• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.2
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• pp.206-214
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• 2003

Mean flow and turbulence properties of developing turbulent flows in a 90 degree square bend with spanwise rotation were measured by a hot-wire anemometer. A slanted wire is rotated into 6 orientations and the voltage outputs from them are combined to obtain the mean velocity and Reynolds stress components. The combinative effects of the centrifugal and Coriolis forces due to the curvature and the rotation of bend on the mean motion and turbulence structures are investigated experimentally. Results show that the two body forces can either enhance or counteract each other depending on the flow direction in the bend.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2009.11a
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• pp.407-408
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• 2009

In this work, a quantitative method of the sequential separation of $^{90}Pu,\;^{90}Sr$ and $^{241}Am$ nuclides was developed in environmental soil samples using by an anion exchange resin connected with a Sr Spec resin. The sequential methods of Pu, $^{90}Sr$ and $^{241}Am$ nuclides can reduce analysis cost and time. With the sequential methodupdated in this study, the activity concentrations of $^{239,240}Pu,\;^{90}Sr$ and $^{241}Am$ in the IAEA reference materials were close to the reference values reported by the IAEA.

• Proceedings of the Korean Radioactive Waste Society Conference
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• 2009.11a
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• pp.131-132
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• 2009

시멘트 고화체 중의 Sr-90 분석을 위한 시료 전처리 방법을 실험을 통하여 확립하였다. 시멘트 고화체 중의 Sr-90 과 같은 베타방출 핵종을 분석하기 위해서는 고화체 시료를 건조, 분쇄, 산처리, Sr-90 분리 및 LSC 를 이용한 Sr-90의 방사능 측정을 해야 한다. 이를 위하여 인수 고화체 시료를 전 처리 하기 전, SRM 1887a portland cement 를 사용하여 여러 산 처리 방법을 통하여 각 원소들의 회수율을 알아보았다. SRM 시료를 통하여 얻은 조건을 참조하여 실제 고화체 시료 5g 씩 3회의 7개 시료들을 전 처리하여 ICP-AES 를 통하여 각 원소들의 회수율을 비교하였다. 또한, 전처리 후 Sr 분리에 Sr-resin (Eichrom)를 이용하기 위해서는 Sr-resin 사용 시 많은 영향을 주는 칼슘의 량을 미리 알아야 한다, 이를 위하여 시멘트 고화체 중 50% 가까이 함유되어 있는 칼슘 량을 반 정량적으로 알아내기 위한 방법을 확립하였다.

• Clinical and Experimental Reproductive Medicine
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• v.25 no.3
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• pp.349-353
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• 1998

It has been well known that infertile women experience not only emotional disturbance but also stress. But there is no concern about male infertility patients. So phychiatric symptoms were studied with SCL-90 (Symptom Check List-90) in 30 infertile men who was operated testicular sperm extraction (TESE) in Samsung Cheil Hospital and in age matched 31 fertile men from Jan. 1998 to Aug. 1998. In 5 symptom dimensions (Obcessive-Compulsive, Interpersonal Sensitivity, Depression, Phobic anxiety, Psychoticisim) scores. The Infertile group scored significantly higher than the control group. The result revealed that infertile men also experienced substantially more psychiatric symptoms than fertile men. Considering this results, psychiatric evaluation and tender care by infertility specialist are necessary for infertile men during and after evaluation and treatment.

• Bulletin of the Korean Chemical Society
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• v.32 no.9
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• pp.3229-3232
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• 2011

A FRET-based high-throughput screening system was developed for the discovery of competitive smallmolecule Hsp90 inhibitors. The biarsenical fluorescein derivative FlAsH and dabcyl-conjugated Hsp90 inhibitor GM were employed as the FRET donor and quencher, respectively. The spatial proximity perturbation between FlAsH-labeled Hsp90N and GM-dabcyl upon treatment of a small molecule led to changes in the FRET-induced fluorescence, monitored in a high-throughput fashion.

