• Title/Summary/Keyword: $\Delta$L

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NMDA Receptor Activation Mediates Neuropathic Pain States Induced by Calcium Channel α2δ1 Subunit (신경병증성 통증과정의 NMDA 수용체 활성과 칼슘통로 α2δ1 Subunit의 영향)

  • Yu, Soo Bong;Lim, Young Soo;Kim, Doo Sik
    • The Korean Journal of Pain
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    • v.22 no.3
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    • pp.210-215
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    • 2009
  • Background: Several studies have indicated that a nerve injury enhances the expression of the voltage-gated calcium channel ${\alpha}2{\delta}1$ subunit (Cav ${\alpha}2{\delta}1$) in sensory neurons and the dorsal spinal cord. This study examined whether NMDA receptor activation is essential for Cav ${\alpha}2{\delta}1$-mediated tactile allodynia in Cav ${\alpha}2{\delta}1$ overexpressing transgenic mice and L5/6 spinal nerve ligated rats (SNL). These two models show similar Cav ${\alpha}2{\delta}1$ upregulation and behavioral hypersensitivity, without and with the presence of other injury factors, respectively. Methods: The transgenic (TG) mice were generated as described elsewhere (Feng et al., 2000). The left L5/6 spinal nerves in the Harlan Sprague Dawley rats were ligated tightly (SNL) to induce neuropathic pain, as described by Kim et al. (1992). Memantine 2 mg/kg (10 ul) was injected directly into the L5/6 spinal region followed by $10{\mu}l$ saline. Tactile allodynia was tested for any mechanical hypersensitivity. Results: The tactile allodynia in the SNL rats could be reversed by an intrathecal injection of memantine 2 mg/kg at 1.5 hours. The tactile allodynia in the Cav ${\alpha}2{\delta}1$ over-expressing TG mice could be reversed by an intrathecal injection of memantine 2 mg/kg at 1.5, 2.0 and 2.5 hours. Conclusions: The behavioral hypersensitivity was similar in the TG mice and nerve injury pain model, supporting the hypothesis that elevated Cav ${\alpha}2{\delta}1$ mediates similar pathways that underlie the pain states in both models. The selective activation of spinal NMDA receptors plays a key role in mediating the pain states in both the nerve-injury rats and TG mice.

COLORIMETRIC ANALYSIS OF COLOR DIFFERENCES BETWEEN DENTIN PORCELAINS (수종의 상아질색도재의 색차이에 대한 연구)

  • Kim, Chang-Seop;Lim, Jang-Seop;Jeong, Chang-Mo;Jeon, Young-Chan
    • The Journal of Korean Academy of Prosthodontics
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    • v.37 no.4
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    • pp.425-432
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    • 1999
  • The purpose of this study is to evaluate the color differences that can exist between different brands of dentin porcelain having identical shade designations. The instrumental colorimetric technique was used to determine these differences. The three brands of dentin porcelain used were Vita VMK-68, Shofu Vintage, and Ceramco II. The three shades selected were the Vita Lumin shades A2, B2, and C2. The color difference values were compared with each other using $L^*,\;a^*,\;b^*$, three variables of the CIELAB color system, and ${\Delta}E$. The results of this study were as follows: 1 Corresponding shades of different brands of dentin porcelain produced different $L^*,\;a^*,\;b^*$ values. 2. The greatest ${\Delta}E$ value in corresponding shade was found to exist between Ceramco II and Shofu Vintage, followed by between Vita VMK-68 and Ceramco II, and then between Vita VMK-68 and Shofu Vintage. 3. The ${\Delta}E$ values in shade C2 were mainly influenced by ${\Delta}L^*$ value ; however none of ${\Delta}L^*,\;{\Delta}a^*,\;{\Delta}b^*$ values had greater influence on ${\Delta}E$ values than the others in shade A2, B2. 4. Shofu Vintage had the highest $b^*$ value, followed by Vita VMK-68, and then Ceramco II.

