• 한국정밀공학회지
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• 제16권3호통권96호
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• pp.180-188
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• 1999

${\mu}$-synthesis is applied to design a robust controller for a seeker scan loop system which has model uncertainty and is subject to a external disturbance due to abrupt missile maneuver. The issue of modelling a real-valued parametric uncertainty of a physical seeker scan loop system is discussed. The two-degree-of-frame control structure is employed to obtain better performance. It is shown that ${\mu}$-synthesis provides a superior framework for the robust control design of a seeker scan loop system which exhibits robust performance. The proposed robust control system satisfies design requirements, and especially shows good scanning performances for conical and rosette scan patterns despite parametric uncertainty in real system model.

• 대한기계학회논문집A
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• 제20권10호
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• pp.3186-3198
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• 1996

When a robot is to have contact with its enviornment, such as a medi-care robot, it would be advantageous for the robot to have a high compliance. For this reason, a robot having not only a flexible link but also an actuator with compliance, is desirable. This paper is concerned with the position and vibration control of 1 degree of freedom flexible robot using a pneumatic artificial muscle actuator. The dynamics of the manipulator assumed to be and Euler-Bernoulli beam are derived on the basis of the linear mathematical modle. Although this pneumatic artifical muscle actuator has many merits for the compliance robot, it is difficult to make an effective control scheme of this system because of ths nonlinearity and uncertainty on the dynamics of the actuator. By designing a controller using .mu.-synthesis, robust performance against measurement noise, various modeling uncertainties on the dynamics of the servo valve, actuator and mainpulator, is achieved. The effectiveness of the proposed control method is illustrated through simulations and experiments.

• 한국지진공학회논문집
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• 제6권6호
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• pp.41-48
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• 2002

이 논문은 지진을 받는 축소 3층 건물모델의 제어 실험에 관한 것이다. 건물모델에 대해 능동 질량 감쇠기를 사용하여 강인제어기인 $\mu$합성 제어기를 설계하고 실험적으로 검증하였다. 외란 입력과 제어용 출력에 적합한 주파수 가중함수를 설정하고 가중함수의 조합을 분석하여 최적의 $\mu$합성 제어기를 제시하였다. 실험 결과 백색잡음 가진 입력에 대한 RMS 응답에서 60-70%의 감소를 보여주었고, 축소 지진 입력에 대한 최대 응답에서 30-45% 정도의 감소효과를 나타내었다. 수치해석결과와 실험의 결과가 매우 정확히 일치하였으며 불확실성을 갖는 구조물에 대하여 제어기가 불확실성의 범위 내에서 강인하다는 것을 보여주었다.

• 제어로봇시스템학회논문지
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• 제5권6호
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• pp.656-666
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• 1999

In this paper, we design the optimal PD control system which has the robust performance. This PD control system is designed by applying genetic algorithm (GA) to the determination of proportional gain KP and derivative gain KD that are given by PD servo controller, to make the output of plant follow the output of reference model optimally. These proportional and derivatibe gains are simultaneously optimized in the search domain guaranteeing the robust performance of system. And, this PD control system is compared with $\mu$ -synthesis control system for the robust performance. The PD control system designed by the proposed method has not only the robust performance but also the better command tracking performance than that of the $\mu$ -synthesis control system. The effectiveness of this control system is verified by computer simulation.

• 대한화장품학회지
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• 제27권1호
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• pp.99-109
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• 2001

Novel glucoconjugates phenolic moiety, 3-(methoxycarbonyl)-4-(hydroxyphenyl)-$\beta$-D-glucopyranoside(4), 3-(methoxyacetyl)-4-(hydroxyphenyl)-$\beta$-D-glucopyranoside(7), 4-(hydroxyphenyl)-$\beta$-D-ribofuranoside(11), were synthesized. In order to investigate their depigmentation effect, inhibitory activity against mushroom tyrosinase and inhibitory activity of melanin synthesis in B16 melanoma cell were evaluated in vitro. Compound 11 showed 92.0$\mu\textrm{g}$/㎖ of tyrosinase inhibitory activity whereas compound 4 and 7 showed very low activity not less than 300$\mu\textrm{g}$/㎖. Inhibitory activities of melanin synthesis in B16 melanoma cell of compound 4, 7, and 11 were 8.7, 15.1, and 36.0%, respectively, at the concentration of 100$\mu\textrm{g}$/㎖. Inhibitory activity of compound 11 was much higher than that of arbutin at the same concentration.

• 제어로봇시스템학회논문지
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• 제4권6호
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• pp.729-737
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• 1998

In this paper, using $\mu$ synthesis algorithm with structured uncertainty, we design controller and apply it for the Two-Inertia resonance(TMS: Two Mass Spring) system. The TMS system is one of the simplest models which generate a torsional vibration. In this system, it is required to design a controller achieving the control performance while suppressing the torsional vibration. Furthermore, when vibration frequency for the system is varying by reason of parameter variations, we should consider parameter variations in controller design. Then, we design two other controller schemes of the PI controller and the standard $H_{\infty}$ controller and compare these controllers with the controller designed by the $\mu$ synthesis robust control method by using simulations and experiments.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.321.1-321.1
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• 2002

