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http://dx.doi.org/10.14405/kjvr.2021.61.e21

CD3+/CD4+/CD5+/CD8+/CD21+/CD34-/CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: a case report  

Shin, Sun Woo (College of Veterinary Medicine, Gyeongsang National University)
Lim, Yu jin (College of Industrial Science, Kongju National University)
Bae, Hyeona (College of Veterinary Medicine, Gyeongsang National University)
Kim, Jihu (College of Veterinary Medicine, Gyeongsang National University)
Cho, ARom (College of Veterinary Medicine, Gyeongsang National University)
Park, Jinho (College of Veterinary Medicine, Jeonbuk National University)
Lee, Dongbin (College of Veterinary Medicine, Gyeongsang National University)
Jung, Dong-In (College of Veterinary Medicine, Gyeongsang National University)
Kim, Sang-ki (College of Industrial Science, Kongju National University)
Yu, DoHyeon (College of Veterinary Medicine, Gyeongsang National University)
Publication Information
Korean Journal of Veterinary Research / v.61, no.3, 2021 , pp. 21.1-21.6 More about this Journal
Abstract
Canine T-zone lymphoma (TZL) is a mature T-cell lymphoma in dogs. The diagnosis and sub-classification are impossible without biopsy or immunophenotyping by flow cytometry. An 11-year-old, spayed, female Golden Retriever presented with lymph node enlargement. Clinical examination was consistent with canine multicentric lymphoma. However, immunophenotyping revealed positive for CD3, CD4, CD5, CD8, CD21, TCRαβ, and MHCII but negative for CD34, CD45, CD79a, and TCRγδ. Histopathology revealed lymphocytes expanding to the cortex-preserving architecture and thinning of the nodal capsule, and CD3 positive but PAX-5 negative. Owing to the indolent nature of TZL, careful monitoring approach without clinical intervention was utilized.
Keywords
lymphoma; flow cytometry; immunophenotyping; dog; case report;
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