• Journal of the Korean Crystal Growth and Crystal Technology
• /
• v.5 no.4
• /
• pp.343-350
• /
• 1995

A Abstract Systematic studies of the effects of crystalline forms of starting powders and p processing variables on the texture of hot - pressed silicon carbide are described. The results I indicate that hot - pressing of $\beta$ - SiC can produce strong textures and composite type duplex microstructure due to the ${\beta} {\rightarrow} {\alpha}$ phase transformation of SiC. The texture variations d during post - annealing have been observed. In the case of using a - SiC as starting pow¬d ders, the degree of preferred orientation by hot - pressing is relatively weak.

• Communications of the Korean Mathematical Society
• /
• v.30 no.4
• /
• pp.403-414
• /
• 2015

Extensions of some classical special functions, for example, Beta function B(x, y) and generalized hypergeometric functions $_pF_q$ have been actively investigated and found diverse applications. In recent years, several extensions for B(x, y) and $_pF_q$ have been established by many authors in various ways. Here, we aim to generalize Appell's hypergeometric functions of two variables and Lauricella's hypergeometric function of three variables by using the extended generalized beta type function $B_p^{({\alpha},{\beta};m)}$ (x, y). Then some properties of the extended generalized Appell's hypergeometric functions and Lauricella's hypergeometric functions are investigated.

• Proceedings of the PSK Conference
• /
• 2003.10b
• /
• pp.136.1-136.1
• /
• 2003

$\beta$-amyloid (A$\beta$) peptide produced from amyloid precursor protein (APP) is a major cause of Alzheimer's disease (AD). Therefore, in early phase of AD, imbalance of the production and the clearance of $A\beta$ is regarded as an important factor to progressive AD presenting senile plaque, a hallmark of AD. In the present study, we wanted to verify whether Rg3 can playa role in helping microglia engulfing $A\beta$ peptides. Validations for the study was conducted by using DiI-Ac-LDL, which attached only on type A macrophage scavenger receptor (MSR-A) and ligands for he receptor, fucoidan. (omitted)

• Clinical and Experimental Reproductive Medicine
• /
• v.28 no.4
• /
• pp.279-286
• /
• 2001

Objective: To elucidate 1) whether there are any differences in the urine concentrations of steroid hormone metabolites between patients with leiomyoma and normal controls 2) the correlation between urinary profiles of steroid hormones and leiomyomas of the uterus according to their type, location, volume, and weight. Materials of Methods : The study population consisted of 37 premenopausal patients with uterine leiomyoma and the control group consisted of 25 premenopausal normal volunteer women without uterine leiomyoma. Confirmation of the existence of uterine leiomyoma was done by ultrasonography and histopathological examination after surgery. The volume of the leiomyoma was estimated by trans-abdominal and/or trans-vaginal ultrasonography. The Leiomyomas were divided into 3 types (subserosal, intramural and submucosal). Seventeen patients had subserosal type of leiomyoma, 10 with the intramural type and 10 with the submucosal type. The locations of the leiomyoma were also divided into 3 groups (fundus, body and isthmus). Seventeen patients showed a fundus location, 10 in body, and 10 in isthmus. We compared urinary profiles of the endogenous steroids between patients with leiomyomas and normal controls, and also investigated the relationship between urinary profiles of the endogenous steroids and leiomyomas according to their type, location, volume and weight by using highly sensitive Gas Chromatography-Mass Spectrometry (GC-MS) system. Results: The mean ages of the patients with leiomyomas and the control group were $43.1{\pm}5.6$ and $40.6{\pm}7.2$ years, the weights were $63.4{\pm}7.3$ and $59.4{\pm}8.1\;kg$, and their heights were $155.4{\pm}4.8$ and $159.3{\pm}4.8\;cm$ respectively. Seventeen patients had subserosal, 10 had intramural, and 10 had submucosal leiomyomas. There were 17 patients with leiomyoma located in fundus, 10 in body and 10 in isthmus. $17{\beta}$-estradiol, 5-AT, 11-keto ET, $11{\beta}$-hydroxy An, $11{\beta}$-hydroxy Et, THS, THA, THE, a-cortolone, a-cortol, $\beta$-cortol, $11{\beta}$-OH Et/$11{\beta}$-OH An and E2/E1 were significantly increased in patients with leiomyoma than in the control group. $17{\beta}$-estradiol was significantly increased in the intramural and the submucosal types than in the subserosal type. There was no significant difference in the concentrations of urinary steroids according to the locations of leiomyomas. There was no significant relationship between the concentration of urinary steroids and the volume of the leiomyomas. $17{\beta}$-estradiol significantly decreased as the weight of uterus increased (r=-0.322, p=0.04). Conclusion: The concentrations of steroid hormone metabolites were generally increased in patients with leiomyoma but were not significantly related to the volume and weight of the leiomyomas. Our study suggests that steroid hormones may be involved in the initiation of leiomyomas but may not be involved in their progression. In addition, the concentrations of steroid hormone metabolites are not related to the leiomyoma type and location.

