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http://dx.doi.org/10.14405/kjvr.20220027

Neuronal ceroid lipofuscinosis in a Border Collie: a case report  

Minsu Seo (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Yoonhoi Koo (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Dongjoon Choi (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Sanggu Kim (Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University)
Taesik Yun (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Yeon Chae (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Dohee Lee (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Hakhyun Kim (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Mhan-Pyo Yang (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Soochong Kim (Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University)
Byeong-Teck Kang (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
Publication Information
Korean Journal of Veterinary Research / v.62, no.4, 2022 , pp. 27.1-27.4 More about this Journal
Abstract
A 2-year-old spayed female Border Collie presented with visual deficits and behavioral changes. Neurological examination revealed bilateral menace response deficit with a normal pupil light reflex. Cerebral cortical thinning, cerebral sulci and cerebellar fissure widening, ventriculomegaly, and cerebral atrophy were observed on magnetic resonance imaging (MRI). Histopathology revealed fluorescent lipopigment accumulation in the cerebrum, and the dog was diagnosed with neuronal ceroid lipofuscinosis. This is the first case report describing the changes in clinical signs, MRI findings, and histopathologic changes in neuronal ceroid lipofuscinosis in Korea.
Keywords
dogs; lysosomal storage diseases; neuronal ceroid-lipofucinoses; congenital abnormalities; aggression;
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