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Long-term Functional and Patient-reported Outcomes Between Intra-corporeal Delta-shaped Gastroduodenostomy and Gastrojejunostomy After Laparoscopic Distal Gastrectomy

  • Sin Hye Park ;Hong Man Yoon ;Keun Won Ryu ;Young-Woo Kim ;Mira Han;Bang Wool Eom
    • Journal of Gastric Cancer
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    • v.23 no.4
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    • pp.561-573
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    • 2023
  • Purpose: This study aimed to compare the long-term functional and patient-reported outcomes between intra-corporeal delta-shaped gastroduodenostomy and gastrojejunostomy after laparoscopic distal gastrectomy for gastric cancer. Materials and Methods: We retrospectively reviewed clinicopathological data from 616 patients who had undergone laparoscopic distal gastrectomy for stage I gastric cancer between January 2015 and September 2020. Among them, 232 patients who had undergone delta-shaped anastomosis and another 232 who had undergone Billroth II anastomosis were matched using propensity scores. Confounding variables included age, sex, body mass index, physical status classification, tumor location, and T classification. Postoperative complications, nutritional outcomes, endoscopic findings, and quality of life (QoL) were compared between the 2 groups. Results: No significant differences in postoperative complications or nutritional parameters between the two groups were observed. Annual endoscopic findings revealed more residual food and less bile reflux in the delta group (P<0.001) than in the Billroth II group. Changes of QoL were significantly different regarding emotional function, insomnia, diarrhea, reflux symptoms, and dry mouth (P=0.007, P=0.002, P=0.013, P=0.001, and P=0.03, respectively). Among them, the delta group had worse insomnia, reflux symptoms, and dry mouth within three months postoperatively. Conclusions: Long-term nutritional outcomes and QoL were comparable between the delta and Billroth II groups. However, more residual food and worse short-term QoL regarding insomnia, reflux symptoms, and dry mouth were observed in the delta group. Longer fasting time before endoscopic evaluation and short-term symptom management would have been helpful for the delta group.

Protonation and Energetical Investigations of Calix[4]-cyclen-benzo-crown-6 and Its Complexes with Zinc and Copper

  • Boonchoo, Thanaporn;Pulpoka, Buncha;Ruangpprnvisuti, Vithaya
    • Bulletin of the Korean Chemical Society
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    • v.25 no.6
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    • pp.819-822
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    • 2004
  • Protonation constants of calix[4]-cyclen-benzo-crown-6, L in 1X$10^{-2}$ M $Bu_4NCF_3SO_3$ in 40% $CH_2Cl_2/CH_3OH$ at $25^{\circ}C$ determined by potentiometric titration are log $K_1$ = 10.91, log $K_2$ = 10.30, log $K_3$ = 6.24 and log $K_4$ = 2.55. Stability constants for the receptor L complexes with Cu(II) and Zn(II) in 1X$10^{-2}$ M $Bu_4NCF_3SO_3$ in 40% $CH_2Cl_2/CH_3OH$ at $25^{\circ}C$ were determined by UV-VIS spectrometric titration. Stability constants of the CuL and ZnL complexes as log $\beta$ are 4.37 and 3.45, respectively. Stabilization energies for protonations of receptor L, derived from ab initio Hartree-Fock method with 6-31G basis set, are ${\Delta}E_1$ = -290.1, ${\Delta}E_2$ = -205.0, ${\Delta}E_3$ = -124.9 and ${\Delta}E_4$ = -26.9 kcal/mol and complexation energy of ZnL complex is -370.3 kcal/mol.

The color comparison of zirconia fabricated by using various coloring liquids (수종의 색소체용액으로 제작된 유색 지르코니아의 색조비교)