To indentify inhibitors of melanogenesis. we compared the effect of some natural products on mushroom tyrosinase. human melanocytic tyrosinase activity and melanin content. The cytotoxicity of the component were also tested on cultured mouse melanoma cells, Each extract significantly inhibited tyrosinase activity and melanin synthesis in vitro and B 16 melanoma cell lines. In B 16 cell lines, watermelon's inner shell extract inhibited tyrosinase activity as strong as kojic acid at 150${\um}g$/${\mu}\ell$ concentration. And morning glory'seed extract inhibited melanin synthesis more than kojic acid at 150${\um}g$/${\mu}\ell$ concentration. Each extract were strong inhibitors of tyrosinase activity and total melanin synthesis in B 16 mouse melanoma cell lines at less than 100${\um}g$/${\mu}\ell$ concetration. These result show that extract of watermelon's inner shell. lettuce. morning glory's seed and licorice root could be developed as skin whitening component of cosmetics.

• Asian-Australasian Journal of Animal Sciences
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• 제6권4호
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• pp.483-489
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• 1993

Bovine fibroblasts were cultured in Dulbecco's Modified Eagle's Medium and then treated with control, insulin (I, $1{\mu}g/ml$), cholera toxin (CT, 0.1-100 ng/ml) or CT (0.1-100 ng/ml) + I ($1{\mu}g/ml$). Cholera toxin, an activator of adenylate cyclase, significantly decreased insulin induced DNA synthesis (p<0.05). The modulation of DNA synthesis apparently involves events occurring in early stage of cell growth, at least between the first 4 and 8 hour of CT treatment. Insulin induced collagen as well as noncollagen synthesis in cell layer, however, these syntheses were reduced by addition of cholera toxin (p<0.05) but were not completely reduced. It is not clear whether the reduction of insulin-induced cell layer collagen or noncollagen proteins by CT is involved in the inhibitory effect on insulin-induced DNA synthesis. However, we could rule out the hypothesis that insulin-induced DNA synthesis is reduced by CT-induced cellular differentiation.

• 대한한의학회지
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• 제23권4호
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• pp.45-54
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• 2002

Objectives: In order to investigate the relationship of Radix Trichosanthis components and the melanin synthesis, the author has analyzed the cell viability and tyrosinase activity, melanin content and morphologic changes in n-hexane, EtOAc, n-BuOH, and H2O fraction. Methods: At first, in order to determine the concentration of the Radix Trichosanthis component, the author investigated the viability of B16 melanoma cell. To measure the effects of Trichosanthes kirilowii extracts (n-BuOH, n-Hexane, EtOAc, H2O fractions) on the viability of A549 cells, A549 cells were treated with various concentrations (from 0.5 to $25{\;}\mu\textrm{g}/ml$) of components of Trichosanthes kirilowii. After 24hrs, the cell viability was measured by MTT assay. The EtOAc components of Trichosanthes kirilowii decreased the viability of A549 cells in a dose-dependent manner. H2O and n-BuOH components had no cell toxicity till $25{\;}\mu\textrm{g}/ml$, the n-hexane component showed minor cell toxicity at $25{\;}\mu\textrm{g}/ml$ and the EtOAc component cell toxicity was revealed at $5{\;}\mu\textrm{g}/ml$ concentration. Results: 1. The results of tyrosinase activity and the Radix Trichosanthis component; n-hexane and EtOAc components controlled it effectively; the n-BuOH components were less effective. 2. The results of melanin content analysis showed that the n-hexane and EtOAc components effectively inhibited, the n-BuOH fraction inhibited less, and H2O component didn't inhibit the terminal melanin formation. 3. In the n-BuOH and H2O component there were no changes, but in the n-hexane component the melanin content was effectively inhibited. 4. In the EtOAc fraction, although the melanin content was inhibited, the cell count was evidently suppressed, Of all of the Radix Trichosanthis components, the n-Hexane and EtOAc fractions inhibited the melanin synthesis best, but owing to its toxicity, the EtOAc components inhibited the cell count. Conclusion: The above results demonstrated that Radix Trichosanthis n-hexane fraction efficiently inhibited the tyrosinase activity and melanin synthesis.

• 한국미생물·생명공학회지
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• 제18권3호
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• pp.239-243
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• 1990

카드뮴 내성 효모, Hansenula anomala B-7 세포에 축적된 카드뮴의 세포내 분포와 단백질 합성에 미치는 카드뮴의 영향 등에 대하여 연구하였다. 세포내 축적된 카드뮴의 84.9는 cytosol 등인 가용성 분획에 존재했다. 세포내 단백질 함량은 카드뮴(1,000$\mu g$0/ml)에 의하여 감소되었으나, 유안(30-75 포화)에 의하여 침전되는 가용성 단백질의 함량은 카드뮴에 의하여 증가되었다. 더욱이 카드뮴(1,00$\mu g$0/ml)의 첨가배지에서 배양된 세포에는 고분자 가용성 단백질이 카드뮴 무첨가 배지에서 배양된 세포에서 보다 증가되었으나, 저분자 단백질은 감소되었다. 이상의 결과로 단백질의 합성은 카드뮴에 의하여 저해되나, 유안(30-75 포화)에 의하여 침전되는 고분자 단백질의 합성은 카드뮴에 의하여 촉진된다.