-L4) and their Gd(III)-complexes of the type $[Gd(L)(H_2O)]{\cdot}nH_2O$ (5: L1; 6: L2; 7: L3; 8: L4) have been prepared and characterized by analytical and spectroscopic techniques. The X-ray crystal structure of 8 has been determined for structural confirmation. The coordination geometry adopts a tricapped trigonal prism geometry with L4 acting as a chelate octadentate and a water molecule in the coordination sphere. Crystals are monoclinic, $P2_1$, a = 14.468(3), b = 19.235(4), c = 13.527(2) $\AA$ $\beta$ = $107.245(3)^{\circ}$, V = 3595.2(11) $\AA^3$, Z = 4, $D_{calc}$ = 1.570. Significant increases in relaxivities are observed with 6 and 7 as compared with that of $Omniscan^{(R)}$, a commercial MR agent: R1 = 12.46 $mM^{-1}\;s^{-1}$, R2 = 8.76 $mM^{-1}\;s^{-1}$ for 6; R1 = 12.77 nm-1 s-1, R2 = 7.60 mM-1 s-1 for 7; R1 = 4.9 $mM^{-1}\;s^{-1}$, R2 = 4.8 $mm^{-1}\;s^{-1}$ for $Omniscan^{(R)}$. In the case of 5, however, both R1 and R2 are found to be lower to show 2.09 $mM^{-1}\;s^{-1}$, and 1.82 $mM^{-1}\;s^{-1}$, respectively.