• Korean Journal of Ichthyology
• /
• v.23 no.1
• /
• pp.21-29
• /
• 2011

Expression analysis of development-related genes was conducted using differential screening of 6-month-old [18M(-), 6M-18M] specific and 18-month-old [6M(-), 18M-6M] specific subtracted cDNA libraries constructed by subtractive hybridization using skeletal muscle of 6- and 18-month-old dark-banded rockfish Sebastes inermis. A total 202 cDNA clones displaying different expression levels in each stage were obtained; among them, 32 clones showing up-regulation were finally selected for further expression analysis. We sequenced the clones and analyzed individual sequences. Genes expressed specifically in 6-month-old skeletal muscle were identified as myosin, adenylate kinase, calsequestrin, dystrobrevin beta, and diphosphate kinase-Z1. Genes showing strong expression in 18-month-old rockfish were identified as desmin, TGFBR2 (transforming growth factor-beta receptor), muscle-type creatine kinase, and cathepsin D. Expression of these genes was checked further in 6-18-30-42 month-old dark-banded rock fish. Rapid reduction of expression was observed in dystrobrevin beta and diphosphate kinase. However, expression of creatine kinase (muscle type) and cathepsin D increased as dark-banded rockfish grew, and remained even after 18 months. The results reported here demonstrate that genes related to muscles contract are expressed at an early stage of development, and genes controlling energy in muscles are predominantly expressed at a late developmental stage.

• Biomolecules & Therapeutics
• /
• v.26 no.6
• /
• pp.560-567
• /
• 2018

In the present study, we tried to examine whether resveratrol regulates the expression of matrix metalloproteinases (MMPs) through affecting nuclear factor-kappa B ($NF-{\kappa}B$) in articular chondrocytes. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription-polymerase chain reaction (RT-PCR) was used to measure interleukin-${\beta}$ ($IL-1{\beta}$)-induced gene expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), ADAMTS-5 and type II collagen. Effect of resveratrol on $IL-1{\beta}$-induced secretion of MMP-3 was investigated in rabbit articular chondrocytes using western blot analysis. To elucidate the action mechanism of resveratrol, effect of resveratrol on $IL-1{\beta}$-induced $NF-{\kappa}B$ signaling pathway was investigated in SW1353, a human chondrosarcoma cell line, by western blot analysis. The results were as follows: (1) resveratrol inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) resveratrol reduced the secretion of MMP-3; (3) resveratrol inhibited $IL-1{\beta}$induced activation (phosphorylation) of inhibitory kappa B kinase (IKK), and thus phosphorylation and degradation of inhibitory kappa $B{\alpha}$ ($I{\kappa}B{\alpha}$); (4) resveratrol inhibited $IL-1{\beta}$-induced phosphorylation and nuclear translocation of $NF-{\kappa}B$ p65. This, in turn, led to the down-regulation of gene expression of MMPs in SW1353 cells. These results suggest that resveratrol can regulate the expression of MMPs through affecting $NF-{\kappa}B$ by directly acting on articular chondrocytes.

• Journal of Sericultural and Entomological Science
• /
• v.40 no.1
• /
• pp.52-59
• /
• 1998

For the construction of plasmid and bmNPV sarrying the FRT recognition site for the FLP recombinases, we synthesized the wild type FRT dligonucleotides. The target FRT sequences consist of three 13bp repeated DNA sequences; two repeats in a direct orientation and one inverted relative to the other two. In addition, there is an 8bp spacer region between the repeats which determune the orientation of the FRT recombination site. In order to place the FRT site both in target BmNPV genome and the transfer vector, we constructed a plasmid, FRT site both in the target BmNPv genome and the transfer vector, we constructed a plasmid, pFRT$\beta$-gal, carrying the FRT sites within the cloning sites of pSV vector and a recombinant BmNPV, vFRTPH, carrying the FRT sites at a downstream of polyhedrin promotor, respectively. In order to test the functionality of the FLP/FRT site-specific recombination system, vFRTPH, pFRT$\beta$-gal and pHsFLP DNA were co-transfected into BmN-4 cells. The resulting recombinant virus was designated a vFRT$\beta$2-gal. From construction analysis of the vFRT$\beta$2-gal with PCR technique it was concluded that the entire pFRT$\beta$-gal plasmid with $\beta$-galactosidase gene and origines of replication flanked by two functional hybrid FRT sequences. The efficiency of recombination was 8.7%, which was higher than that(2.2%) of recombination between a conventional transfer vector and the wild type BmNPV.