  • Oh, Gye-Jeong;Jung, Jong-Hyun
    • Journal of Technologic Dentistry
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    • v.36 no.4
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    • pp.247-253
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    • 2014
  • Purpose: The aim of this study was to evaluate the effect of colored zirconia with different coloring liquids. Methods: Total 30 specimens were prepared. Specimens were classified into 6 groups: IPS e.max Ceram(P), Uncolored zirconia(C), VITA In-Ceram$^{(R)}$2000 YZ LL1(L), Zirkonzahn coloring liquid(Z), Wieland coloring liquid(W), and Kuwotech coloring liquid(K). Four different types of zirconia coloring liquid, VITA In-Ceram$^{(R)}$ 2000 YZ LL1(VITA Zahnfabrik, Germany), Zirkonzahn coloring liquid(Zirkonzahn, Italy), Wieland coloring liquid(Wieland, Germany), Kuwotech coloring liquid(Kuwotech, Korea) were used to fabricate colored zirconia by using infiltrating method and then completely sintered. The color of the all specimens was measured using the spectrophotometer(CM-2600d, Konica Minolta, Japan) and expressed in terms of the 3-coordinated values(CIE $L^*a^*b^*$). Color differences were calculated using the equation $${\Delta}E^*=[({\Delta}L^*)^2+({\Delta}a^*)^2+({\Delta}b^*)^2]^{1/2}$$. Results: $L^*a^*b^*$ values of the colored zirconia were affected by the coloring liquids. The uncolored zirconia(C) group showed the highest $L^*$ value and zirkonzahn coloring liquid(Z) group showed the lowest $L^*$ value. Zirkonzahn coloring liquid(Z) showed the highest $a^*$ value and VITA In-Ceram 2000 YZ LL1(L) group showed the highest $b^*$ value. Generally, the color difference(${\Delta}E^*$) in all groups showed higher than 3.7 except between IPS e.max Ceram(P) and wieland coloring liquid(W) group. Conclusion: Within the limitations of this study, various coloring liquids influenced the $L^*$, $a^*$, and $b^*$ values of colored zirconia. IPS e.max Ceram(P) and wieland coloring liquid(W) group did not show clinically perceiving color difference.

Thermodynamic Parameters of Complexation of Lanthanides by L-proline (Lanthanides-L-proline 착물의 형성에 관한 열역학적 연구)

  • Choi Im-Yeon;Kim Young-Inn;Choi Sung-Nak;Hyun Myung-Ho
    • Journal of the Korean Chemical Society
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    • v.37 no.1
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    • pp.105-111
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    • 1993
  • The stability constants for lanthanides complexes with optically active L-proline (1 : 1) were determined in aqueous solution in the ionic medium of 0.1 M $NaClO_4$ at 25$^{\circ}C$ using a pH titration method. The results show called "gadolinium break" between lighter and heavier lanthanides. The linear relation between the stability constant (log$\beta$1) and the pKa values of ligands indicates that L-proline acts as a bidentate ligand in the complexation. The thermodynamic parameters (${\Delta}H$ and ${\Delta}S$) were also determined using an enthalpy titration method at the same condition. The positive endothermic enthalpy change and positive entropy change clearly indicate that the driving force for the complexation is an entropy effect. The comparison of the thermodynamic parameters of L-proline complexes with anthranilate complexes supports the conclusion that the heterocyclic nitrogen atom and carboxylate of L-proline are involved in the chleate formation. The enthalpy values for L-proline are more positive than the ones for anthranilate complex. The difference in enthalpy change for the complex formation between L-proline complex and anthranilate complex is explained in terms of the basicity of the nitrogen donor atom in the ligand. The relatively large entropy change may be described by the extra dehydration related to the rigidity of L-proline ring.

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The Early Detection of the Spore Using Sonication and Fluorescent Dye in the Field (현장에서 초음파 파쇄와 형광시약을 이용한 포자의 조기 탐지)

  • Ha, Yeon-Chul;Choi, Ki-Bong
    • KSBB Journal
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    • v.26 no.4
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    • pp.305-310
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    • 2011
  • This study was carried out to establish the optimum condition of cell disruption with a sonicator for the detection of the spore, Bacillus anthracis ${\Delta}$-sterne for the purpose of developing automatic fluorometer. The efficiency of sonication on the ${\Delta}$-sterne spore disruption was very weak. The ${\Delta}$-sterne spore with zirconia bead showed greater disruption than the ${\Delta}$-sterne spore alone when sonificated. The volumn of the zirconia bead added in the spore solution has little effect on the disruption efficiency. The detection limit of the ${\Delta}$-sterne spore with zirconia bead and the ${\Delta}$-sterne spore alone was $10^6$ CFU/mL and $5{\times}10^7$ CFU/mL respectively, when sample was sonicated for 20 seconds with a sonicator probe of 13 mm diameter.

