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http://dx.doi.org/10.14405/kjvr.20220020

Primary copper-associated chronic hepatitis without copper metabolism domain containing 1 mutation in a Dalmatian: a case report  

Sumin Yun (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Dohee Lee (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Jimin Oh (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Yeon Chae (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Taesik Yun (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Yoonhoi Koo (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Mhan-Pyo Yang (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Byeong-Teck Kang (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Hakhyun Kim (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Publication Information
Korean Journal of Veterinary Research / v.62, no.4, 2022 , pp. 31.1-31.5 More about this Journal
Abstract
A 12-year-old intact male Dalmatian dog presented hyporexia and vomiting for 1 week. Blood analysis revealed increased liver enzyme activity. Histopathological examination of the liver confirmed chronic hepatitis with fibrosis and necrosis. Copper staining revealed marked copper accumulation (2,770 ppm; normal range, 200 to 400 ppm), prominent in the centrilobular region, and compatible with copper-associated chronic hepatitis. However, copper metabolism domain containing 1 (COMMD1) mutation predisposing to copper accumulation in the liver tissue was not identified. The dog received medications but died 1 month after first visit. This is the first case of primary copper-associated hepatitis without COMMD1 mutation in a Dalmatian dog in South Korea.
Keywords
dogs; liver; penicillamine; rhodanine;
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