• The Journal of the Korea Contents Association
• /
• v.16 no.2
• /
• pp.503-512
• /
• 2016

The purpose of this study was to examine the impact of socioeconomic status on quality of life(QOL) among breast cancer survivors. The data were from breast cancer survivors in their forties, among whom the prevalence in terms of age was the highest in Korea. A total of 607 cases were analyzed and the mean scores of QOL measured by FACT-B were 93.75(SD=21.50). After controlling for the other socio-demographic and medical variables, QOL was significantly correlated to income and job type, which confirms the association between high socioeconomic status and better QOL. Specifically, groups with higher income($${\geq_-}4$$ million won/month, ${\beta}=0.11$, p= .03) and groups with self-employed(${\beta}=0.10$, p= .01) or professional/managerial(${\beta}=0.17$, p< .001) job type showed significantly better QOL. The need for more attention and support, including formal and informal resources, for breast cancer survivors with low socio-economic status and the implication for practice were discussed.

• Corrosion Science and Technology
• /
• v.6 no.3
• /
• pp.128-132
• /
• 2007

For a quantitative inspection on the performance of weathering steel bridges, we have investigated the relationship between the corrosion rate and the composition of the rust layers formed on weathering steel bridges located in various environments in Japan and applied a protective ability index (PAI) to the bridges. The corrosion rates were clearly classified by the PAI, ${\alpha}/{\gamma}*$ and sub index of $({\beta}+s)/{\gamma}*$, where $\alpha$, \gamma*, $\beta$ and s are the mass ratio of crystalline $\alpha-FeOOH$, the total of $\gamma$-FeOOH+ $\beta$-FeOOH + the spinel-type iron oxide (mainly $Fe_3O_4$), $\beta-FeOOH$ and spinel-type iron oxide, analyzed by powder X-ray diffraction, respectively. In the case of ${\alpha}/{\gamma}$*>1, the rust layer works protective enough to reduce the corrosion rate less than 0.01 mm/y. The sub index $({\beta}+s)/{\gamma}*$<0.5 or >0.5 classifies the corrosion rate of the non-protective rust layers, therefore the former state of the rust layer terms inactive and the latter terms active. The quantitative inspection of a weathering steel bridge requires a performance-inspection (PI) and periodical deteriorationinspections (DI). The PI can be completed by checking of the PAI, ${\alpha}/{\gamma}*$. The DI on the weathering steel bridges where deicing salt is sprinkled can be performed by checking the PAI, $({\beta}+s)/{\gamma}*$.

• Journal of Korean Public Health Nursing
• /
• v.28 no.2
• /
• pp.228-240
• /
• 2014

Purpose: This study was conducted in order to determine the influences of knowledge, self-efficacy, and social support on sick role behavior in patients with coronary artery disease. Methods: The participants were 192 patients with coronary artery disease in D city. Data were collected from January 1, 2014 to April 30, 2014 using a questionnaire. Data analysis was performed using SPSS/WIN 19.0 using ANOVA, t-test, Pearson correlation, and stepwise multiple regression. Results: Factors having an influence on sick role behavior were age (70 years old ${\beta}$=.275, p<.001), occupation (Office job ${\beta}$=-.230, p<.001), knowledge (${\beta}$=.204, p<.001), self-efficacy (${\beta}$=.188, p<.001), underlying disease (stroke ${\beta}$=.142, p=.008), and family type (live with their children ${\beta}$=-.128, p=.038). These factors explained 56% of the variance in sick role behavior. Conclusions: More positive knowledge and self-efficacy are needed for the sick role behavior. In addition, results of the study indicated that age, occupation, underlying disease, and family type were very important in predicting health behaviors of patients with coronary artery disease. Thus, it would be necessary to include patients' characteristics in designing an education program for people with coronary artery disease.