Relationship between Physical Properties and Sensibility Obtained from the Rustling Sounds of Silk Fabrics and Their Transformed Colors (실크 직물의 스치는 소리와 변환된 색채의 물리량과 감성간의 관계)

  • 김춘정;최계연;김수아;조길수
    • Proceedings of the Korean Society for Emotion and Sensibility Conference
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    • 2001.11a
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    • pp.1-4
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    • 2001
  • 본 연구에서는 실크 직물 7종의 마찰음을 녹음한 후, 색채 변환시켜 소리와 변환색채에 e한 감성을 평가함으로써 시각과 청각을 만족시킬 수 있는 의류소재 개발에 대한 기초자료를 제공하고자 하였다. 피험자 30명을 대상으로 소리와 변환색채를 차례로 제공한 후 감성을 평가하도록 하였다. 물리량은 소리의 경우 LPT, $\Delta$L, $\Delta$f, ARC를 색채의 경우 RP, GP, BP, CC를 계산하여 감성과의 관계를 조사하였다. 소리와 색채에 대한 감성차원으로는 '우아함', '활동감', '터프함'의 세요인이 도출되었다. 각 감성차원에 대한 소리와 색채 물리량과의 관계를 살펴보면, LPT와 $\Delta$L이 작을수록, 홍색비율이 크고 색채빈도수가 적을수록 우아함차원으로 평가하였으며, LPT와 $\Delta$L의 값이 클수록, 녹색비율이 크고 색채빈도수가 많을수록 활동감차원으로 평가하였다. 또한 ARC값이 작을수록, 홍색비율이 클수록 터프함차원으로 나타났다. 직물별 소리와 색채에 대한 선호도는 전통적인 수자직 직물이 가장 높게 나타났다.

Superconducting Properties and Tunneling Spectroscopy of Bi2Sr2Ca(Cu1-xNix)2O8+δ Film by LPE Method (LPE법으로 성장시킨 Bi2Sr2Ca(Cu1-xNix)2O8+δ 막(film)의 초전도특성 및 터널링 분광)

  • 이민수
    • Journal of the Korean Ceramic Society
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    • v.40 no.5
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    • pp.455-459
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    • 2003
  • Tunneling spectra of B $i_2$S $r_2$Ca(C $u_{1-x}$ N $i_{x}$ )$_2$ $O_{8+}$$\delta$/ film by LPE method have been measured using break junctions. The energy gap 2$\Delta$ and 2$\Delta$/ $k_{B}$ $T_{c}$ $^{zero}$ increased with increase of ft. We obtained the energy gap Parameter 2$\Delta$(4.2 K) = 54.4~64 meV, and corresponding1y $\Delta$/ $k_{B}$ $T_{c}$ $^{zero}$=7.36~10.14, larger than the BCS value. The lattice constant c and critical temperature $T_{c}$ $^{zero}$ decrease with increase of $\chi$$_{L}$.

Effect of Different Coagulants on Quality of Tofu Incorporated with Persimmon Fruit Powder (응고제 종류가 감 분말 첨가 두부의 품질과 저장성에 미치는 영향)

  • Lee, Yun-Rae;Chung, Hun-Sik;Seong, Jong-Hwan;Moon, Kwang-Deog
    • Food Science and Preservation
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    • v.18 no.5
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    • pp.678-683
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    • 2011
  • The effects of coagulant types (magnesium chloride, calcium chloride, calcium sulfate, glucono-${\delta}$-lactone) on yield, quality properties and storability of astringent persimmon powder added tofu were investigated. Yield, hardness, chewness, crispness, and overall acceptability of tofu coagulated by glucono-${\delta}$-lactone were higher than those coagulated by the others. L value, a value, pH, soaking-solution turbidity, and total aerobic bacteria of glucono-${\delta}$-lactone coagulated tofu were lower than those coagulated by the others. Calcium sulfate and calcium chloride coagulated tofu showed relatively high L and b values. Magnesium chloride coagulated tofu had higher sensory score for firmness, taste, overall acceptability than calcium chloride and calcium sulfate coagulated tofu, but there was no significant difference between magnesium chloride and glucono-${\delta}$-lactone. The results suggested that glucono-${\delta}$-lactone and magnesium chloride were found to be the suitable coagulants for processing of the persimmon powder added tofu.