• Journal of Environmental Health Sciences
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• v.21 no.1
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• pp.78-85
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• 1995

Ornithine decarboxylase(ODC) is an indicate enzyme in carcinogenesis. We divided Sprague Dawley rats into six groups: control, electric field exposure, X-ray only irradiation, X-ray irradiation with electric field exposure group, Sr-90 injected group and Sr-90 and electric field complex exposure group. The ODC activity was measured in rat's bone marrow cell every week. The results were summarized as follows: The ODC activitied was increased in X-ray irradiated, Sr-90 injected and Sr-90 and electric field complex exposed group as compared with that of control(p<0.05). The ODC activity was increased comparing that of control neither in X-ray and electric field complex exposed group nor electric field only exposed group. This result suggests that the electric field doesn't have myeloid carcinogenicity and myeloid cancer incidence caused by ionized radiation is suppressed by electric field exposure.

• BMB Reports
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• v.45 no.1
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• pp.1-6
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• 2012

Hsp90 is one of the most conserved molecular chaperones ubiquitously expressed in normal cells and over-expressed in cancer cells. A pool of Hsp90 was found in cancer mitochondria and the expression of the mitochondrial Hsp90 homolog, TRAP1, was also elevated in many cancers. The mitochondrial pool of chaperones plays important roles in regulating mitochondrial integrity, protecting against oxidative stress, and inhibiting cell death. Pharmacological inactivation of the chaperones induced mitochondrial dysfunction and concomitant cell death selectively in cancer cells, suggesting they can be target proteins for the development of cancer therapeutics. Several drug candidates targeting TRAP1 and Hsp90 in the mitochondria have been developed and have shown strong cytotoxic activity in many cancers, but not in normal cells in vitro and in vivo. In this review, recent developments in the study of mitochondrial chaperones and the mitochondria-targeted chaperone inhibitors are discussed.

• Smart Structures and Systems
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• v.19 no.5
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• pp.473-485
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• 2017

Ratcheting behavior of $90^{\circ}$ elbow piping subject to internal pressure 20 MPa and reversed bending 20 kN was investigated using experimental method. The maximum ratcheting strain was found in the circumferential direction of intrados. Ratcheting strain at flanks was also very large. Moreover, the effect of temperature on ratcheting strain of $90^{\circ}$ elbow piping was studied through finite element analysis, and the results were compared with room condition ($25^{\circ}$). The results revealed that ratcheting strain of $90^{\circ}$ elbow piping increased with increasing temperature. Ratcheting boundary of $90^{\circ}$ elbow piping was determined by Chaboche model combined with C-TDF method. The results revealed that there was no relationship between the dimensionless form of ratcheting boundary and temperature.

• 한국전산유체공학회:학술대회논문집
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• 1997.10a
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• pp.17-22
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• 1997

The performances of the CRAYT3E and CRAYC90 were compared in the point of aerodynamics. The CRAYC90 with and without the highest vector option was run, respectively. The CRAYT3E was run with various processors (from 1pe to 32pes). The communication utilities of MPI and SHMEM were used to inform the boundary data to the other processors. The DADI Euler solver, which is implicit scheme and use central difference method, was used. The domain decomposition method was also used. As the result, the CRAYC90 with the highest vector option is 5.7 times faster than the CRAYT3E with 1 processor. However, because of the scalability of the CRAYT3E, the CRAYT3E with more than 6 processors is faster than CRAYC90. In case that 32 processors used, the CRAYT3E is 6 times faster than CRAYC90 with the highest vector option.

• Journal of Microbiology and Biotechnology
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• v.28 no.7
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• pp.1086-1093
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• 2018

Honokiol, a bioactive compound isolated from the cone and bark of Magnolia officinalis, has been shown to have various activities including inhibition of the growth of Candida albicans. We investigated the roles of the Hsp90-calcineurin pathway in the antifungal activity of honokiol. The pharmacologic tool was employed to evaluate the effects of Hsp90 and calcineurin in the antifungal activity of honokiol. We also evaluated the protective effects of the calcineurin inhibitor cyclosporin A (CsA) on honokiol-induced mitochondrial dysfunction by the fluorescence staining method. The Hsp90 inhibitor potentiated the antifungal activity of honokiol. A C. albicans strain with the calcineurin gene deleted displayed enhanced sensitivity to honokiol. However, co-treatment with calcineurin inhibitor CsA attenuated the cytotoxic activity of honokiol due to the protective effect on mitochondria. Our results provide insight into the action mechanism of honokiol.